Cited by 1,940Immune cells in cancerCytokine Signaling Pathways and InteractionsChemokine receptors and signaling

The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.

A cytokine-mediated link between innate immunity, inflammation, and cancer

Open access

Lin, Wan-Wan, Karin, Michael·2007·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

It has been established that cancer can be promoted and/or exacerbated by inflammation and infections. Indeed, chronic inflammation orchestrates a tumor-supporting microenvironment that is an indispensable participant in the neoplastic process. The mechanisms that link infection, innate immunity, inflammation, and cancer are being unraveled at a fast pace. Important components in this linkage are the cytokines produced by activated innate immune cells that stimulate tumor growth and progression. In addition, soluble mediators produced by cancer cells recruit and activate inflammatory cells, which further stimulate tumor progression. However, inflammatory cells also produce cytokines that can limit tumor growth. Here we provide an overview of the current understanding of the role of inflammation-induced cytokines in tumor initiation, promotion, and progression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci31537

Cites

128 of 128 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Inflammation and cancer
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,498
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265

Flagged first, then by citations

Show all 128 references

Research works printed but not linked: 12

Shacter, 2002, Oncology., 16, 217
Sehouli, 2002, Anticancer Res., 22, 3421
Kitakata, 2002, Cancer Res., 62, 6682
Gado, 2001, Haematologica., 86, 227
Tartour, 1999, Cancer Res., 59, 3698
Trinchieri, 2003, Nat. Rev., 3, 133
Erdman, 2003, Cancer Res., 63, 6042
Kohno, 2003, Cancer Res., 63, 5091
Alas, 2001, Clin. Cancer Res., 7, 709
Lech-Maranda, 2006, Eur. Cytokine Netw., 17, 60
Parsons, 1995, Cancer Res., 55, 5548
Engle, 2002, Cancer Res., 62, 6362

