The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Open accessAbstract
Nitrite represents a circulating and tissue storage form of NO whose bioactivation is mediated by the enzymatic action of xanthine oxidoreductase, nonenzymatic disproportionation, and reduction by deoxyhemoglobin, myoglobin, and tissue heme proteins. Because the rate of NO generation from nitrite is linearly dependent on reductions in oxygen and pH levels, we hypothesized that nitrite would be reduced to NO in ischemic tissue and exert NO-dependent protective effects. Solutions of sodium nitrite were administered in the setting of hepatic and cardiac ischemia-reperfusion (I/R) injury in mice. In hepatic I/R, nitrite exerted profound dose-dependent protective effects on cellular necrosis and apoptosis, with highly significant protective effects observed at near-physiological nitrite concentrations. In myocardial I/R injury, nitrite reduced cardiac infarct size by 67%. Consistent with hypoxia-dependent nitrite bioactivation, nitrite was reduced to NO, S-nitrosothiols, N-nitros-amines, and iron-nitrosylated heme proteins within 1-30 minutes of reperfusion. Nitrite-mediated protection of both the liver and the heart was dependent on NO generation and independent of eNOS and heme oxygenase-1 enzyme activities. These results suggest that nitrite is a biological storage reserve of NO subserving a critical function in tissue protection from ischemic injury. These studies reveal an unexpected and novel therapy for diseases such as myocardial infarction, organ preservation and transplantation, and shock states.
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In the citing paper
“Furthermore, the process was demonstrated to be dependent on xanthine oxidoreductase (XOR)”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [160]
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Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Early research indicated a therapeutic role for nitric oxide in cardioprotection in myocardial infarction models, 135 and L-arginine treatment before reperfusion was also organ-protective.133,136,137”
From Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care (2010) · cites this paper as [135]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Pre-clinical studies with nitrate or nitrite also show the potential to protect against ischaemia-reperfusion injury and reduce arterial stiffness, inflammation and intimal thickness.”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [160]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Chronic inhibition of XOR with allopurinol or 3 weeks of tungstenrich diet increased intimal hyperplasia.”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [160]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Even the late introduction of nitrite was able to reverse intimal hyperplasia [160].”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [160]
Experimental — accuracy not yet measured
In the citing paper
“The nitrite (NO2−) anion protects from ischemia-reperfusion injury in vivo1–3,37 and is thought to act as an S-nitrosating agent in the ischemic myocardium2.”
From Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I (2013) · cites this paper as [1]
In the citing paper
“Nitrite is a dietary constituent that protects the heart against I/R injury in many animal models during both ischemia and preconditioning stage [186,187,188,189,190,191,192].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [186]
In the citing paper
“while nitrate supplementation prevents or limits ischemia-reperfusion injury and endothelial dysfunction in both animal[98,120–124] and human[97,125] models of ischemia-reperfusion.”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [121]
In the citing paper
“the nitrate/nitrite content of the fruits and vegetables could contribute to their cardiovascular health benefits in animals [29,33,78,79,80,81,82,83] and humans [31,84,85,86].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [79]
In the citing paper
“Physiologically relevant levels of nitrite have been shown to counter ischemic-reperfusion injury [8–10]”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [9]
In the citing paper
“The efficacy of low concentrations of nitrite in mediating cytoprotection has been demonstrated in a variety of tissues in animal models including heart [8, 9, 55, 118–122] liver [9, 120, 123], brain [124–126], kidney [127, 128], hindlimb [129], and human forearm [23].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [9]
In the citing paper
“pretreatment with this compound, delivered as a salt in the form of sodium nitrite, protects against ischemia/reperfusion (I/R) injury in the heart in preclinical models (7, 19, 20, 40, 46, 60, 79, 189).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [46]
In the citing paper
“nitrite administration reduces skeletal muscle (188), renal (125, 179), and liver (46, 154, 169) injury after ischemia.”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [46]
In the citing paper
