Irisin and myonectin regulation in the insulin resistant muscle: implications to adipose tissue: muscle crosstalk

Gamas, Luis; Matafome, Paulo; Seiça, Raquel

doi:10.1155/2015/359159

Cited by 114Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses

Irisin and myonectin regulation in the insulin resistant muscle: implications to adipose tissue: muscle crosstalk

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Gamas, Luis, Matafome, Paulo, Seiça, Raquel·2015·Journal of Diabetes Research

DOI 10.1155/2015/359159PMC PMC4436512

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Abstract

Myokines are peptides produced and secreted by the skeletal muscle, with autocrine, paracrine, and endocrine actions. Many of them are overexpressed during physical exercise and appear to contribute to the benefits of exercise to metabolic homeostasis. Irisin, resulting from the cleavage of the membrane protein FNDC5, was shown to induce adipocyte browning, with increased lipid oxidation and thermogenesis. Myonectin was only recently discovered and initial studies revealed a role in fatty acid uptake and oxidation in adipose tissue and liver. However, the mechanisms of their regulation by exercise are not entirely established. Impaired secretion and action of myokines, such as irisin and myonectin, may have a role in the establishment of insulin resistance. On the other hand, several studies have shown that insulin resistance in the skeletal muscle may change myokines expression and secretion. This may have consequences on lipid and glucose metabolism in adipose tissue and lead to a vicious cycle between impaired myokines production and insulin resistance. This review summarizes the current knowledge about the influence of skeletal muscle insulin resistance on the secretion of irisin and myonectin, as well as its impact on adipose tissue metabolism.

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Myonectin, as well as irisin, promotes glucose and fatty acid uptake and oxidation in both the liver and adipose tissue, acting more specifically on lipid metabolism mediated by CD36, FATP, and FABP4, but not participating in lipolysis and glucose homeostasis.
“In summary, myonectin, as well as irisin, promote glucose and fatty acid uptake and oxidation in both the liver and AT, acting more specifically on lipid metabolism mediated by CD36, fatty acid transporter protein (FATP) and fatty acid binding protein (FABP4), but not participating in lipolysis and glucose homeostasis (Gamas et al., 2015).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Gamas et al., 2015
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Association between irisin and homocysteine in euglycemic and diabetic subjects
Alis, R., Sanchis‐Gomar, F., Pareja-Galeano, H., Mijares, A. H., Romagnoli, M., Víctor, V. M., & Rocha, M. (2014) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2014.08.017 · Cited by 37 · see citing works
Influence of exercise training and age on uncoupling protein mRNA expression in brown adipose tissue
Scarpace, P. J., Yenice, S., & Tümer, N. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90264-x · Cited by 36 · see citing works

