Cited by 345Lipid metabolism and disordersLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Abnormal in vivo metabolism of apolipoprotein E4 in humans.

Open access

Gregg, R E, Zech, L A, Schaefer, E J, Stark, D, Wilson, D, Brewer, H B·1986·Journal of Clinical Investigation

Open this paper in CoChat — free account

Abstract

Apolipoprotein E (apoE) is important in modulating the catabolism of remnants of triglyceride-rich lipoprotein particles. It is a polymorphic protein with the three common alleles coding for apoE2, apoE3, and apoE4. ApoE3 is considered the normal isoform, while apoE4 is associated both with hypercholesterolemia and type V hyperlipoproteinemia. We quantitated the kinetics of metabolism of apoE4 in 19 normolipidemic apoE3 homozygotes and 1 normolipidemic apoE4 homozygote, and compared this with the metabolism of apoE3 in 12 normolipidemic apoE3 homozygotes. In the apoE3 homozygous subjects, apoE4 was catabolized twice as fast as apoE3, with a mean plasma residence time of 0.37 +/- 0.01 d (+/- SEM) and 0.73 +/- 0.05 (P less than 0.001), respectively. When plasma was fractionated into the lipoprotein subclasses, the greatest amount of labeled apoE4 was present on very low density lipoproteins, while the largest fraction of labeled apoE3 was associated with high density lipoproteins. The plasma apoE concentration was decreased in an apoE4 homozygote compared with the apoE3 homozygotes (3.11 mg/dl vs. 4.83 +/- 0.35 mg/dl). The reduced apoE4 concentration was entirely due to a decreased apoE4 residence time in the apoE4 homozygote (0.36 d vs. 0.73 +/- 0.05 d for apoE3 in apoE3 homozygotes). These results indicate that apoE4 is kinetically different than apoE3, and suggest that the presence of apoE4 in hypercholesterolemic and type V hyperlipoproteinemic individuals may play an important pathophysiological role in the development of these dyslipoproteinemias.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci112645

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM
Havel, R. J., Eder, H. A., & Bragdon, J. H. (1955) · Journal of Clinical Investigation · doi:10.1172/jci103182 · Cited by 8,737
Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol.
Warnick, G. R., Benderson, J., & Albers, J. J. (1982) · Clinical Chemistry · doi:10.1093/clinchem/28.6.1379 · Cited by 2,154
Lipid Research Clinics Program
Renfrew, R. A. (1984) · JAMA · doi:10.1001/jama.1984.03350180015009 · Cited by 829
Lipoprotein receptors and cholesterol homeostasis
Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 756
Human apolipoprotein E. The complete amino acid sequence
Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34702-1 · Cited by 741
Abnormal lipoprotein receptor‐binding activity of the human E apoprotein due to cysteine‐arginine interchange at a single site
Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34954-8 · Cited by 673
Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification
Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563
Polymorphism of apolipoprotein E
Utermann, G., Vogelberg, K. H., Steinmetz, A., Schoenborn, W., Pruin, N., Jaeschke, M., Hees, M. T. I. W. S.-V., & Canzler, H. (1979) · Clinical Genetics · doi:10.1111/j.1399-0004.1979.tb02027.x · Cited by 408
Familial hyperlipoproteinemia type III: Deficiency of a specific apolipoprotein (APO E‐III) in the very‐low‐density lipoproteins
Utermann, G., Jaeschke, M., & Menzel, J. (1975) · FEBS Letters · doi:10.1016/0014-5793(75)81125-2 · Cited by 337
Metabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects.
Packard, C. J., Munro, A. F., Lorimer, A. R., Gotto, A. M., & Shepherd, J. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111644 · Cited by 298

Flagged first, then by citations

Show all 27 references

Research works printed but not linked: 1

[13]13. Gregg, R. E., D. Wilson, E. Rubalcaba, R. Ronan, and H. B. Brewer, Jr. 1983. Immunoquantitation of apolipoprotein E. Proc. Workshop Apolipoprotein Quantitation. 383–401.