“exogenous administration of nitrite correlates with increased levels of S-nitrosothiols in red blood cells and other tissues both in vivo and in vitro [25, 43, 46-53].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“Evidence for a role for NO is dependent largely on attenuation of responses by the NO-scavenger CPTIO [25, 26, 52, 100] and measurement of nitrite-dependent increases in cGMP levels[26, 101].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“Murine based studies of hepatic and myocardial IR injury have shown a ‘U’ shaped profile for nitrite effects; namely protection increases with increasing dose up to a point and then as the dose is increased further, protection is lost and can -if even higher doses are administered, exacerbate injury [52, 114].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“nitration reactions could also explain the loss of protection observed when higher doses of nitrite are administered in the context of IR injury [52, 114].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“the nitrite dose range encompassing protection versus loss of protection in these studies was greater than two or three orders of magnitude.”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“experimental observations show that relatively low doses of nitrite are sufficient to induce dramatic protective effects in vivo.”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“Typically doses of ~50 nmoles have been shown to be protective in models of ischemia reperfusion [52, 114] as well hemorrhagic shock in mice [122] for example.”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“Duranski et al showed that nitrite therapy protects against ischemic tissue injury through a heme oxygenase-1 pathway which further implicated the generation of nitrite dependent NO during therapy.”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [156]
In the citing paper
“cPTIO treatment was shown by numerous groups to attenuate nitrite mediated protection against ischemia-reperfusion injury in vivo indicating that protective mechanisms likely involve NO dependent signaling pathways and molecular responses [47, 89, 156, 162].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [156]
In the citing paper
“This paper proved that near physiological doses of sodium nitrite (high nanomolar) were highly cytoprotective in both myocardial and hepatic ischemia-reperfusion extending previous work from Cosby et al demonstrating that near physiological levels of nitrite anion mediated hypoxic vasodilation responses [19].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [156]
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Citations
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“Previous studies also demonstrated that nitrite therapy given intravenously prior to reperfusion protects against hepatic and myocardial ischemia--reperfusion (I/R) injury [110].”
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“Several mammalian studies have shown that treatment with low doses of nitrite can reduce 47 cell death and infarct size following ischemia-reperfusion events in tissues such as heart and liver 48 (8, 18, 30, 38, 45).”
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“Several studies have documented that administration of nitrite can reduce cell death and infarct size after ischemia/reperfusion in heart and liver tissues of mammals (Webb et al., 2004; Duranski et al., 2005; Hendgen-Cotta et al., 2008; Shiva and Gladwin, 2009).”
BackgroundColburn, T. D., Ferguson, S. K., Holdsworth, C. T., Craig, J. C., Musch, T. I., & Poole, D. C. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00367.2016 · Cited by 16
“NO2 to NO (19, 32, 54, 56) but possibly not the kidney (3, 55).”
Sodium nitrite-derived nitric oxide protects rat testes against ischemia/reperfusion injury
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Potential role for age as a modulator of oral nitrate reductase activity
Ahmed, K. A., Kim, K., Ricart, K. C., Pol, W. V. D., Qi, X., Bamman, M. M., Behrens, C. E., Fisher, G., Boulton, M. E., Morrow, C. D., et al. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.12.001 · Cited by 18
“Saliva nitrite is swallowed, where it elicits NOsignaling in the acidic stomach, but also in all other major organs and tissues by various pH and hypoxia dependent mechanisms [4; 5; 16; 17; 18; 19; 20; 21; 22; 23; 24; 25; 26; 27].”
BackgroundSelf-citationStepuro, I. I., Oparin, A. Y., Stsiapura, V. I., Маскевич, С. А., & Titov, V. Y. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912010051 · Cited by 17
Role of nitric oxide in vascular regulation in fish
Agnisola, C., & Pellegrino, D. (2007) · Advances in experimental biology · doi:10.1016/s1872-2423(07)01013-7 · Cited by 16
Serial measurements of whole blood nitrite in an intensive care setting
Kehmeier, E. S., Kropp, M., Kleinbongard, P., Lauer, T., Balzer, J., Merx, M. W., Heusch, G., Kelm, M., Lepper, W., & Rassaf, T. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.02.014 · Cited by 16
Schatlo, B., Henning, E. C., Pluta, R. M., Latour, L. L., Golpayegani, N., Merrill, M. J., Lewin, N., Chen, Y., & Oldfield, E. H. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600542 · Cited by 16
“Two doses of nitrite were investigated: the maximum tolerated dose with minimal effect on blood pressure (n = 7) and a very low dose (n = 6) previously shown to exert maximum protection against ischemia injury in the heart and liver (Duranski et al, 2005).”
