The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
Open accessAbstract
The present study was aimed at determining whether hepcidin, a recently identified peptide involved in iron metabolism, plays a role in conditions associated with both iron overload and iron deficiency.Hepcidin mRNA levels were assessed in two models of anemia, acute hemolysis provoked by phenylhydrazine and bleeding provoked by repeated phlebotomies.Hepcidin response to hypoxia was also studied, both ex vivo, in human hepatoma cells, and in vivo.Anemia and hypoxia were associated with a dramatic decrease in liver hepcidin gene expression, which may account for the increase in iron release from reticuloendothelial cells and increase in iron absorption frequently observed in these situations.A single injection of turpentine for 16 hours induced a sixfold increase in liver hepcidin mRNA levels and a twofold decrease in serum iron.The hyposideremic effect of turpentine was completely blunted in hepcidin-deficient mice, revealing hepcidin participation in anemia of inflammatory states.These modifications of hepcidin gene expression further suggest a key role for hepcidin in iron homeostasis under various pathophysiological conditions, which may support the pharmaceutical use of hepcidin agonists and antagonists in various iron homeostasis disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“the turpentine-induced hypoferremia was not observed in hepcidin-deficient mice (8), demonstrating that hepcidin is required for iron sequestration during inflammatory conditions”
From IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin (2004) · cites this paper as [8]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“hepcidin synthesis is regulated by dietary iron and iron stores, as well as by tissue oxygenation”
From IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin (2004) · cites this paper as [8]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“decreased in mice with anemia caused by bleeding or hemolysis or in mice with hypoxemia due to decreased ambient oxygen”
From IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin (2004) · cites this paper as [8]
The cited source says what the claim attributes to it.
In the citing paper
“injections of turpentine increased hepcidin mRNA”
From IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin (2004) · cites this paper as [8]
The cited source says what the claim attributes to it.
In the citing paper
“decreased serum iron”
From IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin (2004) · cites this paper as [8]
In the citing paper
“Infection and inflammation induce hepcidin production, driving a decrease in plasma iron concentrations by inhibiting the absorption of iron and promoting the sequestration of iron in macrophages.”
From Iron homeostasis in host defence and inflammation (2015) · cites this paper as [26]
In the citing paper
“The increase in hepcidin secretion in response to infectious or inflammatory stimuli is responsible for the characteristic hypoferraemia of inflammation26,27, which develops within a few hours of a systemic infection or following injection of microbial components or certain cytokines.”
From Iron homeostasis in host defence and inflammation (2015) · cites this paper as [26]
In the citing paper
“Strikingly, anaemia and anoxia both suppress hepcidin production [245,339,340] (Fig 3), such that just while superoxide production is being enhanced by the anoxia there is more iron being absorbed from the intestine and effluxed into the circulation.”
In the citing paper
“A common mechanism of hypoferremia of inflammation is a cytokine-driven increase in hepcidin [15] that downregulates ferroportin and thereby decreases iron flow into extracellular fluid from all its sources.”
From Iron and infection (2018) · cites this paper as [15]
In the citing paper
“Thus, under the influence of increased concentrations of hepcidin, recycled iron is retained in macrophages of the liver and the spleen, and iron absorption is decreased.”
From Iron and infection (2018) · cites this paper as [15]
In the citing paper
“Conversely, hepcidin expression is inhibited by hypoxia and erythropoiesis [11,12].”
