The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Open accessAbstract
Nitrite represents a circulating and tissue storage form of NO whose bioactivation is mediated by the enzymatic action of xanthine oxidoreductase, nonenzymatic disproportionation, and reduction by deoxyhemoglobin, myoglobin, and tissue heme proteins. Because the rate of NO generation from nitrite is linearly dependent on reductions in oxygen and pH levels, we hypothesized that nitrite would be reduced to NO in ischemic tissue and exert NO-dependent protective effects. Solutions of sodium nitrite were administered in the setting of hepatic and cardiac ischemia-reperfusion (I/R) injury in mice. In hepatic I/R, nitrite exerted profound dose-dependent protective effects on cellular necrosis and apoptosis, with highly significant protective effects observed at near-physiological nitrite concentrations. In myocardial I/R injury, nitrite reduced cardiac infarct size by 67%. Consistent with hypoxia-dependent nitrite bioactivation, nitrite was reduced to NO, S-nitrosothiols, N-nitros-amines, and iron-nitrosylated heme proteins within 1-30 minutes of reperfusion. Nitrite-mediated protection of both the liver and the heart was dependent on NO generation and independent of eNOS and heme oxygenase-1 enzyme activities. These results suggest that nitrite is a biological storage reserve of NO subserving a critical function in tissue protection from ischemic injury. These studies reveal an unexpected and novel therapy for diseases such as myocardial infarction, organ preservation and transplantation, and shock states.
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In the citing paper
“Furthermore, the process was demonstrated to be dependent on xanthine oxidoreductase (XOR)”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [160]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Early research indicated a therapeutic role for nitric oxide in cardioprotection in myocardial infarction models, 135 and L-arginine treatment before reperfusion was also organ-protective.133,136,137”
From Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care (2010) · cites this paper as [135]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Pre-clinical studies with nitrate or nitrite also show the potential to protect against ischaemia-reperfusion injury and reduce arterial stiffness, inflammation and intimal thickness.”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [160]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Chronic inhibition of XOR with allopurinol or 3 weeks of tungstenrich diet increased intimal hyperplasia.”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [160]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Even the late introduction of nitrite was able to reverse intimal hyperplasia [160].”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [160]
Experimental — accuracy not yet measured
In the citing paper
“The nitrite (NO2−) anion protects from ischemia-reperfusion injury in vivo1–3,37 and is thought to act as an S-nitrosating agent in the ischemic myocardium2.”
From Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I (2013) · cites this paper as [1]
In the citing paper
“Nitrite is a dietary constituent that protects the heart against I/R injury in many animal models during both ischemia and preconditioning stage [186,187,188,189,190,191,192].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [186]
In the citing paper
“while nitrate supplementation prevents or limits ischemia-reperfusion injury and endothelial dysfunction in both animal[98,120–124] and human[97,125] models of ischemia-reperfusion.”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [121]
In the citing paper
“the nitrate/nitrite content of the fruits and vegetables could contribute to their cardiovascular health benefits in animals [29,33,78,79,80,81,82,83] and humans [31,84,85,86].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [79]
In the citing paper
“Physiologically relevant levels of nitrite have been shown to counter ischemic-reperfusion injury [8–10]”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [9]
In the citing paper
“The efficacy of low concentrations of nitrite in mediating cytoprotection has been demonstrated in a variety of tissues in animal models including heart [8, 9, 55, 118–122] liver [9, 120, 123], brain [124–126], kidney [127, 128], hindlimb [129], and human forearm [23].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [9]
In the citing paper
“pretreatment with this compound, delivered as a salt in the form of sodium nitrite, protects against ischemia/reperfusion (I/R) injury in the heart in preclinical models (7, 19, 20, 40, 46, 60, 79, 189).”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [46]
In the citing paper
“nitrite administration reduces skeletal muscle (188), renal (125, 179), and liver (46, 154, 169) injury after ischemia.”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [46]
In the citing paper
