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Cited by 961

The DOI matches its Crossref record; 562 of the 562 references it cites were found in a registry or an index.

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

Del Re, Dominic P., Amgalan, Dulguun, Linkermann, Andreas, Liu, Qinghang, Kitsis, Richard N.·2019·Physiological Reviews
DOI 10.1152/physrev.00022.2018
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Abstract

Twelve regulated cell death programs have been described. We review in detail the basic biology of nine including death receptor-mediated apoptosis, death receptor-mediated necrosis (necroptosis), mitochondrial-mediated apoptosis, mitochondrial-mediated necrosis, autophagy-dependent cell death, ferroptosis, pyroptosis, parthanatos, and immunogenic cell death. This is followed by a dissection of the roles of these cell death programs in the major cardiac syndromes: myocardial infarction and heart failure. The most important conclusion relevant to heart disease is that regulated forms of cardiomyocyte death play important roles in both myocardial infarction with reperfusion (ischemia/reperfusion) and heart failure. While a role for apoptosis in ischemia/reperfusion cannot be excluded, regulated forms of necrosis, through both death receptor and mitochondrial pathways, are critical. Ferroptosis and parthanatos are also likely important in ischemia/reperfusion, although it is unclear if these entities are functioning as independent death programs or as amplification mechanisms for necrotic cell death. Pyroptosis may also contribute to ischemia/reperfusion injury, but potentially through effects in non-cardiomyocytes. Cardiomyocyte loss through apoptosis and necrosis is also an important component in the pathogenesis of heart failure and is mediated by both death receptor and mitochondrial signaling. Roles for immunogenic cell death in cardiac disease remain to be defined but merit study in this era of immune checkpoint cancer therapy. Biology-based approaches to inhibit cell death in the various cardiac syndromes are also discussed.

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Crossref · 10.1152/physrev.00022.2018

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Metadata

Authors
Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q., & Kitsis, R. N.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2019-10-01
Volume
99
Issue
4
Pages
1765-1817
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00022.2018
OpenAlex
W2964712707
Cited by
961
References
562
FWCI
6.12
Type
journal article
Language
en
Open access
closed

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