Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity
Abstract
Many synapses in the mature CNS are wrapped by a dense extracellular matrix (ECM). Using single-particle tracking and fluorescence recovery after photobleaching, we found that this net-like ECM formed surface compartments on rat primary neurons that acted as lateral diffusion barriers for AMPA-type glutamate receptors. Enzymatic removal of the ECM increased extrasynaptic receptor diffusion and the exchange of synaptic AMPA receptors. Whole-cell patch-clamp recording revealed an increased paired-pulse ratio as a functional consequence of ECM removal. These results suggest that the surface compartments formed by the ECM hinder lateral diffusion of AMPA receptors and may therefore modulate short-term synaptic plasticity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Synaptic ECM molecules interact directly with receptors and ion channels, modulating their migration and properties.
“Synaptic ECM molecules also interact directly with receptors and ion channels, modulating their migration and properties [34, 35].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [35]
Digestion of HA with hyaluronidase modulates synaptic function by increasing AMPA receptor mobility and surface expression of NMDA receptors.
“Digestion of HA with hyaluronidase modulates synaptic function by increasing AMPA receptor mobility (reviewed in [50] and surface expression of NMDA receptors [35, 51].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [35]
Others have suggested altered lateral mobility of AMPAR or changes in local diffusion of Ca2+ in brain tissue following PNN degradation.
“Others have suggested altered lateral mobility of AMPAR53 or changes in the local diffusion of Ca2+ in brain tissue54 following PNN degradation.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [53]
Astrocytes form microdomains modulating glutamatergic synapses and extrasynaptic glutamate receptors, and CSPGs control lateral diffusion of cell surface receptors, extrasynaptic diffusion of negatively charged transmitters such as glutamate, and expression of glial transmitter transporters.
“This possibility is in line with growing evidence indicating that astrocytes form microdomains modulating glutamatergic synapses and extrasynaptic glutamate receptors, and that CSPGs (cell surface bound and as part of ECM) control (i) lateral diffusion of cell surface receptors, (ii) the extrasynaptic diffusion of negatively charged transmitters such as glutamate and (iii) the expression of glial”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [87]
These functions underlie the role of the adult ECM in neuronal excitability, receptor desensitization, long-term potentiation and long-term depression.
“Overall, these functions underlie the role of the adult ECM to neuronal excitability, receptor desensitization, long-term potentiation and long-term depression.59, 87, 88, 90, 91, 92, 93”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [87]
PNNs control the lateral mobility of cell surface molecules including glutamatergic receptors, modulate L-type voltage-dependent calcium channels and voltage-gated potassium channels, and affect the local concentration of calcium ions.
“PNNs control the lateral mobility of cell surface molecules including glutamatergic receptors, thus regulating their availability on the postsynaptic membrane specialization, modulate L-type voltage-dependent calcium channels and voltage-gated potassium channels and affect the local concentration of calcium ions.30, 31, 87, 88”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [87]
Loss of extracellular matrix components increases the mobility of excitatory AMPA receptors, potentially altering the ability of glutamatergic inputs to depolarize the cell.
“Third, the loss of ECM components increases the mobility of excitatory AMPA receptors (Frischknecht et al, 2009), potentially altering the ability of glutamatergic inputs to depolarize the cell.”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Frischknecht et al, 2009
PNNs divide the neuronal surface into multiple compartments that control the lateral diffusion of neurotransmitter receptors within the plasma membrane.
“Second, PNNs divide the neuronal surface into multiple compartments, which control the diffusion of neurotransmitter receptors laterally within the plasma membrane (Fawcett, 2009; Frischknecht et al., 2009).”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Frischknecht et al., 2009
PNNs restrict the lateral diffusion of AMPA receptors and thus allow synaptic desensitization.
“This process, proposed to represent a fundamental mechanism for the maintenance of synaptic receptor pools, has been shown to controlled by PNNs, which restricted the lateral diffusion of AMPA receptors and thus allow synaptic desensitization (Frischknecht and Gundelfinger, 2012; Frischknecht et al., 2009; Heine et al., 2008).”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Frischknecht et al., 2009
Hyaluronidase treatment does not abolish brevican labeling in the AIS.
