The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond

Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

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TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo

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Elimination of Antigen-Presenting Cells and Autoreactive T Cells by Fas Contributes to Prevention of Autoimmunity

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The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

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Intrinsic Lymphotoxin-β Receptor Requirement for Homeostasis of Lymphoid Tissue Dendritic Cells

Kabashima, K., Banks, T. A., Ansel, K. M., Lu, T. T., Ware, C. F., & Cyster, J. G. (2005) · Immunity · doi:10.1016/j.immuni.2005.02.007 · Cited by 327

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

James, J. R., & Vale, R. D. (2012) · Nature · doi:10.1038/nature11220 · Cited by 323

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

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RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

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Fas engagement induces neurite growth through ERK activation and p35 upregulation

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Persistent efficacy of anakinra in patients with tumor necrosis factor receptor–associated periodic syndrome

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Antitumor effect of locally produced CD95 ligand

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Two-Amino Acid Molecular Switch in an Epithelial Morphogen That Regulates Binding to Two Distinct Receptors

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Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma

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RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers

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Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

Takeda, I., Ine, S., Killeen, N., Ndhlovu, L. C., Murata, K., Satomi, S., Sugamura, K., & Ishii, N. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3580 · Cited by 308

Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial)

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Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

Amakawa, R., Hakem, A., Kundig, T. M., Matsuyama, T., Simard, J. J. L., Timms, E., Wakeham, A., Mittruecker, H.-W., Griesser, H., Takimoto, H., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81031-4 · Cited by 305

A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease.

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The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes

Smahi, A. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.20.2371 · Cited by 300

Expression, Localization, and Functional Activity of TL1A, a Novel Th1-Polarizing Cytokine in Inflammatory Bowel Disease

Bamias, G., Martin, C., Marini, M., Hoang, S., Mishina, M., Ross, W. G., Sachedina, M. A., Friel, C. M., Mize, J., Bickston, S. J., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4868 · Cited by 299

Immune regulation by 4‐1BB and 4‐1BBL: complexities and challenges

Wang, C., Lin, G. H. Y., McPherson, A. J., & Watts, T. H. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00765.x · Cited by 298

Identification and functional characterization of DR6, a novel death domain‐containing TNF receptor

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Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases

Croft, M., & Siegel, R. M. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.22 · Cited by 288

Signaling by the tumor necrosis factor receptor superfamily in B‐cell biology and disease

Rickert, R. C., Jellusova, J., & Miletic, A. V. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01067.x · Cited by 285

Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells

Kanamaru, F., Youngnak, P., Hashiguchi, M., Nishioka, T., Takahashi, T., Sakaguchi, S., Ishikawa, I., & Azuma, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7306 · Cited by 285

CD95 ligand induces motility and invasiveness of apoptosis‐resistant tumor cells

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c-FLIPR, a New Regulator of Death Receptor-induced Apoptosis

Golks, A., Brenner, D., Fritsch, C., Krammer, P. H., & Lavrik, I. N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414425200 · Cited by 282

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

Mahmud, S. A., Manlove, L. S., Schmitz, H. M., Xing, Y., Wang, Y., Owen, D. L., Schenkel, J. M., Boomer, J. S., Green, J. M., Yagita, H., et al. (2014) · Nature Immunology · doi:10.1038/ni.2849 · Cited by 281

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

Ermolaeva, M. A., Michallet, M.-C., Papadopoulou, N., Utermöhlen, O., Kranidioti, K., Kollias, G., Tschopp, J., & Pasparakis, M. (2008) · Nature Immunology · doi:10.1038/ni.1638 · Cited by 281

Structural principles of tumor necrosis factor superfamily signaling

Vanamee, É. S., & Faustman, D. L. (2018) · Science Signaling · doi:10.1126/scisignal.aao4910 · Cited by 280

Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

Li, H., Kobayashi, M., Blonska, M., You, Y., & Lin, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600620200 · Cited by 277

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

Wang, L., Yang, J. K., Kabaleeswaran, V., Rice, A. J., Cruz, A. C., Park, A. Y., Yin, Q., Damko, E., Jang, S. B., Raunser, S., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1920 · Cited by 276

TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-κB

Ehrhardt, H., Fulda, S., Schmid, I., Hiscott, J., Debatin, K.-M., & Jeremias, I. (2003) · Oncogene · doi:10.1038/sj.onc.1206520 · Cited by 272

B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses

Xu, S., & Lam, K.-P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.4067-4074.2001 · Cited by 267

Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling

Chen, W., Zhou, Z., Li, L., Zhong, C.-Q., Zheng, X., Wu, X., Zhang, Y., Ma, H., Huang, D., Li, W., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.435545 · Cited by 266

Nonredundant Function of Soluble LTα 3 Produced by Innate Lymphoid Cells in Intestinal Homeostasis

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Targeted Disruption of LIGHT Causes Defects in Costimulatory T Cell Activation and Reveals Cooperation with Lymphotoxin β in Mesenteric Lymph Node Genesis

Scheu, S., Alferink, J., Pötzel, T., Barchet, W., Kalinke, U., & Pfeffer, K. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020215 · Cited by 260

TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation

Takedatsu, H., Michelsen, K. S., Wei, B., Landers, C. J., Thomas, L. S., Dhall, D., Braun, J., & Targan, S. R. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.037 · Cited by 254

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.