Sorted by citations

Items 101–200 of 344

A common Hpa I RFLP of apolipoprotein C-I increases gene transcription and exhibits an ethnically distinct pattern of linkage disequilibrium with the alleles of apolipoprotein E
Xu, Y. K., Berglund, L., Ramakrishnan, R., Mayeux, R. P., Ngai, C. I., Holleran, S., Tycko, B., Leff, T., & Shachter, N. S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33338-1 · Cited by 73
DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA
Yassine, H. N., Croteau, É., Rawat, V., Hibbeln, J. R., Rapoport, S. I., Cunnane, S. C., & Umhau, J. C. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0250-1 · Cited by 80
CSF Apo-E levels associate with cognitive decline and MRI changes
Initiative, F. T. A. D. N., Toledo, J. B., Da, X., Weiner, M. W., Wolk, D. A., Xie, S. X., Arnold, S. E., Davatzikos, C., Shaw, L. M., & Trojanowski, J. Q. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1236-0 · Cited by 71
Angiotensin-Converting Enzyme and Apolipoprotein E Genotypes and Restenosis After Coronary Angioplasty
BOCKXMEER, F. M. V., Mamotte, C. D. S., Gibbons, F. A., Burke, V., & Taylor, R. R. (1995) · Circulation · doi:10.1161/01.cir.92.8.2066 · Cited by 70
Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E
Fazio, S., Lee, Y. L., Ji, Z. S., & Rall, S. C. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116728 · Cited by 71
Interaction between low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) alleles contributes to normal variation in lipid level
Pedersen, J. C., & Berg, K. (1989) · Clinical Genetics · doi:10.1111/j.1399-0004.1989.tb02953.x · Cited by 70
Warfarin dose related to apolipoprotein E (APOE) genotype
Kohnke, H., Sörlin, K., Granath, G., & Wadelius, M. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0936-3 · Cited by 68
Combined effects of lipoprotein lipase and apolipoprotein E polymorphisms on lipid and lipoprotein levels in the Stanislas cohort
Salah, D., Bohnet, K., Gueguen, R., Siest, G., & Visvikis‐Siest, S. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37215-1 · Cited by 68
Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Is It Contributing to Higher Risk of Cognitive Decline and Coronary Heart Disease?
Chouinard‐Watkins, R., & Plourde, M. (2014) · Nutrients · doi:10.3390/nu6104452 · Cited by 73
An analysis of genotype effects and their interactions by using the apolipoprotein E polymorphism and longitudinal data.
Gueguen, R., Visvikis‐Siest, S., Steinmetz, J., Siest, G., & Boerwinkle, E. (1989) · PubMed · Cited by 67
APOE ε3/ε4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer’s disease diagnosis
Fukumoto, H., Ingelsson, M., Gårevik, N., Wahlund, L.-O., Nukina, N., Yaguchi, Y., Shibata, M., Hyman, B. T., Rebeck, G. W., & Irizarry, M. C. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00088-8 · Cited by 63
Comparison of the LDL-receptor binding of VLDL and LDL from apoE4 and apoE3 homozygotes
Mamotte, C. D. S., Sturm, M., Foo, J. I., BOCKXMEER, F. M. V., & Taylor, R. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.3.e553 · Cited by 66
Genetic studies of human apolipoproteins. X. The effect of the apolipoprotein E polymorphism on quantitative levels of lipoproteins in Nigerian blacks.
Sepehrnia, B., Kamboh, M. I., Adams-Campbell, L. L., Bunker, C. H., Nwankwo, M. U., Majumder, P. P., & Ferrell, R. E. (1989) · PubMed · Cited by 65
Structure and Functions of Human Cerebrospinal Fluid Lipoproteins from Individuals of Different APOE Genotypes
Rebeck, G. W., Alonzo, N. C., Berezovska, O., Harr, S. D., Knowles, R. B., Growdon, J. H., Hyman, B. T., & Mendez, A. J. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6710 · Cited by 66
Association of apolipoprotein (Apo)E genotype with plasma apo E levels
