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ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells
Open accessAbstract
Reactive oxygen species (ROS) are by-products of normal cell activity. They are produced in many cellular compartments and play a major role in signaling pathways. Overproduction of ROS is associated with the development of various human diseases (including cancer, cardiovascular, neurodegenerative, and metabolic disorders), inflammation, and aging. Tumors continuously generate ROS at increased levels that have a dual role in their development. Oxidative stress can promote tumor initiation, progression, and resistance to therapy through DNA damage, leading to the accumulation of mutations and genome instability, as well as reprogramming cell metabolism and signaling. On the contrary, elevated ROS levels can induce tumor cell death. This review covers the current data on the mechanisms of ROS generation and existing antioxidant systems balancing the redox state in mammalian cells that can also be related to tumors.
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“In addition to mitochondria, ROS are produced by a variety of enzymes such as NOx, xanthine oxidase, nitric oxide synthase NOS, and in other cell organelles such as the endoplasmic reticulum, peroxisomes, and cytosol [11].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [11]
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Metadata
- Authors
- Snezhkina, A. V., Kudryavtseva, A. V., Kardymon, O. L., Savvateeva, M. V., Melnikova, N. V., Krasnov, G. S., & Dmitriev, A. A.
- Affiliations
- Engelhardt Institute of Molecular Biology (RU)
- Corresponding author
- Snezhkina, Anastasiya V.
- Dmitriev, Alexey A.
- ORCID
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2019-08-05
- Volume
- 2019
- Pages
- 1-17
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC6701375
- OpenAlex
- W2966094674
- Cited by
- 934
- References
- 277
- Citations by year
- 2026: 84 · 2025: 136 · 2024: 161 · 2023: 155 · 2022: 177 · 2021: 129 · 2020: 83 · 2019: 8
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Russian Science Foundation (17-74-20064, 17-75-20105)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- reactive oxygen species, antioxidant defense, oxidative stress, cancer, tumor progression, DNA damage, genomic instability, redox signaling, cancer cell death, treatment resistance, inflammation, aging
- MeSH terms
- Antioxidants, Cell Count, Cell Transformation, Neoplastic, Humans, Reactive Oxygen Species
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