Cited by 612Nitric Oxide and Endothelin EffectsPlatelet Disorders and TreatmentsBlood Coagulation and Thrombosis Mechanisms

The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.

Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis

Loscalzo, Joseph·2001·Circulation Research

DOI 10.1161/hh0801.089861

Open this paper in CoChat — free account

Abstract

Abstract—Nitric oxide (NO) was originally discovered as a vasodilator product of the endothelium. Over the last 15 years, this vascular mediator has been shown to have important antiplatelet actions as well. By activating guanylyl cyclase, inhibiting phosphoinositide 3-kinase, impairing capacitative calcium influx, and inhibiting cyclooxygenase-1, endothelial NO limits platelet activation, adhesion, and aggregation. Platelets are also an important source of NO, and this platelet-derived NO pool limits recruitment of platelets to the platelet-rich thrombus. A deficiency of bioactive NO is associated with arterial thrombosis in animal models, individuals with endothelial dysfunction, and patients with a deficiency of the extracellular antioxidant enzyme glutathione peroxidase-3. This enzyme catalyzes the reduction of hydrogen and lipid peroxides, which limits the availability of these reactive oxygen species to react with and inactivate NO. The complex biochemical reactions that underlie the function and inactivation of NO in the vasculature represent an important set of targets for therapeutic intervention for the prevention and treatment of arterial thrombotic disorders.

Integrity signals

Registry

Crossref · 10.1161/hh0801.089861

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744
Self-citation
Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors
Laufs, U., Fata, V. L., Plutzky, J., & Liao, J. K. (1998) · Circulation · doi:10.1161/01.cir.97.12.1129 · Cited by 1,837
ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91481-4 · Cited by 1,437
Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives
Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7674 · Cited by 1,238
Self-citation
Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.
Ignarro, L. J., Byrns, R. E., Buga, G. M., & Wood, K. S. (1987) · Circulation Research · doi:10.1161/01.res.61.6.866 · Cited by 1,164
Comparative pharmacology of endothelium‐derived relaxing factor, nitric oxide and prostacyclin in platelets
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11310.x · Cited by 811
Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.
Katsuki, S., Arnold, W. P., Mittal, C. K., & Murad, F. (1977) · PubMed · Cited by 700

Flagged first, then by citations

Show all 80 references

Research works printed but not linked: 18

Cunningham M, Loscalzo J. Nitroprusside can induce clinically important platelet dysfunction only detectable in vitro by incubation with reduced thiol. Clin Res. 1985;33:337A.
10.1161/circ.83.6.1904015 · DOI
10.1161/res.61.6.2890446 · DOI
10.1161/res.65.3.2548765 · DOI
10.1161/res.65.3.2504509 · DOI
Keaney JF Jr, Stamler JS, Scharftstein J, Folts JD, Loscalzo J. Nitric oxide forms a stable adduct with serum albumin that has potent antiplatelet properties in vivo. Clin Res. 1992;40:194A. Abstract.
10.1161/res.81.5.865 · DOI
Pigazzi A, Fabian A, Johnson J, Upchurch GR, Loscalzo J. Identification of nitric oxide synthases in human megakaryocytes and platelets. Circulation. 1995;92:I-365.
10.1161/res.84.12.1416 · DOI
10.1161/circ.94.10.2434 · DOI
10.1161/str.31.10.2442 · DOI
10.1161/circ.97.12.1129 · DOI
10.1161/hyp.35.4.904 · DOI
10.1161/circ.94.12.3109 · DOI
10.1161/circ.98.15.1481 · DOI
10.1161/atvb.19.8.2017 · DOI
Voetsch B, Bierl C, Damasceno BP, Annichino-Bizzacchi JM, Arruda VR, Loscalzo J. A novel promoter polymorphism in the plasma glutathione peroxidase gene associated with arterial ischemic stroke in the young. Circulation. 2000;102:II-704.
10.1161/atvb.18.8.1248 · DOI

