Microenvironmental Determinants of Pancreatic Cancer

Retaining cell–cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer

Kondo, J., Endo, H., Okuyama, H., Ishikawa, O., Iishi, H., Tsujii, M., Ohue, M., & Inoue, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015938108 · Cited by 322

The Promise of Targeting Macrophages in Cancer Therapy

Brown, J. M., Recht, L., & Strober, S. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3122 · Cited by 321

Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

Kim, E. J., Sahai, V., Abel, E. V., Griffith, K. A., Greenson, J. K., Takebe, N., Khan, G. N., Blau, J. L., Craig, R., Balis, U. G., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1269 · Cited by 306

Stromal Cells in the Tumor Microenvironment

Denton, A. E., Roberts, E. W., & Fearon, D. T. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-78127-3_6 · Cited by 306

Periostin Creates a Tumor-Supportive Microenvironment in the Pancreas by Sustaining Fibrogenic Stellate Cell Activity

Erkan, M., Kleeff, J., Gorbachevski, A., Reiser, C., Mitkus, T., Esposito, I., Giese, T., Büchler, M. W., Giese, N. A., & Friess, H. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.031 · Cited by 305

Selective Filtering of Particles by the Extracellular Matrix: An Electrostatic Bandpass

Lieleg, O., Baumgärtel, R. M., & Bausch, A. R. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.07.009 · Cited by 304

Modulation of neutrophil granulocytes in the tumor microenvironment: Mechanisms and consequences for tumor progression

Dumitru, C. A., Lang, S., & Brandau, S. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.02.005 · Cited by 303

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

Hosein, A. N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E., Verma, U., & Brekken, R. A. (2019) · JCI Insight · doi:10.1172/jci.insight.129212 · Cited by 302

Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models

Thompson, C. B., Shepard, H. M., O'Connor, P. M., Kadhim, S., Jiang, P., Osgood, R. J., Bookbinder, L. H., Li, X., Sugarman, B. J., Connor, R. J., et al. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0470 · Cited by 298

Inter‐ and intra‐tumoural heterogeneity in cancer‐associated fibroblasts of human pancreatic ductal adenocarcinoma

Neuzillet, C., Tijeras‐Raballand, A., Ragulan, C., Cros, J., Patil, Y., Martinet, M., Erkan, M., Kleeff, J., Wilson, J., Apte, M., et al. (2019) · The Journal of Pathology · doi:10.1002/path.5224 · Cited by 295

Stromal disrupting effects of nab-paclitaxel in pancreatic cancer

Alvarez, R., Musteanu, M., Garcia-Garcia, E., Lopez-Casas, P. P., Megias, D., Guerra, C., Muñoz, M., Quijano, Y., Cubillo, A., Rodriguez-Pascual, J., et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.415 · Cited by 293

Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6Clow F4/80+ Extratumoral Macrophages

Beatty, G. L., Winograd, R., Evans, R. A., Long, K. B., Luque, S. L., Lee, J. W., Clendenin, C., Gladney, W. L., Knoblock, D. M., Guirnalda, P. D., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.010 · Cited by 293

Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed

Hurwitz, H. I., Uppal, N., Wagner, S. A., Bendell, J. C., Beck, J. T., Wade, S. M., Nemunaitis, J. J., Stella, P. J., Pipas, J. M., Wainberg, Z. A., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.61.4578 · Cited by 292

Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

Erkan, M., Reiser-Erkan, C., Michalski, C. W., Deucker, S., Sauliunaite, D., Streit, S., Esposito, I., Friess, H., & Kleeff, J. (2009) · Neoplasia · doi:10.1593/neo.81618 · Cited by 291

Nerve Dependence: From Regeneration to Cancer

Boilly, B., Faulkner, S., Jobling, P., & Hondermarck, H. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.005 · Cited by 290

The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance

Fearon, D. T. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0002 · Cited by 288

Artificial three-dimensional niches deconstruct pancreas development in vitro

Greggio, C., De Franceschi, F., Figueiredo-Larsen, M., Gobaa, S., Ranga, A., Semb, H., Lutolf, M., & Grapin-Botton, A. (2013) · Development · doi:10.1242/dev.096628 · Cited by 287

Targeting the LOX / hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

Miller, B. W., Morton, J. P., Pinese, M., Saturno, G., Jamieson, N. B., McGhee, E., Timpson, P., Leach, J., McGarry, L., Shanks, E., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404827 · Cited by 286

Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase

Weizman, N., Krelin, Y., Shabtay-Orbach, A., Amit, M., Binenbaum, Y., Wong, R. J., & Gil, Z. (2014) · Oncogene · doi:10.1038/onc.2013.357 · Cited by 281

