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Cited by 963

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Regular Physical Exercise Corrects Endothelial Dysfunction and Improves Exercise Capacity in Patients With Chronic Heart Failure

Hambrecht, Rainer, Fiehn, Eduard, Weigl, Claudia, Gielen, Stephan, Hamann, Caroline, Kaiser, Ralf, Yu, Jiangtao, Adams, Volker, Niebauer, Josef, Schuler, Gerhard·1998·Circulation
DOI 10.1161/01.cir.98.24.2709
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Abstract

Background —The purpose of this study was to determine the effects of systemic exercise training on endothelium-mediated arteriolar vasodilation of the lower limb and its relation to exercise capacity in chronic heart failure (CHF). Endothelial dysfunction is a key feature of CHF, contributing to increased peripheral vasoconstriction and impaired exercise capacity. Local handgrip exercise has previously been shown to enhance endothelium-dependent vasodilation in conduit and resistance vessels in CHF. Methods and Results —Twenty patients were prospectively randomized to a training group (n=10, left ventricular ejection fraction [LVEF] 24±4%) or a control group (n=10, LVEF 23±3%). At baseline and after 6 months, peak flow velocity was measured in the left femoral artery using a Doppler wire; vessel diameter was determined by quantitative angiography. Peripheral blood flow was calculated from average peak velocity (APV) and arterial cross-sectional area. After exercise training, nitroglycerin-induced endothelium-independent vasodilation remained unaltered (271% versus 281%, P =NS). Peripheral blood flow improved significantly in response to 90 μg/min acetylcholine by 203% (from 152±79 to 461±104 mL/min, P <0.05 versus control group) and the inhibiting effect of L-NMMA increased by 174% (from −46±25 to −126±19 mL/min, P <0.05 versus control group). Peak oxygen uptake increased by 26% ( P <0.01 versus control group). The increase in peak oxygen uptake was correlated with the endothelium-dependent change in peripheral blood flow (r=0.64, P <0.005). Conclusions —Regular physical exercise improves both basal endothelial nitric oxide (NO) formation and agonist-mediated endothelium-dependent vasodilation of the skeletal muscle vasculature in patients with CHF. The correction of endothelium dysfunction is associated with a significant increase in exercise capacity.

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Metadata

Authors
Hambrecht, R., Fiehn, E., Weigl, C., Gielen, S., Hamann, C., Kaiser, R., Yu, J., Adams, V., Niebauer, J., & Schuler, G.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-12-15
Volume
98
Issue
24
Pages
2709-2715
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.98.24.2709
OpenAlex
W2061974967
Cited by
963
References
4
FWCI
48.48
Type
journal article
Language
en
Open access
closed

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