Sorted by citations

Items 101–200 of 611

Sex differences and the effects of sex hormones on hemostasis and vascular reactivity
Schwertz, D. W., & Penckofer, S. M. (2001) · Heart & Lung · doi:10.1067/mhl.2001.118764 · Cited by 83
The Role of Adiponectin in Atherosclerosis and Thrombosis
Ekmekçi, H., & Ekmekçi, Ö. B. (2006) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/107602960601200203 · Cited by 85
Endothelial Aging Associated with Oxidative Stress Can Be Modulated by a Healthy Mediterranean Diet
Marı́n, C., Yubero‐Serrano, E. M., López‐Miranda, J., & Pérez‐Jiménez, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14058869 · Cited by 84
Signal processing and generation of bioactive nitric oxide in a model prototissue
Liu, S., Zhang, Y., He, X., Li, M., Huang, J., Yang, X., Wang, K., Mann, S., & Liu, J. (2022) · Nature Communications · doi:10.1038/s41467-022-32941-6 · Cited by 78
Reduction of Thrombosis and Bacterial Infection via Controlled Nitric Oxide (NO) Release from S -Nitroso- N -acetylpenicillamine (SNAP) Impregnated CarboSil Intravascular Catheters
Wo, Y., Brisbois, E. J., Wu, J., Li, Z., Major, T. C., Mohammed, A., Wang, X., Colletta, A., Bull, J. L., Matzger, A. J., et al. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00622 · Cited by 79
Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics
Dzhalilova, D. S., & Makarova, O. V. (2020) · Biomedicines · doi:10.3390/biomedicines8100428 · Cited by 79
Alterations in Platelet Function During Aging: Clinical Correlations with Thromboinflammatory Disease in Older Adults
Mohebali, D., Kaplan, D., Carlisle, M., Supiano, M. A., & Rondina, M. T. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12700 · Cited by 79
Mechanisms of Human Erythrocytic Bioactivation of Nitrite
Liu, C., Wajih, N., Liu, X., Basu, S., Janes, J., Marvel, M., Keggi, C., Helms, C. C., Lee, A. N., Belanger, A. M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.609222 · Cited by 76
Nitric Oxide Inhibits Hetero-adhesion of Cancer Cells to Endothelial Cells: Restraining Circulating Tumor Cells from Initiating Metastatic Cascade
Lu, Y., Yu, T., Liang, H., Wang, J., Xie, J., Shao, J., Gao, Y., Yu, S., Chen, S., Wang, L., et al. (2014) · Scientific Reports · doi:10.1038/srep04344 · Cited by 76
Endothelial progenitor cells accelerate the resolution of deep vein thrombosis
Li, W., & Li, X. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.07.007 · Cited by 76
Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels
Riba, R., Nicolaou, A., Troxler, M. A., Homer‐Vanniasinkam, S., & Naseem, K. M. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.02.008 · Cited by 76
Dimethylarginine Dimethylaminohydrolase Promotes Endothelial Repair After Vascular Injury
Konishi, H., Sydow, K., & Cooke, J. P. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.068 · Cited by 76
LOX-1 Receptor Blockade Abrogates oxLDL-induced Oxidative DNA Damage and Prevents Activation of the Transcriptional Repressor Oct-1 in Human Coronary Arterial Endothelium
Thum, T., & Borlak, J. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708309200 · Cited by 74
Comparison of endothelial cells grown on different stent materials
Yeh, H., Lu, S., Tian, T.-Y., Hong, R., Lee, W., & Tsai, C. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30595 · Cited by 74
Changes in coronary endothelial function predict progression of allograft vasculopathy after heart transplantation
Hollenberg, S. M., Klein, L. W., Parrillo, J. E., Scherer, M. D., Burns, D. E., Tamburro, P., Bromet, D. S., Satran, A., & Costanzo, M. R. (2004) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(03)00150-5 · Cited by 73