“Of note is hyaluronidase treatment does not abolish brevican labeling in the AIS (Frischknecht et al., 2009).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Frischknecht et al., 2009
Cites
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679 · see citing works
Regulation of AMPA receptor lateral movements
Borgdorff, A. J., & Choquet, D. (2002) · Nature · doi:10.1038/nature00780 · Cited by 542 · see citing works
Self-citationDityatev, A., Brückner, G., Dityateva, G., Grosche, J., Kleene, R., & Schachner, M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20361 · Cited by 365 · see citing works
Brückner, G., Brauer, K., Härtig, W., Wolff, J. R., Rickmann, M. J., Derouiche, A., Delpech, B., Girard, N., Oertel, W. H., & Reichenbach, A. (1993) · Glia · doi:10.1002/glia.440080306 · Cited by 358 · see citing works
Ashby, M. C., Maier, S. R., Nishimune, A., & Henley, J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1235-06.2006 · Cited by 302 · see citing works
Dendritic Spine Dynamics Are Regulated by Monocular Deprivation and Extracellular Matrix Degradation
Oray, S., Majewska, A., & Sur, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.001 · Cited by 296 · see citing works
Lu, J., Helton, T. D., Blanpied, T. A., Rácz, B., Newpher, T. M., Weinberg, R. J., & Ehlers, M. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.041 · Cited by 273 · see citing works
Neurofascin assembles a specialized extracellular matrix at the axon initial segment
Hedstrom, K. L., Xu, X., Ogawa, Y., Frischknecht, R., Seidenbecher, C. I., Shrager, P., & Rasband, M. N. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705119 · Cited by 268 · see citing works
Self-citationPhotoinactivation of native AMPA receptors reveals their real-time trafficking
Adesnik, H., Nicoll, R. A., & England, P. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.11.030 · Cited by 234 · see citing works
John, N., Krügel, H., Frischknecht, R., Smalla, K.-H., Schultz, C., Kreutz, M. R., Gundelfinger, E. D., & Seidenbecher, C. I. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.01.011 · Cited by 122 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Perineuronal nets stabilize the grid cell network
Christensen, A. C., Lensjø, K. K., Lepperød, M. E., Dragly, S.-A., Sutterud, H., Blackstad, J. S., Fyhn, M., & Hafting, T. (2021) · Nature Communications · doi:10.1038/s41467-020-20241-w · Cited by 1,865 · see citing works
Astrocytes Control Synapse Formation, Function, and Elimination
Chung, W.-S., Allen, N. J., & Eroglu, C. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020370 · Cited by 839 · see citing works
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
Allen, N. J., Bennett, M. L., Foo, L. C., Wang, G. X., Chakraborty, C., Smith, S. J., & Barres, B. A. (2012) · Nature · doi:10.1038/nature11059 · Cited by 764 · see citing works
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity
Nguyen, P. T., Dorman, L. C., Pan, S., Vainchtein, I. D., Han, R. T., Nakao-Inoue, H., Taloma, S. E., Barron, J. J., Molofsky, A. B., Kheirbek, M. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.050 · Cited by 615 · see citing works
The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
Fawcett, J. W., Oohashi, T., & Pizzorusso, T. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0196-3 · Cited by 589 · see citing works
Unraveling mechanisms of homeostatic synaptic plasticity
Pozo, K., & Goda, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.028 · Cited by 565 · see citing works
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
Carulli, D., Pizzorusso, T., Kwok, J. C. F., Putignano, E., Poli, A., Forostyak, S., Andrews, M. R., Deepa, S. S., Glant, T. T., & Fawcett, J. W. (2010) · Brain · doi:10.1093/brain/awq145 · Cited by 495 · see citing works
Extracellular Matrix: Functions in the Nervous System
Barros, C. S., Franco, S. J., & Muller, U. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005108 · Cited by 506 · see citing works
ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, D. L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2551 · Cited by 479 · see citing works
Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity
Sorg, B. A., Berretta, S., Blacktop, J. M., Fawcett, J. W., Kitagawa, H., Kwok, J. C. F., & Miquel, M. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2351-16.2016 · Cited by 454 · see citing works
