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The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans
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Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans
Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., et al. (2009) · Diabetes · doi:10.2337/db09-0530 · Cited by 1,848
Understanding the Physiology of FGF21
Fisher, F. M., & Maratos-Flier, E. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105339 · Cited by 912
Magkos, F., Fraterrigo, G., Yoshino, J., Luecking, C., Kirbach, K., Kelly, S. C., de las Fuentes, L., He, S., Okunade, A. L., Patterson, B. W., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.005 · Cited by 886 · cited 1×
“Resistin was initially discovered weight loss of more than 16% (46).”
BackgroundThe ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
Kosteli, A., Sugaru, E., Haemmerle, G., Martin, J. F., Lei, J., Zechner, R., & Ferrante, A. W. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42845 · Cited by 726 · cited 4×
“As part of our experimental protocol, we added BSA after the addition of FFAs to sequester the FFAs, which demonstrated the effects of FFAs on uncoupling.”
BackgroundInfluentialMetabolic Signaling in Fuel-Induced Insulin Secretion
Prentki, M., Matschinsky, F. M., & Madiraju, S. R. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.018 · Cited by 548
Research works printed but not linked: 62
- 10.1177/2042018811398517 · DOI
- 10.1016/S0014-2999(02)01421-8 · DOI
- Arch, 1984, Treatment of obesity with thermogenic beta-adrenoceptor agonists: studies on BRL 26830A in rodents, Int J Obes, 8 Suppl 1, 1
- 10.1093/ajcn/38.4.549 · DOI
- 10.1124/jpet.118.255778 · DOI
- 10.1016/j.cmet.2010.03.004 · DOI
- 10.1016/j.cell.2012.05.016 · DOI · Paper page
- 10.1172/JCI44271 · DOI · Paper page
- 10.1016/j.cell.2013.12.021 · DOI
- 10.1038/nm.4031 · DOI
- 10.1016/j.cmet.2017.12.005 · DOI
- 10.1038/s41586-018-0801-z · DOI
- 10.1056/NEJMoa0810780 · DOI · Paper page
- 10.1016/j.mam.2019.07.001 · DOI
- Porter, 2015, The therapeutic potential of brown adipocytes in humans, Front Endocrinol (Lausanne), 6, 10.3389/fendo.2015.00156 · DOI
- 10.1016/j.cmet.2015.09.007 · DOI
- 10.1038/nm.4429 · DOI
- 10.1016/j.cell.2015.09.035 · DOI · Paper page
- 10.1016/j.cmet.2019.05.005 · DOI
- 10.1172/JCI45887 · DOI · Paper page
- 10.1016/j.cmet.2015.06.022 · DOI
- 10.1016/j.cmet.2014.06.011 · DOI
- Frontini, 2013, White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma, Biochim Biophys Acta, 1831, 950, 10.1016/j.bbalip.2013.02.005 · DOI
- 10.1038/nature13528 · DOI
- Finlin, 2018, Human adipose beiging in response to cold and mirabegron, JCI Insight, 3, 10.1172/jci.insight.121510 · DOI · Paper page
- 10.1016/j.cmet.2014.12.009 · DOI · Paper page
- 10.2337/db18-0462 · DOI · Paper page
- 10.1111/dom.13516 · DOI
- 10.1111/ijcp.12433 · DOI
- Bergman, 2002, The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes, Eur J Clin Invest, 32 Suppl 3, 35, 10.1046/j.1365-2362.32.s3.5.x · DOI · Paper page
- 10.1530/JME-13-0258 · DOI
- 10.1016/j.tem.2015.01.005 · DOI
