Adiponectin, Cardiovascular Function, and Hypertension

Prevalence of Overweight and Obesity in the United States, 1999-2004

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Global burden of hypertension: analysis of worldwide data

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Prevalence and trends in obesity among US adults, 1999–2000

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Increased oxidative stress in obesity and its impact on metabolic syndrome

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Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): A randomised trial against atenolol

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Prevalence of Overweight and Obesity in the United States

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Prevalence and Trends in Overweight Among US Children and Adolescents, 1999-2000

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Selected major risk factors and global and regional burden of disease

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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

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Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

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Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

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Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial

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The Spread of the Obesity Epidemic in the United States, 1991-1998

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AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

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Adipose Tissue, Inflammation, and Cardiovascular Disease

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cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

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Hypertension Prevalence and Blood Pressure Levels in 6 European Countries, Canada, and the United States

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Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

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Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity

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Adipose Tissue

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Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin

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Identification of Telmisartan as a Unique Angiotensin II Receptor Antagonist With Selective PPARγ–Modulating Activity

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Dynamic activation of endothelial nitric oxide synthase by Hsp90

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Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells

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The spread of the obesity epidemic in the United States

Mokdad, A. H., Serdula, M. K., & Dietz, W. H. (1999) · Cited by 985

Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma

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The Kidney, Hypertension, and Obesity

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Body Mass Index and the Prevalence of Hypertension and Dyslipidemia

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Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

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Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

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Obesity-Associated Hypertension

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Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors

Iwaki, M., Matsuda, M., Maeda, N., Funahashi, T., Matsuzawa, Y., Makishima, M., & Shimomura, I. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1655 · Cited by 747

Angiotensin Type 1 Receptor Blockers Induce Peroxisome Proliferator–Activated Receptor-γ Activity

Schupp, M., Janke, J., Clasen, R., Unger, T., & Kintscher, U. (2004) · Circulation · doi:10.1161/01.cir.0000127955.36250.65 · Cited by 707

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

Mao, X., Kikani, C. K., Riojas, R. A., Langlais, P. R., Wang, L., Ramos, F. J., Fang, Q., Christ-Roberts, C. Y., Hong, J., Kim, R. Y., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1404 · Cited by 671

Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function

Goldstein, B. J., & Scalia, R. G. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0518 · Cited by 647

Hypoadiponectinemia Is an Independent Risk Factor for Hypertension

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Association of Hypoadiponectinemia With Impaired Vasoreactivity

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Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPAR Agonists: A Potential Mechanism of Insulin Sensitization

Combs, T. P., Wagner, J. A., Berger, J. P., Doebber, T. W., Wang, W., Zhang, B. B., Tanen, M., Berg, A. H., O’Rahilly, S., Savage, D. B., et al. (2002) · Endocrinology · doi:10.1210/endo.143.3.8662 · Cited by 568

Adiponectin Multimeric Complexes and the Metabolic Syndrome Trait Cluster

Lara‐Castro, C., Luo, N., Wallace, P., Klein, R. L., & Garvey, W. T. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-1105 · Cited by 480

Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension

Furuhashi, M., Ura, N., Higashiura, K., Murakami, H., Tanaka, M., Moniwa, N., Yoshida, D., & Shimamoto, K. (2003) · Hypertension · doi:10.1161/01.hyp.0000078490.59735.6e · Cited by 460

How to assess sympathetic activity in humans

Grassi, G., & Esler, M. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917060-00001 · Cited by 455

THE REGULATION AND PHARMACOLOGY OF ENDOTHELIAL NITRIC OXIDE SYNTHASE

Dudzinski, D. M., Igarashi, J., Greif, D. M., & Michel, T. M. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121844 · Cited by 424

Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000222368.43759.a1 · Cited by 400

The sympathetic nervous system and the metabolic syndrome

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Obesity hypertension: role of leptin and sympathetic nervous system

Hall, J. E. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02077-5 · Cited by 361

Hypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation

Tan, K. C. B., Xu, A., Chow, W.-S., Lam, M. C., Ai, V. H. G., Tam, S., & Lam, K. S. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031012 · Cited by 356

Adiponectin actions in the cardiovascular system

Hopkins, T. A., Ouchi, N., Shibata, R., & Walsh, K. X. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.009 · Cited by 331

Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells

Cheng, K. K. Y., Lam, K. S. L., Wang, Y., Huang, Y., Carling, D., Wu, D., Wong, C., & Xu, A. (2007) · Diabetes · doi:10.2337/db06-1580 · Cited by 318

Secretion of the Adipocyte-Specific Secretory Protein Adiponectin Critically Depends on Thiol-Mediated Protein Retention

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Selective Angiotensin II Receptor Antagonism Reduces Insulin Resistance in Obese Zucker Rats

Henriksen, E. J., Jacob, S., Kinnick, T. R., Teachey, M. K., & Krekler, M. (2001) · Hypertension · doi:10.1161/hy1101.092970 · Cited by 293

Relation of obesity and diet to sympathetic nervous system activity.

