Cited by 4,143Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismImmune cells in cancer

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Inflammation, stress, and diabetes

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Wellen, Kathryn E., Hotamisligil, Gökhan S.·2005·Journal of Clinical Investigation

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Abstract

Over the last decade, an abundance of evidence has emerged demonstrating a close link between metabolism and immunity.It is now clear that obesity is associated with a state of chronic low-level inflammation.In this article, we discuss the molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes.We also consider mechanisms through which the inflammatory response may be initiated and discuss the reasons for the inflammatory response in obesity.We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease. Inflammation, stress, and diabetesSurvival of multicellular organisms depends on the ability to fight infection and heal damage and the ability to store energy for times of low nutrient availability or high energy need.Metabolic and immune systems are therefore among the most basic requirements across the animal kingdom, and many nutrient and pathogen-sensing systems have been highly conserved from organisms such as Caenorhabditis elegans and Drosophila to mammals.Perhaps not surprisingly, metabolic and immune pathways have also evolved to be closely linked and interdependent.Many hormones, cytokines, signaling proteins, transcription factors, and bioactive lipids can function in both metabolic and immune roles.In addition to using some of the same cellular machinery, metabolic and immune systems also regulate each other.The normal inflammatory response relies upon metabolic support, and energy redistribution, particularly the mobilization of stored lipid, plays an important role in fighting infection during the acute-phase response (1).The basic inflammatory response thus favors a catabolic state and suppresses anabolic pathways, such as the highly conserved and powerful insulin signaling pathway.The integration of metabolism and immunity, which under normal conditions is beneficial for the maintenance of good health, can become deleterious under conditions of metabolic challenge, as exemplified by the immunosuppression characteristic of malnourished or starving individuals (1-3).Famine has been a prominent hazard to human health throughout history, and for thousands of years the link between infection and poor nutrition has been well recognized.Today this threat is as widespread as ever, and there are approximately 1 billion undernourished individuals worldwide (3).In the past century, however, the pendulum has also swung in the opposite direction, and now as many if not more people are overweight or obese (4).With the advent of this chronic metabolic overload, a new set of problems and complications at the intersection of metabolism and immunity has emerged, including the obesity-linked inflammatory diseases diabetes, fatty liver disease, airway inflammation, and atherosclerosis (5).There is now a wealth of evidence indicating close ties between metabolic and immune systems.Among the many reasons to

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Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
Retracted
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

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Endocrine Functions of Adipose Tissue
Waki, H., & Tontonoz, P. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.2.010506.091859 · Cited by 348
Islet Inflammation in Type 2 Diabetes
Donath, M. Y., Schumann, D., Faulenbach, M. V., Ellingsgaard, H., Perren, A. A., & Ehses, J. A. (2008) · Diabetes Care · doi:10.2337/dc08-s243 · Cited by 351
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
Davis, J. E., Gabler, N. K., Walker‐Daniels, J., & Spurlock, M. E. (2008) · Obesity · doi:10.1038/oby.2008.210 · Cited by 334
Non-alcoholic fatty liver disease and the metabolic syndrome: An update
Rector, R. S., Thyfault, J. P., Wei, Y., & Ibdah, J. A. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.185 · Cited by 337
FABP4 Attenuates PPARγ and Adipogenesis and Is Inversely Correlated With PPARγ in Adipose Tissues
Garin-Shkolnik, T., Rudich, A., Hotamışlıgil, G. S., & Rubinstein, M. (2013) · Diabetes · doi:10.2337/db13-0436 · Cited by 344
Gut microflora as a target for energy and metabolic homeostasis
Cani, P. D., & Delzenne, N. M. (2007) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3282efdebb · Cited by 332
The impact of aging on adipose function and adipokine synthesis
Mancuso, P., & Bouchard, B. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00137 · Cited by 314
Toll-like receptors: linking inflammation to metabolism
Könner, A. C., & Brüning, J. C. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.007 · Cited by 338
Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers
Kern, L., Mittenbühler, M., Vesting, A., Ostermann, A., Wunderlich, C., & Wunderlich, F. (2018) · Cancers · doi:10.3390/cancers11010024 · Cited by 331
Islet Inflammation Impairs the Pancreatic β-Cell in Type 2 Diabetes
Donath, M. Y., Böni‐Schnetzler, M., Ellingsgaard, H., & Ehses, J. A. (2009) · Physiology · doi:10.1152/physiol.00032.2009 · Cited by 339