“exogenous administration of nitrite correlates with increased levels of S-nitrosothiols in red blood cells and other tissues both in vivo and in vitro [25, 43, 46-53].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“Evidence for a role for NO is dependent largely on attenuation of responses by the NO-scavenger CPTIO [25, 26, 52, 100] and measurement of nitrite-dependent increases in cGMP levels[26, 101].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“Murine based studies of hepatic and myocardial IR injury have shown a ‘U’ shaped profile for nitrite effects; namely protection increases with increasing dose up to a point and then as the dose is increased further, protection is lost and can -if even higher doses are administered, exacerbate injury [52, 114].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“nitration reactions could also explain the loss of protection observed when higher doses of nitrite are administered in the context of IR injury [52, 114].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“the nitrite dose range encompassing protection versus loss of protection in these studies was greater than two or three orders of magnitude.”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“experimental observations show that relatively low doses of nitrite are sufficient to induce dramatic protective effects in vivo.”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“Typically doses of ~50 nmoles have been shown to be protective in models of ischemia reperfusion [52, 114] as well hemorrhagic shock in mice [122] for example.”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [52]
In the citing paper
“Duranski et al showed that nitrite therapy protects against ischemic tissue injury through a heme oxygenase-1 pathway which further implicated the generation of nitrite dependent NO during therapy.”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [156]
In the citing paper
“cPTIO treatment was shown by numerous groups to attenuate nitrite mediated protection against ischemia-reperfusion injury in vivo indicating that protective mechanisms likely involve NO dependent signaling pathways and molecular responses [47, 89, 156, 162].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [156]
In the citing paper
“This paper proved that near physiological doses of sodium nitrite (high nanomolar) were highly cytoprotective in both myocardial and hepatic ischemia-reperfusion extending previous work from Cosby et al demonstrating that near physiological levels of nitrite anion mediated hypoxic vasodilation responses [19].”
From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [156]
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Citations
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“Although a protective role for nitrite has been shown under conditions of ischaemia and reperfusion [39, 43, 44], the situation regarding arrhythmias is less clear and has not yet been examined in large animal models.”
BackgroundComplex I syndrome in myocardial stunning and the effect of adenosine
Valdez, L. B., Zaobornyj, T., Bombicino, S. S., Iglesias, D. E., Boveris, A., Donato, M., D’Annunzio, V., Buchholz, B., & Gelpi, R. J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.007 · Cited by 32
“There is evidence that S-nitrosation of complex I proteins is associated with cytoprotection from the damage caused by I/R [71,72].”
BackgroundPellegrino, D., Shiva, S., Angelone, T., Gladwin, M. T., & Tota, B. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.02.007 · Cited by 30
Self-citationIntracellular ATP Concentration Contributes to the Cytotoxic and Cytoprotective Effects of Adenosine
Li, S., Li, X., Guo, H., Liu, S., Huang, H., Liu, N., Yang, C., Tang, P., & Liu, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076731 · Cited by 30
“Cell viability assay The effects of drugs on the cell viability were determined using the MTS assay (CellTiter 96H AQueous One Solution Cell Proliferation Assay; Promega Corporation, Madison, WI, USA) as reported previously [9].”
MethodNitrite is a positive modulator of the Frank-Starling response in the vertebrate heart
Angelone, T., Gattuso, A., Imbrogno, S., Mazza, R., & Tota, B. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00616.2011 · Cited by 30
Nitrite therapy for protection against ischemia-reperfusion injury
Lefer, D. J. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00470.2005 · Cited by 30
Self-citationMyoglobin’s novel role in nitrite-induced hypoxic vasodilation
Hendgen-Cotta, U. B., Kelm, M., & Rassaf, T. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2013.06.006 · Cited by 30
Ischemic preconditioning modulates ROS to confer protection in liver ischemia and reperfusion
Bystrom, P. V., Foley, N. C., Toledo-Pereyra, L. H., & Quesnelle, K. M. (2017) · EXCLI journal · doi:10.17179/excli2017-166 · Cited by 30
“be mediated by reversible S-nitrosation of cysteines (Duranski et al., 2005).”
BackgroundCai, Y. G., Zhang, B., Shalamu, A., Gao, T., & Ge, J. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-2583 · Cited by 28
“Some studies have achieved good results, but they are still rarely transformed into specific therapeutic measures in the clinical field (32-34).”