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Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases
Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382 · see citing works
“It is fundamental to characterize molecules that may present a function mimicking the effects of physical exercise and consequently positively modulating lipid homeostasis and lipogenesis in AT (Gamas et al., 2015).”
Background
Muscle function and fat content in relation to sarcopenia, obesity and frailty of old age — An overview
Buch, A., Carmeli, E., Boker, L. K., Marcus, Y., Shefer, G., Kis, O., Berner, Y., & Stern, N. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.01.008 · Cited by 227 · see citing works
Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation
Mazur-Bialy, A. I., Pocheć, E., & Zarawski, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040701 · Cited by 203 · see citing works
Regulation of myokine expression: Role of exercise and cellular stress
Ost, M., Coleman, V., Kasch, J., & Klaus, S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.018 · Cited by 131 · see citing works
Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives
Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129 · see citing works
Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions
Muñoz, I. Y. M., Camarillo-Romero, E. D. S., & Garduño‐García, J. D. J. (2018) · International Journal of Endocrinology · doi:10.1155/2018/7816806 · Cited by 116 · see citing works
A new paradigm in sarcopenia: Cognitive impairment caused by imbalanced myokine secretion and vascular dysfunction
Jo, D., Yoon, G., Kim, O. Y., & Song, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112636 · Cited by 83 · see citing works
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works
Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin
Park, E. J., Myint, P. K., Ito, A., Appiah, M. G., Darkwah, S. O., Kawamoto, E., & Shimaoka, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.588066 · Cited by 80 · see citing works
Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway
Ye, X., Shen, Y., Ni, C., Ye, J., Xin, Y., Zhang, W., & Ren, Y. (2019) · Peptides · doi:10.1016/j.peptides.2019.170120 · Cited by 72 · see citing works
Skeletal Muscle Dysfunction in the Development and Progression of Nonalcoholic Fatty Liver Disease
Altajar, S., & Baffy, G. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00065 · Cited by 70 · see citing works
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics
Shroff, T., Aina, K. O., Maaß, C., Cipriano, M., Lambrecht, J., Tacke, F., Mosig, A. S., & Loskill, P. (2022) · Open Biology · doi:10.1098/rsob.210333 · Cited by 69 · see citing works
The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial
Hadi, A., Arab, A., Hajianfar, H., Talaei, B., Miraghajani, M. S., Babajafari, S., Marx, W., & Tavakoly, R. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102315 · Cited by 67 · see citing works
Myokines: a descriptive review
Barbalho, S. M., Neto, E. V. P., Goulart, R. D. Á., Bechara, M. D., Chagas, E. F. B., Audi, M., Campos, L. M. G., Guiguer, É. L., Buchaim, R. L., Buchaim, D. V., et al. (2020) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.20.10884-3 · Cited by 67 · see citing works
Taurine supplementation associated with exercise increases mitochondrial activity and fatty acid oxidation gene expression in the subcutaneous white adipose tissue of obese women
de Carvalho, F. G., Brandão, C., Batitucci, G., Souza, A. D. O., Ferrari, G. D., Alberici, L. C., Muñoz, V. R., Pauli, J. R., de Moura, L. P., Ropelle, E. R., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.09.044 · Cited by 64 · see citing works
Irisin: A Potential Link between Physical Exercise and Metabolism—An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People
Benedini, S., Dozio, E., Invernizzi, P. L., Vianello, E., Banfi, G., Terruzzi, I. M., Luzi, L., & Romanelli, M. M. C. (2017) · Journal of Diabetes Research · doi:10.1155/2017/1039161 · Cited by 63 · see citing works
Uncovering the Role of p38 Family Members in Adipose Tissue Physiology
Leiva, M., Matesanz, N., Pulgarín-Alfaro, M., Nikolić, I., & Sabio, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.572089 · Cited by 58 · see citing works
Green cardamom supplementation improves serum irisin, glucose indices, and lipid profiles in overweight or obese non-alcoholic fatty liver disease patients: a double-blind randomized placebo-controlled clinical trial
