Relationship between Plasma Profiles of Oxytocin and Adrenocorticotropic Hormone during Suckling or Breast Stimulation in Women
Open accessAbstract
Oxytocin (OT) administration has been shown to inhibit adrenocorticotropic hormone (ACTH)/cortisol secretion in several experimental conditions. In the present study, the plasma OT responses to suckling in 7 lactating women or to mechanical breast stimulation in 6 normally menstruating women (experimental tests) or to sham stimuli in the same subjects (control tests) were measured and correlated with the simultaneous changes in plasma ACTH/cortisol levels. All women showed similar basal levels of OT, ACTH and cortisol, which remained unmodified after sham stimulation. In contrast, both suckling and breast stimulation produced a significant increase in plasma OT levels and a significant decrease in plasma ACTH concentrations. When OT and ACTH data were considered together, a significant negative correlation was found between the OT increase and the simultaneous ACTH decline. Plasma cortisol levels were lower during suckling or breast stimulation than in control conditions. These data show an inverse relationship between plasma OT and ACTH levels during suckling and breast stimulation in humans, suggesting an inhibitory influence of OT on ACTH/cortisol secretion in a physiological condition.
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Plasma CORT decreases in human mothers, potentially through the suckling-induced OT that can inhibit ACTH secretion.
“On the other hand, plasma CORT decreases in human mothers (54), potentially through the suckling-induced OT (55) that can inhibit ACTH secretion (56).”
From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [55]
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“In human, OT infusion inhibited the plasma ACTH in response to corticotropin-releasing hormone (CRH), found, for example, in the case of suckling and breast stimulation [25].”
BackgroundThe contributions of parental lactation on offspring development: It's not udder nonsense!
Wijenayake, S., Martz, J., Lapp, H. E., Storm, J. A., Champagne, F. A., & Kentner, A. C. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105375 · Cited by 27 · see citing works
“Studies show that suckling decreases cortisol as well as adrenocorticotrophic hormone (ACTH), which causes the release of cortisol from the adrenal cortex (Chiodera et al., 1991; Handlin et al., 2009).”
BackgroundThe Role of Oxytocin in Alzheimer’s Disease and Its Relationship with Social Interaction
Takahashi, J., Yamada, D., Nagano, W., & Saitoh, A. (2023) · Cells · doi:10.3390/cells12202426 · Cited by 25 · see citing works
“OXT can suppress the activity of the HPA axis [50–53].”
BackgroundStimulatory and inhibitory regulators of the hypothalamo–pituitary–adrenocortical axis
Jessop, D. S. (1999) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.1999.0039 · Cited by 24 · see citing works
Breastfeeding and Maternal Mental and Physical Health
Hahn‐Holbrook, J., Schetter, C. D., & Haselton, M. G. (2013) · doi:10.1002/9781394260454.ch17 · Cited by 24 · see citing works
Effects of Breastfeeding on Stress Measured by Saliva Cortisol Level and Perceived Stress
Mizuhata, K., Taniguchi, H., Hikita, N., Shimada, M., & Morokuma, S. (2020) · Asian/Pacific Island Nursing Journal · doi:10.31372/20200503.1100 · Cited by 23 · see citing works
“Chiodera et al. (1991) measured the serum oxytocin and adrenocorticotropin hormone levels and 135 reported that oxytocin levels were inversely correlated with hypothalamic-pituitary axis activity and cortisol secretion.”
BackgroundDiscussions and perspectives regarding oxytocin as a biomarker in human investigations
Mera, J. C. C., Molano, M. A. C., López, C. C. G., Triana, C. A., & Cotrina, J. A. M. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08289 · Cited by 21 · see citing works
“Authors reported their results in units pmol/l, with a range of variation of OXT between 2 and 15 (Chiodera et al., 1991).”
BackgroundHalpern, C. T. (2006) · New Directions for Child and Adolescent Development · doi:10.1002/cd.159 · Cited by 21 · see citing works
Wendy Saltzman, A., & Abbott, D. H. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.05.005 · Cited by 21 · see citing works
“In women, breastfeeding causes acute reductions in circulating ACTH and cortisol levels, but does not appear to have chronic effects on baseline ACTH or cortisol concentrations [50,51].”
Hasiec, M., & Misztal, T. (2018) · International Journal of Endocrinology · doi:10.1155/2018/3786038 · Cited by 20 · see citing works
“[33] showed no differences in cortisol and ACTH concentrations in breastfeeding women 5–7 days after parturition compared to nonlactating subjects.”
BackgroundCampbell, A. C., & Cross, C. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199738403.013.0012 · Cited by 21 · see citing works
Ocytocine et stress de la mère au cours de la lactation en post-partum
Boutet, C., Vercueil, L., Schelstraete, C., Buffin, A., & Legros, J. (2006) · Annales d Endocrinologie · doi:10.1016/s0003-4266(06)72589-6 · Cited by 19 · see citing works
Increased Serum and Urinary Oxytocin Concentrations after Nasal Administration in Beagle Dogs
Temesi, A., Thuróczy, J., Balogh, L., & Miklósi, Á. (2017) · Frontiers in Veterinary Science · doi:10.3389/fvets.2017.00147 · Cited by 18 · see citing works
Ejaculate Collection Influences the Salivary Oxytocin Concentrations in Breeding Male Pigs
López-Arjona, M., Padilla, L., Roca, J., Cerón, J. M. C., & Martı́nez-Subiela, S. (2020) · Animals · doi:10.3390/ani10081268 · Cited by 18 · see citing works
“In addition, oxytocin inhibits the secretion of glucocorticoids, the hormones associated with anxiety and stress [3].”
Background
- Authors
- Chiodera, P., Salvarani, C., Bacchi-Modena, A., Spallanzani, R., Cigarini, C., Alboni, A., Gardini, E., & Coiro, V.
- Affiliations
- University of Parma (IT)
- ORCID
- Salvarani, C.
- Venue
- Hormone Research
- Publisher
- S. Karger AG
- Published
- 2008-12-02
- Volume
- 35
- Issue
- 3-4
- Pages
- 119-123
- ISSN
- 0301-0163 (ISSN-L)
- 1423-0046
- OpenAlex
- W2089029246
- Cited by
- 154
- References
- 0
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 1 · 2018: 19 · 2017: 1 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Hormone Research (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, ACTH, cortisol, suckling, breast stimulation, lactation, hypothalamic-pituitary-adrenal axis, negative feedback, plasma hormone levels, women
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Breast, Humans, Hydrocortisone, Infant, Newborn, Lactation, Oxytocin, Reference Values, Sucking Behavior, Postpartum Period
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