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Identification of human exercise-induced myokines using secretome analysis
Open accessAbstract
Endurance exercise is associated with significant improvements in cardio-metabolic risk parameters. A role for myokines has been hypothesized, yet limited information is available about myokines induced by acute endurance exercise in humans. Therefore, the aim of the study was to identify novel exercise-induced myokines in humans. To this end, we carried out a 1 h one-legged acute endurance exercise intervention in 12 male subjects and a 12 wk exercise training intervention in 18 male subjects. Muscle biopsies were taken before and after acute exercise or exercise training and were subjected to microarray-based analysis of secreted proteins (secretome). For acute exercise, secretome analysis resulted in a list of 86 putative myokines, which was reduced to 29 by applying a fold-change cut-off of 1.5. Based on that shortlist, a selection of putative myokines was measured in the plasma by ELISA or multiplex assay. From that selection, CX3CL1 (fractalkine) and CCL2 (MCP-1) increased at both mRNA and plasma levels. From the known myokines, only IL-6 and FGF 21 changed at the mRNA level, whereas none of the known myokines changed at the plasma level. Secretome analysis of exercise training intervention resulted in a list of 69 putative myokines. Comparing putative myokines altered by acute exercise and exercise training revealed a limited overlap of only 13 genes. In conclusion, this study identified CX3CL1 and CCL2 as myokines that were induced by acute exercise at the gene expression and plasma level and that may be involved in communication between skeletal muscle and other organs.
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Metadata
- Authors
- Catoire, M., Mensink, M., Kalkhoven, E., Schrauwen, P., & Kersten, S.
- Affiliations
- Wageningen University & Research (NL)
- University Medical Center Utrecht (NL)
- Maastricht University Medical Centre (NL)
- Corresponding author
- Kersten, Sander
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2014-04-01
- Volume
- 46
- Issue
- 7
- Pages
- 256-267
- ISSN
- 1094-8341 (ISSN-L)
- 1531-2267
- OpenAlex
- W2164285684
- Cited by
- 179
- References
- 49
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 17 · 2023: 19 · 2022: 12 · 2021: 12 · 2020: 18 · 2019: 14 · 2018: 19 · 2017: 16 · 2016: 14 · 2015: 17 · 2014: 3
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Physiological Genomics (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- myokines, acute endurance exercise, exercise training, secretome, skeletal muscle, fractalkine, MCP-1, interleukin-6, FGF21, plasma biomarkers
- MeSH terms
- Adult, Enzyme-Linked Immunosorbent Assay, Humans, Male, Middle Aged, Muscle Proteins, Exercise, Muscle, Skeletal, Real-Time Polymerase Chain Reaction
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