Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 949

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

CREB: A Major Mediator of Neuronal Neurotrophin Responses

Open access
Finkbeiner, Steven, Tavazoie, Sohail F, Maloratsky, Anna, Jacobs, Kori M, Harris, Kristen M, Greenberg, Michael E·1997·Neuron

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0896-6273(00)80395-5

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 7 references

Research works printed but not linked: 85

  1. Alberini, 1994, C/EBP is an immediate-early gene required for the consolidation of long-term facilitation, Cell, 76, 1099, 10.1016/0092-8674(94)90386-7 · DOI · Paper page
  2. Arenas, 1994, Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo, Nature, 367, 368, 10.1038/367368a0 · DOI
  3. Bar-Sagi, 1985, Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation, Cell, 42, 841, 10.1016/0092-8674(85)90280-6 · DOI · Paper page
  4. Bartsch, 1995, Aplysia CREB2 represses long-term facilitation, Cell, 83, 979, 10.1016/0092-8674(95)90213-9 · DOI · Paper page
  5. Baxter, 1995, Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells, Eur. J. Biochem, 234, 84, 10.1111/j.1432-1033.1995.084_c.x · DOI
  6. Berninger, 1993, BDNF and NT-3 induce intracellular Ca2+ elevation in hippocampal neurones, Neuroreport, 4, 1303, 10.1097/00001756-199309150-00004 · DOI
  7. Blanquet, 1997, Brain-derived neurotrophic factor increases Ca2+/calmodulin-dependent protein kinase 2 activity in hippocampus, J. Biol. Chem, 272, 24133, 10.1074/jbc.272.39.24133 · DOI
  8. Bonni, 1993, Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus, Science, 262, 1575, 10.1126/science.7504325 · DOI
  9. Bonni, 1995, Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals, Mol. Cell Neurosci, 6, 168, 10.1006/mcne.1995.1015 · DOI · Paper page
  10. Cabelli, 1995, Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF, Science, 267, 1662, 10.1126/science.7886458 · DOI · Paper page
  11. Cherrington, 1989, Human cytomegalovirus transactivates the α promoter-enhancer via an 18-base-pair repeat element, J. Virol, 63, 1435, 10.1128/JVI.63.3.1435-1440.1989 · DOI · Paper page
  12. Chomczynski, 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem, 162, 156, 10.1016/0003-2697(87)90021-2 · DOI · Paper page
  13. D'Arcangelo, 1993, A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions, Mol. Cell. Biol, 13, 3146, 10.1128/MCB.13.6.3146 · DOI
  14. D'Arcangelo, 1996, Activation of codependent transcription factors is required for transcriptional induction of the vgf gene by nerve growth factor and Ras, Mol. Cell. Biol, 16, 4621, 10.1128/MCB.16.9.4621 · DOI
  15. Diamond, 1992, Sensory nerves in adult rats regenerate and restore sensory function to the skin independently of endogenous NGF, J. Neurosci, 12, 1467, 10.1523/JNEUROSCI.12-04-01467.1992 · DOI
  16. Diamond, 1992, Endogenous NGF and nerve impulses regulate the collateral sprouting of sensory axons in the skin of the adult rat, J. Neurosci, 12, 1454, 10.1523/JNEUROSCI.12-04-01454.1992 · DOI · Paper page
  17. Dichter, 1977, Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line, Nature, 268, 501, 10.1038/268501a0 · DOI · Paper page
  18. Domenico, 1989, ras p21 protein promotes survival and fiber outgrowth of cultured embyronic neurons, Neuron, 2, 1087, 10.1016/0896-6273(89)90233-X · DOI
  19. Dudley, 1995, A synthetic inhibitor of the mitogen-activated protein kinase cascade, Proc. Natl. Acad. Sci. USA, 92, 7686, 10.1073/pnas.92.17.7686 · DOI · Paper page
  20. Ellis, 1995, Activating transcription factor-1 is a specific antagonist of the cylic adenosine 3′,5′-monophosphate (cAMP) response element binding protein-1-mediated response to cAMP, Mol. Endocrinol, 9, 255
