Optimism, Cynical Hostility, and Incident Coronary Heart Disease and Mortality in the Women’s Health Initiative
Open accessAbstract
Background— Trait optimism (positive future expectations) and cynical, hostile attitudes toward others have not been studied together in relation to incident coronary heart disease (CHD) and mortality in postmenopausal women. Methods and Results— Participants were 97 253 women (89 259 white, 7994 black) from the Women’s Health Initiative who were free of cancer and cardiovascular disease at study entry. Optimism was assessed by the Life Orientation Test–Revised and cynical hostility by the cynicism subscale of the Cook Medley Questionnaire. Cox proportional hazard models produced adjusted hazard ratios (AHRs) for incident CHD (myocardial infarction, angina, percutaneous coronary angioplasty, or coronary artery bypass surgery) and total mortality (CHD, cardiovascular disease, or cancer related) over ≈8 years. Optimists (top versus bottom quartile [“pessimists”]) had lower age-adjusted rates (per 10 000) of CHD (43 versus 60) and total mortality (46 versus 63). The most cynical, hostile women (top versus bottom quartile) had higher rates of CHD (56 versus 44) and total mortality (63 versus 46). Optimists (versus pessimists) had a lower hazard of CHD (AHR 0.91, 95% CI 0.83 to 0.99), CHD-related mortality (AHR 0.70, 95% CI 0.55 to 0.90), cancer-related mortality (blacks only; AHR 0.56, 95% CI 0.35 to 0.88), and total mortality (AHR 0.86, 95% CI 0.79 to 0.93). Most (versus least) cynical, hostile women had a higher hazard of cancer-related mortality (AHR 1.23, 95% CI 1.09 to 1.40) and total mortality (AHR 1.16, 95% CI 1.07 to 1.27; this effect was pronounced in blacks). Effects of optimism and cynical hostility were independent. Conclusions— Optimism and cynical hostility are independently associated with important health outcomes in black and white women. Future research should examine whether interventions designed to change attitudes would lead to altered risk.
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Cardiovascular researchers have identified that optimism, positive psychological constructs, and subjective well-being are linked to significantly better cardiovascular outcomes, decreased rehospitalization and reduced risk of mortality.
“Cardiovascular researchers have identified that optimism, positive psychological constructs, and subjective well‐being are linked to significantly better cardiovascular outcomes, decreased rehospitalization and reduced risk of mortality. 19 , 21 , 64 , 65 , 66”
From Positive psychological well-being in women with obesity: A scoping review of qualitative and quantitative primary research (2022) · cites this paper as [64]
The Results (Multivariable Cox Proportional Hazard Models; page unavailable) report significantly lower coronary heart disease and mortality hazards among more optimistic women. The introductory passage (labeled Abstract > Conclusions; page unavailable) also reports prior evidence of less rehospitalization after bypass surgery among optimistic people. This paper does not establish the same associations for subjective well-being or positive psychological constructs generally, and rehospitalization was not an outcome of its own study. (LLM, conf=0.86)
Experimental — accuracy not yet measuredAn optimistic frame of mind is associated with healthy aging and a lower risk of CVD, including stroke and heart failure, and a lower risk of all-cause mortality.
“An optimistic frame of mind has been shown to be associated with healthy aging 60 and a lower risk of CVD, 61 including stroke 62 and heart failure, 63 and a lower risk of all-cause mortality. 64”
From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [61]
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- Authors
- Tindle, H. A., Chang, Y.-F., Kuller, L. H., Manson, J. E., Robinson, J. G., Rosal, M. C., Siegle, G. J., & Matthews, K. A.
- Affiliations
- University of Iowa (US)
- ORCID
- Venue
- Circulation
- Published
- 2009-08-25
- Volume
- 120
- Issue
- 8
- Pages
- 656-662
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC2901870
- OpenAlex
- W2107049851
- Cited by
- 483
- References
- 43
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 16 · 2023: 66 · 2022: 26 · 2021: 18 · 2020: 52 · 2019: 31 · 2018: 26 · 2017: 26 · 2016: 37 · 2015: 33 · 2014: 23 · 2013: 30 · 2012: 25
- FWCI
- 34.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship@UMassChan (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- Women's Health Initiative
- National Institutes of Health (HL076852, HL076852/076858)
- National Heart, Lung, and Blood Institute (HL 076858, HL 076852, R24HL076852, R24HL076858)
- National Institute of Mental Health (K02MH082998)
- National Center for Research Resources (KL2RR024154)
- National Center for Complementary and Integrative Health (L30 AT002496)
- Topics
- Social Sciences › Psychology › Applied Psychology › Optimism, Hope, and Well-being
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- dispositional optimism, cynical hostility, coronary artery disease, cardiovascular mortality, cancer mortality, postmenopausal women, racial differences, Life Orientation Test-Revised, Women's Health Initiative
- MeSH terms
- Aged, Attitude, Coronary Disease, Female, Follow-Up Studies, Hostility, Humans, Middle Aged, Surveys and Questionnaires, Risk Factors, Comorbidity, Incidence, Multivariate Analysis, Proportional Hazards Models, Women's Health, Age Distribution, Postmenopause, Black People, White People
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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