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The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology
Open accessAbstract
The mitochondrial permeability transition (PT) is a permeability increase of the inner mitochondrial membrane mediated by a channel, the permeability transition pore (PTP). After a brief historical introduction, we cover the key regulatory features of the PTP and provide a critical assessment of putative protein components that have been tested by genetic analysis. The discovery that under conditions of oxidative stress the F-ATP synthases of mammals, yeast, and Drosophila can be turned into Ca 2+-dependent channels, whose electrophysiological properties match those of the corresponding PTPs, opens new perspectives to the field. We discuss structural and functional features of F-ATP synthases that may provide clues to its transition from an energy-conserving into an energy-dissipating device as well as recent advances on signal transduction to the PTP and on its role in cellular pathophysiology.
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Metadata
- Authors
- Bernardi, P., Rasola, A., Forte, M., & Lippe, G.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2015-10
- Volume
- 95
- Issue
- 4
- Pages
- 1111-1155
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2202366653
- Cited by
- 577
- References
- 52
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- green
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