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The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond
Open accessAbstract
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF) include 19 ligands and 29 receptors that play important roles in the modulation of cellular functions. The communication pathways mediated by TNFSF/TNFRSF are essential for numerous developmental, homeostatic, and stimulus-responsive processes in vivo. TNFSF/TNFRSF members regulate cellular differentiation, survival, and programmed death, but their most critical functions pertain to the immune system. Both innate and adaptive immune cells are controlled by TNFSF/TNFRSF members in a manner that is crucial for the coordination of various mechanisms driving either co-stimulation or co-inhibition of the immune response. Dysregulation of these same signaling pathways has been implicated in inflammatory and autoimmune diseases, highlighting the importance of their tight regulation. Investigation of the control of TNFSF/TNFRSF activities has led to the development of therapeutics with the potential to reduce chronic inflammation or promote anti-tumor immunity. The study of TNFSF/TNFRSF proteins has exploded over the last 30 yr, but there remains a need to better understand the fundamental mechanisms underlying the molecular pathways they mediate to design more effective anti-inflammatory and anti-cancer therapies.
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The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo
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Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers
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Atlas of the plasma proteome in health and disease in 53,026 adults
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Cytokine and Chemokine Signals of T‐Cell Exclusion in Tumors
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Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms
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Metadata
- Authors
- Dostert, C., Grusdat, M., Letellier, E., & Brenner, D.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2019-01-01
- Volume
- 99
- Issue
- 1
- Pages
- 115-160
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2898567584
- Cited by
- 498
- References
- 469
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.