From Hepcidin and Host Defense against Infectious Diseases (2015) · cites this paper as [11]
In the citing paper
“In addition, the amount of hepcidin mRNA in liver cells is decreased in response to hypoxia and ineffective erythropoiesis (overlapping with the response to iron deficiency) 99,105 and induced in response to treatment with lipopolysaccharide or by inflammation of other etiologies.92,99”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [99]
In the citing paper
“Initially, murine hepcidin mRNA was shown to be elevated in response to iron overload 92 and decreased in response to iron deficiency.99,100”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [99]
In the citing paper
“Experimental studies in cultured cells, in animal models and in human subjects have established that hepcidin production is O2-sensitive and involves the HIF pathway.”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [192]
In the citing paper
“A study that examined postmortem unfixed frozen brain sections from elderly normal or PD-affected individuals showed that individual neurons from brains of individuals with PD had significantly elevated iron concentrations (220).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [220]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324
Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233
Self-citationSevere iron deficiency anemia in transgenic mice expressing liver hepcidin
Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., & Vaulont, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072632499 · Cited by 880
Self-citationRegulators of iron balance in humans [see comments]
Finch, C. (1994) · Blood · doi:10.1182/blood.v84.6.1697.1697 · Cited by 455
Milanini, J., Viñals, F., Pouysségur, J., & Pagès, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18165 · Cited by 315
Iron metabolism in the erythrophagocytosing Kupffer cell
Kondo, H. G., Saito, K., Grasso, J. P., & Aisen, P. (1988) · Hepatology · doi:10.1002/hep.1840080108 · Cited by 125
Kelley‐Loughnane, N., Sabla, G. E., Ley, C. A., Aronow, B. J., & Bezerra, J. A. (2002) · Hepatology · doi:10.1053/jhep.2002.31351 · Cited by 77
Raja, K. B., Simpson, R. J., Pippard, M. J., & Peters, T. J. (1988) · British Journal of Haematology · doi:10.1111/j.1365-2141.1988.tb04217.x · Cited by 72
Flagged first, then by citations
Research works printed but not linked: 3
- Raja, 1990, Int J Exp Pathol, 71, 785
- Mazure, 2002, Cancer Res, 62, 1158
- Torrance, 1980, Meth Hematol, 1, 90
Cited by
Sorted by citations
Items 101–200 of 1,019
Proinflammatory state, hepcidin, and anemia in older persons
Ferrucci, L., Semba, R. D., Guralnik, J. M., Ershler, W. B., Bandinelli, S., Patel, K. V., Sun, K., Woodman, R. C., Andrews, N. C., Cotter, R. J., et al. (2010) · Blood · doi:10.1182/blood-2009-02-201087 · Cited by 245
Gehrke, S. G., Kulaksiz, H., Herrmann, T. R. W., Riedel, H.-D., Bents, K., Veltkamp, C., & Stremmel, W. (2003) · Blood · doi:10.1182/blood-2002-11-3610 · Cited by 246
Molecular Mechanisms of Hepcidin Regulation: Implications for the Anemia of CKD
Babitt, J. L., & Lin, H. Y.-F. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.12.030 · Cited by 245
Valore, E. V., & Ganz, T. (2008) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.07.009 · Cited by 234
Regulation of iron acquisition and iron distribution in mammals
Ganz, T., & Nemeth, E. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.03.014 · Cited by 237
Yoon, D., Pastore, Y. D., Divoký, V., Liu, E., Mlodnicka, A., Rainey, K., Poňka, P., Semenza, G. L., Schumacher, A., & Prchal, J. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602329200 · Cited by 231
Brasse–Lagnel, C., Karim, Z., Letteron, P., Bekri, S., Bado, A., & Beaumont, C. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.12.037 · Cited by 230
Self-citationExpression and localization of hepcidin in macrophages: a role in host defense against tuberculosis
Sow, F. B., Florence, W. C., Satoskar, A. R., Schlesinger, L. S., Zwilling, B. S., & Lafuse, W. P. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407216 · Cited by 229
Song, S.-N. J., Tomosugi, N., Kawabata, H., Ishikawa, T., Nishikawa, T., & Yoshizaki, K. (2010) · Blood · doi:10.1182/blood-2010-03-271791 · Cited by 228
Lin, B., Chen, S., Cao, Z., Lin, Y., Mo, D., Zhang, H., Gu, J., Dong, M., Liu, Z., & Xu, A. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.03.001 · Cited by 231
The role of iron homeostasis in remodeling immune function and regulating inflammatory disease
Mu, Q., Chen, L., Gao, X., Shen, S., Sheng, W., Min, J., & Wang, F. (2021) · 中国科学通报：英文版 · doi:10.1016/j.scib.2021.02.010 · Cited by 232
Galy, B., Ferring–Appel, D., Miñana, B., Bell, O., Janser, H., Muckenthaler, M. U., Schümann, K., & Hentze, M. W. (2005) · Blood · doi:10.1182/blood-2005-04-1365 · Cited by 224
Hepcidin: regulation of the master iron regulator
Rishi, G., Wallace, D. F., & Subramaniam, V. N. (2015) · Bioscience Reports · doi:10.1042/bsr20150014 · Cited by 223
Anderson, E. R., & Shah, Y. M. (2012) · Comprehensive physiology · doi:10.1002/cphy.c120016 · Cited by 262
Lawen, A., & Lane, D. J. R. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4271 · Cited by 220
Wullaert, A., Loo, G., Heyninck, K., & Beyaert, R. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0031 · Cited by 221
Role of the hypoxia inducible factors HIF in iron metabolism
Peyssonnaux, C., Nizet, V., & Johnson, R. S. (2008) · Cell Cycle · doi:10.4161/cc.7.1.5145 · Cited by 217
Effect of hepcidin on intestinal iron absorption in mice
Laftah, A. H., Ramesh, B., Simpson, R. J., Solanky, N., Bahram, S., Schümann, K., Debnam, E. S., & Srai, S. K. S. (2004) · Blood · doi:10.1182/blood-2003-03-0953 · Cited by 217
Association of hemochromatosis with infectious diseases: expanding spectrum
Khan, F. A., Fisher, M. A., & Khakoo, R. A. (2007) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2007.04.007 · Cited by 216
The orchestration of body iron intake: how and where do enterocytes receive their cues?