Extracellular matrix and perineuronal nets in CNS repair
Kwok, J. C. F., Dick, G., Wang, D., & Fawcett, J. W. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20974 · Cited by 395 · see citing works
The perineuronal net and the control of CNS plasticity
Wang, D., & Fawcett, J. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1375-y · Cited by 373 · see citing works
Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students
Lepeta, K., Lourenco, M. V., Schweitzer, B. C., Martino Adami, P. V., Banerjee, P., Catuara‐Solarz, S., de La Fuente Revenga, M., Guillem, A. M., Haidar, M., Ijomone, O. M., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13713 · Cited by 386 · see citing works
Self-citationAstrocyte regulation of synaptic behavior
Allen, N. J. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013053 · Cited by 343 · see citing works
Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons
Chang, M. C., Park, J. M., Pelkey, K. A., Grabenstatter, H. L., Xu, D., Linden, D. J., Sutula, T. P., McBain, C. J., & Worley, P. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2621 · Cited by 316 · see citing works
Perineuronal Nets Suppress Plasticity of Excitatory Synapses on CA2 Pyramidal Neurons
Carstens, K. E., Phillips, M. L., Pozzo-Miller, L., Weinberg, R. J., & Dudek, S. M. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0245-16.2016 · Cited by 271 · see citing works
Molecular signals of plasticity at the tetrapartite synapse
Dityatev, A., & Rusakov, D. A. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.12.006 · Cited by 267 · see citing works
Romberg, C., Yang, S., Melani, R., Andrews, M. R., Horner, A. E., Spillantini, M. G., Bussey, T. J., Fawcett, J. W., Pizzorusso, T., & Saksida, L. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.6267-11.2013 · Cited by 231 · see citing works
Enwright, J. F., Sanapala, S., Foglio, A., Berry, R., Fish, K. N., & Lewis, D. A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.24 · Cited by 223 · see citing works
Regulation of AMPA receptor surface diffusion by PSD-95 slots
Opazo, P., Sainlos, M., & Choquet, D. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.010 · Cited by 234 · see citing works
Self-citationLocal Impermeant Anions Establish the Neuronal Chloride Concentration
Glykys, J., Dzhala, V., Egawa, K., Balena, T., Saponjian, Y., Kuchibhotla, K. V., Bacskai, B. J., Kahle, K. T., Zeuthen, T., & Staley, K. J. (2014) · Science · doi:10.1126/science.1245423 · Cited by 212 · see citing works
Kochlamazashvili, G., Henneberger, C., Bukalo, O., Dvoretskova, E., Senkov, O., Lievens, P. M.-J., Westenbroek, R., Engel, A. K., Catterall, W. A., Rusakov, D. A., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.030 · Cited by 215 · see citing works
Perineuronal Nets Enhance the Excitability of Fast-Spiking Neurons
Balmer, T. S. (2016) · eneuro · doi:10.1523/eneuro.0112-16.2016 · Cited by 220 · see citing works
Tewari, B. P., Chaunsali, L., Campbell, S. L., Patel, D. C., Goode, A. E., & Sontheimer, H. (2018) · Nature Communications · doi:10.1038/s41467-018-07113-0 · Cited by 208 · see citing works
Slaker, M., Churchill, L., Todd, R. P., Blacktop, J. M., Zuloaga, D. G., Raber, J., Darling, R. A., Brown, T. E., & Sorg, B. A. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3592-14.2015 · Cited by 208 · see citing works
Faissner, A., Pyka, M., Geissler, M., Sobik, T., Frischknecht, R., Gundelfinger, E. D., & Seidenbecher, C. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.01.001 · Cited by 207 · see citing works
Self-citationAggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity
Rowlands, D., Lensjø, K. K., Dinh, T., Yang, S., Andrews, M. R., Hafting, T., Fyhn, M., Fawcett, J. W., & Dick, G. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1122-18.2018 · Cited by 204 · see citing works
Three mechanisms assemble central nervous system nodes of Ranvier
Susuki, K., Chang, K.-J., Zollinger, D. R., Liu, Y., Ogawa, Y., Eshed-Eisenbach, Y., Dours-Zimmermann, M. T., Oses-Prieto, J. A., Burlingame, A. L., Seidenbecher, C. I., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.005 · Cited by 186 · see citing works
Self-citationExtracellular matrix abnormalities in schizophrenia
Berretta, S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.010 · Cited by 179 · see citing works