  21. Enslen, 1994, Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation, J. Biol. Chem, 269, 15520, 10.1016/S0021-9258(17)40710-1 · DOI · Paper page
  22. Fanger, 1995, Differential regulation of neuronal sodium channel expression by endogenous and exogenous tyrosine kinase receptors expressed in rat pheochromocytoma cells, J. Neurosci, 15, 202, 10.1523/JNEUROSCI.15-01-00202.1995 · DOI
  23. Feig, 1988, Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP, Mol. Cell. Biol, 8, 3235, 10.1128/MCB.8.8.3235 · DOI · Paper page
  24. Foulkes, 1991, CREM gene, Cell, 64, 739, 10.1016/0092-8674(91)90503-Q · DOI · Paper page
  25. Frank, 1994, CREB, Cell, 79, 5, 10.1016/0092-8674(94)90394-8 · DOI · Paper page
  26. Gaiddon, 1996, Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons, J. Neurochem, 66, 2279, 10.1046/j.1471-4159.1996.66062279.x · DOI
  27. Garber, 1989, Regulation of ionic currents in pheochromocytoma cells by nerve growth factor and dexamethasone, J. Neurosci, 9, 3976, 10.1523/JNEUROSCI.09-11-03976.1989 · DOI
  28. Ginty, 1993, Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock, Science, 260, 238, 10.1126/science.8097062 · DOI · Paper page
  29. Graham, 1991, Distinct protein targets for signals acting at the c-fos serum response element, Science, 251, 189, 10.1126/science.1898992 · DOI
  30. Greene, 1995, Early events in neurotrophin signalling via Trk and p75 receptors, Curr. Opin. Neurobiol, 5, 579, 10.1016/0959-4388(95)80062-X · DOI · Paper page
  31. Hagag, 1986, Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21, Nature, 319, 680, 10.1038/319680a0 · DOI · Paper page
  32. Halegoua, 1996, Dissecting the mode of action of a neuronal growth factor, Curr. Topics Microbiol. Immunol, 165, 119
  33. Harris, 1984, Development onset of long-term potentiation in area CA1 of the rat hippocampus, J. Physiol, 346, 27, 10.1113/jphysiol.1984.sp015005 · DOI
  34. Hyman, 1991, BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra, Nature, 350, 230, 10.1038/350230a0 · DOI · Paper page
  35. Ip, 1993, Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF, J. Neurosci, 13, 3394, 10.1523/JNEUROSCI.13-08-03394.1993 · DOI · Paper page
  36. Ip, 1993, Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells, Neuron, 10, 137, 10.1016/0896-6273(93)90306-C · DOI · Paper page
  37. Iwata, 1996, Neurotrophin-3 increases the DNA-binding activities of several transcription factors in a mouse osteoblastic cell line, Biochim. Biophys. Acta, 1311, 85, 10.1016/0167-4889(95)00199-9 · DOI
  38. Jensen, 1989, Preservation of neuronal ultrastructure in hippocampal slices using rapid microwave-enhanced fixation, J. Neurosci. Meth, 29, 217, 10.1016/0165-0270(89)90146-5 · DOI
  39. Kang, 1995, Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus, Science, 267, 1658, 10.1126/science.7886457 · DOI · Paper page
  40. Kang, 1996, A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity, Science, 273, 1402, 10.1126/science.273.5280.1402 · DOI · Paper page
  41. Kaplan, 1994, Neurotrophin signal transduction by the Trk receptor, J. Neurobiol, 25, 1404, 10.1002/neu.480251108 · DOI · Paper page
  42. Kim, 1997, PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma1 phosphorylation on tyrosine residues 783 and 1254, Cell, 65, 435, 10.1016/0092-8674(91)90461-7 · DOI · Paper page
  43. Klein, 1990, Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system, Development, 109, 845, 10.1242/dev.109.4.845 · DOI · Paper page
  44. Kobayashi, 1995, ATF-1CREB heterodimer is involved in constitutive expression of the housekeeping Na,K-ATPase α1 subunit gene, Nucl. Acids Res, 23, 2848, 10.1093/nar/23.15.2848 · doi:10.1093/nar/23.15.2848