Nitric oxide bioavailability in malaria
Sobolewski, P., Gramaglia, I., Frangos, J. A., Intaglietta, M., & van der Heyde, H. C. (2005) · Trends in Parasitology · doi:10.1016/j.pt.2005.07.002 · Cited by 74
Resistance to antiplatelet drugs: current status and future research
Tantry, U. S., Bliden, K. P., & Gurbel, P. A. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.12.2027 · Cited by 72
Chronic thromboembolic pulmonary hypertension: the magic of pathophysiology
Simonneau, G., Dorfmüller, P., Guignabert, C., Mercier, O. M., & Humbert, M. J. C. (2021) · Annals of Cardiothoracic Surgery · doi:10.21037/acs-2021-pte-10 · Cited by 73
The role of polyphenols in cardiovascular disease.
Michalska, M., Gluba-Brzózka, A., Mikhailidis, D. P., Nowak, P. J., Bielecka-Dabrowa, A. M., Rysz, J., & Banach, M. (2010) · PubMed · Cited by 71
The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model
Hu, W., Jin, R. C., Zhang, J., You, T., Peng, Z., Ge, X., Bronson, R. T., Halperin, J. A., Loscalzo, J., & Qin, X. (2010) · Blood · doi:10.1182/blood-2010-01-267112 · Cited by 70
Self-citation
Electrochemically Modulated Nitric Oxide (NO) Releasing Biomedical Devices via Copper(II)-Tri(2-pyridylmethyl)amine Mediated Reduction of Nitrite
Ren, H., Wu, J., Xi, C., Lehnert, N., Major, T., Bartlett, R. H., & Meyerhoff, M. E. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am406066a · Cited by 69
The AMP-Activated Protein Kinase Plays a Role in Antioxidant Defense and Regulation of Vascular Inflammation
Jansen, T., Kvandová, M., Daiber, A., Stamm, P., Frenis, K., Schulz, E., Münzel, T., & Kröller-Schön, S. (2020) · Antioxidants · doi:10.3390/antiox9060525 · Cited by 68
Hemocompatibility of Poly(vinyl alcohol)–Gelatin Core–Shell Electrospun Nanofibers: A Scaffold for Modulating Platelet Deposition and Activation
Merkle, V. M., Martin, D., Hutchinson, M., Tran, P. L., Behrens, A., Hossainy, S., Sheriff, J., Bluestein, D., Wu, X., & Slepian, M. J. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01671 · Cited by 68
Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation
Radziwon‐Balicka, A., Lesyk, G. M., Back, V., Fong, T., Loredo-Calderón, E. L., Dong, B., El-Sikhry, H. E., El-Sherbeni, A. A., El‐Kadi, A. O. S., Ogg, S. C., et al. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx179 · Cited by 68
Nitric oxide and blood: a review
Wallis, J. P. (2005) · Transfusion Medicine · doi:10.1111/j.1365-3148.2005.00542.x · Cited by 68
The Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas receptor axis: A potential target for treating thrombotic diseases
Fraga‐Silva, R. A., Silva, D. D., Montecucco, F., Mach, F., Stergiopulos, N., da Silva, R., & Santos, R. A. S. (2012) · Thrombosis and Haemostasis · doi:10.1160/th12-06-0396 · Cited by 66
Paraoxonase-1 activity modulates endothelial function in patients with peripheral arterial disease
Pasqualini, L., Cortese, C., Marchesi, S., Siepi, D., Pirro, M., Vaudo, G., Liberatoscioli, L., Gnasso, A., Schillaci, G., & Mannarino, E. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.030 · Cited by 65
Low-intensity (400 mW/cm 2 , 500 kHz) pulsed transcranial ultrasound preconditioning may mitigate focal cerebral ischemia in rats
Li, H., Sun, J., Zhang, D., Omire-Mayor, D., Lewin, P. A., & Tong, S. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.02.008 · Cited by 66
Potential markers and metabolic processes involved in the mechanism of radiation-induced heart injury
