The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Sodium/Calcium Exchange: Its Physiological Implications
Abstract
The Na+/Ca 2+exchanger, an ion transport protein, is expressed in the plasma membrane (PM) of virtually all animal cells. It extrudes Ca 2+in parallel with the PM ATP-driven Ca 2+pump. As a reversible transporter, it also mediates Ca 2+entry in parallel with various ion channels. The energy for net Ca 2+transport by the Na+/Ca 2+exchanger and its direction depend on the Na+, Ca 2+, and K+gradients across the PM, the membrane potential, and the transport stoichiometry. In most cells, three Na+are exchanged for one Ca 2+. In vertebrate photoreceptors, some neurons, and certain other cells, K+is transported in the same direction as Ca 2+, with a coupling ratio of four Na+to one Ca 2+plus one K+. The exchanger kinetics are affected by nontransported Ca 2+, Na+, protons, ATP, and diverse other modulators. Five genes that code for the exchangers have been identified in mammals: three in the Na+/Ca 2+exchanger family ( NCX1, NCX2, and NCX3) and two in the Na+/Ca 2+plus K+family ( NCKX1 and NCKX2). Genes homologous to NCX1 have been identified in frog, squid, lobster, and Drosophila. In mammals, alternatively spliced variants of NCX1 have been identified; dominant expression of these variants is cell type specific, which suggests that the variations are involved in targeting and/or functional differences. In cardiac myocytes, and probably other cell types, the exchanger serves a housekeeping role by maintaining a low intracellular Ca 2+concentration; its possible role in cardiac excitation-contraction coupling is controversial. Cellular increases in Na+concentration lead to increases in Ca 2+concentration mediated by the Na+/Ca 2+exchanger; this is important in the therapeutic action of cardiotonic steroids like digitalis. Similarly, alterations of Na+and Ca 2+apparently modulate basolateral K+conductance in some epithelia, signaling in some special sense organs (e.g., photoreceptors and olfactory receptors) and Ca 2+-dependent secretion in neurons and in many secretory cells. The juxtaposition of PM and sarco(endo)plasmic reticulum membranes may permit the PM Na+/Ca 2+exchanger to regulate sarco(endo)plasmic reticulum Ca 2+stores and influence cellular Ca 2+signaling.
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Citations
Cites
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“Both NCKX1 and NCKX2 are distantly related to the gene family of the more common potassium-independent Na–Ca exchangers (NCX) (Schwarz and Benzer, 1997) [for a recent review on NCX, see Blaustein and Lederer (1999)].”
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Metadata
- Authors
- Blaustein, M. P., & Lederer, W. J.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 1999-07-01
- Volume
- 79
- Issue
- 3
- Pages
- 763-854
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2335815721
- Cited by
- 1,736
- References
- 4
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
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