Daneshi‐Maskooni, M., Keshavarz, S. A., Qorbani, M., Mansouri, S., Alavian, S. M., Badri-Fariman, M., Jazayeri-Tehrani, S. A., & Sotoudeh, G. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2465-0 · Cited by 57 · see citing works
Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus
Elizondo‐Montemayor, L., González-Gil, A. M., Tamez‐Rivera, O., Toledo‐Salinas, C., Peschard-Franco, M., Rodríguez-Gutiérrez, N. A., Silva‐Platas, C., & García‐Rivas, G. (2019) · Mediators of Inflammation · doi:10.1155/2019/6737318 · Cited by 55 · see citing works
Adipose may actively delay progression of NAFLD by releasing tumor‐suppressing, anti‐fibrotic miR ‐122 into circulation
Baranova, A. V., Maltseva, D. V., & Tonevitsky, A. (2018) · Obesity Reviews · doi:10.1111/obr.12765 · Cited by 52 · see citing works
Current Evidence of the Role of the Myokine Irisin in Cancer
Tsiani, E., Tsakiridis, N., Kouvelioti, R., Jaglanian, A., & Klentrou, P. (2021) · Cancers · doi:10.3390/cancers13112628 · Cited by 51 · see citing works
The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype
Hwang, Y., Jeon, W. S., Park, C., & Youn, B. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0319-8 · Cited by 51 · see citing works
Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression
Brun, J., Berthou, F., Trajkovski, M., Maechler, P., Foti, M., & Bonnet, N. (2017) · Diabetes · doi:10.2337/db17-0116 · Cited by 47 · see citing works
Relationship between grip strength and newly diagnosed nonalcoholic fatty liver disease in a large-scale adult population
Meng, G., Wu, H., Fang, L., Li, C., Yu, F., Zhang, Q., Liu, L., Du, H., Shi, H., Xia, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep33255 · Cited by 46 · see citing works
Dihydromyricetin delays the onset of hyperglycemia and ameliorates insulin resistance without excessive weight gain in Zucker diabetic fatty rats
Liu, L., Wan, J., Lang, H., Si, M., Zhu, J., Zhou, Y. G., & Mi, M. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.10.028 · Cited by 45 · see citing works
Elevated circulating irisin is associated with lower risk of insulin resistance: association and path analyses of obese Chinese adults
Shi, X., Lin, M., Liu, C., Xiao, F., Liu, Y., Huang, P., Zeng, X. Y., Yan, B., Liu, S., Li, X., et al. (2016) · BMC Endocrine Disorders · doi:10.1186/s12902-016-0123-9 · Cited by 42 · see citing works
Synergistic effect of carnosine on browning of adipose tissue in exercised obese rats; a focus on circulating irisin levels
Schaalan, M. F., Ramadan, B. K., & Elwahab, A. H. A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26370 · Cited by 42 · see citing works
The C1q/TNF-related proteins (CTRPs) in pathogenesis of obesity-related metabolic disorders: Focus on type 2 diabetes and cardiovascular diseases
Shanaki, M., Shabani, P., Goudarzi, A., Omidifar, A., Bashash, D., & Emamgholipour, S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117913 · Cited by 38 · see citing works
Association of handgrip strength with the prevalence of metabolic syndrome in US adults: the national health and nutrition examination survey
Ji, C., Xia, Y., Tong, S., Wu, Q., & Zhao, Y. (2020) · Aging · doi:10.18632/aging.103097 · Cited by 35 · see citing works
Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
de Carvalho, F. G., Brandão, C., Muñoz, V. R., Batitucci, G., Tavares, M. E. A., Teixeira, G. R., Pauli, J. R., de Moura, L. P., Ropelle, E. R., Cintra, D. E., et al. (2021) · Amino Acids · doi:10.1007/s00726-021-03041-4 · Cited by 35 · see citing works
New insight of obesity-associated NAFLD: Dysregulated “crosstalk” between multi-organ and the liver?
Wang, Y., Wu, L.-L., Qi, X.-Y., Wang, Y.-Y., Liao, Z., Liu, J., & Xiao, X. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2021.12.013 · Cited by 35 · see citing works
The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial
Daneshi‐Maskooni, M., Keshavarz, S. A., Mansouri, S., Qorbani, M., Alavian, S. M., Badri-Fariman, M., Jazayeri-Tehrani, S. A., & Sotoudeh, G. (2017) · Trials · doi:10.1186/s13063-017-1979-3 · Cited by 33 · see citing works
The Effect of n-3 Polyunsaturated Fatty Acids Supplementation on Serum Irisin in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial
Ansari, S., Djalali, M., Honarvar, N. M., Mazaherioun, M., Zarei, M., Agh, F., Gholampour, Z., & Javanbakht, M. H. (2017) · Intern J Endocrinol Metab · doi:10.5812/ijem.40614 · Cited by 34 · see citing works
Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation
Zhou, N., Gong, L., Zhang, E., & Wang, X. (2024) · PeerJ · doi:10.7717/peerj.17267 · Cited by 34 · see citing works