Slezák, J., Kura, B., Babál, P., Barančı́k, M., Ferko, M., Frimmel, K., Kaločayová, B., Kukreja, R. C., Lazou, A., Mézešová, L., et al. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0121 · Cited by 67
Role of the coagulation system in the pathogenesis of sickle cell disease
Nasimuzzaman, M., & Malik, P. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000193 · Cited by 65
Pathophysiological Aspects of Aging in Venous Thromboembolism: An Update
Akrivou, D., Perlepe, G., Kirgou, P., Gourgoulianis, K. I., & Malli, F. (2022) · Medicina · doi:10.3390/medicina58081078 · Cited by 65
L-Arginine and Nitric Oxide in Vascular Regulation—Experimental Findings in the Context of Blood Donation
Kurhaluk, N., & Tkaczenko, H. (2025) · Nutrients · doi:10.3390/nu17040665 · Cited by 62
“These dietary interventions not only facilitate donor recovery but also help prevent such complications as hypoperfusion and platelet aggregation by exploiting the vasodilatory and antiplatelet properties of NO [80,106].”
Effect of angiotensin II type 1 receptor antagonism on endothelial function: role of bradykinin and nitric oxide
Landmesser, U., & Drexler, H. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000220405.38622.23 · Cited by 62
Reduced Vascular NO Bioavailability in Diabetes Increases Platelet Activation In Vivo
Schäfer, A., Alp, N. J., Cai, S., Lygate, C. A., Neubauer, S., Eigenthaler, M., Bauersachs, J. K., & Channon, K. M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000138072.76902.dd · Cited by 62
Platelet Glycoprotein IIb/IIIa Receptor Blockade Improves Vascular Nitric Oxide Bioavailability in Patients With Coronary Artery Disease
Heitzer, T. A., Ollmann, I., Koeke, K., Meinertz, T., & Münzel, T. F. (2003) · Circulation · doi:10.1161/01.cir.0000081774.31064.62 · Cited by 62
Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humans
Oteiza, P. I., Fraga, C. G., & Galleano, M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101914 · Cited by 64
Drug releasing systems in cardiovascular tissue engineering
Spadaccio, C., Chello, M., Trombetta, M., Rainer, A., Toyoda, Y., & Genovese, J. A. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00532.x · Cited by 63
Rosuvastatin Reduces Platelet Activation in Heart Failure
Schäfer, A., Fraccarollo, D., Eigenthaler, M., Tas, P. W. L., Firnschild, A., Frantz, S., Ertl, G., & Bauersachs, J. K. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000161926.43967.df · Cited by 61
Disulfide Bonds as Regulators of Integrin Function in Thrombosis and Hemostasis
Mor-Cohen, R. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6149 · Cited by 59
Astragalus polysaccharide ameliorates H2O2-induced human umbilical vein endothelial cell injury
Han, R., Tang, F., Lü, M., Xu, C., Hu, J., Mei, M., & Wang, H. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6515 · Cited by 58
Oxidative stress in endothelial cell dysfunction and thrombosis
Loscalzo, J. (2002) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000073600 · Cited by 58
Self-citation
Óxido nítrico: revisão
Cerqueira, N. F., & Yoshida, W. B. (2002) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-86502002000600011 · Cited by 64
Endothelial nitric oxide synthase, vascular integrity and human exceptional longevity
Puca, A. A., Carrizzo, A., Ferrario, A., Villa, F., & Vecchione, C. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-26 · Cited by 59
Interaction between smoking and PON2 Ser311Cys polymorphism as a determinant of the risk of myocardial infarction
Martinelli, N., Girelli, D., Olivieri, O., Stranieri, C., Trabetti, E., Pizzolo, F., Friso, S., Tenuti, I., Cheng, S., Grow, M. A., et al. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01292.x · Cited by 57