The extracellular matrix and perineuronal nets in memory
Fawcett, J. W., Fyhn, M., Jendelova, P., Kwok, J. C. F., Ruzicka, J., & Sorg, B. A. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01634-3 · Cited by 169 · see citing works
Happel, M. F. K., Niekisch, H., Castiblanco Rivera, L. L., Ohl, F. W., Deliano, M., & Frischknecht, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310272111 · Cited by 176 · see citing works
Self-citationColeman, L. G., Liu, W., Oguz, I., Styner, M., & Crews, F. T. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.021 · Cited by 170 · see citing works
Cellot, G., Toma, F. M., Kasap Varley, Z., Laishram, J., Villari, A., Quintana, M., Cipollone, S., Prato, M., & Ballerini, L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1332-11.2011 · Cited by 158 · see citing works
Morawski, M., Brückner, G., Jäger, C., Seeger, G., Matthews, R. T., & Arendt, T. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00557.x · Cited by 157 · see citing works
Morawski, M., Brückner, G., Jäger, C., Seeger, G., & Arendt, T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.022 · Cited by 156 · see citing works
Pantazopoulos, H., Markota, M., Jaquet, F., Ghosh, D., Wallin, A., Santos, A., Caterson, B., & Berretta, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.128 · Cited by 153 · see citing works
Berretta, S., Pantazopoulos, H., Markota, M., Brown, C., & Batzianouli, E. T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.040 · Cited by 152 · see citing works
Geissler, M., Gottschling, C., Aguado, A., Rauch, U., Wetzel, C. H., Hatt, H., & Faissner, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3275-12.2013 · Cited by 140 · see citing works
The perineuronal net component of the extracellular matrix in plasticity and epilepsy
McRae, P. A., & Porter, B. E. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.08.007 · Cited by 143 · see citing works
Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology
Yang, S., Cacquevel, M., Saksida, L. M., Bussey, T. J., Schneider, B. L., Aebischer, P., Melani, R., Pizzorusso, T., Fawcett, J. W., & Spillantini, M. G. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2014.11.013 · Cited by 138 · see citing works
Riga, D., Kramvis, I., Koskinen, M. K., van Bokhoven, P., van der Harst, J. E., Heistek, T. S., Jaap Timmerman, A., van Nierop, P., van der Schors, R. C., Pieneman, A. W., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8753 · Cited by 128 · see citing works
Lensjø, K. K., Christensen, A. C., Tennøe, S., Fyhn, M., & Hafting, T. (2017) · eneuro · doi:10.1523/eneuro.0379-16.2017 · Cited by 133 · see citing works
Wingert, J. C., & Sorg, B. A. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.673210 · Cited by 129 · see citing works
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory
Foscarin, S., Raha-Chowdhury, R., Fawcett, J. W., & Kwok, J. C. F. (2017) · Aging · doi:10.18632/aging.101256 · Cited by 139 · see citing works
Dzyubenko, E., Gottschling, C., & Faissner, A. (2016) · Neural Plasticity · doi:10.1155/2016/5214961 · Cited by 134 · see citing works
Converting juvenile into adult plasticity: a role for the brain's extracellular matrix
Gundelfinger, E. D., Frischknecht, R., Choquet, D., & Heine, M. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07253.x · Cited by 136 · see citing works
Self-citationAggrecan: Beyond cartilage and into the brain
Morawski, M., Brückner, G., Arendt, T., & Matthews, R. T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.01.010 · Cited by 136 · see citing works
Pyka, M., Wetzel, C., Aguado, A., Geissler, M., Hatt, H., & Faissner, A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07690.x · Cited by 131 · see citing works
Seizure-like activity in hyaluronidase-treated dissociated hippocampal cultures
Vedunova, M., Sakharnova, T., Mitroshina, E., Perminova, M., Pimashkin, A., Zakharov, Y., Dityatev, A., & Mukhina, I. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00149 · Cited by 107 · see citing works
Cerebellar plasticity and associative memories are controlled by perineuronal nets
Carulli, D., Broersen, R., de Winter, F., Muir, E. M., Mešković, M., de Waal, M., de Vries, S., Boele, H.-J., Canto, C. B., De Zeeuw, C. I., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916163117 · Cited by 110 · see citing works
Astrocyte–neuron interplay in maladaptive plasticity.