High-intensity interval training improved fasting blood glucose and lipid profiles in type 2 diabetic rats more than endurance training; possible involvement of irisin and betatrophin
Amri, J., Parastesh, M., Sadegh, M., Latifi, S. A., & Alaee, M. (2019) · Physiology International · doi:10.1556/2060.106.2019.24 · Cited by 32 · see citing works
The Effect of Exercise Training on Irisin Secretion in Patients with Type 2 Diabetes: A Systematic Review
Vecchiato, M., Zanardo, E., Battista, F., Quinto, G., Bergia, C., Palermi, S., Duregon, F., Ermolao, A., & Neunhäeuserer, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010062 · Cited by 32 · see citing works
Role of irisin in effects of chronic exercise on muscle and bone in ovariectomized mice
Kawao, N., Iemura, S., Kawaguchi, M., Mizukami, Y., Takafuji, Y., & Kaji, H. (2021) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01201-2 · Cited by 30 · see citing works
Bone Muscle Crosstalk in Spinal Cord Injuries: Pathophysiology and Implications for Patients’ Quality of Life
Invernizzi, M., Alessandro de, S. I. R. E., Carda, S., Venetis, K., Renò, F., Cisari, C., & Fusco, N. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00601-7 · Cited by 29 · see citing works
The influence of concurrent training intensity on serum irisin and abdominal fat in postmenopausal women
Rashti, B. A., Mehrabani, J., Damirchi, A., & Babaei, P. (2019) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2019.90810 · Cited by 28 · see citing works
Involvement of the p62/Nrf2/HO-1 pathway in the browning effect of irisin in 3T3-L1 adipocytes
Tsai, Y.-C., Wang, C.-W., Wen, B.-Y., Hsieh, P., Lee, Y., Yen, M., & Cheng, P. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110915 · Cited by 25 · see citing works
Targeting White Adipose Tissue with Exercise or Bariatric Surgery as Therapeutic Strategies in Obesity
de Carvalho, F. G., & Sparks, L. M. (2019) · Biology · doi:10.3390/biology8010016 · Cited by 24 · see citing works
Muscle as an Endocrine Organ
Legaard, G. E., & Pedersen, B. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814593-7.00013-x · Cited by 24 · see citing works
Relationship Between Handgrip Strength and Nonalcoholic Fatty Liver Disease: Nationwide Surveys
Lee, K. (2018) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2018.0077 · Cited by 23 · see citing works
Serum irisin levels in patients with psoriasis
Baran, A. M., Myśliwiec, H., Kiluk, P., Świderska, M., & Flisiak, I. (2016) · Journal of Dermatological Treatment · doi:10.1080/09546634.2016.1254327 · Cited by 22 · see citing works
Switching off the furnace: brown adipose tissue and lactation
Król, E., & Speakman, J. R. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.06.003 · Cited by 21 · see citing works
Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus
Xuan, X., Lin, J., Zhang, Y., Zhou, L., Xu, L., Jia, J., Zhao, B., Lin, Z., Zhu, Q. N., Li, L., et al. (2020) · Journal of Clinical Medicine Research · doi:10.14740/jocmr4261 · Cited by 21 · see citing works
Relationship between Grip Strength and Nonalcoholic Fatty Liver Disease in Men Living with HIV Referred to a Metabolic Clinic
Debroy, P., Lake, J. E., Malagoli, A., & Guaraldi, G. (2019) · The Journal of Frailty & Aging · doi:10.14283/jfa.2018.37 · Cited by 20 · see citing works
Comparative effects of high-intensity interval training and moderate-intensity continuous training on soleus muscle fibronectin type III domain-containing protein 5, myonectin and glucose transporter type 4 gene expressions: a study on the diabetic rat model
Rahmati-Ahmadabad, S., Rostamkhani, F., Meftahi, G. H., & Shirvani, H. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06633-1 · Cited by 18 · see citing works
Myokines: Novel therapeutic targets for diabetic nephropathy
Yang, M., Luo, S., Yang, J., Chen, W., He, L., Liu, D., Zhao, L., & Wang, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1014581 · Cited by 18 · see citing works
Myonectin inhibits the differentiation of osteoblasts and osteoclasts in mouse cells
Kawaguchi, M., Kawao, N., Takafuji, Y., Ishida, M., & Kaji, H. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03967 · Cited by 16 · see citing works
Circulating Irisin Is Reduced in Male Patients with Type 1 and Type 2 Myotonic Dystrophies
Dozio, E., Passeri, E., Cardani, R., Benedini, S., Aresta, C., Valaperta, R., Romanelli, M. M. C., Meola, G., Sansone, V., & Corbetta, S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00320 · Cited by 16 · see citing works