Larson, I. A., Ordovás, J. M., DeLuca, C., Barnard, J. R., Feussner, G., & Schaefer, E. J. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00280-4 · Cited by 64
Self-citation
Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma
Huang, Y., von Eckardstein, A., Wu, S., & Assmann, G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118336 · Cited by 49
Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes
Minihane, A. M. (2016) · Nutrients · doi:10.3390/nu8030123 · Cited by 64
Cholesterol and Alzheimer's disease
Wolozin, B. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300525 · Cited by 33
The effect of fasting triacylglyceride concentration and apolipoprotein E polymorphism on postprandial lipemia.
Brown, A. J., & Roberts, D. C. K. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.6.1737 · Cited by 62
Apolipoprotein E and viral infection: Risks and Mechanisms
Chen, F., Ke, Q., Wei, W., Cui, L., & Wang, Y. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.07.031 · Cited by 60
Alterations in cholesterol metabolism–related genes in sporadic Alzheimer's disease
Picard, C., Julien, C., Frappier, J., Miron, J., Théroux, L., Dea, D., Breitner, J. C. S., & Poirier, J. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.01.018 · Cited by 60
Apolipoprotein E Carboxyl-terminal Fragments Are Complexed to Amyloids A and L
Castaño, E. M., Prelli, F., Pras, M., & Frangione, B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17610 · Cited by 59
Lipoproteins, neurobiology, and Alzheimer's disease: structure and function of apolipoprotein E
Weisgraber, K. H., Pitas, R. E., & Mahley, R. W. (1994) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(94)90212-7 · Cited by 58
Influence of LDL receptor gene mutation and apo E polymorphism on lipoprotein response to simvastatin treatment among adolescents with heterozygous familial hypercholesterolemia
Vohl, M., Szöts, F., Lelièvre, M., Lupien, P.-J., Bergeron, J., Gagné, C., & Couture, P. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00584-6 · Cited by 57
Evidence That the Apolipoprotein E-Genotype Effects on Lipid Levels Can Change with Age in Males: A Longitudinal Analysis
Jarvik, G. P., Goode, E. L., Austin, M. A., Auwerx, J. H., Deeb, S. S., Schellenberg, G. D., & Reed, T. (1997) · The American Journal of Human Genetics · doi:10.1086/513902 · Cited by 57
Effects of the apolipoprotein E polymorphism on levels of lipids, lipoproteins, and apolipoproteins among Mexican-Americans in Starr County, Texas.
Hanis, C. L., Hewett‐Emmett, D., Douglas, T., Bertin, T., & Schull, W. J. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.2.362 · Cited by 57
Interaction between BMI and APOE genotype is associated with changes in the plasma long-chain–PUFA response to a fish-oil supplement in healthy participants
Chouinard‐Watkins, R., Conway, V., Minihane, A. M., Jackson, K. G., Lovegrove, J. A., & Plourde, M. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.103507 · Cited by 63
Native Complex Formation between Apolipoprotein E Isoforms and the Alzheimer's Disease Peptide Aβ
Chan, W., Fornwald, J. A., Brawner, M. E., & Wetzel, R. B. (1996) · Biochemistry · doi:10.1021/bi952852v · Cited by 57
Apolipoprotein E polymorphism, age and coronary heart disease
Kolovou, G. D., & Anagnostopoulou, K. K. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.11.001 · Cited by 54
In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS
Wildsmith, K. R., Basak, J. M., Patterson, B. W., Pyatkivskyy, Y., Kim, J., Yarasheski, K. E., Wang, J. X., Mawuenyega, K. G., Jiang, H., Parsadanian, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038013 · Cited by 54
“Peripheral blood ApoE metabolism is partially understood [13– 17], where ApoE4 is catabolized twice as fast as ApoE3 [15].”
Background
Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma
Baker-Nigh, A. T., Mawuenyega, K. G., Bollinger, J. G., Ovod, V., Kasten, T., Franklin, E. E., Liao, F., Jiang, H., Holtzman, D., Cairns, N. J., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.721779 · Cited by 54
The Role of Apolipoprotein E in Guillain-Barré Syndrome and Experimental Autoimmune Neuritis
Zhang, H., Wu, J., & Zhu, J. (2010) · BioMed Research International · doi:10.1155/2010/357412 · Cited by 57
Impact of Apo E Phenotype on the Regulation of Cholesterol Metabolism
Miettinen, T. A. (1991) · Annals of Medicine · doi:10.3109/07853899109148045 · Cited by 53
Isoform-Dependent Cholesterol Efflux From Macrophages by Apolipoprotein E Is Modulated by Cell Surface Proteoglycans
Hara, M., Matsushima, T., Satoh, H., Iso-o, N., Noto, H., Togo, M., Kimura, S., Hashimoto, Y., & Tsukamoto, K. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000054199.78458.4b · Cited by 53
APOE4 Genotype Exerts Greater Benefit in Lowering Plasma Cholesterol and Apolipoprotein B than Wild Type (E3/E3), after Replacement of Dietary Saturated Fats with Low Glycaemic Index Carbohydrates
Griffin, B. A., Walker, C. G., Jebb, S. A., Moore, C. S., Frost, G. S., Goff, L. M., Sanders, T. A. B., Lewis, F., Griffin, M., Gitau, R., et al. (2018) · Nutrients · doi:10.3390/nu10101524 · Cited by 54
The lipoprotein lipase S447X polymorphism and plasma lipids
Lee, J., Tan, C. S., Chia, K., Tan, C., Chew, S., Ordovás, J. M., & Tai, E. S. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400016-jlr200 · Cited by 52
Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE-deficient mice
Tsukamoto, K., Maugeais, C., Glick, J. M., & Rader, D. J. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32059-9 · Cited by 52
Genetic studies of human apolipoproteins. XVI. APOE polymorphism and cholesterol levels in the Mayans of the Yucatan Peninsula, Mexico
Kamboh, M. I., Weiss, K. M., & Ferrell, R. E. (1991) · Clinical Genetics · doi:10.1111/j.1399-0004.1991.tb02981.x · Cited by 52
Genetic influences on age‐related change in total cholesterol, low density lipoprotein‐cholesterol and triglyceride levels: Longitudinal apolipoprotein E genotype effects
Jarvik, G. P., Austin, M. A., Fabsitz, R. R., Auwerx, J. H., Reed, T., Christian, J. C., & Deeb, S. S. (1994) · Genetic Epidemiology · doi:10.1002/gepi.1370110407 · Cited by 52
Apolipoprotein E polymorphism alters the association between body fatness and plasma lipoproteins in women.
Pouliot, M. C., Després, J., Moorjani, S., Lupien, P., Tremblay, A., & Bouchard, C. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42742-7 · Cited by 52
Apolipoprotein E and Low‐Density Lipoprotein Binding and Internalization in Primary Cultures of Rat Astrocytes: Isoform‐Specific Alterations
Guillaume, D., Bertrand, P., Dea, D., Davignon, J., & Poirier, J. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062410.x · Cited by 51
Independent effects of APOE on cholesterol metabolism and brain A levels in an Alzheimer disease mouse model
Mann, K. M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh199 · Cited by 48
Underexpression of the apolipoprotein E4 isoform in an Italian population.
James, R. W., Boemi, M., Giansanti, R., Fumelli, P., & Pometta, D. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.10.1456 · Cited by 50
APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
Fallaize, R., Carvalho-Wells, A. L., Tierney, A. C., Marín, C., Kieć‐Wilk, B., Dembinska-Kiec, A., Drevon, C. A., Defoort, C., López‐Miranda, J., Risérus, U., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05802-2 · Cited by 54
Apolipoprotein E Polymorphism Is Not Associated with Longevity or Disability in a Sample of Italian Octo- and Nonagenarians
Bader, G., Zuliani, G., Kostner, G. M., & Fellin, R. (1998) · Gerontology · doi:10.1159/000022030 · Cited by 48