Swimming reduces the severity of atherosclerosis in apolipoprotein E deficient mice by antioxidant effects
OKABE, T., SHIMADA, K., HATTORI, M., MURAYAMA, T., Yokode, M., Kita, T., & Kishimoto, C. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.02.019 · Cited by 56
Thromboresistant/anti-biofilm catheters via electrochemically modulated nitric oxide release
Ren, H., Colletta, A., Koley, D., Wu, J., Xi, C., Major, T. C., Bartlett, R. H., & Meyerhoff, M. E. (2015) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2014.12.003 · Cited by 55
Impaired flow-mediated vasodilation in type 2 diabetes: Lack of relation to microvascular dysfunction
Meyer, M. F., Lieps, D., Schatz, H., & Pfohl, M. (2008) · Microvascular Research · doi:10.1016/j.mvr.2008.03.001 · Cited by 54
Association Between the T-786C eNOS Polymorphism and Idiopathic Osteonecrosis of the Head of the Femur
Glueck, C. J., Wang, P., Freiberg, R. A., Oghene, J., & Fontaine, R. N. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200711000-00018 · Cited by 54
Nitric Oxide in the Pathogenesis of Cardiac Disease
Raij, L. R. (2006) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2006.06025.x · Cited by 59
Unresolved roles of platelet nitric oxide synthase
Naseem, K. M., & RIBA, R. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02802.x · Cited by 54
Pharmacologic Profile and Therapeutic Potential of NCX 4016, a Nitric Oxide‐releasing Aspirin, for Cardiovascular Disorders
Gresele, P., & Momi, S. (2006) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2006.00148.x · Cited by 53
Decreased levels of serum nitric oxide in different forms of dementia
Corzo, L., Zas, R., Rodríguez, S., Fernández‐Novoa, L., & Cacabelos, R. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.05.008 · Cited by 53
Decreased Plasma Concentration of Nitric Oxide Metabolites in Dogs with Untreated Mitral Regurgitation
Pedersen, H. D., Schütt, T., Søndergaard, R., Qvortrup, K., Olsen, L. H., & Kristensen, A. T. (2003) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2003.tb02431.x · Cited by 53
S1P and eNOS regulation
IGARASHI, J. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.06.008 · Cited by 53
Exploring the medicinal significance of l-Arginine mediated nitric oxide in preventing health disorders
Oyovwi, M. O., & Atere, A. D. (2024) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2024.100175 · Cited by 51
A fish oil-rich diet reduces vascular oxidative stress in apoE–/–mice
Casós, K., Zaragozá, M. C., Žarković, N., Žarković, K., Andrišić, L., Portero‐Otín, M., Cacabelos, D., & Mitjavila, M. T. (2010) · Free Radical Research · doi:10.3109/10715762.2010.485992 · Cited by 51
Molecular mechanisms of pulmonary hypertension
Yildiz, P. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.01.018 · Cited by 54
P-Selectin/PSGL-1 and Other Interactions between Platelets, Leukocytes, and Endothelium
McEver, R. P. (2007) · Elsevier eBooks · doi:10.1016/b978-012369367-9/50774-6 · Cited by 50
Diabetes and Inflammation
Cosentino, F., & Assenza, G. E. (2004) · Herz · doi:10.1007/s00059-004-2635-8 · Cited by 51
Increased plasma S-nitrosothiol levels in chronic haemodialysis patients
Massy, Z. A. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/18.1.153 · Cited by 50
Ectonucleotidase activities are altered in serum and platelets of l-NAME-treated rats
Fürstenau, C. R., Trentin, D. D. S., Gossenheimer, A. N., Ramos, D. B., Casali, É. A., Barreto‐Chaves, M. L. M., & Sarkis, J. J. F. (2008) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2008.04.009 · Cited by 50