Frazer, D. M., & Anderson, G. J. (2003) · Blood Cells Molecules and Diseases · doi:10.1016/s1079-9796(03)00039-1 · Cited by 211
Hemochromatosis: An endocrine liver disease
Pietrangelo, A. (2007) · Hepatology · doi:10.1002/hep.21886 · Cited by 212
“Iron accumulation in cells may result from (1) increased iron influx, (2) decreased efflux, or, more rarely, (3) altered intracellular trafficking.”
BackgroundHepcidin Expression in the Liver: Relatively Low Level in Patients with Chronic Hepatitis C
Fujita, N., Sugimoto, R., Takeo, M., Urawa, N., Mifuji, R., Tanaka, H., Kobayashi, Y., Iwasa, M., Watanabe, S., Adachi, Y., et al. (2007) · Molecular Medicine · doi:10.2119/2006-00057.fujita · Cited by 211
Lauth, X., Babon, J. J., Stannard, J. A., Singh, S., Nizet, V., Carlberg, J. M., Ostland, V. E., Pennington, M. W., Norton, R. S., & Westerman, M. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411154200 · Cited by 207
Hepcidin and Host Defense against Infectious Diseases
Michels, K., Nemeth, E., Ganz, T., & Mehrad, B. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004998 · Cited by 205
Anemia of inflammation: the hepcidin link
Roy, C. N., & Andrews, N. C. (2005) · Current Opinion in Hematology · doi:10.1097/00062752-200503000-00001 · Cited by 203
Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders
Camaschella, C. (2005) · Blood · doi:10.1182/blood-2005-05-1857 · Cited by 198
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
Rivera, S., Liu, L., Nemeth, E., Gabayan, V., Sorensen, O. E., & Ganz, T. (2005) · Blood · doi:10.1182/blood-2004-08-3375 · Cited by 196
Corradini, E., Meynard, D., Wu, Q., Chen, S., Ventura, P., Pietrangelo, A., & Babitt, J. L. (2011) · Hepatology · doi:10.1002/hep.24359 · Cited by 194
Haase, V. H. (2021) · Kidney International Supplements · doi:10.1016/j.kisu.2020.12.002 · Cited by 205
Ashby, D. R., Gale, D. P., Busbridge, M., Murphy, K. G., Duncan, N. D., Cairns, T. D., Taube, D. H., Bloom, S. R., Tam, F. W. K., Chapman, R., et al. (2010) · Haematologica · doi:10.3324/haematol.2009.013136 · Cited by 191
Alves, F. M., Lane, D. J. R., Nguyen, T. P. M., Bush, A. I., & Ayton, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02088-5 · Cited by 212
Détivaud, L., Nemeth, E., Boudjéma, K., Turlin, B., Troadec, M., Leroyer, P., Ropert, M., Jacquelinet, S., Courselaud, B., Ganz, T., et al. (2005) · Blood · doi:10.1182/blood-2004-12-4855 · Cited by 191
Pathways underlying iron accumulation in human nonalcoholic fatty liver disease
Aigner, E., Theurl, I., Theurl, M., Lederer, D., Haufe, H., Dietze, O., Strasser, M., Datz, C., & Weiss, G. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1374 · Cited by 190
Theurl, I., Mattle, V., Seifert, M., Mariani, M., Marth, C., & Weiss, G. (2006) · Blood · doi:10.1182/blood-2005-08-3364 · Cited by 188
Hypoxia-inducible factors link iron homeostasis and erythropoiesis
Shah, Y. M., & Xie, L. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.12.031 · Cited by 187
Leptin Increases the Expression of the Iron Regulatory Hormone Hepcidin in HuH7 Human Hepatoma Cells
Chung, B., Matak, P., McKie, A. T., & Sharp, P. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2366 · Cited by 188
Role of hepcidin in the pathophysiology and diagnosis of anemia
D’Angelo, G. (2013) · Blood Research · doi:10.5045/br.2013.48.1.10 · Cited by 193
Sun, C. C., Vaja, V., Babitt, J. L., & Lin, H. Y.-F. (2011) · American Journal of Hematology · doi:10.1002/ajh.23110 · Cited by 185
Iron Homeostasis in the Neonate
Collard, K. J. (2009) · PEDIATRICS · doi:10.1542/peds.2008-1047 · Cited by 183
Nairz, M., Theurl, I., Ludwiczek, S., Theurl, M., Mair, S. M., Fritsche, G., & Weiss, G. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00942.x · Cited by 182
Semrin, G., Fishman, D. S., Bousvaros, A., Zholudev, A., Saunders, A. C., Correia, C. E., Nemeth, E., Grand, R. J., & Weinstein, D. A. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000235097.86360.04 · Cited by 181
Iron homeostasis in the metabolic syndrome