BackgroundPattillo, C. B., Fang, K., Pardue, S., & Kevil, C. G. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.11.008 · Cited by 15
Inflammation Activation Contributes to Adipokine Imbalance in Patients with Acute Coronary Syndrome
Li, R., Chen, L.-Z., Zhao, S., & Huang, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151916 · Cited by 15
“After 3 weeks, AMI models (all mice in AMI, low-statin and high-statin groups, rather than in sham group) were established by surgical ligation of the left coronary artery as described previously [10].”
MethodHyperpolarized [15N]nitrate as a potential long lived hyperpolarized contrast agent for MRI
Gamliel, A., Uppala, S., Sapir, G., Harris, T., Nardi‐Schreiber, A., Shaul, D., Sosna, J., Gomori, J. M., & Katz‐Brull, R. (2019) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2019.01.001 · Cited by 16
Lewis, S. E., Rosencrance, C. B., DeVallance, E., Giromini, A. P., Williams, X. M., Oh, J., Schmidt, H. M., Straub, A. C., Chantler, P. D., Patel, R. P., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.012 · Cited by 19
Self-citationAkinmoladun, A. C., Olowe, J., Komolafe, K., Ogundele, J. O., & Olaleye, M. T. (2016) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2015.10.007 · Cited by 15
“[44] Duranski MR, Greer JJ, Dejam A, Jaganmohan S, Hogg N, Langston W, Patel RP, Yet SF, Wang X, Kevil CG, Gladwin MT, Lefer DJ.”
BackgroundMechanisms of Nitrite Reduction in Ischemia in the Cardiovascular System
Webb, A., & Ahluwalia, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00017-4 · Cited by 15
The macrophage stimulating anti-cancer agent, RRx-001, protects against ischemia-reperfusion injury
Cabrales, P., Caroen, S. Z., Oronsky, A. L., Carter, C. A., Trepel, J. B., Summers, T. A., Reid, T. R., Oronsky, N. C., Lybeck, M., & Oronsky, B. T. (2017) · Expert Review of Hematology · doi:10.1080/17474086.2017.1324779 · Cited by 15
“In myocardial I/R injury nitrite reduced cardiac infarct size by 67%.(13) In skeletal I/R Wang et al and Murata et al demonstrated that low dose nitrite significantly attenuated vasoconstriction, arteriole stagnation, and capillary no-reflow.”
BackgroundGumanova, N. G. (2021) · Russian Journal of Preventive Medicine · doi:10.17116/profmed202124101119 · Cited by 14
Abu‐Amara, M., Yang, S. Y., Quaglia, A., Rowley, P., Tapuria, N., Fuller, B. J., Davidson, B. R., & Seifalian, A. M. (2012) · Transplantation · doi:10.1097/tp.0b013e31824cd59d · Cited by 14
Nitrite Protects Neurons Against Hypoxic Damage Through S -nitrosylation of Caspase-6
Chen, Y.-J., Liu, Y., Liu, Y., Lee, Y.-B., Huang, H.-C., Chen, Y.-Y., Shih, Y., Lee, Y., Cheng, C., & Meng, T. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7522 · Cited by 14
“Because nitrite reductase only acts and releases NO in hypoxic conditions but not in healthy normoxic environment, moderate level of nitrite is often considered harmless to the physiological status (18, 35).”
Protective effect of exogenous nitrite in postoperative ileus
Cosyns, S., Shiva, S., & Lefebvre, R. A. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13255 · Cited by 13
“…4871 mechanisms of action suggested in the protective effect of nitrite-derived NO against I/R injury, namely reversible inhibition of mitochondrial complex I by S-nitrosation (Shiva et al., 2007; Dezfulian et al., 2009) and activation of sGC by NO (Duranski et al., 2005; Jung et al., 2006).”
BackgroundMethodResultInfluentialLundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466-c2 · Cited by 14
Self-citationEffects of dietary inorganic nitrate on static and dynamic breath-holding in humans
Schiffer, T. A., Larsen, F. J., Lundberg, J. O., Weitzberg, E., & Lindholm, P. (2012) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2012.09.008 · Cited by 14
Matavelli, L. C., Kadowitz, P. J., Navar, L. G., & Majid, D. S. A. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90487.2008 · Cited by 14
“Circulating nitrite anion has been reported to have cytoprotective effects in pathologic conditions by acting as a direct vasodilator (10) or as a NO compound donor (12).”
Intracavernosal administration of sodium nitrite as an erectile pharmacotherapy
Lasker, G. F., Matt, C. J., Badejo, A. M., Casey, D. B., Dhaliwal, J. S., Murthy, S. N., & Kadowitz, P. J. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y10-032 · Cited by 14
Preserving vessel function during ischemic disease: new possibilities of inorganic nitrite therapy
Kevil, C. G., & Patel, R. P. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.9.1175 · Cited by 14
Self-citationYavuz, C., Yazıcı, S., Karahan, O., Demirtaş, S., Çalışkan, A., Güçlü, O., Ertaş, F., & Mavitaş, B. (2013) · Biomarkers · doi:10.3109/1354750x.2012.745165 · Cited by 13
“In recent studies, other pathways available for maintenance and synthesis of NO in these conditions have been found (Duranski et al., 2005; Rassaf et al., 2007; Shiva et al., 2007).”
BackgroundNitroxyl accelerates the oxidation of oxyhemoglobin by nitrite
Bellavia, L., DuMond, J. F., Perlegas, A. S., King, S. B., & Kim‐Shapiro, D. B. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.03.006 · Cited by 13
“Nitrite has been shown to be a signaling molecule [49] with cytoprotective applications against ischemia-reperfusion injury [50; 51].”
BackgroundNitrite, a novel method to decrease ischemia/reperfusion injury in the rat liver
Björnsson, B. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i6.1775 · Cited by 13
Eriksson, K. E., Eidhagen, F., Liška, J., Franco‐Cereceda, A., Lundberg, J. O., & Weitzberg, E. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.06.046 · Cited by 13
Formation of nitri- and nitrosylhemoglobin in systems modeling the Maillard reaction
Kosmachevskaya, O. V., Шумаев, К. Б., Nasybullina, E. I., & Topunov, A. F. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0792 · Cited by 13
Corti, P., Tejero, J., & Gladwin, M. T. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.020 · Cited by 13
Self-citationNitrite consumption in ischemic rat heart catalyzed by distinct blood-borne and tissue factors
McNulty, P. H., Scott, S., Kehoe, V., Kozak, M., Sinoway, L. I., & Li, J. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00050.2008 · Cited by 13
Végh, Á., Gönczi, M., Miskolczi, G., & Kovács, M. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00076 · Cited by 13
“A number of studies in various experimental animal models have proved that nitrite anion has an important biological function and might represent an effective means to attenuate ischemia and reperfusion injury (e.g., Webb et al., 2004; Duranski et al., 2005; Shiva et al., 2007).”
BackgroundKim, F., Dezfulian, C., Empey, P. E., Morrell, M. R., Olsufka, M., Scruggs, S., Kudenchuk, P. J., May, S. J., Maynard, C. C., Sayre, M. R., et al. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.04.060 · Cited by 11
Kazemirad, H., & Kazerani, H. R. (2018) · Phytotherapy Research · doi:10.1002/ptr.6150 · Cited by 12
“Similar effects were observed in an in vivo model when nitrite, a biological precursor of NO, was injected into the left ventricle prior to the induction of myocardial infarction (Duranski et al., 2005).”