Design considerations for nanotherapeutics in oncology

Stylianopoulos, T., & Jain, R. K. (2015) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.07.015 · Cited by 280

Collagen Type I Induces Disruption of E-Cadherin–Mediated Cell-Cell Contacts and Promotes Proliferation of Pancreatic Carcinoma Cells

Koenig, A., Mueller, C., Hasel, C., Adler, G., & Menke, A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2804 · Cited by 277

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

Wörmann, S. M., Song, L., Ai, J., Diakopoulos, K. N., Kurkowski, M. U., Görgülü, K., Ruess, D., Campbell, A., Doglioni, C., Jodrell, D., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.010 · Cited by 276

Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy

Di Caro, G., Cortese, N., Castino, G. F., Grizzi, F., Gavazzi, F., Ridolfi, C., Capretti, G., Mineri, R., Todoric, J., Zerbi, A., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309193 · Cited by 275

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Chronopoulos, A., Robinson, B., Sarper, M., Cortes, E., Auernheimer, V., Lachowski, D., Attwood, S., García, R., Ghassemi, S., Fabry, B., et al. (2016) · Nature Communications · doi:10.1038/ncomms12630 · Cited by 274

Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan

Tammi, R. H., Kultti, A., Kosma, V.-M., Pirinen, R., Auvinen, P., & Tammi, M. I. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.005 · Cited by 272

The Effect of Radiation on the Immune Response to Cancers

Park, B., Yee, C., & Lee, K.-M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15010927 · Cited by 272

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Vennin, C., Mélénec, P., Rouet, R., Nobis, M., Cazet, A. S., Murphy, K. J., Herrmann, D., Reed, D. A., Lucas, M. C., Warren, S. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10968-6 · Cited by 268

Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1

Shintani, Y., Fukumoto, Y., Chaika, N., Svoboda, R., Wheelock, M. J., & Johnson, K. R. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708137 · Cited by 267

The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

Lu, C., Paschall, A. V., Shi, H., Savage, N., Waller, J. L., Sabbatini, M. E., Oberlies, N. H., Pearce, C., & Liu, K. (2017) · Journal of the National Cancer Institute · doi:10.1093/jnci/djw283 · Cited by 266

Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance

Zhang, Y., Yan, W., Collins, M. A., Bednar, F., Rakshit, S., Zetter, B. R., Stanger, B. Z., Chung, I., Rhim, A. D., & di Magliano, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1558-t · Cited by 261

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Lomberk, G., Blum, Y., Nicolle, R., Nair, A., Gaonkar, K. S., Marisa, L., Mathison, A., Sun, Z., Yan, H., Elarouci, N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04383-6 · Cited by 261

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

Zinselmeyer, B. H., Heydari, S., Sacristán, C., Nayak, D., Cammer, M., Herz, J., Cheng, X., Davis, S. J., Dustin, M. L., & McGavern, D. B. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121416 · Cited by 258

Neural plasticity in pancreatitis and pancreatic cancer

Demir, I. E., Friess, H., & Ceyhan, G. O. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.166 · Cited by 255

Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis

Kalli, M., & Stylianopoulos, T. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00055 · Cited by 252

CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer

Neesse, A., Frese, K. K., Bapiro, T. E., Nakagawa, T., Sternlicht, M. D., Seeley, T. W., Pilarsky, C., Jodrell, D. I., Spong, S. M., & Tuveson, D. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300415110 · Cited by 246

Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis

Timmermann, B., Kerick, M., Roehr, C., Fischer, A., Isau, M., Boerno, S. T., Wunderlich, A., Barmeyer, C., Seemann, P., Koenig, J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015661 · Cited by 243

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

Bauer, C. A., Kim, E. Y., Marangoni, F., Carrizosa, E., Claudio, N. M., & Mempel, T. R. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66375 · Cited by 238

Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer

Adiseshaiah, P. P., Crist, R. M., Hook, S. S., & McNeil, S. E. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.119 · Cited by 238

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Schönhuber, N., Seidler, B., Schuck, K., Veltkamp, C., Schachtler, C., Zukowska, M., Eser, S., Feyerabend, T. B., Paul, M. C., Eser, P., et al. (2014) · Nature Medicine · doi:10.1038/nm.3646 · Cited by 237

Paracrine Regulation of Pancreatic Cancer Cell Invasion by Peripheral Nerves

Gil, Z., Cavel, O., Kelly, K., Brader, P., Rein, A., Gao, S. P., Carlson, D. L., Shah, J. P., Fong, Y., & Wong, R. J. (2010) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djp456 · Cited by 237

Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance

Dubrot, J., Duraes, F. V., Potin, L., Capotosti, F., Brighouse, D., Suter, T., LeibundGut-Landmann, S., Garbi, N., Reith, W., Swartz, M. A., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132000 · Cited by 227