Cerebral Vasculature Is the Major Target of Oxidative Protein Alterations in Bacterial Meningitis
Schaper, M., Gergely, S., Lykkesfeldt, J., Zbären, J., Leib, S. L., Täuber, M. G., & Christen, S. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.7.605 · Cited by 49
Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation
Hsiao, G., Wang, Y., Tzu, N.-H., Fong, T.-H., Shen, M., Lin, K.-H., Chou, D., & Sheu, J. (2005) · Journal of Laboratory and Clinical Medicine · doi:10.1016/j.lab.2005.03.018 · Cited by 48
Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function
Pang, P. D., Abbott, M., Abdi, M., Fucci, Q., Chauhan, N., Mistri, M., Proctor, B. M., Chin, M. C., Wang, B., Yin, W., et al. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx304 · Cited by 50
Self-citation
Protective Effects of Methotrexate against Proatherosclerotic Cytokines: A Review of the Evidence
Mangoni, A. A., Zinellu, A., Sotgia, S., Carru, C., Piga, M., & Erre, G. L. (2017) · Mediators of Inflammation · doi:10.1155/2017/9632846 · Cited by 47
Nitric oxide pathology and therapeutics in sickle cell disease
Kim‐Shapiro, D. B., & Gladwin, M. T. (2018) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-189009 · Cited by 51
Regulation of Microvascular Thromboembolism In Vivo
Egbrink, M. G. A. O., van Gestel, M. A., Broeders, M. A. W., Tangelder, G. J., Heemskerk, J. W. M., Reneman, R. S., & Slaaf, D. W. (2005) · Microcirculation · doi:10.1080/10739680590925628 · Cited by 47
NCX-4016 (NO-Aspirin) Inhibits Lipopolysaccharide-Induced Tissue Factor Expression In Vivo
Fiorucci, S., Mencarelli, A., Meneguzzi, A., Lechi, A., Morelli, A., Soldato, P. D., & Minuz, P. (2002) · Circulation · doi:10.1161/01.cir.0000039341.57809.1e · Cited by 47
Fine air pollution particles induce endothelial senescence via redox-sensitive activation of local angiotensin system
Sharma, K., Lee, H.-H., Gong, D.-S., Park, S., Yi, E., Schini‐Kerth, V. B., & Oak, M. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.05.066 · Cited by 46
Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice
Yang, H. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)03086-8 · Cited by 45
Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin
Hu, W., Ferris, S. P., Tweten, R. K., Wu, G., Radaeva, S., Gao, B., Bronson, R. T., Halperin, J. A., & Qin, X. (2007) · Nature Medicine · doi:10.1038/nm1674 · Cited by 45
Homocysteine Activates Platelets In Vitro
Mohan, I. V., Jagroop, I. A., Mikhailidis, D. P., & Stansby, G. P. (2007) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029607308390 · Cited by 45
Replicative senescence promotes prothrombotic responses in endothelial cells: role of NADPH oxidase- and cyclooxygenase-derived oxidative stress
Silva, G. C., Abbas, M., Khemais-Benkhiat, S., Burban, M., Ribeiro, T. P., Toti, F., Idris-Khodja, N., Côrtes, S. F., & Schini-Kerth, V. B. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.04.006 · Cited by 44
Aspirin resistance: Truth or dare
Lordkipanidzé, M., Pharand, C., Palisaitis, D., & Diodati, J. G. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.05.011 · Cited by 44
Peripheral arterial disease and Virchow’s triad
Bennett, P. C., Silverman, S., Gill, P. S., & Lip, G. Y. H. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-08-0518 · Cited by 44
Abundance of Plasma Antioxidant Proteins Confers Tolerance to Acute Hypobaric Hypoxia Exposure
Padhy, G., Sethy, N. K., Ganju, L., & Bhargava, K. (2013) · High Altitude Medicine & Biology · doi:10.1089/ham.2012.1095 · Cited by 44