Datz, C., Felder, T. K., Niederseer, D., & Aigner, E. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12032 · Cited by 181
Iron regulation and erythropoiesis
Nemeth, E. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3282f73335 · Cited by 177
Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation
Roy, C. N., Mak, H. H., Akpan, I., Losyev, G., Zurakowski, D., & Andrews, N. C. (2007) · Blood · doi:10.1182/blood-2006-10-051755 · Cited by 178
Oxidative stress and neurodegeneration: the involvement of iron
Carocci, A., Catalano, A. A., Sinicropi, M. S., & Genchi, G. (2018) · BioMetals · doi:10.1007/s10534-018-0126-2 · Cited by 188
Besson-Fournier, C., Latour, C., Kautz, L., Bertrand, J., Ganz, T., Roth, M.-P., & Coppin, H. (2012) · Blood · doi:10.1182/blood-2012-02-411470 · Cited by 179
Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
Liu, X.-B., Nguyen, N.-B., Marquess, K. D., Yang, F., & Haile, D. J. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.006 · Cited by 186
Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation
Schmidt, P. J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.650150 · Cited by 188
The liver: conductor of systemic iron balance
Meynard, D., Babitt, J. L., & Lin, H. Y.-F. (2013) · Blood · doi:10.1182/blood-2013-06-427757 · Cited by 181
Bao, B., Peatman, E., Li, P., He, C., & Liu, Z. (2005) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2005.03.006 · Cited by 178
Regulation of Hepcidin and Iron-Overload Disease
Lee, P. L., & Beutler, E. (2009) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092205 · Cited by 174
Merle, U., Fein, E., Gehrke, S. G., Stremmel, W., & Kulaksiz, H. (2007) · Endocrinology · doi:10.1210/en.2006-1331 · Cited by 173
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation
Steinbicker, A. U., Sachidanandan, C., Vonner, A. J., Yusuf, R. Z., Deng, D. Y., Lai, C. S., Rauwerdink, K. M., Winn, J. C., Saez, B., Cook, C. M., et al. (2011) · Blood · doi:10.1182/blood-2010-10-313064 · Cited by 173
Oxidative stress in β-thalassaemia and sickle cell disease
Voskou, S., Aslan, M., Fanis, P., Phylactides, M., & Kleanthous, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.07.018 · Cited by 175
The Hepcidin-Ferroportin System as a Therapeutic Target in Anemias and Iron Overload Disorders
Ganz, T., & Nemeth, E. (2011) · Hematology · doi:10.1182/asheducation-2011.1.538 · Cited by 172
Urinary hepcidin in congenital chronic anemias
Kearney, S. L., Nemeth, E., Neufeld, E. J., Thapa, D., Ganz, T., Weinstein, D. A., & Cunningham, M. J. (2007) · Pediatric Blood & Cancer · doi:10.1002/pbc.20616 · Cited by 172
Hepcidin Is Involved in Iron Regulation in the Ischemic Brain
Ding, H., Yan, C.-Z., Shi, H., Zhao, Y., Chang, S., Yu, P., Wu, W., Zhao, C., Chang, Y., & Duan, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025324 · Cited by 172
Rodrigues, P., Vázquez-Dorado, S., Neves, J. V., & Wilson, J. M. (2006) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2006.02.005 · Cited by 169
Copper Availability Contributes to Iron Perturbations in Human Nonalcoholic Fatty Liver Disease
Aigner, E. S., Theurl, I., Haufe, H., Seifert, M., Hohla, F., Scharinger, L., Stickel, F., Mourlane, F., Weiß, G., & Datz, C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.007 · Cited by 165
The Regulation of Cellular Iron Metabolism
Chua, A. C. G., Graham, R. M., Trinder, D., & Olynyk, J. K. (2007) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360701428257 · Cited by 172
Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
Prentice, A. M., Doherty, C. P., Abrams, S. A., Cox, S. E., Atkinson, S. H., Verhoef, H., Armitage, A. E., & Drakesmith, H. (2012) · Blood · doi:10.1182/blood-2011-11-391219 · Cited by 167
Ganz, T. (2004) · Current Opinion in Hematology · doi:10.1097/00062752-200407000-00004 · Cited by 166
Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli
Huang, H., Constante, M., Layoun, A., & Santos, M. M. (2009) · Blood · doi:10.1182/blood-2008-08-173641 · Cited by 164
Hepcidins in amphibians and fishes: Antimicrobial peptides or iron-regulatory hormones?