BackgroundXu, G. G., Deshpande, T. M., Ghatge, M. S., Mehta, A. Y., Omar, A. M., Ahmed, M. H., Venitz, J., Abdulmalik, O. Y., Zhang, Y., & Safo, M. K. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b01074 · Cited by 12
El consumo de nitrato y su potencial efecto benéfico sobre la salud cardiovascular
Brayan Moreno, C., Karen Soto, O., & González, D. R. (2015) · Revista chilena de nutrición · doi:10.4067/s0717-75182015000200013 · Cited by 13
Quesnelle, K. M., Guimarães, D. A., Rao, K., Singh, A. B., Wang, Y., Hogg, N., & Shiva, S. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.08.005 · Cited by 11
Self-citationEarly administration of isosorbide dinitrate improves survival of cyanide-poisoned rabbits
Lavon, O. (2014) · Clinical Toxicology · doi:10.3109/15563650.2014.990564 · Cited by 11
Dias, L., Bekhti, N., Kuznetsov, M. L., Ferreira, J. A. B., Bacariza, C., & da Silva, J. A. L. (2017) · Chemistry - A European Journal · doi:10.1002/chem.201705385 · Cited by 11
Heart Mitochondrial Nitric Oxide Synthase
Zaobornyj, T., & Valdez, L. B. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00003-9 · Cited by 11
“There is evidence that S-nitrosation of complex I proteins is associated with cytoprotection from the damage caused by ische- mia–reperfusion (Duranski et al., 2005; Prime et al., 2009).”
BackgroundPellegrino, D., & Parisella, M. L. (2010) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/157489010791515340 · Cited by 11
“In fact, it is well documented that the NO2 ability to mediate cytoprotection after I/R in a number of organs and species [27,29-37].”
BackgroundFrérart, F., Lobysheva, I. I., Gallez, B., Dessy, C., & Féron, O. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0388 · Cited by 12
“Nitrite was for instance shown to contribute to hypoxic vasodilation (5-7) and to protect several organs, including heart, liver, kidney, and brain, from ischemia-reperfusion injuries (8-13).”
BackgroundIbba, S. V., Ghonim, M. A., Pyakurel, K., Lammi, M. R., Mishra, A., & Boulares, A. H. (2016) · Mediators of Inflammation · doi:10.1155/2016/1984703 · Cited by 11
Linking proximal and downstream signalling events in hepatic ischaemia/reperfusion injury
Jeyabalan, G., Tsung, A., & Billiar, T. R. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340957 · Cited by 11
Saying Yes to Exercise and NO to Cardiac Injury
Bezzerides, V. J., & Rosenzweig, A. (2011) · Circulation Research · doi:10.1161/circresaha.111.247122 · Cited by 11
Liu, Y., Buerk, D. G., Barbee, K. A., & Jaron, D. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.08.003 · Cited by 10
Nitrate-Reducing Oral Bacteria: Linking Oral and Systemic Health
Bryan, N. S., & Petrosino, J. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_3 · Cited by 11
Vitturi, D. A., Maynard, C. C., Olsufka, M., Straub, A. C., Krehel, N., Kudenchuk, P. J., Nichol, G., Sayre, M. R., Kim, F., & Dezfulian, C. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101463 · Cited by 10
“This implies that other biological factors are more important in nitrite-mediated signaling than mere precursor availability, and may explain the broad therapeutic range reported in prior nitrite preclinical studies [7,8].”
BackgroundIron(II) porphyrins induced conversion of nitrite into nitric oxide: A computational study
Zhang, T., Liu, Y. D., & Zhong, R. G. (2015) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2015.06.005 · Cited by 10
Naja naja atra Venom Protects against Manifestations of Systemic Lupus Erythematosus in MRL/lpr Mice
Zhu, J., Cui, K., Kou, J., Wang, S., Xu, Y., Ding, Z.-H., Han, R., & Qin, Z. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/969482 · Cited by 10
“Glutamate pyruvate transaminase (ALT) and creatine kinase (CK) in serum are used in the evaluation of liver and heart injury [53].”