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Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo

Ouedraogo, R., Gong, Y., Berzins, B., Wu, X., Mahadev, K., Hough, K., Chan, L., Goldstein, B. J., & Scalia, R. G. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29623 · Cited by 265

Adiponectin gene expression is inhibited by β‐adrenergic stimulation via protein kinase A in 3T3‐L1 adipocytes

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Hypoadiponectinemia as a Predictor for the Development of Hypertension

Chow, W.-S., Cheung, B. M. Y., Tso, A. W. K., Xu, A., Wat, N. M. S., Fong, C. H.-Y., Ong, L. H. Y., Tam, S., Tan, K. C. B., Janus, E. D., et al. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.086835 · Cited by 262

PPARγ-Activating Angiotensin Type-1 Receptor Blockers Induce Adiponectin

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Mechanisms of Early Insulin-Sensitizing Effects of Thiazolidinediones in Type 2 Diabetes

Tonelli, J., Li, W., Kishore, P., Pajvani, U. B., Kwon, E., Weaver, C. L., Scherer, P. E., & Hawkins, M. A. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1621 · Cited by 247

Effects of Weight Loss in Overweight/Obese Individuals and Long-Term Hypertension Outcomes: A Systematic Review

Aucott, L., Poobalan, A., Smith, W. C. S., Avenell, A., Jung, R., & Broom, J. (2005) · Hypertension · doi:10.1161/01.hyp.0000165680.59733.d4 · Cited by 241

Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum

Kusminski, C. M., McTernan, P. G., Schraw, T., Kos, K., O’Hare, J. P., Ahima, R. S., Kumar, S., & Scherer, P. E. (2007) · Diabetologia · doi:10.1007/s00125-006-0577-9 · Cited by 225

Globular adiponectin upregulates nitric oxide production in vascular endothelial cells

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Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression

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Brain Adipocytokine Action and Metabolic Regulation

Ahima, R. S., Qi, Y., Singhal, N. S., Jackson, M. B., & Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-s018 · Cited by 150

The Renin-Angiotensin System and Its Receptors

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Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance

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Molecular activation of PPARγ by angiotensin II type 1-receptor antagonists

Erbe, D. V., Gartrell, K., Zhang, Y., Suri, V., Kirincich, S. J., Will, S., Perreault, M., Wang, S., & Tobin, J. F. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.05.002 · Cited by 135

Sympathetic Overdrive and Cardiovascular Risk in the Metabolic Syndrome

Grassi, G. M. (2006) · Hypertension Research · doi:10.1291/hypres.29.839 · Cited by 131

Stimulated HSP90 binding to eNOS and activation of the PI3–Akt pathway contribute to globular adiponectin-induced NO production: Vasorelaxation in response to globular adiponectin

Wang, X., Satoh, H., Kase, H., Suzuki, K., & Hattori, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.111 · Cited by 116

Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome

Yılmaz, M. İ., Sönmez, A., Çağlar, K., Celık, T., Yenicesu, M., Eyileten, T., Açıkel, C., Oğuz, Y., Yavuz, İ., & Vural, A. (2007) · Nephrology · doi:10.1111/j.1440-1797.2007.00764.x · Cited by 112

Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats.

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Cold Exposure Suppresses Serum Adiponectin Levels through Sympathetic Nerve Activation in Mice

Imai, J., Katagiri, H., Yamada, T., Ishigaki, Y., Ogihara, T., Uno, K., Hasegawa, Y., Gao, J., Ishihara, H., Sasano, H., et al. (2006) · Obesity · doi:10.1038/oby.2006.130 · Cited by 91

Blockade of Sympathetic Nervous System Activity by Rilmenidine Increases Plasma Adiponectin Concentration in Patients With Essential Hypertension

Nowak, Ł., Adamczak, M., & Wiecek, A. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.026 · Cited by 59

Rosiglitazone — Continued Uncertainty about Safety

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The effect of losartan and amlodipine on serum adiponectin in Japanese adults with essential hypertension

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Vascular protection in diabetes: a pharmacological view of angiotensin II type 1 receptor blockers

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World Hypertension Day 2007

Jones, D. W., & Hall, J. E. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.088740 · Cited by 34

World Hypertension Day

Smith, E. R. (2006) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(06)70274-4 · Cited by 16

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

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Endothelial dysfunction and vascular disease - a 30th anniversary update

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Endothelial dysfunction and vascular disease

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Obesity, kidney dysfunction and hypertension: mechanistic links

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Adiponectin regulation and function

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Research of the Adiponectin and Cardiovascular Disease Relation

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Adiponectin and Hypertension

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Antihypertensive treatment, adiponectin and cardiovascular risk

Karthikeyan, V., & Lip, G. Y. H. (2006) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002113 · Cited by 8

Adiponectin and Cardiovascular Disease

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