Increased density of senile plaques (SP), but not neurofibrillary tangles (NFT), in non-demented individuals with the apolipoprotein E4 allele: comparison to confirmed Alzheimer's disease patients
Sparks, D. L., Scheff, S. W., Liu, H., Landers, T. M., Danner, F., Coyne, C. M., & Hunsaker, J. C. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(96)00008-1 · Cited by 48
Causes of high blood cholesterol.
Grundy, S. M., & Vega, G. L. (1990) · Circulation · doi:10.1161/01.cir.81.2.412 · Cited by 46
The Underlying Molecular Mechanism of Apolipoprotein E Polymorphism: Relationships to Lipid Disorders, Cardiovascular Disease, and Alzheimer’s Disease
Contois, J. H., Anamani, D. E., & Tsongalis, G. J. (1996) · Clinics in Laboratory Medicine · doi:10.1016/s0272-2712(18)30290-7 · Cited by 45
Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer’s disease
Giannisis, A., Al-Grety, A., Carlsson, H., Patra, K., Twohig, D., Sando, S. B., Lauridsen, C., Berge, G., Grøntvedt, G. R., Bråthen, G., et al. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-022-01058-9 · Cited by 46
Harmful Effects of Increased LDLR Expression in Mice With Human APOE*4 But Not APOE*3
Malloy, S. I., Altenburg, M. K., Knouff, C., Lanningham-Foster, L., Parks, J. S., & Maeda, N. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000094963.07902.fb · Cited by 37
LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice
Kypreos, K. E., & Zannis, V. I. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500322-jlr200 · Cited by 45
ApoE ε2/ε3/ε4 polymorphism, ApoC-III/ApoE ratio and metabolic syndrome
Olivieri, O., Martinelli, N., Bassi, A., Trabetti, E., Girelli, D., Pizzolo, F., Friso, S., Pignatti, P. F., & Corrocher, R. (2007) · Clinical and Experimental Medicine · doi:10.1007/s10238-007-0142-y · Cited by 46
Function and Comorbidities of Apolipoprotein E in Alzheimer′s Disease
Leduc, V., Domenger, D., Beaumont, L. D., Lalonde, D., Jasmin, S. B., & Poirier, J. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/974361 · Cited by 46
Characterization of Apolipoprotein E-containing Lipoproteins in Cerebrospinal Fluid: Effect of Phenotype on the Distribution of Apolipoprotein E
Yamauchi, K., Tozuka, M., Hidaka, H., Hidaka, E., Kondo, Y., & Katsuyama, T. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.9.1431 · Cited by 41
Apolipoprotein E polymorphism association with lipoprotein profile in endogenous hypertriglyceridemia and familial hypercholesterolemia.
Dallongeville, J., Roy, M., LeBoeuf, N. R., Xhignesse, M., Davignon, J., & Lussier‐Cacan, S. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.2.272 · Cited by 44
Kinetics of plasma apolipoprotein E isoforms by LC-MS/MS: a pilot study
Blanchard, V., Ramin-Mangata, S., Billon-Crossouard, S., Aguesse, A., Durand, M., Chemello, K., Nativel, B., Flet, L., Chétiveaux, M., Jacobi, D., et al. (2018) · Journal of Lipid Research · doi:10.1194/jlr.p083576 · Cited by 43
S-Nitrosylation of ApoE in Alzheimer’s Disease
Abrams, A. J., Farooq, A., & Wang, G. (2011) · Biochemistry · doi:10.1021/bi200266v · Cited by 43
Pyrene Fluorescence Analysis Offers New Insights into the Conformation of the Lipoprotein-Binding Domain of Human Apolipoprotein E
Patel, A., Khumsupan, P., & Narayanaswami, V. (2010) · Biochemistry · doi:10.1021/bi901902e · Cited by 43
Apolipoprotein E phenotypes in patients with gout: relation with hypertriglyceridaemia.
Moriwaki, Y., Yamamoto, T., Takahashi, S., Tsutsumi, Z., & Higashino, K. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.5.351 · Cited by 44
Apolipoprotein E Genotype Is Associated with Macular Pigment Optical Density
Loane, E., McKay, G. J., Nolan, J. M., & Beatty, S. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4397 · Cited by 43
Apolipoprotein E and atherosclerosis in Alaska Natives