Shi, J. N., & Camus, A. C. (2005) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2005.10.009 · Cited by 167
Finberg, K. E., Whittlesey, R. L., Fleming, M. D., & Andrews, N. C. (2010) · Blood · doi:10.1182/blood-2009-05-224808 · Cited by 167
Review article: the iron overload syndromes
Siddique, A., & Kowdley, K. V. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05051.x · Cited by 162
Mastrogiannaki, M., Matak, P., Mathieu, J. R. R., Delga, S., Mayeux, P., Vaulont, S., & Peyssonnaux, C. (2011) · Haematologica · doi:10.3324/haematol.2011.056119 · Cited by 171
Self-citationDeGregorio‐Rocasolano, N., Martı́, O., & Gasull, T. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00085 · Cited by 162
The anaemia of cancer: death by a thousand cuts
Spivak, J. L. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1648 · Cited by 166
First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
Wallace, D. F., Summerville, L., Lusby, P. E., & Subramaniam, V. N. (2005) · Gut · doi:10.1136/gut.2004.062018 · Cited by 160
HIF‐prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism
Haase, V. H. (2017) · Hemodialysis International · doi:10.1111/hdi.12567 · Cited by 164
Murphy, A., Witcher, D. R., Luan, P., & Wroblewski, V. J. (2007) · Blood · doi:10.1182/blood-2006-11-057471 · Cited by 158
Hepcidin-ferroportin axis in health and disease
Ginzburg, Y. Z. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.002 · Cited by 171
Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology
Alnuwaysir, R. I. S., Hoes, M. F., van Veldhuisen, D. J., van der Meer, P., & Beverborg, N. G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010125 · Cited by 175
Restless legs syndrome – Theoretical roles of inflammatory and immune mechanisms
Weinstock, L. B., Walters, A. S., & Paueksakon, P. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.09.003 · Cited by 158
Erythropoietic regulators of iron metabolism
Ganz, T. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.003 · Cited by 160
Interferon‐γ limits the availability of iron for intramacrophage Salmonella typhimurium
Nairz, M., Fritsche, G., Brunner, P., Talasz, H., Hantke, K., & Weiss, G. (2008) · European Journal of Immunology · doi:10.1002/eji.200738056 · Cited by 151
Iron in the Tumor Microenvironment-Connecting the Dots
Pfeifhofer-Obermair, C., Tymoszuk, P., Petzer, V., Weiss, G., & Nairz, M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00549 · Cited by 151
Piperno, A., Galimberti, S., Mariani, R., Pelucchi, S., Ravasi, G., Lombardi, C., Bilo, G., Revera, M., Giuliano, A., Faini, A., et al. (2011) · Blood · doi:10.1182/blood-2010-08-299859 · Cited by 151
Cappellini, M. D., Porter, J. B., Viprakasit, V., & Taher, A. T. (2018) · Blood Reviews · doi:10.1016/j.blre.2018.02.001 · Cited by 165
Inherited iron overload disorders
Piperno, A., Pelucchi, S., & Mariani, R. (2020) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2019.11.15 · Cited by 156
Zhang, A., West, A. P., Wyman, A. E., Björkman, P. J., & Enns, C. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506207200 · Cited by 149
Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations
Dallalio, G. A., Law, E., & Means, R. T. (2005) · Blood · doi:10.1182/blood-2005-07-2854 · Cited by 149
Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis
Piperno, A., Girelli, D., Nemeth, E., Trombini, P., Bozzini, C., Poggiali, E., Phung, Y., Ganz, T., & Camaschella, C. (2007) · Blood · doi:10.1182/blood-2007-06-096503 · Cited by 149
Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB
Sonnweber, T., Nachbaur, D., Schroll, A., Nairz, M., Seifert, M., Demetz, E., Haschka, D., Mitterstiller, A.-M., Kleinsasser, A., Burtscher, M., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305317 · Cited by 145