- 10.1002/mus.10092 · DOI · Paper page
- Nolan, 2006, Fatty acid signaling in the beta-cell and insulin secretion, Diabetes, 55 Suppl 2, S16, 10.2337/db06-S003 · DOI · Paper page
- Ježek, 2018, Fatty acid-stimulated insulin secretion vs. lipotoxicity, Molecules, 23, 10.3390/molecules23061483 · DOI
- Distel, 1992, Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms, J Biol Chem, 267, 5937, 10.1016/S0021-9258(18)42645-2 · DOI
- 10.1016/j.cmet.2018.06.020 · DOI
- 10.1073/pnas.1901655116 · DOI
- 10.1038/nm.3891 · DOI · Paper page
- 10.1172/JCI68993 · DOI · Paper page
- 10.1172/JCI67803 · DOI
- 10.2337/db15-1372 · DOI · Paper page
- 10.1371/journal.pone.0017247 · DOI · Paper page
- 10.1016/j.cmet.2016.04.029 · DOI
- 10.1152/ajpendo.00284.2016 · DOI
- 10.1038/nature17399 · DOI
- 10.2337/dc08-1625 · DOI
- 10.7326/0003-4819-149-5-200809020-00005 · DOI
- Kern, 1999, Effect of weight loss on muscle fiber type, fiber size, capillarity, and succinate dehydrogenase activity in humans, J Clin Endocrinol Metab, 84, 4185
- 10.1016/j.pharmthera.2008.06.003 · DOI
- 10.1254/jphs.12271FP · DOI
- 10.1016/j.cell.2014.06.005 · DOI
- 10.1016/j.cmet.2016.04.011 · DOI · Paper page
- 10.1038/nm.2277 · DOI · Paper page
- 10.1016/j.cmet.2013.06.016 · DOI · Paper page
- 10.2337/db16-1057 · DOI
- 10.1038/s41598-018-37187-1 · DOI · Paper page
- 10.1210/js.2019-00148 · DOI
- 10.1016/j.cmet.2016.07.014 · DOI · Paper page
- 10.1113/JP274611 · DOI
- 10.1074/jbc.M114.628487 · DOI
- 10.1161/ATVBAHA.109.186957 · DOI
Cited by
Brown adipose tissue is associated with cardiometabolic health
Becher, T., Palanisamy, S., Kramer, D. J., Eljalby, M., Marx, S. J., Wibmer, A. G., Butler, S. D., Jiang, C. S., Vaughan, R., Schöder, H., et al. (2021) · Nature Medicine · doi:10.1038/s41591-020-1126-7 · Cited by 743
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation
Blondin, D. P., Nielsen, S., Kuipers, E. N., Severinsen, M. C., Jensen, V. H., Miard, S., Jespersen, N. Z., Kooijman, S., Boon, M. R., Fortin, M., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.07.005 · Cited by 331
Targeting skeletal muscle mitochondrial health in obesity
Pileggi, C. A., Hooks, B. G., McPherson, R., Dent, R. R. M., & Harper, M.-E. (2022) · Clinical Science · doi:10.1042/cs20210506 · Cited by 21
CL316,243 and skeletal muscle metabolism: Role of sex and estrogen receptor beta
Maloney, A., Lee, J., Queathem, E. D., Schaller, K. A., Buckhary, S., Lubahn, D. B., Valentine, R. J., & Vieira-Potter, V. J. (2025) · Journal of Endocrinology · doi:10.1530/joe-25-0005 · Cited by 1
Metadata
- Authors
- Finlin, B. S., Memetimin, H., Zhu, B., Confides, A. L., Vekaria, H. J., El Khouli, R. H., Johnson, Z. R., Westgate, P. M., Chen, J., Morris, A. J., Sullivan, P. G., Dupont-Versteegden, E. E., & Kern, P. A.
- Venue
- Journal of Clinical Investigation
- Published
- 2020-03-23
- Volume
- 130
- Issue
- 5
- Pages
- 2319-2331
- ISSN
- 0021-9738
- 1558-8238
- Cited by
- 250
- References
- 13
- Language
- en
- Funders
- NIDDK (DK112282, DK 71349)
- NIGMS (P30GM127211)
- NCATS (UL1TR001998)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.