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

Cedervall, J., Zhang, Y., Huang, H., Zhang, L., Femel, J., Dimberg, A., & Olsson, A.-K. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3299 · Cited by 226

Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells

Schneider, E., Schmid-Kotsas, A., Zhao, J., Weidenbach, H., Schmid, R. M., Menke, A., Adler, G., Waltenberger, J., Grünert, A., & Bachem, M. G. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.2.c532 · Cited by 225

Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread

Wong, P.-P., Demircioglu, F., Ghazaly, E., Alrawashdeh, W., Stratford, M. R. L., Scudamore, C. L., Cereser, B., Crnogorac-Jurcevic, T., McDonald, S., Elia, G., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.10.015 · Cited by 223

Collagen I Promotes Metastasis in Pancreatic Cancer by Activating c-Jun NH2-Terminal Kinase 1 and Up-regulating N-Cadherin Expression

Shintani, Y., Hollingsworth, M. A., Wheelock, M. J., & Johnson, K. R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2322 · Cited by 221

Pancreatic Stellate Cells and Pancreatic Cancer Cells: An Unholy Alliance

Vonlaufen, A., Phillips, P. A., Xu, Z., Goldstein, D., Pirola, R. C., Wilson, J. S., & Apte, M. V. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1132 · Cited by 220

A phase I dose escalation trial of tremelimumab (CP-675,206) in combination with gemcitabine in chemotherapy-naive patients with metastatic pancreatic cancer

Aglietta, M., Barone, C., Sawyer, M. B., Moore, M. J., Miller, W. H., Bagalà, C., Colombi, F., Cagnazzo, C., Gioeni, L., Wang, E., et al. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu205 · Cited by 219

Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into Checkpoint-Responsive Tumors by Reprogramming Tumor-Infiltrating MDSCs

Christmas, B. J., Rafie, C. I., Hopkins, A. C., Scott, B. A., Ma, H. S., Cruz, K. A., Woolman, S., Armstrong, T. D., Connolly, R. M., Azad, N. A., et al. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0070 · Cited by 219

Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes

Maurer, C., Holmstrom, S. R., He, J., Laise, P., Su, T., Ahmed, A., Hibshoosh, H., Chabot, J. A., Oberstein, P. E., Sepulveda, A. R., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317706 · Cited by 216

Growth inhibition of polyoma transformed cells by contact with static normal fibroblasts

Stoker, M. G. P., Shearer, M., & O’Neill, C. (1966) · Journal of Cell Science · doi:10.1242/jcs.1.3.297 · Cited by 216

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice

Jurcak, N. R., Rucki, A. A., Muth, S., Thompson, E., Sharma, R., Ding, D., Zhu, Q., Eshleman, J. R., Anders, R. A., Jaffee, E. M., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.05.065 · Cited by 215

Pharmacological targeting of the protein synthesis mTOR /4E‐ BP 1 pathway in cancer‐associated fibroblasts abrogates pancreatic tumour chemoresistance

Duluc, C., Moatassim‐Billah, S., Chalabi‐Dchar, M., Perraud, A., Samain, R., Breibach, F., Gayral, M., Cordelier, P., Delisle, M., Bousquet‐Dubouch, M., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404346 · Cited by 214

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

Hessmann, E., Patzak, M. S., Klein, L., Chen, N., Kari, V, Ramu, I., Bapiro, T. E., Frese, K. K., Gopinathan, A., Richards, F. M., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-311954 · Cited by 202

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer

Vennin, C., Murphy, K. J., Morton, J. P., Cox, T. R., Pajic, M., & Timpson, P. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.11.280 · Cited by 202

Inflammatory networks and immune surveillance of pancreatic carcinoma

Vonderheide, R. H., & Bayne, L. J. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.01.006 · Cited by 200

Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts

Nicolle, R., Blum, Y., Marisa, L., Loncle, C., Gayet, O., Moutardier, V., Turrini, O., Giovannini, M., Bian, B., Bigonnet, M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.003 · Cited by 199

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

Shimoda, M., Principe, S., Jackson, H. W., Luga, V., Fang, H., Molyneux, S. D., Shao, Y. W., Aiken, A., Waterhouse, P. D., Karamboulas, C., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3021 · Cited by 197

GM-CSF Mediates Mesenchymal–Epithelial Cross-talk in Pancreatic Cancer

Waghray, M., Yalamanchili, M., Dziubinski, M., Zeinali, M., Erkkinen, M., Yang, H., Schradle, K. A., Urs, S., Pasca Di Magliano, M., Welling, T. H., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0947 · Cited by 197

Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines.