Sorted by citations

Items 301–400 of 999

Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats
Chen, H., Liao, H., Liu, Y., Zheng, Y., Wu, X., Su, Z., Zhang, X., Lai, Z., Lai, X., Lin, Z., et al. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.11.017 · Cited by 106
Synergistic Effect of Combination of Phenethyl Isothiocyanate and Sulforaphane or Curcumin and Sulforaphane in the Inhibition of Inflammation
Cheung, K. L., Khor, T. O., & Kong, A. T. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9734-9 · Cited by 106
The anti-inflammatory effects of platinum nanoparticles on the lipopolysaccharide-induced inflammatory response in RAW 264.7 macrophages
Rehman, M. U., Yoshihisa, Y., Miyamoto, Y., & Shimizu, T. (2012) · Inflammation Research · doi:10.1007/s00011-012-0512-0 · Cited by 106
Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone
Rasul, A., Khan, M. N., Ali, M., Li, J., & Li, X. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/248532 · Cited by 108
Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-κB/ZEB1 signal pathway.
Gu, K., Li, M., Shen, J., Liu, F., Cao, J., Jin, S., & Yu, Y. (2015) · PubMed Central · Cited by 105
Molecular mechanisms involved in dendritic cell dysfunction in cancer
Tang, M., Diao, J., & Cattral, M. S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2317-8 · Cited by 106
Inhibition of IL1β by Canakinumab May Be Effective against Diverse Molecular Subtypes of Lung Cancer: An Exploratory Analysis of the CANTOS Trial
Wong, C. C., Baum, J., Silvestro, A., Beste, M. T., Dharan, B., Xu, S., Wang, Y. A., Wang, T., PRESCOTT, M. F., Krajkovich, L., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3176 · Cited by 105
Cytokine-based transformation of immune surveillance into tumor-promoting inflammation
Mumm, J. B., & Oft, M. (2008) · Oncogene · doi:10.1038/onc.2008.275 · Cited by 108
Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway
Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1320-y · Cited by 106
Inflammation and CYP3A4-mediated drug metabolism in advanced cancer: impact and implications for chemotherapeutic drug dosing
Kacevska, M., Robertson, G. R., Clarke, S. J., & Liddle, C. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.2.137 · Cited by 104
Cornuside Suppresses Lipopolysaccharide-Induced Inflammatory Mediators by Inhibiting Nuclear Factor-Kappa B Activation in RAW 264.7 Macrophages
Choi, Y. H., Jin, G. Y., Li, G. Z., & Yan, G. H. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.959 · Cited by 103
Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early breast cancer (Alliance A011401): study design
Ligibel, J. A., Barry, W. T., Alfano, C. M., Hershman, D. L., Irwin, M. L., Neuhouser, M. L., Thomson, C. A., Delahanty, L. M., Frank, E. S., Spears, P., et al. (2017) · npj Breast Cancer · doi:10.1038/s41523-017-0040-8 · Cited by 104
Does interleukin-6 link explain the link between tumour necrosis, local and systemic inflammatory responses and outcome in patients with colorectal cancer?
Guthrie, G. J. K., Roxburgh, C. S. D., Horgan, P. G., & McMillan, D. C. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.07.003 · Cited by 103
Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways
Sturm, C., & Wagner, A. E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091890 · Cited by 101
The role of immunity in elderly cancer
Malaguarnera, L., Cristaldi, E., & Malaguarnera, M. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.06.002 · Cited by 103
Lung Inflammation, Injury, and Proliferative Response after Repetitive Particulate Hexavalent Chromium Exposure
Beaver, L. M., Stemmy, E. J., Schwartz, A. M., Damsker, J. M., Constant, S. L., Ceryak, S. M., & Patierno, S. R. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900715 · Cited by 104
Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models
Li, R., Huang, Y., & Lin, J. (2020) · Nature Communications · doi:10.1038/s41467-019-14065-6 · Cited by 102
Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth
Li, J., Xia, Y., Sun, B., Zheng, N., Li, Y., Pang, X., Yang, F., Zhao, X., Ji, Z., Yu, H., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01112-5 · Cited by 108
NF-κB: Governing Macrophages in Cancer
Cornice, J., Verzella, D., Arboretto, P., Vecchiotti, D., Capece, D., Zazzeroni, F., & Franzoso, G. (2024) · Genes · doi:10.3390/genes15020197 · Cited by 108
A Systems Biology Approach to Understanding the Mechanisms of Action of Chinese Herbs for Treatment of Cardiovascular Disease
Li, B., Xu, X. J., Wang, X., Yu, H., Li, X., Tao, W., Wang, Y., & Yang, L. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131013501 · Cited by 100
