Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
Open accessAbstract
Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders.
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Microglial cells express TLR1-TLR9 and their co-receptors, which promote microglial activation.
“Microglial cells express these receptors (TLR1-TLR9) and their co-receptors, which promote microglial activation (Gonzalez et al., 2014).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Gonzalez et al., 2014
M1 microglial cells present amoeboid morphology as well as high phagocytic capacity and motility.
“M1 microglial cells present amoeboid morphology as well as high phagocytic capacity and motility (Varnum and Ikezu, 2012; Gonzalez et al., 2014; Jones and Bouvier, 2014).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Gonzalez et al., 2014
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- Authors
- González, H., Elgueta, D., Montoya, A., & Pacheco, R.
- Affiliations
- Fundación Ciencia and Vida (CL)
- Universidad Andrés Bello (CL)
- Universidad San Sebastián (CL)
- Corresponding author
- Pacheco, Rodrigo
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 274
- Issue
- 1-2
- Pages
- 1-13
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2003129702
- Cited by
- 352
- References
- 150
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 24 · 2023: 24 · 2022: 19 · 2021: 45 · 2020: 34 · 2019: 38 · 2018: 46 · 2017: 30 · 2016: 28 · 2015: 33 · 2014: 6
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- FONDECYT (1130271)
- CONICYT (PFB-16)
- Universidad San Sebastián (2011-0001-R)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglia, neuroinflammation, neurodegenerative diseases, neuroimmune regulation, microglial activation, intercellular communication, microglia-neuron interaction, blood-brain barrier, T cell infiltration, Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis
- MeSH terms
- Animals, Blood-Brain Barrier, Humans, Immune Tolerance, Neuritis, Neuroimmunomodulation, Microglia, Neurodegenerative Diseases
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