Papa, M., De Luca, C., Petta, F., Alberghina, L., & Cirillo, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.010 · Cited by 104 · see citing works
Brain extracellular matrix retains connectivity in neuronal networks
Bikbaev, A., Frischknecht, R., & Heine, M. (2015) · Scientific Reports · doi:10.1038/srep14527 · Cited by 88 · see citing works
Self-citationLendvai, D., Morawski, M., Négyessy, L., Gáti, G., Jäger, C., Baksa, G., Glasz, T., Attems, J., Tanila, H., Arendt, T., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1042-0 · Cited by 93 · see citing works
Hayani, H., Song, I., & Dityatev, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00149 · Cited by 84 · see citing works
Szepesi, Z., Hosy, E., Ruszczycki, B., Bijata, M., Pyskaty, M., Bikbaev, A., Heine, M., Choquet, D., Kaczmarek, L., & Wlodarczyk, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098274 · Cited by 83 · see citing works
Self-citationPersistent decrease in multiple components of the perineuronal net following status epilepticus
McRae, P. A., Baranov, E., Rogers, S. L., & Porter, B. E. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08268.x · Cited by 85 · see citing works
Murase, S., Lantz, C. L., & Quinlan, E. M. (2017) · eLife · doi:10.7554/elife.27345 · Cited by 87 · see citing works
Alaiyed, S., McCann, M., Mahajan, G., Rajkowska, G., Stockmeier, C. A., Kellar, K. J., Wu, J. Y., & Conant, K. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.2387-19.2020 · Cited by 84 · see citing works
Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors
Graves, A. R., Roth, R. H., Tan, H. L., Zhu, Q., Bygrave, A. M., Lopez-Ortega, E., Hong, I., Spiegel, A. C., Johnson, R. C., Vogelstein, J. T., et al. (2021) · eLife · doi:10.7554/elife.66809 · Cited by 84 · see citing works
Diverse functions of perineuronal nets
Karetko, M., & Skangiel-Kramska, J. (2009) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2009-1766 · Cited by 76 · see citing works
Slaker, M. L., Jorgensen, E. T., Hegarty, D. M., Liu, X., Kong, Y., Zhang, F., Linhardt, R. J., Brown, T. E., Aicher, S. A., & Sorg, B. A. (2018) · eneuro · doi:10.1523/eneuro.0221-18.2018 · Cited by 64 · see citing works
Hirono, M., Watanabe, S., Karube, F., Fujiyama, F., Kawahara, S., Nagao, S., Yanagawa, Y., & Misonou, H. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.3238-17.2018 · Cited by 53 · see citing works
Wiera, G., Wozniak, G., Bajor, M., Kaczmarek, L., & Mozrzymas, J. W. (2013) · Hippocampus · doi:10.1002/hipo.22112 · Cited by 57 · see citing works
Incubation of depression: ECM assembly and parvalbumin interneurons after stress
Spijker, S., Koskinen, M.-K., & Riga, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.015 · Cited by 55 · see citing works
Yu, Z., Chen, N., Hu, D., Chen, W., Yuan, Y., Meng, S., Zhang, W., Lu, L., Han, Y., & Shi, J. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00004 · Cited by 52 · see citing works
McRae, P. A., Baranov, E., Sarode, S., Brooks-Kayal, A. R., & Porter, B. E. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.015 · Cited by 49 · see citing works
How to scale down postsynaptic strength
Tatavarty, V., Sun, Q., & Turrigiano, G. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1676-13.2013 · Cited by 50 · see citing works
Hyaluronan synthesis by developing cortical neurons in vitro
Fowke, T. M., Karunasinghe, R. N., Bai, J.-Z., Jordan, S., Gunn, A. J., & Dean, J. M. (2017) · Scientific Reports · doi:10.1038/srep44135 · Cited by 47 · see citing works
Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia
Pantazopoulos, H., Boyer-Boiteau, A., Holbrook, E. H., Jang, W., Hahn, C.-G., Arnold, S. E., & Berretta, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.08.013 · Cited by 47 · see citing works
“Mailstop 149, 115 Mill Street, 1 617 855 2040. retta). ghts reserved. differentiation and migration, maturation of synapses and regulation of neurotransmitter receptor availability (Meyer-Puttlitz et al., 1996; Frischknecht et al., 2009; Maeda et al., 2010).”
BackgroundYoshino, Y., Shimazawa, M., Nakamura, S., Inoue, S., Yoshida, H., Shimoda, M., Okada, Y., & Hara, H. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.138 · Cited by 39 · see citing works
The needs of a synapse—How local organelles serve synaptic proteostasis
Grochowska, K. M., Andres‐Alonso, M., Karpova, A., & Kreutz, M. R. (2022) · The EMBO Journal · doi:10.15252/embj.2021110057 · Cited by 38 · see citing works
Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation
Van’t Spijker, H. M., Rowlands, D., Rossier, J., Haenzi, B., Fawcett, J. W., & Kwok, J. C. F. (2019) · Neural Plasticity · doi:10.1155/2019/6804575 · Cited by 31 · see citing works
Chemistry and Function of Glycosaminoglycans in the Nervous System
Schwartz, N. B., & Domowicz, M. S. (2014) · Advances in Neurobiology · doi:10.1007/978-1-4939-1154-7_5 · Cited by 25 · see citing works
The cell wall polymer initiates plasma membrane partitioning in mycobacteria
Kado, T., Akbary, Z., Motooka, D., Sparks, I. L., Melzer, E. S., Nakamura, S., Rojas, E. R., Morita, Y. S., & Siegrist, M. S. (2022) · doi:10.1101/2022.06.12.495848 · Cited by 16 · see citing works
“For example, enzymatic removal of neuronal extracellular matrix (Frischknecht et al., 2009) or the plant or bacterial cell wall (Daněk et al., 2020; Feraru et al., 2011; Martinière et al., 2012; McKenna et al., 2019; Wagner et al., 2020) can alter some of which are normally enriched in domains.”
Background
- Authors
- Frischknecht, R., Heine, M., Perrais, D., Seidenbecher, C. I., Choquet, D., & Gundelfinger, E. D.
- Affiliations
- Leibniz Institute for Neurobiology (DE)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Choquet, Daniel
- Gundelfinger, Eckart D
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2009-05-31
- Volume
- 12
- Issue
- 7
- Pages
- 897-904
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2059480421
- Cited by
- 554
- References
- 10
- Citations by year
- 2026: 22 · 2025: 25 · 2024: 35 · 2023: 19 · 2022: 31 · 2021: 42 · 2020: 41 · 2019: 30 · 2018: 43 · 2017: 29 · 2016: 38 · 2015: 27 · 2014: 43 · 2013: 33 · 2012: 31
- FWCI
- 13.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- extracellular matrix, AMPA receptors, lateral diffusion, short-term plasticity, paired-pulse ratio, extrasynaptic receptors, synaptic transmission, primary neurons
- MeSH terms
- Animals, Brain, Cells, Cultured, Dendrites, Extracellular Matrix, Hyaluronoglucosaminidase, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Receptors, AMPA, Patch-Clamp Techniques, Fluorescence Recovery After Photobleaching, Mice, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