Adipocyte/macrophage fatty acid–binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice
Furuhashi, M., Fucho, R., Görgün, C. Z., Tuncman, G., Cao, H., & Hotamisligil, G. S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34750 · Cited by 332
Probiotics and Prebiotics: Present Status and Future Perspectives on Metabolic Disorders
Yoo, J. Y., & Kim, S. S. (2016) · Nutrients · doi:10.3390/nu8030173 · Cited by 335
TNF- downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
Valerio, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28570 · Cited by 327
Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
Ilan, Y., Maron, R., Tukpah, A.-M. C., Maioli, T. U., Murugaiyan, G., Yang, K., Wu, H. Y., & Weiner, H. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908771107 · Cited by 327
Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment
Smith, B. W., & Adams, L. A. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.72 · Cited by 334
Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake
JafariNasabian, P., Inglis, J. E., Reilly, W., Kelly, O. J., & Ilich, J. Z. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0603 · Cited by 310
Increased Adipose Tissue Oxygen Tension in Obese Compared With Lean Men Is Accompanied by Insulin Resistance, Impaired Adipose Tissue Capillarization, and Inflammation
Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P., Konings, E., Jocken, J. W. E., Čajlaković, M., Ribitsch, V., Clément, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.027813 · Cited by 324
Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice
Bradley, R. L., Jeon, J. Y., Liu, F.-F., & Maratos–Flier, E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00309.2007 · Cited by 323
Systemic infection, inflammation and acute ischemic stroke
McColl, B. W., Allan, S. M., & Rothwell, N. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.019 · Cited by 319
CCL2/CCR2 signaling in cancer pathogenesis
Hao, Q., Vadgama, J. V., & Wang, P. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00589-8 · Cited by 324
Vitamin status in morbidly obese patients: a cross-sectional study
Aasheim, E. T., Hofsø, D., Hjelmesæth, J., Birkeland, K. I., & Bøhmer, T. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.362 · Cited by 316
LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition
Rong, X., Albert, C. J., Hong, C., Duerr, M. A., Chamberlain, B. T., Tarling, E. J., Ito, A., Gao, J., Wang, B., Edwards, P. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.002 · Cited by 323
The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling
DiAngelo, J. R., Bland, M. L., Bambina, S., Cherry, S. R., & Birnbaum, M. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906749106 · Cited by 311
Systemic Inflammation Alters the Kinetics of Cerebrovascular Tight Junction Disruption after Experimental Stroke in Mice
McColl, B. W., Rothwell, N. J., & Allan, S. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2674-08.2008 · Cited by 320
Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice
Carvalho, B. M., Guadagnini, D., Tsukumo, D. M. L., Schenka, A. A., Latuf-Filho, P., Vassallo, J., Dias, J. C., Kubota, L. T., Carvalheira, J. B. C., & Saad, M. J. A. (2012) · Diabetologia · doi:10.1007/s00125-012-2648-4 · Cited by 324
Update on Bispectral Index monitoring
Johansen, J. W. (2006) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2005.08.004 · Cited by 312
Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent
Mehdi, S. F., Pusapati, S., Anwar, M. S., Lohana, D., Kumar, P., Nandula, S. A., Nawaz, F. K., Tracey, K., Yang, H., LeRoith, D., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148209 · Cited by 317
Treatment of Obese Diabetic Mice With a Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels, and Improves Insulin Sensitivity and Glucose Tolerance
Li, M., Kim, D. H., Tsenovoy, P. L., Peterson, S. J., Rezzani, R., Rodella, L. F., Aronow, W. S., Ikehara, S., & Abraham, N. G. (2008) · Diabetes · doi:10.2337/db07-1764 · Cited by 313
Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
Diamant, M., Blaak, E. E., & de Vos, W. M. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00797.x · Cited by 308
Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids
Todoric, J., Löffler, M. G., Huber, J., Bilban, M., Reimers, M., Kadl, A., Zeyda, M., Waldhäusl, W., & Stulnig, T. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0300-x · Cited by 318
Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERα-deficient mice
Ribas, V., Nguyen, M. T. A., Henstridge, D. C., Nguyen, A.-K., Beaven, S. W., Watt, M. J., & Hevener, A. L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00504.2009 · Cited by 309
Inflammatory Process in Type 2 Diabetes: The Role of Cytokines
ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.039 · Cited by 309
The emerging role of HDL in glucose metabolism
Drew, B. G., Rye, K.-A., Duffy, S. J., Barter, P., & Kingwell, B. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.235 · Cited by 307
Adipose tissue macrophages
Zeyda, M., & Stulnig, T. M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.003 · Cited by 316
Positive affect and markers of inflammation: discrete positive emotions predict lower levels of inflammatory cytokines.
Stellar, J. E., John-Henderson, N., Anderson, C. L., Gordon, A. M., McNeil, G. D., & Keltner, D. (2015) · Emotion · doi:10.1037/emo0000033 · Cited by 307
Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis
Sung, H., Doh, K., Son, J. E., Park, J. G., Bae, Y., Choi, S., Nelson, S. M. L., Cowling, R. A., Nagy, K. V., Michael, I. P., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.010 · Cited by 317
(n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights
Kalupahana, N. S., Claycombe, K. J., & Moustaid-Moussa, N. (2011) · Advances in Nutrition · doi:10.3945/an.111.000505 · Cited by 305
Comparison of gut microbiota in adult patients with type 2 diabetes and healthy individuals
Sedighi, M., Razavi, S., Navab-Moghadam, F., Khamseh, M. E., Alaei-Shahmiri, F., Mehrtash, A., & Amirmozafari, N. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.08.038 · Cited by 306
Role of Leptin in Inflammation and Vice Versa
Pérez-Pérez, A., Sánchez-Jiménez, F., Vilariño-García, T., & Sánchez-Margalet, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165887 · Cited by 330
Fucoxantin: A Treasure from the Sea
D’Orazio, N., Gemello, E., Gammone, M. A., Girolamo, M. D., Ficoneri, C., & Riccioni, G. (2012) · Marine Drugs · doi:10.3390/md10030604 · Cited by 305
Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity
Pietiläinen, K. H., Naukkarinen, J., Rissanen, A., Saharinen, J., Ellonen, P., Keränen, H., Suomalainen, A., Götz, A., Suortti, T., Yki‐Järvinen, H., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050051 · Cited by 303
Better living through microbial action: the benefits of the mammalian gastrointestinal microbiota on the host
Leser, T. D., & Mølbak, L. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01941.x · Cited by 316
Regulation of Renal Fatty Acid and Cholesterol Metabolism, Inflammation, and Fibrosis in Akita and OVE26 Mice With Type 1 Diabetes
Proctor, G., Jiang, T., Iwahashi, M., Wang, Z., Li, J., & Levi, M. (2006) · Diabetes · doi:10.2337/db05-0603 · Cited by 303
Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity
Aerts, J. M. F. G., Ottenhoff, R., Powlson, A., Grefhorst, A., van Eijk, M., Dubbelhuis, P. F., Aten, J., Kuipers, F., Serlie, M. J. M., Wennekes, T., et al. (2007) · Diabetes · doi:10.2337/db06-1619 · Cited by 301
Role of Gut Microbiota in the Aetiology of Obesity: Proposed Mechanisms and Review of the Literature
Khan, M. J., Gerasimidis, K., Edwards, C. A., & Shaikh, M. G. (2016) · Journal of Obesity · doi:10.1155/2016/7353642 · Cited by 315
High-Fat Diet Reduces the Formation of Butyrate, but Increases Succinate, Inflammation, Liver Fat and Cholesterol in Rats, while Dietary Fibre Counteracts These Effects
Jakobsdottir, G., Xu, J., Molin, G., Ahrné, S., & NYMAN, M. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080476 · Cited by 295
The Role of Ceramides in Insulin Resistance
Sokołowska, E., & Błachnio-Zabielska, A. U. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00577 · Cited by 310
Indications for Surgery for Obesity and Weight-Related Diseases: Position Statements from the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO)
De Luca, M., Angrisani, L., Himpens, J., Busetto, L., Scopinaro, N., Weiner, R., Sartori, A., Stier, C., Lakdawala, M., Bhasker, A. G., et al. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2271-4 · Cited by 296
Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis
Grattagliano, I., Palmieri, V. O., Portincasa, P., Moschetta, A., & Palasciano, G. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.06.011 · Cited by 301
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
Khodabandehloo, H., Gorgani‐Firuzjaee, S., Panahi, G., & Meshkani, R. (2015) · Translational research · doi:10.1016/j.trsl.2015.08.011 · Cited by 307
Role of PGC-1α Signaling in Skeletal Muscle Health and Disease
Kang, C., & Li Ji, L. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06738.x · Cited by 291
Non-alcoholic fatty liver disease
Smith, B. W., & Adams, L. A. (2011) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2011.596521 · Cited by 300
The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_9 · Cited by 299
Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model
Maeda, H. (2009) · Molecular Medicine Reports · doi:10.3892/mmr_00000189 · Cited by 290
Diabetes Incidence and Long-Term Exposure to Air Pollution
Andersen, Z. J., Raaschou‐Nielsen, O., Ketzel, M., Jensen, S. S., Hvidberg, M., Loft, S. H., Tjønneland, A. M., Overvad, K., & Sørensen, M. (2011) · Diabetes Care · doi:10.2337/dc11-1155 · Cited by 289
Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: A review
He, F.-F., & Li, Y.-M. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00670-3 · Cited by 289
High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice
van der Heijden, R. A., Sheedfar, F., Morrison, M. C., Hommelberg, P. P. H., Kor, D., Kloosterhuis, N., Gruben, N., Youssef, S. A., de Bruin, A., Hofker, M. H., et al. (2015) · Aging · doi:10.18632/aging.100738 · Cited by 301
Aging Up-Regulates Expression of Inflammatory Mediators in Mouse Adipose Tissue
Wu, D., Ren, Z., Pae, M., Guo, W., Cui, X., Merrill, A. H., & Meydani, S. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4829 · Cited by 293
Inflammatory lipid mediators in adipocyte function and obesity
Iyer, A., Fairlie, D. P., Prins, J. B., Hammock, B. D., & Brown, L. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.264 · Cited by 290
PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue
Matsubara, T., Mita, A., Minami, K., Hosooka, T., Kitazawa, S., Takahashi, K., Tamori, Y., Yokoi, N., Watanabe, M., Matsuo, E., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.002 · Cited by 287
Cellular and molecular effects ofn−3 polyunsaturated fatty acids on adipose tissue biology and metabolism
Flachs, P., Rossmeisl, M., Bryhn, M., & Kopecký, J. (2008) · Clinical Science · doi:10.1042/cs20070456 · Cited by 293
Inflammation and endoplasmic reticulum stress in obesity and diabetes
Hotamışlıgil, G. S. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.238 · Cited by 287
Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity
Law, I. K. M., Xu, A., Lam, K. S. L., Berger, T., Mak, T. W., Vanhoutte, P. M., Liu, J. T. C., Sweeney, G., Zhou, M., Yang, B., et al. (2010) · Diabetes · doi:10.2337/db09-1541 · Cited by 297
Nutrigenomics: From Molecular Nutrition to Prevention of Disease
Afman, L. A., & Müller, M. M. (2006) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2006.01.001 · Cited by 290
Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes
Yassour, M., Lim, M. Y., Yun, H. S., Tickle, T. L., Sung, J., Song, Y., Lee, K., Franzosa, E. A., Morgan, X. C., Gevers, D., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0271-6 · Cited by 293
Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance
Asrih, M., & Jornayvaz, F. R. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0201 · Cited by 292
Targeting PI3K/AKT signaling pathway in obesity.
Savova, M., Mihaylova, L., Tews, D., Wabitsch, M., & Georgiev, M. (2023) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2023.114244 · Cited by 260
Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice
Caricilli, A. M., Picardi, P. K., de Abreu, L. L., Ueno, M., Prada, P. O., Ropelle, E. R., Hirabara, S. M., Castoldi, Â., Moraes‐Vieira, P. M., Câmara, N. O. S., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001212 · Cited by 285
Retracted
Psoriasis and Obesity
Jensen, P., & Skov, L. (2016) · Dermatology · doi:10.1159/000455840 · Cited by 281
Altered Adipose and Plasma Sphingolipid Metabolism in Obesity
Samad, F., Hester, K. D., Yang, G., Hannun, Y. A., & Bielawski, J. (2006) · Diabetes · doi:10.2337/db06-0330 · Cited by 285
Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells: A Review
Fain, J. N. (2010) · Mediators of Inflammation · doi:10.1155/2010/513948 · Cited by 301
A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease
Tuncman, G., Erbay, E., Hom, X., Vivo, I. D., Campos, H., Rimm, E. B., & Hotamışlıgil, G. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602178103 · Cited by 277
Curcumin Supplementation Lowers TNF-α, IL-6, IL-8, and MCP-1 Secretion in High Glucose-Treated Cultured Monocytes and Blood Levels of TNF-α, IL-6, MCP-1, Glucose, and Glycosylated Hemoglobin in Diabetic Rats
Jain, S. K., Rains, J., Croad, J. L., Larson, B. W., & Jones, K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2140 · Cited by 277
Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults
Vanegas, S. M., Meydani, M., Barnett, J. B., Goldin, B., Kane, A., Rasmussen, H., Brown, C., Vangay, P., Knights, D., Jonnalagadda, S., et al. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.146928 · Cited by 277
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Blood-brain barrier permeability and physical exercise
Małkiewicz, M. A., Szarmach, A., Sabisz, A., Cubała, W. J., Szurowska, E., & Winklewski, P. J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1403-x · Cited by 276
Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders?
Harris, K. A., Kassis, A. N., Major, G. C., & Chou, C. J. (2012) · Journal of Obesity · doi:10.1155/2012/879151 · Cited by 289
The Role of Gut Microbiota on Insulin Resistance
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Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites
Russo, S. L. M. L., Kwiatkowski, M., Govorukhina, N. I., Bischoff, R., & Melgert, B. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.746151 · Cited by 286
Stress and Wound Healing
Christian, L. M., Graham‐Engeland, J. E., Padgett, D. A., Glaser, R., & Kiecolt‐Glaser, J. K. (2006) · NeuroImmunoModulation · doi:10.1159/000104862 · Cited by 290
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The influence of yoga-based programs on risk profiles in adults with type 2 diabetes mellitus: a systematic review
Innes, K. E., & Vincent, H. K. (2007) · Evidence-Based Complementary and Alternative Medicine · doi:10.1093/ecam/nel103 · Cited by 268
Magnesium, inflammation, and obesity in chronic disease
Nielsen, F. H. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00293.x · Cited by 269
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Yung, J. H. M., & Giacca, A. (2020) · Cells · doi:10.3390/cells9030706 · Cited by 284
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Berridge, M. J. (2017) · Biochemical Journal · doi:10.1042/bcj20170042 · Cited by 279
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Dong, Y., Zhang, M., Liang, B., Xie, Z., Zhao, Z., Asfa, S., Choi, H. C., & Zou, M. (2010) · Circulation · doi:10.1161/circulationaha.109.900928 · Cited by 262
Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding
Cani, P. D., Delzenne, N. M., Amar, J., & Burcelin, R. (2008) · Pathologie Biologie · doi:10.1016/j.patbio.2007.09.008 · Cited by 272
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Shelton, R. C., & Miller, A. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.004 · Cited by 264
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Polycystic ovary syndrome and mitochondrial dysfunction
Zhang, J., Bao, Y.-G., Zhou, X., & Zheng, L. (2019) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-019-0509-4 · Cited by 273
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Wei, Y., Chen, K., Whaley‐Connell, A. T., Stump, C. S., Ibdah, J. A., & Sowers, J. R. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00561.2007 · Cited by 270
Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism
Gomes, P., Outeiro, T. F., & Cavadas, C. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.001 · Cited by 259
Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats
Hsieh, F.-C., Lee, C.-L., Chai, C., Chen, W., Lu, Y.-C., & Wu, C. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-35 · Cited by 262
Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
Alkhouri, N., Carter-Kent, C. A., & Feldstein, A. E. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.6 · Cited by 259
Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis
Williams, K. W., Liu, T., Kong, X., Fukuda, M., Deng, Y., Berglund, E. D., Deng, Z., Gao, Y., Liu, T., Sohn, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.002 · Cited by 258
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Wang, J., Chen, W., & Wang, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01065 · Cited by 269
Immunity as a link between obesity and insulin resistance
Kalupahana, N. S., Moustaïd‐Moussa, N., & Claycombe, K. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.011 · Cited by 264

Authors: Wellen, K. E., & Hotamisligil, G. S.
Affiliations: Harvard University (US)
ORCID: Wellen, Kathryn E.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2005-05-02
Volume: 115
Issue: 5
Pages: 1111-1119
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci25102
PMC: PMC1087185
OpenAlex: W2064119981
Cited by: 4,143
References: 118
Citations by year: 2026: 76 · 2025: 104 · 2024: 92 · 2023: 130 · 2022: 177 · 2021: 169 · 2020: 209 · 2019: 221 · 2018: 233 · 2017: 193 · 2016: 215 · 2015: 226 · 2014: 239 · 2013: 276 · 2012: 264
FWCI: 138.15
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
National Institutes of Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: obesity-associated inflammation, low-grade inflammation, type 2 diabetes, insulin signaling, stress response, innate immunity, innate lymphoid cells, Th17 cells, Th1 cells, Th2 cells, regulatory T cells, Treg cell function, Treg cell homeostasis
MeSH terms: Animals, Diabetes Mellitus, Humans, Inflammation, Insulin Resistance, Macrophages, Obesity, Stress, Physiological, Adipocytes

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