Exercise-Released Myokines in the Control of Energy Metabolism
Open accessAbstract
Physical activity reduces cardiometabolic risk, while physical inactivity increases chronic diseases risk. This led to the idea that exercise-induced muscle contraction contributes to metabolic regulation and health. It is now well established that skeletal muscle, through the release of endocrine factors, i.e., so-called myokines, crosstalk with metabolic organs such as adipose tissue, liver and pancreas. Recent advances suggested that a number of myokines are able to modulate adipose tissue metabolism and thermogenic activity, liver endogenous glucose production and β-cell insulin secretion. This novel paradigm offers a compelling hypothesis and molecular basis to explain the link between physical inactivity and chronic diseases. Herein, we review major findings and recent advances linking exercise, myokines secretion and inter-organ crosstalk. Identifying the molecular mediators linking physical activity to metabolic health could open the path toward novel therapeutic targets in metabolic diseases.
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Exercise stimulates release of myokines and adipokines that coordinate inter-tissue communication between skeletal muscle, adipose tissue, liver, and brain.
“exercise stimulates the release of myokines and adipokines, bioactive molecules that coordinate inter-tissue communication between skeletal muscle, adipose tissue, the liver, and the brain [4].”
From Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging (2025) · cites this paper as [4]
The Introduction and Conclusion describe exercise-induced myokine secretion and communication between skeletal muscle and metabolic organs, including adipose tissue and liver. The Brain section also discusses possible muscle–brain communication. Our copy does not establish the claim that exercise stimulates adipokine release or that adipokines participate in this communication. (LLM, conf=0.88)
Experimental — accuracy not yet measuredExercise induces systemic and tissue-specific adaptations that enhance mitochondrial biogenesis, improve insulin sensitivity, modulate inflammatory pathways, and promote favorable remodeling of skeletal muscle and adipose tissue.
“Exercise induces a range of systemic and tissue-specific adaptations that enhance mitochondrial biogenesis, improve insulin sensitivity, modulate inflammatory pathways, and promote the favorable remodeling of skeletal muscle and adipose tissue [4,5,6].”
From Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging (2025) · cites this paper as [4]
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Chronic Low or High Nutrient Intake and Myokine Levels
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Sarcopenic obesity, physical activity, and their combined impact on biological aging in US adults
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Serum creatinine to cystatin C ratio in relation to heart failure with preserved ejection fraction
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The Role of Sarcopenia in Heart Failure with Depression
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- Authors
- Laurens, C., Bergouignan, A., & Moro, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2020-02-13
- Volume
- 11
- Pages
- 91-91
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC7031345
- OpenAlex
- W3005849761
- Cited by
- 159
- References
- 87
- Citations by year
- 2026: 24 · 2025: 19 · 2024: 25 · 2023: 20 · 2022: 25 · 2021: 31 · 2020: 14
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Centre National d’Etudes Spatiales
- Société Française de Nutrition
- Région Occitanie Pyrénées-Méditerranée
- National Institute of Diabetes and Digestive and Kidney Diseases (R00DK100465, P30DK048520)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- myokines, physical activity, energy metabolism, organ crosstalk, skeletal muscle, adipose tissue, thermogenesis, hepatic glucose production, insulin secretion, pancreatic beta cells, physical inactivity, cardiometabolic risk, metabolic disorders
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