Biomarkers of Atrial Fibrillation Recurrence in Patients with Paroxysmal or Persistent Atrial Fibrillation Following External Direct Current Electrical Cardioversion
Demirel, O., Berezin, A. Е., Mirna, M., Boxhammer, E., Gharibeh, S. X., Hoppe, U. C., & Lichtenauer, M. (2023) · Biomedicines · doi:10.3390/biomedicines11051452 · Cited by 15 · see citing works
Obesity, Osteoarthritis, and Myokines: Balancing Weight Management Strategies, Myokine Regulation, and Muscle Health
Timofte, D. V., Tudor, R. C., Mocanu, V., & Labusca, L. S. (2024) · Nutrients · doi:10.3390/nu16234231 · Cited by 15 · see citing works
Irisin and Cardiometabolic Disorders in Obesity: A Systematic Review
Pinho, J. D. S., Camacho, F. A., Cavararo, C. D. S., Baião, P. F., Medeiros, R. F., Barroso, S. G., & de Matos, A. C. (2023) · International Journal of Inflammation · doi:10.1155/2023/5810157 · Cited by 14 · see citing works
Factors Associated With Changes in Body Composition Shortly After Orthotopic Liver Transplantation
Brito-Costa, A., Pereira‐da‐Silva, L., Papoila, A. L., Alves, M., Mateus, É., Nolasco, F. E. B., & Barroso, E. (2016) · Transplantation · doi:10.1097/tp.0000000000001202 · Cited by 14 · see citing works
The overall computer/mobile devices usage time is related to newly diagnosed non-alcoholic fatty liver disease: a population-based study
Meng, G., Liu, F., Fang, L., Li, C., Zhang, Q., Liu, L., Wu, H., Du, H., Shi, H., Xia, Y., et al. (2016) · Annals of Medicine · doi:10.1080/07853890.2016.1219454 · Cited by 13 · see citing works
The interrelationship between physical activity and metabolic regulation of breast cancer progression in obesity via cytokine control
Guennec, D. L., & Rossary, A. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.02.001 · Cited by 12 · see citing works
Possible Mechanisms Linking Obesity, Steroidogenesis, and Skeletal Muscle Dysfunction
Sheptulina, A. F., Antyukh, K. Y., Kiselev, A. R., Mitkovskaya, N. P., & Drapkina, O. M. (2023) · Life · doi:10.3390/life13061415 · Cited by 11 · see citing works
Managing complexity: Dealing with systemic crosstalk in bovine physiology
Bradford, B. J., Yuan, K., & Ylioja, C. M. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-10271 · Cited by 11 · see citing works
Skeletal muscle as a protagonist in the pregnancy metabolic syndrome
Narváez-Sánchez, R., Calderón, J. C., Vega, G., Almanza, M. C. T., & Ospina, S. O. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.02.049 · Cited by 11 · see citing works
Circulating irisin levels reflect visceral adiposity in non-diabetic patients undergoing hemodialysis
Yılmaz, H., Çakmak, M., Darçın, T., İnan, O., Şahiner, E. S., Demir, C., Aktaş, A., Bilgiç, M. A., & Akçay, A. (2016) · Renal Failure · doi:10.3109/0886022x.2016.1172918 · Cited by 11 · see citing works
Irisin improves delayed bone repair in diabetic female mice
Kinoshita, Y., Takafuji, Y., Okumoto, K., Takada, Y., Ehara, H., Mizukami, Y., Kawao, N., Jo, J., Tabata, Y., & Kaji, H. (2022) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-022-01353-3 · Cited by 10 · see citing works
A systematic review of “myokines and metabolic regulation”
Leon‐Ariza, H. H., Mendoza-Navarrete, M. P., Maldonado-Arango, M. I., & Botero‐Rosas, D. A. (2018) · Apunts Sports Medicine · doi:10.1016/j.apunts.2018.09.003 · Cited by 8 · see citing works
Erythroferrone Expression in Anemic Rheumatoid Arthritis Patients: Is It Disordered Iron Trafficking or Disease Activity?
Youssef, S. R., Hassan, E. H., Morad, C. S., Elged, A. A. E., & El‐Gamal, R. A. E. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s327465 · Cited by 8 · see citing works
The association between grip strength and incident carotid atherosclerosis in middle-aged and older adults: The TCLSIH cohort study
Zhang, B., Wang, X., Gu, Y., Zhang, Q., Liu, L., Meng, G., Wu, H., Zhang, S., Zhang, T., Li, H., et al. (2022) · Maturitas · doi:10.1016/j.maturitas.2022.09.008 · Cited by 8 · see citing works
Impact of spinach thylakoid extract-induced 12-week high-intensity functional training on specific adipokines in obese males
Saeidi, A., Motamedi, P., Hoteit, M., Sadek, Z., Ramadan, W., Dara, M. M., Almaqhawi, A., Shahrbanian, S., Abednatanzi, H., Escobar, K. A., et al. (2024) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2024.2398467 · Cited by 7 · see citing works
The impact of acute morning versus evening high-intensity interval training on circulating irisin levels and metabolic parameters in overweight postmenopausal women
