Cited by 353Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research StudiesNeurological Disease Mechanisms and Treatments

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

Open access
González, Hugo, Elgueta, Daniela, Montoya, Andro, Pacheco, Rodrigo·2014·Journal of Neuroimmunology

Abstract

Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders.

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Crossref · 10.1016/j.jneuroim.2014.07.012

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149 of 149 references verified0 citation errors · 0 not checkable

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Authors
González, H., Elgueta, D., Montoya, A., & Pacheco, R.
Affiliations
  • Fundación Ciencia and Vida (CL)
  • Universidad Andrés Bello (CL)
  • Universidad San Sebastián (CL)
Corresponding author
Pacheco, Rodrigo
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2014-09
Volume
274
Issue
1-2
Pages
1-13
ISSN
0165-5728 (ISSN-L)
OpenAlex
W2003129702
Cited by
352
References
150
Citations by year
2026: 7 · 2025: 17 · 2024: 24 · 2023: 24 · 2022: 19 · 2021: 45 · 2020: 34 · 2019: 38 · 2018: 46 · 2017: 30 · 2016: 28 · 2015: 33 · 2014: 6
FWCI
2.62
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
  • FONDECYT (1130271)
  • CONICYT (PFB-16)
  • Universidad San Sebastián (2011-0001-R)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
microglia, neuroinflammation, neurodegenerative diseases, neuroimmune regulation, microglial activation, intercellular communication, microglia-neuron interaction, blood-brain barrier, T cell infiltration, Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis
MeSH terms
Animals, Blood-Brain Barrier, Humans, Immune Tolerance, Neuritis, Neuroimmunomodulation, Microglia, Neurodegenerative Diseases

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