Scheer, W. D., Boudreau, D. A., Malcom, G. T., & Middaugh, J. P. (1995) · Atherosclerosis · doi:10.1016/0021-9150(94)05483-y · Cited by 43
Postprandial lipoprotein metabolism in normotriglyceridemic non-insulin-dependent diabetic patients: Influence of apolipoprotein E polymorphism
Reznik, Y., Pousse, P., Herrou, M., Morello, R., MAHOUDEAU, J. A., Drosdowsky, M. A., & Fradin, S. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90201-2 · Cited by 43
Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136 → Ser) variant in multigenerational pedigree studies
Pocovi, M., Cenarro, A., Civeir, F., Myers, R. H., Casao, E., Esteban, M., & Ordovas, J. M. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)06745-0 · Cited by 42
A gene-gender interaction affecting plasma lipoproteins in a genetic isolate.
Hegele, R. A., Evans, A. J., Tu, L., Ip, G., Brunt, J., & Connelly, P. W. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.671 · Cited by 42
Glycation of apolipoprotein E impairs its binding to heparin: identification of the major glycation site
Shuvaev, V. V., Fujii, J., Kawasaki, Y., Itoh, H., Hamaoka, R., Barbier, A., Ziegler, O., Siest, G., & Taniguchi, N. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(99)00047-2 · Cited by 41
The Apolipoprotein E Genotype Predicts Postprandial Hypertriglyceridemia in Patients with the Metabolic Syndrome
Cardona, F., Morcillo, S., Gonzalo‐Marín, M., & Tinahones, F. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1912 · Cited by 40
Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity
Wardell, M., Rall, S., Schaefer, E., Kane, J., & Weisgraber, K. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42076-0 · Cited by 40
Self-citation
Interaction between variant apolipoproteins C-II and E that affects plasma lipoprotein concentrations.
Hegele, R. A., Breckenridge, W. C., Cox, D. W., Maguire, G. F., Little, J. A., & Connelly, P. W. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.5.1303 · Cited by 39
The apolipoprotein E gene and the serum low-density lipoprotein cholesterol response to dietary fiber
Jenkins, D. J. A., Hegele, R. A., Jenkins, A. L., Connelly, P. W., Hallak, K., Bracci, P. M., Kashtan, H., Corey, P., Pintilia, M., Stern, H., et al. (1993) · Metabolism · doi:10.1016/0026-0495(93)90217-c · Cited by 39
Apolipoprotein E polymorphism and plasma lipid, lipoprotein, and apolipoprotein levels in Italian children
Xu, C., Talmud, P. J., Angelico, F., Ben, M. D., Savill, J., Humphries, S. E., & Vogler, G. P. (1991) · Genetic Epidemiology · doi:10.1002/gepi.1370080605 · Cited by 39
Apolipoprotein E Gene Polymorphism and Serum Lipid Levels in the Guangxi Hei Yi Zhuang and Han Populations
Yin, R., Pan, S., Wu, J., Lin, W., & Dezhai, Y. (2008) · Experimental Biology and Medicine · doi:10.3181/0709-rm-254 · Cited by 38
Human LDL Receptor Enhances Sequestration of ApoE4 and VLDL Remnants on the Surface of Hepatocytes but Not Their Internalization in Mice
Altenburg, M. K., Arbonés-Mainar, J. M., Johnson, L. A., Wilder, J., & Maeda, N. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.164863 · Cited by 38
Enhanced Upregulation of the Fcγ Receptor IIIa (CD16a) During In Vitro Differentiation of ApoE4/4 Monocytes
Stöhr, J., Schindler, G., Rothe, G., & Schmitz, G. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.9.1424 · Cited by 39
Interactions between age and apoE genotype on fasting and postprandial triglycerides levels
Carvalho-Wells, A. L., Jackson, K. G., Gill, R. D., Olano-Martin, E., Lovegrove, J. A., Williams, C. M., & Minihane, A. M. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.06.036 · Cited by 40
APOE genotype modifies the association between plasma omega-3 fatty acids and plasma lipids in the Multi-Ethnic Study of Atherosclerosis (MESA)
