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Habitual versus Goal-directed Action Control in Parkinson Disease
Open accessAbstract
This study presents the first direct investigation of the hypothesis that dopamine depletion of the dorsal striatum in mild Parkinson disease leads to impaired stimulus-response habit formation, thereby rendering behavior slow and effortful. However, using an instrumental conflict task, we show that patients are able to rely on direct stimulus-response associations when a goal-directed strategy causes response conflict, suggesting that habit formation is not impaired. If anything our results suggest a disease severity-dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior.
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In the citing paper
“one attempt to test this found results that indicated it was goal-directed learning that appeared to be impaired in patients with this neurodegenerative disease (Nelson and Killcross, 2006, de Wit et al., 2011).”
From The role of habit in compulsivity (2016) · cites this paper as de Wit et al., 2011
In the citing paper
“Briefly, the instrumental learning task was developed to distinguish between goal-directed and habit-based learning,19 and has been used successfully in studies to establish habits in both animals and humans.24,41, 42, 43, 44”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [42]
In the citing paper
“Indeed, previous studies have demonstrated that both humans and animals adopt an S–R habitual learning strategy to solve this incongruent trial type.19,41, 42, 43, 44”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [42]
In the citing paper
“In these trials, goal-directed learning is disadvantageous, and performance relies solely on habitual control via direct S–R associations.”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [42]
In the citing paper
“For example, patients with Parkinson's disease show an imbalance between goal-directed and habit learning.42”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [42]
In the citing paper
“They also showed that (goal-directed) performance in a posttraining devaluation test covaried negatively with disease severity, arguing that model-based influences were impaired.”
From Goals and Habits in the Brain (2013) · cites this paper as de Wit et al., 2011
In the citing paper
“They showed that subjects with the disease could solve the task, arguing that habit formation may not have been eliminated.”
From Goals and Habits in the Brain (2013) · cites this paper as de Wit et al., 2011
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Gera, R., Or, M. B., Tavor, I., Roll, D., Cockburn, J., Barak, S., Tricomi, E. M., O’Doherty, J. P., & Schönberg, T. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.12.520188 · Cited by 5
Electrophysiology of goal-directed versus habitual control during outcome devaluation
Yousuf, M., Heldmann, M., Münte, T. F., & Doñamayor, N. (2019) · Cortex · doi:10.1016/j.cortex.2019.08.002 · Cited by 5
K369I Tau Mice Demonstrate a Shift Towards Striatal Neuron Burst Firing and Goal-directed Behaviour
Mo, M., Jönsson, M. E., Mathews, M. A., Johnstone, D. M., Ke, Y. D., Ittner, L. M., Balleine, B. W., Furlong, T. M., & Camp, A. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.09.023 · Cited by 2
Control of Behaviour by Competing Learning Systems
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Metadata
- Authors
- de Wit, S., Barker, R. A., Dickinson, A. D., & Cools, R.
- Affiliations
- 1University of Amsterdam, The Netherlands
- University of Cambridge (GB)
- Radboud University Medical Center (NL)
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press - Journals
- Published
- 2011-05-01
- Volume
- 23
- Issue
- 5
- Pages
- 1218-1229
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W2136439930
- Cited by
- 116
- References
- 74
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 15 · 2017: 11 · 2016: 5 · 2015: 6 · 2014: 13 · 2013: 8 · 2012: 10
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Fast Grants
- Parkinson's UK (K-0610)
- Universiteit van Amsterdam
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- Parkinson's disease, habitual behavior, goal-directed behavior, dopamine depletion, dorsal striatum, stimulus-response associations, response conflict, disease severity, action control
- MeSH terms
- Aged, Analysis of Variance, Association Learning, Conditioning, Operant, Discrimination Learning, Dopamine, Goals, Habits, Humans, Male, Middle Aged, Parkinson Disease, Reaction Time, Reference Values, Severity of Illness Index, Dopamine Agents, Case-Control Studies, Matched-Pair Analysis, Neostriatum
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