PPAR‐γ – a possible drug target for complicated pregnancies
McCarthy, F. P., Delany, A. C., Kenny, L. C., & Walsh, S. K. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12069 · Cited by 43
Inhibition of Nitric Oxide and Antiphospholipid Antibody-Mediated Thrombosis
Mineo, C. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-013-0324-4 · Cited by 43
Perturbations in paracrine control of the circulation: Role of the endothelial‐derived vasomediators, endothelin‐1 and nitric oxide
Mawji, I. A., & Marsden, P. A. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10242 · Cited by 43
Design, synthesis and evaluation of nitric oxide releasing derivatives of 3-n-butylphthalide as antiplatelet and antithrombotic agents
Wang, X., Li, Y., Zhao, Q., Min, Z., Zhang, C., Lai, Y., Ji, H., Peng, S., & Zhang, Y. (2011) · Organic & Biomolecular Chemistry · doi:10.1039/c1ob05478c · Cited by 43
Possible involvement of plasma antioxidant defences in training-associated decrease of platelet responsiveness in humans
Massimo, C. D., Scarpelli, P., Penco, M., & Ciancarelli, M. G. T. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-003-0998-9 · Cited by 43
Surface markers of platelet function in idiopathic nephrotic syndrome in children
Tkaczyk, M., & Baj, Z. (2002) · Pediatric Nephrology · doi:10.1007/s00467-002-0865-7 · Cited by 43
Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in mice
Weldy, C. S., Luttrell, I. P., White, C. C., Morgan‐Stevenson, V., Bammler, T. K., Beyer, R. P., Afsharinejad, Z., Kim, F., Chitaley, K., & Kavanagh, T. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.006 · Cited by 42
Nitric Oxide and its Antithrombotic Action in the Cardiovascular System
Reichenbach, G., Momi, S., & Gresele, P. (2005) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1568006053005047 · Cited by 42
Atherothrombosis: Plaque instability and thrombogenesis
Ruberg, F. L., Leopold, J. A., & Loscalzo, J. (2002) · Progress in Cardiovascular Diseases · doi:10.1053/pcad.2002.123469 · Cited by 42
Self-citation
Near‐infrared II photobiomodulation augments nitric oxide bioavailability via phosphorylation of endothelial nitric oxide synthase
Yokomizo, S., Roeßing, M., Morita, A., Kopp, T., Ogawa, E., Katagiri, W., Feil, S. C., Huang, P. L., Atochin, D. N., & Kashiwagi, S. (2022) · The FASEB Journal · doi:10.1096/fj.202101890r · Cited by 41
Viewpoint: The Prothrombotic State in Heart Failure: A Maladaptive Inflammatory Response?
Chong, A., & Lip, G. Y. H. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.05.009 · Cited by 42
New Mechanism of Action for Cilostazol: Interplay Between Adenosine and Cilostazol in Inhibiting Platelet Activation
Sun, B., Le, S. N. T., Lin, S., Fong, M., Guertin, M., Liu, Y., Tandon, N. N., Yoshitake, M., & Kambayashi, J. (2002) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200210000-00011 · Cited by 41
Differential expression and anti‐oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization
Xu, X. P., Leng, J.-Y., Gao, F., Zhao, Z., Deng, W., Liang, X., Zhang, Y.-J., Zhang, Z., Li, M., Sha, A., et al. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.02.043 · Cited by 40
A rhodamine-deoxylactam based fluorescent probe for fast and selective detection of nitric oxide in living cells
Jiang, W., Li, Y., Liu, H., Zhou, D.-Y., Ouyang, J., Yi, L., & Li, C. (2019) · Talanta · doi:10.1016/j.talanta.2019.01.061 · Cited by 40
Iatrogenic Hyperviscosity and Thrombosis
Meiselman, H. J., & Baskurt, O. K. (2012) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0032-1325616 · Cited by 40
Insights into the Role of Glutathione Peroxidase 3 in Non-Neoplastic Diseases