  45. Korte, 1995, Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor, Proc. Natl. Acad. Sci. USA, 92, 8856, 10.1073/pnas.92.19.8856 · DOI · Paper page
  46. Kremer, 1991, Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of Src and Ras actions, J. Cell Biol, 115, 809, 10.1083/jcb.115.3.809 · DOI
  47. Liu, 1993, Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation, J. Biol. Chem, 268, 6714, 10.1016/S0021-9258(18)53308-1 · DOI
  48. Lohof, 1993, Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF, Nature, 363, 350, 10.1038/363350a0 · DOI · Paper page
  49. Marsh, 1993, Signal transduction events mediated by the BDNF receptor gp 145trkB in primary hippocampal pyramidal cell culture, J. Neurosci, 13, 4281, 10.1523/JNEUROSCI.13-10-04281.1993 · DOI
  50. Martin, 1996, Cell adhesion molecules, CREB, and the formation of new synaptic connections, Neuron, 17, 567, 10.1016/S0896-6273(00)80188-9 · DOI
  51. Matthews, 1994, Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression, Mol. Cell. Biol, 140, 6107, 10.1128/MCB.14.9.6107 · DOI · Paper page
  52. Miranti, 1995, Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a CaM kinase, Mol. Cell. Biol, 15, 3672, 10.1128/MCB.15.7.3672 · DOI
  53. Nakamura, 1995, An immunohistochemical study of Ca2+/calmodulin-dependent protein kinase IV in the rat central nervous system, Neuroscience, 68, 181, 10.1016/0306-4522(95)00092-W · DOI
  54. Ng, 1993, Activation of p21ras by nerve growth factor in embryonic sensory neurons and PC12 cells, J. Biol. Chem, 268, 25329, 10.1016/S0021-9258(19)74395-6 · DOI
  55. Niswender, 1995, Quantitative imaging of green fluorescent protein in cultured cells, J. Microsc, 180, 109, 10.1111/j.1365-2818.1995.tb03665.x · DOI
  56. Oppenheim, 1992, Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death, Nature, 350, 755, 10.1038/360755a0 · DOI · Paper page
  57. Park, 1995, Activation of Ca2+/calmodulin-dependent protein kinase (CaM-kinase IV) by CaM-kinase kinase in Jurkat T lymphocytes, J. Biol. Chem, 270, 30464, 10.1074/jbc.270.51.30464 · DOI
  58. Pende, 1994, Glutamate regulates intracellular calcium and gene expression in oligodendrocyte progenitors through the activation of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, Proc. Natl. Acad. Sci. USA, 91, 3215, 10.1073/pnas.91.8.3215 · DOI
  59. Prakash, 1996, Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo, Nature, 381, 702, 10.1038/381702a0 · DOI
  60. Rivera, 1990, The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation, Genes Dev, 4, 255, 10.1101/gad.4.2.255 · DOI
  61. Robertson, 1995, Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements, Neuron, 14, 241, 10.1016/0896-6273(95)90282-1 · DOI · Paper page
  62. Rosen, 1994, Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras, Neuron, 12, 1207, 10.1016/0896-6273(94)90438-3 · DOI · Paper page
  63. Schnell, 1994, Neurotrophin-3 enhances sprouting of corticospinal tract during development and after spinal cord lesion, Nature, 367, 170, 10.1038/367170a0 · DOI · Paper page
  64. Segal, 1996, Signal transduction by neurotrophins, Annu. Rev. Neurosci, 19, 463, 10.1146/annurev.ne.19.030196.002335 · DOI · Paper page
  65. Sendtner, 1992, Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section, Nature, 360, 757, 10.1038/360757a0 · DOI · Paper page
  66. Sheng, 1990, Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB, Neuron, 4, 571, 10.1016/0896-6273(90)90115-V · DOI · Paper page
  67. Sheng, 1991, CREB, Science, 252, 1427, 10.1126/science.1646483 · DOI · Paper page
  68. Shyu, 1989, The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways, Genes Dev, 3, 60, 10.1101/gad.3.1.60 · DOI · Paper page