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Gene transfer of Fas ligand induces tumor regression in vivo

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Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis

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Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation

Walczak, H. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008698 · Cited by 242

Fas engagement accelerates liver regeneration after partial hepatectomy

Desbarats, J., & Newell, M. K. (2000) · Nature Medicine · doi:10.1038/78688 · Cited by 241

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

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Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion

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CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

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Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

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Constitutive Expression of LIGHT on T Cells Leads to Lymphocyte Activation, Inflammation, and Tissue Destruction

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Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS)

Lobito, A. A., Kimberley, F. C., Muppidi, J. R., Komarow, H., Jackson, A. J., Hull, K. M., Kastner, D. L., Screaton, G. R., & Siegel, R. M. (2006) · Blood · doi:10.1182/blood-2005-11-006783 · Cited by 229

FLIPL induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

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The TNF-Family Receptor DR3 is Essential for Diverse T Cell-Mediated Inflammatory Diseases

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Solution of the Structure of the TNF-TNFR2 Complex

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Regulation of cell surface APO‐1/Fas (CD95) ligand expression by metalloproteases

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The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

Pobezinskaya, Y. L., Kim, Y.-S., Choksi, S., Morgan, M. J., Li, T., Liu, C., & Liu, Z. (2008) · Nature Immunology · doi:10.1038/ni.1639 · Cited by 216

TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration

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The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System

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Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis

Hao, Z., Duncan, G. S., Seagal, J., Su, Y.-W., Hong, C., Haight, J., Chen, N.-J., Elia, A., Wakeham, A., Li, W. Y., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.016 · Cited by 212

During Viral Infection of the Respiratory Tract, CD27, 4-1BB, and OX40 Collectively Determine Formation of CD8+ Memory T Cells and Their Capacity for Secondary Expansion

Hendriks, J., Xiao, Y., Rossen, J. W. A., van der Sluijs, K. F., Sugamura, K., Ishii, N., & Borst, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1665 · Cited by 212

Molecular aspects of hypohidrotic ectodermal dysplasia

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Permanent correction of an inherited ectodermal dysplasia with recombinant EDA

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Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor Ox40

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TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses

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The costimulation-regulated duration of PKB activation controls T cell longevity

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Src kinase phosphorylates Caspase‐8 on Tyr380: a novel mechanism of apoptosis suppression

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Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

Zheng, C., Kabaleeswaran, V., Wang, Y., Cheng, G., & Wu, H. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.009 · Cited by 205

CD40–CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4 + T cells

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Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

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Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2- and TRAF5-mediated NF-κB Activation

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Lymphotoxin Controls the IL-22 Protection Pathway in Gut Innate Lymphoid Cells during Mucosal Pathogen Challenge

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GENETIC DISORDERS OF PROGRAMMED CELL DEATH IN THE IMMUNE SYSTEM

Bidère, N., Su, H. C., & Lenardo, M. J. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090513 · Cited by 197

Role of CD27/CD70 pathway of activation in immunity and tolerance

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Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells

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Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome

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TRAF Proteins in CD40 Signaling

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Multiple signaling pathways promote B lymphocyte stimulator–dependent B-cell growth and survival

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A Novel Mechanism of TRAF Signaling Revealed by Structural and Functional Analyses of the TRADD–TRAF2 Interaction

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NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

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Targeting B-Cell Maturation Antigen in Multiple Myeloma

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The coevolution of gene family trees

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Reconstitution of the Death-Inducing Signaling Complex Reveals a Substrate Switch that Determines CD95-Mediated Death or Survival

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Cachetin/TNF-α in Septic Shock and Septic Adult Respiratory Distress Syndrome

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Fas–Fas Ligand: Checkpoint of T Cell Functions in Multiple Sclerosis

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Demyelination and other neurological adverse events after anti-TNF therapy

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Autoinflammatory Diseases with Periodic Fevers

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Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma

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The CD27–CD70 pathway and pathogenesis of autoimmune disease

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Enhanced CD4+ T Cell Proliferation and Th2 Cytokine Production in DR6-Deficient Mice

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Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease

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Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Mediated Proliferation of Tumor Cells with Receptor-Proximal Apoptosis Defects

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Smac mimetics as IAP antagonists

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B Cell and BAFF Dependence of IFN-α–Exaggerated Disease in Systemic Lupus Erythematosus-Prone NZM 2328 Mice

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Complete Loss of Fas Ligand Gene Causes Massive Lymphoproliferation and Early Death, Indicating a Residual Activity of gld Allele

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GITR+ regulatory T cells in the treatment of autoimmune diseases

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The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways

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Erratum: The role of CD95 and CD95 ligand in cancer

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Emerging Functions of RANKL in Lymphoid Tissues

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Aspects of the tabby—crinkled—downless syndrome : I.The development of tabby teeth

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Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency

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B‐cell responses to B‐cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta

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The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator

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RANKL/RANK: from bone loss to the prevention of breast cancer

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The Critical Role of LIGHT, a TNF Family Member, in T Cell Development

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The Role of TL1A and DR3 in Autoimmune and Inflammatory Diseases

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TWEAK/Fn14 Pathway: A Nonredundant Role in Intestinal Damage in Mice Through a TWEAK/Intestinal Epithelial Cell Axis

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Formation of Virus-like Clusters Is an Intrinsic Property of the Tumor Necrosis Factor Family Member BAFF (B Cell Activating Factor)

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The CD95/CD95L signaling pathway: A role in carcinogenesis

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A Totally Sex-linked Gene in the House Mouse

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Neutralization of Membrane TNF, but Not Soluble TNF, Is Crucial for the Treatment of Experimental Colitis

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CD95 in cancer: tool or target?

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Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction

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XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway

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The role of CD27 in anti-viral T-cell immunity

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Key facts and hot spots on tumor necrosis factor receptor‐associated periodic syndrome

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Atlas of the plasma proteome in health and disease in 53,026 adults

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Tumor Necrosis Factor Receptors: Pleiotropic Signaling Complexes and Their Differential Effects

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Cytokine and Chemokine Signals of T‐Cell Exclusion in Tumors

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Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury

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