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Cited by 478

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Mitochondrial Integrity and Function in Atherogenesis

Ballinger, Scott W., Patterson, Cam, Knight-Lozano, Cynthia A., Burow, David L., Conklin, Caryl A., Hu, Zhaoyong, Reuf, Johannes, Horaist, Chris, Lebovitz, Russell, Hunter, Glenn C., McIntyre, Ken, Runge, Marschall S.·2002·Circulation
DOI 10.1161/01.cir.0000023921.93743.89
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Abstract

Background — Coronary atherosclerotic disease remains the leading cause of death in the Western world. Although the exact sequence of events in this process is controversial, reactive oxygen and nitrogen species (RS) likely play an important role in vascular cell dysfunction and atherogenesis. Oxidative damage to the mitochondrial genome with resultant mitochondrial dysfunction is an important consequence of increased intracellular RS. Methods and Results — We examined the contribution of mitochondrial oxidant generation and DNA damage to the progression of atherosclerotic lesions in human arterial specimens and atherosclerosis-prone mice. Mitochondrial DNA damage not only correlated with the extent of atherosclerosis in human specimens and aortas from apolipoprotein E −/− mice but also preceded atherogenesis in young apolipoprotein E −/− mice. Apolipoprotein E −/− mice deficient in manganese superoxide dismutase, a mitochondrial antioxidant enzyme, exhibited early increases in mitochondrial DNA damage and a phenotype of accelerated atherogenesis at arterial branch points. Conclusions — Mitochondrial DNA damage may result from RS production in vascular tissues and may in turn be an early event in the initiation of atherosclerotic lesions.

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Crossref · 10.1161/01.cir.0000023921.93743.89

Cites

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Metadata

Authors
Ballinger, S. W., Patterson, C., Knight-Lozano, C. A., Burow, D. L., Conklin, C. A., Hu, Z., Reuf, J., Horaist, C., Lebovitz, R., Hunter, G. C., McIntyre, K., & Runge, M. S.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-07-30
Volume
106
Issue
5
Pages
544-549
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000023921.93743.89
OpenAlex
W2098883620
Cited by
478
References
6
FWCI
5.08
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.