Liang, S., Steffen, L. M., Steffen, B. T., Guan, W., Weir, N. L., Rich, S. S., Manichaikul, A. W., Vargas, J. D., & Tsai, M. Y. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.02.004 · Cited by 37
Examination of Lipid-bound Conformation of Apolipoprotein E4 by Pyrene Excimer Fluorescence
Drury, J., & Narayanaswami, V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414019200 · Cited by 37
ApoE Genotype Does Not Predict Lipid Response to Changes in Dietary Saturated Fatty Acids in a Heterogeneous Normolipidemic Population
Lefevre, M., Ginsberg, H. N., Kris‐Etherton, P. M., Elmer, P. J., Stewart, P. W., Ershow, A. G., Pearson, T. A., Roheim, P. S., Ramakrishnan, R., Derr, J., et al. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2914 · Cited by 36
Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans
Cohn, J. S., Batal, R., Tremblay, M., Jacques, H., Veilleux, L., Rodriguez, C., Mamer, O., & Davignon, J. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300209-jlr200 · Cited by 35
Extracellular Proteolysis of Apolipoprotein E (apoE) by Secreted Serine Neuronal Protease
Tamboli, I. Y., Heo, D., & Rebeck, G. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093120 · Cited by 35
Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells
Liu, Y., Yang, L., Conde‐Knape, K., Beher, D., Shearman, M. S., & Shachter, N. S. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400317-jlr200 · Cited by 36
Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease
Yang, Y., Keene, C. D., Peskind, E. R., Galasko, D. R., Hu, S., Cudaback, E., Wilson, A. M., Li, G., Yu, C., Montine, K. S., et al. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000207 · Cited by 35
Lipid binding ability of human apolipoprotein E N-terminal domain isoforms: correlation with protein stability?
Weers, P. M. M., Narayanaswami, V., Choy, N., Luty, R., Hicks, L. D., Kay, C. M., & Ryan, R. O. (2002) · Biophysical Chemistry · doi:10.1016/s0301-4622(02)00300-9 · Cited by 33
Genetic predictors of common disease: Apolipoprotein E genotype as a paradigm
Jarvik, G. P. (1997) · Annals of Epidemiology · doi:10.1016/s1047-2797(97)00028-8 · Cited by 34
Influence of apo E phenotype on postprandial triglyceride and glucose responses in subjects with and without coronary heart disease
Dart, A. M. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)06062-5 · Cited by 34
Influence of Aging and Menopause on Postprandial Lipoprotein Responses in Healthy Adult Women
Nabeno, Y., Fukuchi, Y., Matsutani, Y., & Naito, M. (2007) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.14.142 · Cited by 33
Carotid artery intima‐media thickness and brachial artery flow‐mediated vasodilation in asymptomatic Japanese male subjects amongst apolipoprotein E phenotypes
Haraki, T., Takegoshi, T., Kitoh, C., WAKASUGI, T., Saga, T., Hirai, J. ‐., Aoyama, T., Inazu, A., & Mabuchi, H. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.01011.x · Cited by 33
Association of apolipoprotein ɛ4 allele with hypertriglyceridemia in obesity
Fumeron, F., Rigaud, D., Bertiere, M. C., Bardon, S., Dely, C., & Apfelbaum, M. (1988) · Clinical Genetics · doi:10.1111/j.1399-0004.1988.tb02873.x · Cited by 33
Apolipoprotein E phenotype and cholesterol metabolism in familial hypercholesterolemia
GYLLING, H., Kuusi, T., Vanhanen, H., & Miettinen, T. A. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90064-6 · Cited by 33
Evidence for differential effects of apoE3 and apoE4 on HDL metabolism
Hopkins, P. C. R., Huang, Y., McGuire, J. G., & Pitas, R. E. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200172-jlr200 · Cited by 31
Association of apolipoprotein E with α2-macroglobulin in human plasma
Krimbou, L., Tremblay, M., Davignon, J., & Cohn, J. S. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33316-2 · Cited by 26