BackgroundCombined hypoxia and sodium nitrite pretreatment for cardiomyocyte protection in vitro
Hsieh, A., Feric, N. T., & Radisic, M. (2015) · Biotechnology Progress · doi:10.1002/btpr.2039 · Cited by 10
“0 lM) and tissue (1–20 lM).(26) We did not observe any significant difference in CM viability with or without NaNO2 during the hypoxia/reoxygenation cycle (Supporting Information Figure 2), suggesting that the effects of pretreatment are distinct from continuous NaNO2 treatment in our model.”
ResultGao, J., Cheng, Z., Jiang, S., Wills, M. V., Wehbe, A., Rajah, G. B., Geng, X., & Ding, Y. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03506-5 · Cited by 9
Conahey, G. R., Power, G. G., Hopper, A. O., Terry, M. H., Kirby, L. S., & Blood, A. B. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e318180f08b · Cited by 10
“Dose-ranging studies in both the human (23,31) and mouse (32) demonstrate the vasoactive and cytoprotective effects of nitrite are potent, with physiologic effects observed with increases of blood nitrite concentrations as small as 20%, which approaches the precision limits of the nitrite assay.”
BackgroundGlutathione supplementation to University of Wisconsin solution causes endothelial dysfunction
Tambyraja, A. L., Mitchell, R. T., Driscoll, P. J., Deans, C., Parks, R. W., Rahman, I., & Megson, I. L. (2007) · Transplant Immunology · doi:10.1016/j.trim.2007.06.002 · Cited by 9
Role of nitric oxide in liver transplantation: Should it be routinely used?
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Rathod, K. S., Jones, D. A., Van-Eijl, T. J. A., Tsang, H., Warren, H. R., Hamshere, S. M., Kapil, V., Jain, A., Deaner, A., Poulter, N. R., et al. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012728 · Cited by 8
“Indeed, nitrite-derived NO protects against myocardial ischaemia/reperfusion injury in pre-clinical models, 19 20 attenuates vascular smooth muscle cell proliferation in a model of balloon injury in rats, 21 protects against endothelial dysfunction 22 23 and attenuates platelet reactivity in…”
Therapeutic Application of Nitric Oxide in Human Diseases
Namkoong, S., & Kim, Y. (2010) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2010.18.4.351 · Cited by 9
“NO provides cytoprotective effects in different organs, including liver (Duranski et al., 2005), heart (Webb et al.”
BackgroundChen, Q., Fabry, M. E., Rybicki, A. C., Suzuka, S. M., Balazs, T. C., Etzion, Z., de Jong, K., Akoto, E. K., Canterino, J. E., Kaul, D. K., et al. (2012) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2011.12.002 · Cited by 9
Self-citation
Metadata
- Authors
- Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., Gladwin, M. T., & Lefer, D. J.
- Affiliations
- Louisiana State University Health Sciences Center Shreveport (US)
- Medical College of Wisconsin (US)
- University of Alabama at Birmingham (US)
- Brigham and Women's Hospital (US)
- National Institutes of Health (US)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2005-04-14
- Volume
- 115
- Issue
- 5
- Pages
- 1232-1240
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1077170
- OpenAlex
- W2098453482
- Cited by
- 674
- References
- 70
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 9 · 2023: 7 · 2022: 21 · 2021: 22 · 2020: 20 · 2019: 18 · 2018: 23 · 2017: 40 · 2016: 31 · 2015: 45 · 2014: 42 · 2013: 42 · 2012: 59
- FWCI
- 28.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (2R01-HL60849, R01HL060849)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01-1 DK-43785, P01DK043785)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- nitrite, nitric oxide, ischemia-reperfusion injury, cardioprotection, hepatoprotection, sodium nitrite, S-nitrosothiols, nitrosamines, liver necrosis, apoptosis, organ preservation, myocardial infarction
- MeSH terms
- Animals, Heme Oxygenase (Decyclizing), Liver, Membrane Proteins, Mice, Inbred C57BL, Myocardium, Nitrites, Peritoneum, Reperfusion Injury, Nitric Oxide Synthase, Mice, Heme Oxygenase-1
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