BackgroundCardiovascular prevention by dietary nitrate and nitrite
Lundberg, J. O. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00246.2009 · Cited by 29
Formation and role of plasma S-nitrosothiols in liver ischemia-reperfusion injury
Glantzounis, G. K., Rocks, S. A., Sheth, H. D., Knight, I., Salacinski, H. J., Davidson, B. R., Winyard, P. G., & Seifalian, A. M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.020 · Cited by 29
Soluble guanylate cyclase-α1is required for the cardioprotective effects of inhaled nitric oxide
Nagasaka, Y., Buys, E. S., Spagnolli, E., Steinbicker, A. U., Hayton, S. R., Rauwerdink, K. M., Brouckaert, P., Zapol, W. M., & Bloch, K. D. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00948.2010 · Cited by 28
Donzelli, S., Switzer, C., Thomas, D. D., Ridnour, L. A., Espey, M. G., Isenberg, J. S., Tocchetti, C. G., King, S. B., Lazzarino, G., Miranda, K. M., et al. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1363 · Cited by 29
“That tissue has the capacity of reducing nitrite to NO was verified in humans in a seminal study in which administration of nitrite was demonstrated to induce vasodilatation, particularly under hypoxic and can attenuate ischemia–reperfusion injury in the heart and liver (29, 100).”
Kelpke, S. S., Chen, B., Bradley, K. M., Teng, X., Chumley, P., Brandon, A., Yancey, B., Moore, B., Head, H., Viera, L., et al. (2012) · Kidney International · doi:10.1038/ki.2012.116 · Cited by 28
Self-citationSun, J., Zhang, X., Wang, X., Peng, J., Song, G., Di, Y., Feng, F., & Wang, S. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202213765 · Cited by 28
Self-citationHeart Failure Management: The Present and the Future
Jameel, M. N., & Zhang, J. J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2488 · Cited by 28
“Similarly, nitrite resulted in an improved cardiac function in eNOS KO and heme-oxygenase KO mice (42).”
InfluentialEmerging role of nitrite in myocardial protection
Lefer, D. J. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-1804-y · Cited by 27
“It has been universally shown that nitrite-mediated protection is independent of eNOS and heme oxygenase-1 enzyme activities (Duranski et al., 2005) and completely dependent on NO generation, as evidenced by the complete blockage of protection by the NO scavengers 2-(4-carboxyphenyl)4,4,5,5-tetramethylimidazole-1-oxyl…”
BackgroundInfluentialSelf-citationEndothelin B receptor stimulation inhibits suicidal erythrocyte death
Föller, M., Mahmud, H., Qadri, S. M., Gu, S., Braun, M., Bobbala, D., Hocher, B., & Lang, F. J. W. (2010) · The FASEB Journal · doi:10.1096/fj.10-159483 · Cited by 28
Ntessalen, M., Procter, N. E. K., Schwarz, K., Loudon, B. L., Minnion, M., Fernandez, B. O., Vassiliou, V. S., Vauzour, D., Madhani, M., Constantin‐Teodosiu, D., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz245 · Cited by 28
“to inhibit platelet aggregation (15, 16), promote vasodilation (17), ameliorate pulmonary hypertension (18–20), and attenuate cardiac ischemia-reperfusion injury in experimental models (21, 22).”
BackgroundXi, L., Zhu, S.-G., Hobbs, D. C., & Kukreja, R. C. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01257.x · Cited by 27
“Nitrate intake has been shown to exert a number of beneficial effects to attenuate myocardial ischemia-reperfusion injury [11, 12], hypertension [13, 14] and platelet aggregation [38].”
Role of sGC-dependent NO signalling and myocardial infarction risk
Wobst, J., Kessler, T., Dang, T. A., Erdmann, J., & Schunkert, H. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1265-3 · Cited by 28
Hon, Y. Y., Sun, H., Dejam, A., & Gladwin, M. T. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.034355 · Cited by 27
“…Maher et al., 2008), exert cytoprotective effects during ischemia-reperfusion of the heart and liver in vitro and in animals (Webb et al., 2004; Duranski et al., 2005; Gonzalez et al., 2008), improve hemodynamics in a canine model of acute pulmonary thromboembolism (Dias-Junior et al., 2006),…”
BackgroundSelf-citationA Cell-Based Phenotypic Assay to Identify Cardioprotective Agents
Guo, S., Olm-Shipman, A. J., Walters, A. M., Urciuoli, W. R., Devito, S., Nadtochiy, S. M., Wojtovich, A. P., & Brookes, P. S. (2012) · Circulation Research · doi:10.1161/circresaha.111.263715 · Cited by 27
Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney
Zhang, G., Han, H., Zhuge, Z., Dong, F., Jiang, S., Wang, W., Guimarães, D. D., Schiffer, T. A., Lai, E. Y., Carvalho, L. R. R. A., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101836 · Cited by 27
Stefano, G. B., & Kream, R. M. (2011) · Medical Science Monitor · doi:10.12659/msm.881972 · Cited by 27
Jensen, F. B., Hansen, M. N., Montesanti, G., & Wang, T. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.093179 · Cited by 27
“Conceivably, nitrite-linked NO and SNO formation provide cytoprotection in liver and brain – like in the heart – as supported by mammalian ischemia/reperfusion experiments addressing these organs (Duranski et al., 2005; Jung et al., 2006; Shiva et al., 2007a; Dezfulian et al., 2012).”
BackgroundBertuglia, S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01371.2007 · Cited by 27
“Accumulating evidence suggest that NOx level is a determinant in I/R and that the application of nitrite as a direct NO donor for treatment of ischemic disorders confers a substantial dose-dependent cytoprotective effect, limiting necrosis and preserving organ function (19, 24).”
Hibernation reduces cellular damage caused by warm hepatic ischemia–reperfusion in ground squirrels
Otis, J. P., Pike, A. C., Torrealba, J. R., & Carey, H. V. (2017) · Journal of Comparative Physiology B · doi:10.1007/s00360-017-1056-y · Cited by 27
The cytoprotective effect of nitrite is based on the formation of dinitrosyl iron complexes
Dungel, P., Perlinger, M., Weidinger, A., Redl, H. R., & Kozlov, A. V. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.012 · Cited by 26
Liang, Z., Chen, H., Gong, X., Shi, B., Lin, L., Tao, F.-Y., Wu, Q., Fang, M., Li, H., Lu, C., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.745693 · Cited by 26
Nitric Oxide and its Metabolites in the Critical Phase of Illness: Rapid Biomarkers in the Making
Mian, A. I., Aranke, M., & Bryan, N. S. (2013) · The Open Biochemistry Journal · doi:10.2174/1874091x01307010024 · Cited by 26
Inhalation of NO during myocardial ischemia reduces infarct size and improves cardiac function
Neye, N., Enigk, F., Shiva, S., Habazettl, H., Plesnila, N., Kuppe, H., Gladwin, M. T., & Kuebler, W. M. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2605-1 · Cited by 26
“Accordingly, nitrite administration in these studies was either timed to the onset of reperfusion [24, 25, 36, 37], or nitrite was given prophylactically as a dietary supplement [25, 38, 39].”
Self-citationHybrid Nitric Oxide Donor and its Carrier for the Treatment of Peripheral Arterial Diseases
Le, D., Kuriakose, A. E., Nguyen, D. X., Nguyen, K. T., & Acharya, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-08441-9 · Cited by 25
Rutin in rat liver ischemia/reperfusion injury: Effect on DDAH/NOS pathway
Lanteri, R., Acquaviva, R., Giacomo, C. D., Sorrenti, V., Destri, G. L., Santangelo, M., Vanella, L., & Cataldo, A. D. (2007) · Microsurgery · doi:10.1002/micr.20345 · Cited by 25
“However other studies reported harmful effects of NO over-exposure,(8,9) suggesting a critical role of dose and duration of NO exposure and indicating a narrow therapeutic safety window for NO in I/R pathophysiology.(2,10)”
BackgroundCurrent Pharmacological Advances in the Treatment of Cardiac Arrest
Papastylianou, A., & Mentzelopoulos, S. D. (2011) · Emergency Medicine International · doi:10.1155/2012/815857 · Cited by 25
Williams, D., Venardos, K. M., BYRNE, M. J., Joshi, M. S., Horlock, D., Lam, N. T., Gregorevic, P., McGee, S. L., & Kaye, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104643 · Cited by 25
“Mitochondrial dysfunction is increasingly understood to be central to the pathophysiology of heart failure and ischemiareperfusion injury [5,6].”
BackgroundHameed, R. M. A., & Medany, S. S. (2018) · Synthetic Metals · doi:10.1016/j.synthmet.2018.11.011 · Cited by 25
Jones, J. A., Ninnis, J. R., Hopper, A. O., Ibrahim, Y., Merritt, T. A., Wan, K., Power, G. G., & Blood, A. B. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113496118 · Cited by 24
Effects of long term nitrite therapy on functional recovery in experimental ischemia model
Jung, K.-H., Chu, K., Lee, S.-T., Sunwoo, J.-S., Park, D.-K., Kim, J.-H., Kim, S., Lee, S. K., Kim, M., & Roh, J.-K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.116 · Cited by 23
Badejo, A. M., Hodnette, C., Dhaliwal, J. S., Casey, D. B., Pankey, E., Murthy, S. N., Nossaman, B. D., Hyman, A. L., & Kadowitz, P. J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00959.2009 · Cited by 32
“Recent studies provide support for the hypothesis that the nitrite anion represents a storage form of NO that can have therapeutic effects (12, 15, 19, 27).”
BackgroundRedox therapeutics in hepatic ischemia reperfusion injury
Patel, R. P., Lang, J. D., Smith, A. B., & Crawford, J. H. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v6.i1.1 · Cited by 23
Self-citationSiriussawakul, A., Chen, L. I., & Lang, J. D. (2012) · Journal of Transplantation · doi:10.1155/2012/819382 · Cited by 23
“The cytoprotective effect of nitrite in cardiac and hepatic ischemia-reperfusion in mice demonstrates the potential for nitrite, in addition to inhaled NO, to be used as treatment to modulate IRI [15].”
BackgroundThe Therapeutic Strategies Targeting Mitochondrial Metabolism in Cardiovascular Disease
Huang, X. J., Zeng, Z., Li, S., Xie, Y., & Tong, X. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122760 · Cited by 25
Nicholson, C. K., Lambert, J. P., Chow, C.-W., Lefer, D. J., & Calvert, J. W. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.08.002 · Cited by 22
“Therefore, the decreased nitrite reductase activity could also explain why the VE groups did not display greater infarct-size lowering effects given that the cytoprotective effects of nitrite are dependent on NO generation [9,28,29].”
Self-citationThe Nitrate–Nitrite–Nitric Oxide Pathway in Mammals
Lundberg, J. O., Weitzberg, E., Shiva, S., & Gladwin, M. T. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_3 · Cited by 26
Self-citationNebulized nitrite protects rat lung grafts from ischemia reperfusion injury
Okamoto, T., Tang, X., Janocha, A., Farver, C. F., Gladwin, M. T., & McCurry, K. R. (2013) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.04.006 · Cited by 22
Self-citationSofla, A. Y. N., Cirkovic, B. A., Hsieh, A., Miklas, J. W., Filipović, N., & Radisic, M. (2013) · Biomicrofluidics · doi:10.1063/1.4791649 · Cited by 22
Nitrite therapy improves survival postexposure to chlorine gas
Honavar, J., Doran, S. F., Oh, J., Steele, C. H., Matalon, S., & Patel, R. P. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00079.2014 · Cited by 22
Self-citationWajih, N., Liu, X., Shetty, P., Basu, S., Wu, H., Hogg, N., Patel, R. P., Furdui, C. M., & Kim‐Shapiro, D. B. (2016) · Redox Biology · doi:10.1016/j.redox.2016.04.004 · Cited by 25
Self-citationHypoxia and Anoxia Tolerance of Vertebrate Hearts: An Evolutionary Perspective
Tota, B., Angelone, T., Mancardi, D., & Cerra, M. C. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3310 · Cited by 22
“It elicits a biphasic protection, as observed in several I=R models, such as the in vitro perfused Langendorff rat heart (81) and an in vivo murine model of myocardial infarction (22).”
DHAWAN, V. M., Schwalb, D. J., Shumway, M. J., Warren, M. C., Wexler, R. S., Zemtseva, I. S., Zifcak, B. M., & Janero, D. R. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.011 · Cited by 22
Mother Was Right: Eat Your Vegetables and Do Not Spit!
Wink, D. A., & Paolocci, N. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.106617 · Cited by 23
Portella, R. D. L., Bickta, J., & Shiva, S. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6260 · Cited by 21
“Numerous studies have demonstrated that nitrite decreases infarct size in murine models of myocardial (7, 21, 37, 60, 86, 195).”
InfluentialSodium Nitrite Mitigates Ventilator-induced Lung Injury in Rats
Pickerodt, P. A., Emery, M. J., Zarndt, R., Martin, W., Francis, R. C. E., Boemke, W., & Swenson, E. R. (2012) · Anesthesiology · doi:10.1097/aln.0b013e3182655f80 · Cited by 21
“in mouse hepatic and cardiac I/R injuries using comparable dosages.(11) In rat brain I/R injury, neuroprotection was maximal at 10-fold higher nitrite dosing, but was reduced or absent at higher and lower dosages.”
BackgroundThe GTN patch: a simple and effective new approach to cardioprotection?
Yellon, D. M., He, Z., Khambata, R. S., Ahluwalia, A., & Davidson, S. M. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0681-2 · Cited by 21
“in the CAESAR trial, but intracoronary or oral nitrite has successfully reduced infarct size in other animal studies [7, 16, 32, 36].”
ResultManagement of Refractory Ventricular Fibrillation (Prehospital and Emergency Department)
Bell, S. M., Lam, D. H., Kearney, K. E., & Hira, R. S. (2018) · Cardiology Clinics · doi:10.1016/j.ccl.2018.03.007 · Cited by 21
Buelna‐Chontal, M., García‐Niño, W. R., Silva‐Palacios, A., Enríquez‐Cortina, C., & Zazueta, C. (2021) · Antioxidants · doi:10.3390/antiox10050749 · Cited by 21
“In addition, NO donors including S-nitrosoglutathione (GSNO) [60], glyceryl trinitrate (GTN) [61], nitrite [62], or paramagnetic nanoparticles coated with S-nitrosothiols [63] prevent IR injury.”
BackgroundResult
Metadata
- Authors
- Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., Gladwin, M. T., & Lefer, D. J.
- Affiliations
- Louisiana State University Health Sciences Center Shreveport (US)
- Medical College of Wisconsin (US)
- University of Alabama at Birmingham (US)
- Brigham and Women's Hospital (US)
- National Institutes of Health (US)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2005-04-14
- Volume
- 115
- Issue
- 5
- Pages
- 1232-1240
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1077170
- OpenAlex
- W2098453482
- Cited by
- 674
- References
- 70
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 9 · 2023: 7 · 2022: 21 · 2021: 22 · 2020: 20 · 2019: 18 · 2018: 23 · 2017: 40 · 2016: 31 · 2015: 45 · 2014: 42 · 2013: 42 · 2012: 59
- FWCI
- 28.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (2R01-HL60849, R01HL060849)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01-1 DK-43785, P01DK043785)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- nitrite, nitric oxide, ischemia-reperfusion injury, cardioprotection, hepatoprotection, sodium nitrite, S-nitrosothiols, nitrosamines, liver necrosis, apoptosis, organ preservation, myocardial infarction
- MeSH terms
- Animals, Heme Oxygenase (Decyclizing), Liver, Membrane Proteins, Mice, Inbred C57BL, Myocardium, Nitrites, Peritoneum, Reperfusion Injury, Nitric Oxide Synthase, Mice, Heme Oxygenase-1
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