Effects of probucol on plasma lipids and lipoproteins in familial hypercholesterolemic patients with and without apolipoprotein E4
Eto, M., Sato, T., Watanabe, K., Iwashima, Y., & Makino, I. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90007-6 · Cited by 32
Effect of Apolipoprotein E4 Allele on Plasma LDL Cholesterol Response to Diet Therapy in Type 2 Diabetic Patients
Saito, M., Eto, M., Nitta, H., Kanda, Y., Shigeto, M., Nakayama, K., Tawaramoto, K., Kawasaki, F., Kamei, S., Kohara, K., et al. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1276 · Cited by 31
High‐Cholesterol Diet FacilitatesAnaplasma phagocytophilumInfection and Up‐Regulates Macrophage Inflammatory Protein–2 and CXCR2 Expression in Apolipoprotein E–Deficient Mice
Xiong, Q., Wang, X., & Rikihisa, Y. (2007) · The Journal of Infectious Diseases · doi:10.1086/514819 · Cited by 31
Differential effects of apoE4 and activation of ABCA1 on brain and plasma lipoproteins
Boehm-Cagan, A., Bar, R., Harats, D., Shaish, A., Levkovitz, H., Bielicki, J. K., Johansson, J. O., & Michaelson, D. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0166195 · Cited by 29
Clinical chemistry of common apolipoprotein E isoforms
Dijck-Brouwer, J., van Doormaal, J. J., & Muskiet, F. A. J. (1996) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00256-1 · Cited by 30
Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors
Shatwan, I. M., Winther, K. H., Ellahi, B., Elwood, P. C., Ben‐Shlomo, Y., Givens, I. D., Rayman, M. P., Lovegrove, J. A., & Vimaleswaran, K. S. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0744-2 · Cited by 31
Plasma Kinetics of Cholesteryl Ester Transfer Protein in the Rabbit
McPherson, R., Lau, P., Kussie, P. H., Barrett, P. H. R., & Tall, A. R. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.1.203 · Cited by 27
Effect of atorvastatin on plasma apoE metabolism in patients with combined hyperlipidemia
Cohn, J. S., Tremblay, M., Batal, R., Jacques, H., Veilleux, L., Rodriguez, C., Barrett, P. H. R., Dubreuil, D., Roy, M., Bernier, L., et al. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200016-jlr200 · Cited by 27
Molecular Biology of Human Apolipoproteins B and E and Associated Diseases of Lipoprotein Metabolism
Zannis, V. I. (1989) · Advances in lipid research · doi:10.1016/b978-0-12-024923-7.50005-4 · Cited by 26
Lack of influence of apolipoprotein E4 on lipoprotein levels in the island population of Sardinia
Deiana, Pes, G. M., Carru, C., Errigo, A., Pettinato, Carcassi, C., 박기오, & Contu (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00271.x · Cited by 26

Authors: Gregg, R. E., Zech, L. A., Schaefer, E. J., Stark, D., Wilson, D., & Brewer, H. B.
Affiliations: Tufts University (US)
ORCID: Gregg, R E
Schaefer, E J
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1986-09-01
Volume: 78
Issue: 3
Pages: 815-821
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci112645
PMC: PMC423680
OpenAlex: W1990170200
Cited by: 345
References: 27
Citations by year: 2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 9 · 2012: 8
FWCI: 11.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
NIH Clinical Center
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: APOE ε4, apolipoprotein E3, APOE polymorphism, plasma residence time, VLDL, high-density lipoprotein, type V hyperlipoproteinemia, hypercholesterolemia, dyslipoproteinemia
MeSH terms: Adolescent, Adult, Apolipoproteins E, Female, Homozygote, Humans, Hypercholesterolemia, Hyperlipoproteinemia Type V, Iodine Radioisotopes, Kinetics, Lipoproteins, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Male, Phenotype, Apolipoprotein E3, Apolipoprotein E4, Lipoproteins, IDL

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Abnormal in vivo metabolism of apolipoprotein E4 in humans.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks