Cited by 358Regulation of Appetite and ObesityNeuroscience of respiration and sleepAdipose Tissue and Metabolism

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Interactions Between the Melanocortin System and Leptin in Control of Sympathetic Nerve Traffic

Haynes, William G., Morgan, Donald A., Djalali, Ali, Sivitz, William I., Mark, Allyn L.·1999·Hypertension

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Abstract

Leptin plays an important role in regulation of body weight through regulation of food intake and sympathetically mediated thermogenesis. The hypothalamic melanocortin system, via activation of the melanocortin-4 receptor (MC4-R), decreases appetite and weight, but its effects on sympathetic nerve activity (SNA) are unknown. In addition, it is not known whether sympathoactivation to leptin is mediated by the melanocortin system. We tested the interactions between these systems in regulation of brown adipose tissue (BAT) and renal and lumbar SNA in anesthetized Sprague-Dawley rats. Intracerebroventricular administration of the MC4-R agonist MT-II (200 to 600 pmol) produced a dose-dependent sympathoexcitation affecting BAT and renal and lumbar beds. This response was completely blocked by the MC4-R antagonist SHU9119 (30 pmol ICV). Administration of leptin (1000 microg/kg IV) slowly increased BAT SNA (baseline, 41+/-6 spikes/s; 6 hours, 196+/-28 spikes/s; P=0.001) and renal SNA (baseline, 116+/-16 spikes/s; 6 hours, 169+/-26 spikes/s; P=0.014). Intracerebroventricular administration of SHU9119 did not inhibit leptin-induced BAT sympathoexcitation (baseline, 35+/-7 spikes/s; 6 hours, 158+/-34 spikes/s; P=0.71 versus leptin alone). However, renal sympathoexcitation to leptin was completely blocked by SHU9119 (baseline, 142+/-17 spikes/s; 6 hours, 146+/-25 spikes/s; P=0.007 versus leptin alone). This study demonstrates that the hypothalamic melanocortin system can act to increase sympathetic nerve traffic to thermogenic BAT and other tissues. Our data also suggest that leptin increases renal SNA through activation of hypothalamic melanocortin receptors. In contrast, sympathoactivation to thermogenic BAT by leptin appears to be independent of the melanocortin system.

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Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G. E., & Grüters, A. (1998) · Nature Genetics · doi:10.1038/509 · Cited by 1,769
Identification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,499
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
Lu, D., Willard, D. H., Patel, I. R., Kadwell, S. H., Overton, L. K., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) · Nature · doi:10.1038/371799a0 · Cited by 1,075

Show all 34 references

Research works printed but not linked: 2

Egawa M, Yoshimatsu H, Bray GA. Preoptic area injection of corticotrophin-releasing hormone stimulates sympathetic activity. Am J Physiol. 1990;259:R799–R806.
Morgan DA, Thorén P, Staudt SM, Mark AL. Differential effects of anesthesia on heart rate (HR), renal (RSNA), and lumbar sympathetic nerve activity (LSNA) in the rat. FASEB J. 1988;2:A1690. Abstract.

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Background
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Gopalakrishnan, G. S., Gardner, D. S., Rhind, S. M., Rae, M. T., Kyle, C. E., Brooks, A. N., Walker, R. M., Ramsay, M., Keisler, D. H., Stephenson, T. J., et al. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00687.2003 · Cited by 134
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Rahmouni, K. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.225 · Cited by 110
The physiological role of melanocortin receptors
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Autonomic Nervous System in the Control of Energy Balance and Body Weight: Personal Contributions
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Brain effects of melanocortins☆
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Tanida, M., Yamamoto, N., Shibamoto, T., & Rahmouni, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056660 · Cited by 88
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Morse, S. A., Zhang, R., Thakur, V., & Reisin, E. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200512000-00008 · Cited by 88
Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin
Zhang, Y., Kilroy, G. E., Henagan, T. M., Prpic‐Uhing, V., Richards, W. G., Bannon, A. W., Mynatt, R. L., & Gettys, T. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3851com · Cited by 87
The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure
Shimizu, H., Inoue, K., & Mori, M. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0144 · Cited by 88
Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension
Fisher, J. P., & Fadel, P. J. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2009.047332 · Cited by 85
Biased signaling at neural melanocortin receptors in regulation of energy homeostasis
Yang, L.-K., & Tao, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.04.010 · Cited by 84

Authors: Haynes, W. G., Morgan, D. A., Djalali, A., Sivitz, W. I., & Mark, A. L.
Affiliations: University of Iowa (US)
ORCID: Haynes, William G.
Morgan, Donald A.
Sivitz, William I.
Mark, Allyn L.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-01
Volume: 33
Issue: 1
Pages: 542-547
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/01.hyp.33.1.542
OpenAlex: W2038872854
Cited by: 358
References: 34
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 12 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 22 · 2013: 17 · 2012: 5
FWCI: 7.07
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
Pharmaceutical Research and Manufacturers of America Foundation
National Institutes of Health (5p50hl044546-05, 5r29hl043514-05)
National Heart, Lung, and Blood Institute (HL-43514, HL-14388, HL-44546, P01HL014388)
National Institute of Neurological Disorders and Stroke
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: melanocortin system, leptin, melanocortin-4 receptor, sympathetic activity, brown adipose tissue, thermogenesis, renal sympathetic nerve activity, lumbar sympathetic nerve activity, hypothalamus, melanotan II, SHU9119, appetite regulation, body weight regulation
MeSH terms: Animals, Adipose Tissue, Brown, Cerebral Ventricles, Infusions, Intravenous, Injections, Intraventricular, Kidney, Male, Melanocyte-Stimulating Hormones, Proteins, Recombinant Proteins, Sympathetic Nervous System, Rats, Sprague-Dawley, Receptors, Corticotropin, Leptin, Receptor, Melanocortin, Type 4, Rats

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Interactions Between the Melanocortin System and Leptin in Control of Sympathetic Nerve Traffic

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