  69. Snider, 1988, Nerve growth factor enhances dendritic arborization of sympathetic ganglion cells in developing mammals, J. Neurosci, 8, 2628, 10.1523/JNEUROSCI.08-07-02628.1988 · DOI
  70. Soltoff, 1992, Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase, J. Biol. Chem, 267, 17472, 10.1016/S0021-9258(18)41950-3 · DOI
  71. Spitzer, 1994, Spontaneous Ca2+ spikes and waves in embryonic neurons, Trends Neurosci, 17, 115, 10.1016/0166-2236(94)90120-1 · DOI
  72. Stephens, 1994, Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma1 to mediate NGF responses, Neuron, 12, 691, 10.1016/0896-6273(94)90223-2 · DOI · Paper page
  73. Stoop, 1995, Potentiation of transmitter release by ciliary neurotrophic factor requires somatic signaling, Science, 267, 695, 10.1126/science.7839148 · DOI
  74. Sun, 1994, Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity, Genes Dev, 8, 2527, 10.1101/gad.8.21.2527 · DOI · Paper page
  75. Tokumitsu, 1990, KN-62,1-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-yrosyl]-4-ph enylpiperazine, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II, J. Biol. Chem, 265, 4315, 10.1016/S0021-9258(19)39565-1 · DOI · Paper page
  76. Toledo-Aral, 1995, A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction, Neuron, 14, 607, 10.1016/0896-6273(95)90317-8 · DOI · Paper page
  77. Treisman, 1985, Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences, Cell, 42, 889, 10.1016/0092-8674(85)90285-5 · DOI · Paper page
  78. Vaillancourt, 1995, Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation, Mol. Cell. Biol, 15, 3644, 10.1128/MCB.15.7.3644 · DOI
  79. Valius, 1993, Phospholipase C-gamma1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal, Cell, 73, 321, 10.1016/0092-8674(93)90232-F · DOI · Paper page
  80. Vetter, 1991, Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene, Proc. Natl. Acad. Sci. USA, 88, 5650, 10.1073/pnas.88.13.5650 · DOI · Paper page
  81. Walton, 1992, A dominant repressor of cyclic adenosine 3′,5′-monophosphate (cAMP)-regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo, Mol. Endocrin, 6, 647
  82. Widmer, 1993, Rapid phosphorylation of phospholipase C gamma1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat cortical neurons, J. Neurochem, 60, 2111, 10.1111/j.1471-4159.1993.tb03496.x · DOI
  83. Xia, 1996, Calcium influx via the NMDA receptor induces immediate early gene expression by a MAP kinase/ERK-dependent mechanism, J. Neurosci, 1625, 5425, 10.1523/JNEUROSCI.16-17-05425.1996 · DOI · Paper page
  84. Xing, 1996, Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase, Science, 273, 959, 10.1126/science.273.5277.959 · DOI · Paper page
  85. Zirrgiebel, 1995, Characterization of TrkB receptor-mediated signaling pathways in rat cerebellar granule cell neurons, J. Neurochem, 65, 2241, 10.1046/j.1471-4159.1995.65052241.x · DOI

Cited by

See all 949

Metadata

Authors
Finkbeiner, S., Tavazoie, S. F., Maloratsky, A., Jacobs, K. M., Harris, K. M., & Greenberg, M. E.
Venue
Neuron
Publisher
Elsevier BV
Published
1997-11
Volume
19
Issue
5
Pages
1031-1047
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2162710298
Cited by
949
References
7
FWCI
11.52
Type
journal article
Language
en
Open access
bronze
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: CREB: A Major Mediator of Neuronal Neurotrophin Responses. https://app.cochat.ai/papers/10.1016/s0896-6273(00)80395-5
The paper
Finkbeiner, S., Tavazoie, S. F., Maloratsky, A., Jacobs, K. M., Harris, K. M., & Greenberg, M. E. (1997). CREB: A Major Mediator of Neuronal Neurotrophin Responses. Neuron. https://doi.org/10.1016/s0896-6273(00)80395-5

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.