Zhang, N., Liao, H., Lin, Z., & Tang, Q. (2024) · Biomolecules · doi:10.3390/biom14060689 · Cited by 40
Red Blood Cell Abnormalities as the Mirror of SARS-CoV-2 Disease Severity: A Pilot Study
Bouchla, A., Kriebardis, A. G., Georgatzakou, H. Τ., Fortis, S. P., Thomopoulos, T. P., Lekkakou, L., Markakis, K. P., Gkotzias, D., Panagiotou, A., Papageorgiou, E. G., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.825055 · Cited by 39
Genetic determinants of response to aspirin: Appraisal of 4 candidate genes
Lordkipanidzé, M., Diodati, J. G., Palisaitis, D., Schampaert, É., Turgeon, J., & Pharand, C. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.02.019 · Cited by 38
The interaction of vasoactive substances during exercise modulates platelet aggregation in hypertension and coronary artery disease
Petidis, K., Δούμα, Σ., Doumas, M. N., Basagiannis, I., Vogiatzis, K., & Zamboulis, C. (2008) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-8-11 · Cited by 38
Polymer nanocomposites enhance S-nitrosoglutathione intestinal absorption and promote the formation of releasable nitric oxide stores in rat aorta
Wu, W., Perrin‐Sarrado, C., Ming, H., Lartaud, I., Maincent, P., Hu, X., Sapin‐Minet, A., & Gaucher, C. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.05.006 · Cited by 38
Unique Contribution of Haptoglobin and Haptoglobin Genotype in Aneurysmal Subarachnoid Hemorrhage
Blackburn, S., Kumar, P. T., McBride, D. W., Zeineddine, H. A., Leclerc, J. L., Choi, H. A., Dash, P. K., Grotta, J. C., Aronowski, J. A., Cardenas, J. C., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00592 · Cited by 39
Activation of Non-Heme Iron-Nitrosyl Complexes: Turning Up the Heat
Lehnert, N., Fujisawa, K., Camarena, S., Dong, H. T., & White, C. J. (2019) · ACS Catalysis · doi:10.1021/acscatal.9b03219 · Cited by 38
Platelet-mediated vascular dysfunction during acute lung injury
Dixon, T., Gozal, E., & Roberts, A. M. (2012) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2012.665463 · Cited by 41
Increased Plasma S-Nitrosothiol Concentrations Predict Cardiovascular Outcomes among Patients with End-Stage Renal Disease
Massy, Z. A., Fumeron, C., Borderie, D., Tuppin, P., Nguyen‐Khoa, T., Benoit, M., Jacquot, C., Buisson, C., Drüeke, T. B., Ekindjian, O. G., et al. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000106716.22153.bb · Cited by 38

Authors: Loscalzo, J.
Affiliations: Boston University (US)
Corresponding author: Loscalzo, Joseph
ORCID: Loscalzo, Joseph
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-04-27
Volume: 88
Issue: 8
Pages: 756-762
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/hh0801.089861
OpenAlex: W2113684546
Cited by: 612
References: 80
Citations by year: 2026: 18 · 2025: 21 · 2024: 22 · 2023: 21 · 2022: 22 · 2021: 19 · 2020: 25 · 2019: 15 · 2018: 28 · 2017: 25 · 2016: 16 · 2015: 24 · 2014: 27 · 2013: 28 · 2012: 29
FWCI: 3.28
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL61795, HL 55993, HL58976, R01HL058976, P50HL055993)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords: nitric oxide, platelet activation, arterial thrombosis, endothelial dysfunction, glutathione peroxidase 3, phosphatidylinositol 3-kinase, cyclooxygenase-1, guanylate cyclase, platelet aggregation, thromboprophylaxis
MeSH terms: Animals, Arteries, Blood Platelets, Endothelium, Vascular, Glutathione Peroxidase, Humans, Nitric Oxide, Thrombosis, Vasodilator Agents, Platelet Activation, Reactive Oxygen Species, Nitric Oxide Donors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks