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Cited by 1,053

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

Wyckoff, Jeffrey B., Wang, Yarong, Lin, Elaine Y., Li, Jiu-feng, Goswami, Sumanta, Stanley, E. Richard, Segall, Jeffrey E., Pollard, Jeffrey W., Condeelis, John·2007·Cancer Research
DOI 10.1158/0008-5472.can-06-1823
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Abstract

Although the presence of macrophages in tumors has been correlated with poor prognosis, until now there was no direct observation of how macrophages are involved in hematogenous metastasis. In this study, we use multiphoton microscopy to show, for the first time, that tumor cell intravasation occurs in association with perivascular macrophages in mammary tumors. Furthermore, we show that perivascular macrophages of the mammary tumor are associated with tumor cell intravasation in the absence of local angiogenesis. These results show that the interaction between macrophages and tumor cells lying in close proximity defines a microenvironment that is directly involved in the intravasation of cancer cells in mammary tumors. [Cancer Res 2007;67(6):2649–56]

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Metadata

Authors
Wyckoff, J. B., Wang, Y., Lin, E. Y., Li, J.-F., Goswami, S., Stanley, E. R., Segall, J. E., Pollard, J. W., & Condeelis, J.
Venue
Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2007-03-15
Volume
67
Issue
6
Pages
2649-2656
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
DOI
10.1158/0008-5472.can-06-1823
OpenAlex
W2037489902
Cited by
1,053
References
4
FWCI
17.11
Type
journal article
Language
en
Open access
closed

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