Ku, E., Vecchio, L. D., Eckardt, K., Haase, V. H., Johansen, K. L., Nangaku, M., Tangri, N., Waikar, S. S., Więcek, A., Cheung, M., et al. (2023) · Kidney International · doi:10.1016/j.kint.2023.05.009 · Cited by 162
Anaemia in inflammatory rheumatic diseases
Weiss, G., & Schett, G. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.183 · Cited by 146
Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells
Chaston, T., Chung, B., Mascarenhas, M., Marks, J., Patel, B., Srai, S. K., & Sharp, P. (2008) · Gut · doi:10.1136/gut.2007.131722 · Cited by 145
Peters, D. G., Connor, J. R., & Meadowcroft, M. D. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.007 · Cited by 146
A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin
Kim, A., Fung, E., Parikh, S. G., Valore, E. V., Gabayan, V., Nemeth, E., & Ganz, T. (2014) · Blood · doi:10.1182/blood-2013-08-521419 · Cited by 145
Ross, S. L., Tran, L., Winters, A., Lee, K.-J., Plewa, C., Foltz, I., King, C., Miranda, L. P., Allen, J., Beckman, H., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.017 · Cited by 145
Hemochromatosis: Genetics and Pathophysiology
Beutler, E. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.57.121304.131310 · Cited by 142
Song, S.-N. J., Iwahashi, M., Tomosugi, N., Uno, K., Yamana, J., Yamana, S., Isobe, T., Ito, H., Kawabata, H., & Yoshizaki, K. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4323 · Cited by 143
Macrophage Iron, Hepcidin, and Atherosclerotic Plaque Stability
Sullivan, J. L. (2007) · Experimental Biology and Medicine · doi:10.3181/0703-mr-54 · Cited by 147
Robach, P., Cairo, G., Gelfi, C., Bernuzzi, F., Pilegaard, H., Viganò, A., Santambrogio, P., Cerretelli, P., Calbet, J. A. L., Moutereau, S., et al. (2007) · Blood · doi:10.1182/blood-2006-08-040006 · Cited by 141
The pathophysiology and pharmacology of hepcidin
Ruchala, P. P., & Nemeth, E. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.01.004 · Cited by 141
Inhibition of iron transport across human intestinal epithelial cells by hepcidin
Yamaji, S., Sharp, P., Ramesh, B., & Srai, S. K. (2004) · Blood · doi:10.1182/blood-2004-03-0829 · Cited by 139
Iron, lipocalin, and kidney epithelia
Yang, J., Mori, K., Li, J. Y., & Barasch, J. M. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00008.2003 · Cited by 139
Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption
Vanoaica, L., Darshan, D., Richman, L., Schümann, K., & Kühn, L. C. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.08.003 · Cited by 137
Genetics, genetic testing, and management of hemochromatosis: 15 years since hepcidin
Pietrangelo, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.06.045 · Cited by 136
Metadata
- Authors
- Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Service de Santé des Armées (FR)
- Inserm (FR)
- Corresponding author
- Vaulont, Sophie
- Venue
- Journal of Clinical Investigation
- Published
- 2002-10-01
- Volume
- 110
- Issue
- 7
- Pages
- 1037-1044
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W4243766541
- Cited by
- 1,214
- References
- 14
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 16 · 2023: 36 · 2022: 33 · 2021: 35 · 2020: 63 · 2019: 52 · 2018: 53 · 2017: 55 · 2016: 44 · 2015: 45 · 2014: 71 · 2013: 58 · 2012: 61
- FWCI
- 20.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Keywords
- hepcidin, iron homeostasis, anemia, hypoxia, inflammation, iron deficiency, iron overload, phlebotomy, turpentine, hepatoma cells, serum iron, reticuloendothelial cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