Menke, A., Philippi, C., Vogelmann, R., Seidel, B., Lutz, M. P., Adler, G., & Wedlich, D. (2001) · PubMed · Cited by 196

TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis

Principe, D. R., DeCant, B., Mascariñas, E., Wayne, E. A., Diaz, A. M., Akagi, N., Hwang, R., Pasche, B., Dawson, D. W., Fang, D., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1293 · Cited by 196

Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis

Oudin, M. J., & Weaver, V. M. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.030817 · Cited by 196

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

Welstead, G. G., Creyghton, M. P., Bilodeau, S., Cheng, A. W., Markoulaki, S., Young, R. A., & Jaenisch, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210787109 · Cited by 194

Augmenting Antitumor Immune Responses with Epigenetic Modifying Agents

Héninger, E., Krueger, T. E. G., & Lang, J. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00029 · Cited by 194

Regulation of Pancreatic Tumor Cell Proliferation and Chemoresistance by the Histone Methyltransferase Enhancer of Zeste Homologue 2

Ougolkov, A. V., Bilim, V. N., & Billadeau, D. D. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1013 · Cited by 193

Pathology of pancreatic cancer

Haeberle, L., & Esposito, I. (2019) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2019.06.02 · Cited by 193

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

Mahajan, U. M., Langhoff, E., Goni, E., Costello, E., Greenhalf, W., Halloran, C., Ormanns, S., Kruger, S., Boeck, S., Ribback, S., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.08.009 · Cited by 192

Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas

Fendrich, V., Esni, F., Garay, M. V. R., Feldmann, G., Habbe, N., Jensen, J. N., Dor, Y., Stoffers, D., Jensen, J., Leach, S. D., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.011 · Cited by 191

A Novel Chimeric Antigen Receptor Against Prostate Stem Cell Antigen Mediates Tumor Destruction in a Humanized Mouse Model of Pancreatic Cancer

Abate-Daga, D., Lagisetty, K. H., Tran, E., Zheng, Z., Gattinoni, L., Yu, Z., Burns, W. R., Miermont, A. M., Teper, Y., Rudloff, U., et al. (2014) · Human Gene Therapy · doi:10.1089/hum.2013.209 · Cited by 191

Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice

Seifert, L., Werba, G., Tiwari, S., Giao Ly, N. N., Nguy, S., Alothman, S., Alqunaibit, D., Avanzi, A., Daley, D., Barilla, R., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.070 · Cited by 190

Understanding Metastasis in Pancreatic Cancer: A Call for New Clinical Approaches

Tuveson, D. A., & Neoptolemos, J. P. (2012) · Cell · doi:10.1016/j.cell.2011.12.021 · Cited by 188

CD10+ Pancreatic Stellate Cells Enhance the Progression of Pancreatic Cancer

Ikenaga, N., Ohuchida, K., Mizumoto, K., Cui, L., Kayashima, T., Morimatsu, K., Moriyama, T., Nakata, K., Fujita, H., & Tanaka, M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.084 · Cited by 186

Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence

Reimann, M., Lee, S., Loddenkemper, C., Dörr, J. R., Tabor, V., Aichele, P., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.043 · Cited by 184

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

Nagathihalli, N. S., Castellanos, J. A., Shi, C., Beesetty, Y., Reyzer, M. L., Caprioli, R., Chen, X., Walsh, A. J., Skala, M. C., Moses, H. L., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.058 · Cited by 184

Lack of immunoediting in murine pancreatic cancer reversed with neoantigen

Evans, R. A., Diamond, M. S., Rech, A. J., Chao, T., Richardson, M. W., Lin, J. H., Bajor, D. L., Byrne, K. T., Stanger, B. Z., Riley, J. L., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88328 · Cited by 180

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors

Djurec, M., Graña, O., Lee, A., Troulé, K., Espinet, E., Cabras, L., Navas, C., Blasco, M. T., Martín-Díaz, L., Burdiel, M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717802115 · Cited by 178

The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer

Boone, B. A., Orlichenko, L., Schapiro, N. E., Loughran, P., Gianfrate, G. C., Ellis, J. T., Singhi, A. D., Kang, R., Tang, D., Lotze, M. T., et al. (2015) · Cancer Gene Therapy · doi:10.1038/cgt.2015.21 · Cited by 172

Orthotopic Transplantation Models of Pancreatic Adenocarcinoma Derived From Cell Lines and Primary Tumors and Displaying Varying Metastatic Activity

Loukopoulos, P., Kanetaka, K., Takamura, M., Shibata, T., Sakamoto, M., & Hirohashi, S. (2004) · Pancreas · doi:10.1097/00006676-200410000-00004 · Cited by 172

What We Have Learned About Pancreatic Cancer From Mouse Models

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Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma

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