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Cited by 354

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Mode of Delivery – Effects on Gut Microbiota and Humoral Immunity

Huurre, Anu, Kalliomäki, Marko, Rautava, Samuli, Rinne, Minna, Salminen, Seppo, Isolauri, Erika·2008·Neonatology
DOI 10.1159/000111102
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Abstract

Background: The rate of caesarean deliveries has increased 10-fold worldwide during the past decades. Objective: To evaluate differences in the establishment of gut microbiota in infants born by vaginal or caesarean delivery and its impact on mucosal immunity. Methods: Altogether, 165 consecutive children, prospectively followed from birth at our clinic in Turku, Finland, were gathered; 141 (85%) were born by vaginal delivery and 24 (15%) by caesarean section. Blood was drawn at physician visits for indirect evaluation of mucosal immunity by ELISPOT assay. Faecal samples were obtained for determination of the gut microbiota by fluorescence in situ hybridization of bacterial cells. Results: Infants delivered by caesarean section harboured fewer bifidobacteria at an early age and were shown to mount a stronger humoral immune response. At 1 month of age, the total gut bacterial cell counts per 1 g faeces were higher in vaginally delivered infants (9.9 × 10 9, 95% CI 7.9 × 10 9–1.2 × 10 10) as compared to caesarean section delivered (3.1 × 10 9, 95% CI 1.1 × 10 9–8.6 × 10 9) (p = 0.001). This distinction was mainly due to the greater number of bifidobacteria in vaginally delivered infants (1.9 × 10 9, 95% CI 6.3 × 10 8–5.6 × 10 9 vs. 1.5 × 10 6, 95% CI 4.1 × 10 2–5.7 × 10 9, respectively) (p = 0.001). During the first year of life, the total number of IgA-, IgG- and IgM-secreting cells was lower (p = 0.03, p = 0.02, p = 0.11, respectively) in infants born by vaginal delivery than in those born by caesarean section, possibly reflecting excessive antigen exposure across the vulnerable gut barrier. Conclusions: Our findings demonstrate that the mode of delivery may have, possibly via gut microbiota development, significant effects on immunological functions in the infant (http://www.clinicaltrials.gov/ct/gui/show/NCT00167700).

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Metadata

Authors
Huurre, A., Kalliomäki, M., Rautava, S., Rinne, M., Salminen, S., & Isolauri, E.
Venue
Neonatology
Publisher
S. Karger AG
Published
2007-11-16
Volume
93
Issue
4
Pages
236-240
ISSN
  • 1661-7800 (ISSN-L)
  • 1661-7819
DOI
10.1159/000111102
OpenAlex
W1999477419
Cited by
354
References
2
FWCI
2.04
Type
journal article
Language
en
Open access
closed

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