Jafari, A., & Kazemi, F. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112821 · Cited by 7 · see citing works
Obesity as a Whole-Body Regulatory Disorder: A Systems Biology Framework for Metaflammation, Accelerated Aging, and Colorectal Cancer Risk
Dutta, G., Mishra, P., Mishra, S. P., & Badhai, J. (2026) · Onco · doi:10.3390/onco6030031 · Cited by 6 · see citing works
Effect of Resistance Training with Two Different Volumes on Serum Myonectin Levels in Rats Fed with Sucrose Solution
Adigozalpour, M., & Safarzade, A. (2017) · Annals of Applied Sport Science · doi:10.18869/acadpub.aassjournal.5.2.11 · Cited by 6 · see citing works
Comparison of the effects of high-intensity interval training and moderate-intensity continuous training on indices of liver and muscle tissue in high-fat diet-induced male rats with non-alcoholic fatty liver disease
Sini, Z. K., Afzalpour, M. E., Ahmadi, M. M., Sardar, M. A., Khaleghzadeh, H., Gorgani‐Firuzjaee, S., Hofmeister, M., Akaras, E., & Azimkhani, A. (2022) · Egyptian Liver Journal · doi:10.1186/s43066-022-00229-5 · Cited by 6 · see citing works
Plasma irisin and the brain-derived neurotrophic factor levels in sedentary subjects: effect of 8-weeks lifestyle intervention
Rádiková, Ž., Mosna, L., Eckerstorfer, C., Bajer, B., Havranová, A., Imrich, R., Vlček, M., & Penesová, A. (2024) · Endocrine Regulations · doi:10.2478/enr-2024-0013 · Cited by 6 · see citing works
Liquiritigenin Alleviates Hepatic Metabolic Inflammation Through Regulation of Muscle–Liver Crosstalk Signal of Myonectin
Qin, H., Chen, J.-M., Xu, Z.-Y., Chen, J.-F., Fu, Y., Wang, Z., Liu, X., & Zheng, W. (2025) · Phytotherapy Research · doi:10.1002/ptr.70014 · Cited by 5 · see citing works
Long-term GABA administration improves FNDC5, TFAM, and UCP3 mRNA expressions in the skeletal muscle and serum irisin levels in chronic type 2 diabetic rats
Yazdanimoghaddam, F., Ghasemi, M., Teamparvar, H., Soltani, N., Aghaei, M., Rezazadeh, H., & Zadhoush, F. (2022) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02211-9 · Cited by 6 · see citing works
Raspberry Ketone Promotes FNDC5 Protein Expression via HO-1 Upregulation in 3T3-L1 Adipocytes
Tsai, Y.-C., Chen, J.-H., Lee, Y., Yen, M., & Cheng, P. (2022) · The Chinese Journal of Physiology · doi:10.4103/cjp.cjp_95_21 · Cited by 5 · see citing works
Myonectin in grass carp (Ctenopharyngodon idella): Molecular cloning and effect of nutrition state, insulin and glucagon on myonectin expression
Yang, G., Liang, X., Jiang, Y., Li, C., Hu, J., Zhang, Y., Zhang, X., Chang, X., Hu, W., Li, K., et al. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101306 · Cited by 6 · see citing works
Coenzyme Q10 ameliorates obesity by promoting white adipose tissue browning and preserving mitochondrial dynamics in ovariectomized rats fed a high-fat diet
Pan, T., Chen, S., Kung, C.-W., Chen, H.-Y., Cheng, P., Shen, H., Shyu, I., & Lee, Y. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110187 · Cited by 4 · see citing works
Effects of an energy drink on myonectin in the liver, kidney and skeletal muscle of exercised rats
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Authors: Gamas, L., Matafome, P., & Seiça, R.
Affiliations: Laboratory of Physiology, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal
Universidade Politécnica de Coimbra (PT)
University of Coimbra (PT)
Corresponding author: Matafome, Paulo
ORCID: Matafome, Paulo
Seiça, Raquel
Venue: Journal of Diabetes Research
Publisher: Wiley
Published: 2015
Volume: 2015
Pages: 1-8
ISSN: 2314-6745 (ISSN-L)
2314-6753
DOI: 10.1155/2015/359159
PMC: PMC4436512
OpenAlex: W1496273172
Cited by: 114
References: 75
Citations by year: 2026: 3 · 2025: 6 · 2024: 12 · 2023: 6 · 2022: 11 · 2021: 11 · 2020: 17 · 2019: 14 · 2018: 9 · 2017: 8 · 2016: 15 · 2015: 2
FWCI: 1.39
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Journal of Diabetes Research (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: irisin, myonectin, myokines, skeletal muscle insulin resistance, FNDC5, adipose tissue metabolism, physical activity, adipocyte browning, thermogenesis, fatty acid oxidation, lipid metabolism, glucose metabolism
MeSH terms: Adipose Tissue, Animals, Cell Communication, Collagen, Diabetes Mellitus, Type 2, Fibronectins, Humans, Insulin Resistance, Obesity, Exercise, Muscle, Skeletal

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Irisin and myonectin regulation in the insulin resistant muscle: implications to adipose tissue: muscle crosstalk

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