Flavone deglycosylation increases their anti‐inflammatory activity and absorption
Hostetler, G. L., Riedl, K. M., Cárdenas, H., Toro, M. D., Arango, D., Schwartz, S. J., & Doseff, A. I. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100596 · Cited by 100
Diet components can suppress inflammation and reduce cancer risk
Hardman, W. E. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.3.233 · Cited by 100
Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Peña‐Oyarzún, D., Bravo, R., Díaz‐Vegas, A., Aleman, L., Chiong, M., García, L., Claudia Bambs, S., Troncoso, R., Cifuentes, M., Morselli, E., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.084 · Cited by 108
Increasing the Antigenicity of Synthetic Tumor‐Associated Carbohydrate Antigens by Targeting Toll‐Like Receptors
Ingale, S., Wolfert, M. A., Buskas, T., & Boons, G. (2009) · ChemBioChem · doi:10.1002/cbic.200800596 · Cited by 99
Photoaging and skin cancer: Is the inflammasome the missing link?
Awad, F., Assrawi, E., Louvrier, C., Jumeau, C., Giurgea, I., Amselem, S., & Karabina, S. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.03.003 · Cited by 101
The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer
Badoual, C., Bouchaud, G., Agueznay, N. E. H., Mortier, E., Hans, S., Gey, A., Fernani, F., Peyrard, S., Laurent‐Puig, P., Bruneval, P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6842 · Cited by 98
Comorbidities and Systemic Effects of Chronic Obstructive Pulmonary Disease
Choudhury, G., Rabinovich, R., & MacNee, W. (2014) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2013.10.007 · Cited by 101
The complex interplay between inflammation, the microbiota and colorectal cancer
Arthur, J. C., & Jobin, C. (2013) · Gut Microbes · doi:10.4161/gmic.24220 · Cited by 99
Organochlorine pesticides induce inflammation, ROS production, and DNA damage in human epithelial ovary cells: An in vitro study
Shah, H. K., Sharma, T., & Banerjee, B. D. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125691 · Cited by 96
Links between Infections, Lung Cancer, and the Immune System
Budişan, L., Zănoagă, O., Braicu, C., Pîrlog, R., Covaliu, B. F., Eşanu, V., Korban, S. S., & Berindan‐Neagoe, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179394 · Cited by 107
Hepatitis B virus X protein stimulates IL-6 expression in hepatocytes via a MyD88-dependent pathway
Xiang, W., Feng, W.-F., Ke, W., Sun, Z., Chen, Z., & Liu, W. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.08.006 · Cited by 95
Suicide and cancer: Where do we go from here?
Spoletini, I., Gianni, W., Caltagirone, C., Madaio, R., Repetto, L., & Spalletta, G. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.05.005 · Cited by 164
Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice
Martinez, R. M., Pinho-Ribeiro, F. A., Steffen, V. S., Silva, T. C. C., Caviglione, C. V., Bottura, C., Fonseca, M. J. V., Vicentini, F. T. M. C., Vignoli, J. A., Baracat, M. M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146296 · Cited by 96
Inflammation in uveal melanoma
Bronkhorst, I. H. G., & Jager, M. J. (2012) · Eye · doi:10.1038/eye.2012.253 · Cited by 96
The Nuclear Hormone Receptor PPARγas a Therapeutic Target in Major Diseases
Schmidt, M. V., Brüne, B., & von Knethen, A. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.213 · Cited by 94
An immunologic portrait of cancer
Ascierto, M. L., Giorgi, V. D., Liu, Q., Bedognetti, D., Spivey, T., Murtas, D., Uccellini, L., Ayotte, B. D., Stroncek, D. F., Chouchane, L., et al. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-146 · Cited by 94
Identification and Validation of an Individualized Prognostic Signature of Bladder Cancer Based on Seven Immune Related Genes
Qiu, H., Hu, X., He, C. H., Yu, B., Li, Y., & Li, J. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00012 · Cited by 95
Colorectal Dysplasia in Chronic Inflammatory Bowel Disease: Pathology, Clinical Implications, and Pathogenesis
Harpaz, N., & Polydorides, A. D. (2010) · Archives of Pathology & Laboratory Medicine · doi:10.5858/134.6.876 · Cited by 96
Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression
Schmitz, M. L., & Kracht, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.10.004 · Cited by 94
Metabolic syndrome, obesity and cancer risk
Belladelli, F., Montorsi, F., & Martini, A. (2022) · Current Opinion in Urology · doi:10.1097/mou.0000000000001041 · Cited by 94
Role of the nervous system in cancer metastasis
Li, S., Sun, Y., & GAO, D. (2013) · Oncology Letters · doi:10.3892/ol.2013.1168 · Cited by 94
The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis
Negri, L., & Ferrara, N. (2018) · Physiological Reviews · doi:10.1152/physrev.00012.2017 · Cited by 99
Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review
Ciążyńska, M. A., Olejniczak‐Staruch, I., Sobolewska-Sztychny, D., Narbutt, J., Skibińska, M., & Lesiak, A. (2021) · Life · doi:10.3390/life11040326 · Cited by 100
Recent Advances in the Research of Hepatitis B Virus-Related Hepatocellular Carcinoma
Kao, J., Chen, P., & Chen, D. (2010) · Advances in cancer research · doi:10.1016/b978-0-12-380888-2.00002-9 · Cited by 93
Novel biphasic role for lymphocytes revealed during resolving inflammation
Rajakariar, R., Lawrence, T., Byström, J., Hilliard, M., Colville‐Nash, P., Bellingan, G. J., Fitzgerald, D. J., Yaqoob, M., & Gilroy, D. W. (2008) · Blood · doi:10.1182/blood-2007-08-108936 · Cited by 92
Silibinin modulates the NF-κb pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women
Giorgi, V. S. I., Peraçoli, M. T. S., Peraçoli, J. C., Witkin, S. S., & Castro, C. F. B. (2012) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2012.06.004 · Cited by 93
Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity
Kim, J. Y., Lim, S., Kim, G., Yun, H. J., Ahn, S. G., & Choi, H. S. (2014) · Oncogene · doi:10.1038/onc.2014.418 · Cited by 92
Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma
Sun, Y., Liu, N., Guan, X., Wu, H., Sun, Z., & Zeng, H. (2016) · Mediators of Inflammation · doi:10.1155/2016/5715719 · Cited by 92
Targeting the Canonical WNT/β-Catenin Pathway in Cancer Treatment Using Non-Steroidal Anti-Inflammatory Drugs
Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2019) · Cells · doi:10.3390/cells8070726 · Cited by 94
Janus kinase inhibitors: A therapeutic strategy for cancer and autoimmune diseases
Hosseini, A., Gharibi, T., Marofi, F., Javadian, M., Babaloo, Z., & Baradaran, B. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29593 · Cited by 94
IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals
Oh, J., Cho, M.-C., Kim, J., Lee, S. Y., Kim, H. J., Park, E. S., Ban, J. O., Kang, J.-W., Lee, D.-H., Shim, J.-H., et al. (2011) · Oncogene · doi:10.1038/onc.2011.52 · Cited by 93
Carcinogenesis as a Result of Multiple Inflammatory and Oxidative Hits: a Comprehensive Review from Tumor Microenvironment to Gut Microbiota
Morgillo, F., Dallio, M., Corte, C. M. D., Gravina, A. G., Viscardi, G., Loguercio, C., Ciardiello, F., & Federico, A. (2018) · Neoplasia · doi:10.1016/j.neo.2018.05.002 · Cited by 99
Sonodynamic Nano-LYTACs Reverse Tumor Immunosuppressive Microenvironment for Cancer Immunotherapy
Xu, M., Hu, Y., Wu, J., Liu, J., & Pu, K. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c13022 · Cited by 93
Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma
Tamburini, B. A. J., Phang, T. L., Fosmire, S. P., Scott, M. C., Trapp, S., Duckett, M. M., Robinson, S. R., Slansky, J. E., Sharkey, L. C., Cutter, G., et al. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-619 · Cited by 91
Ethyl acetate extracts of alfalfa (Medicago sativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo
Hong, Y., Chao, W., Chen, M., & Lin, B. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-64 · Cited by 91
Induction of Bv8 Expression by Granulocyte Colony-stimulating Factor in CD11b+Gr1+ Cells
Qu, X., Zhuang, G., Yu, L., Meng, G., & Ferrara, N. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.326801 · Cited by 96
K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia
Okumura, T., Ericksen, R. E., Takaishi, S., Wang, S. S. W., Dubeykovskiy, Z., Shibata, W., Betz, K. S., Muthupalani, S., Rogers, A. B., Fox, J. G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1506 · Cited by 91
Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors
Souto, J. C., Vila, L., & Brú, A. (2009) · Medicinal Research Reviews · doi:10.1002/med.20185 · Cited by 90
Silver nanoparticles induce pro‐inflammatory gene expression and inflammasome activation in human monocytes
Murphy, A., Casey, A., Byrne, G., Chambers, G., & Howe, O. L. (2016) · Journal of Applied Toxicology · doi:10.1002/jat.3315 · Cited by 91
Tumor Associated Macrophages Protect Colon Cancer Cells from TRAIL-Induced Apoptosis through IL-1β- Dependent Stabilization of Snail in Tumor Cells
Kaler, P., Galea, V. P., Augenlicht, L. H., & Klampfer, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011700 · Cited by 89
Lifestyle and biological factors influence the relationship between mental health and low-grade inflammation
Gialluisi, A., Bonaccio, M., Castelnuovo, A. F. D., Costanzo, S., Curtis, A. D., Sarchiapone, M., Cerletti, C., Donati, M. B., de Gaetano, G., Iacoviello, L., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.041 · Cited by 94
Tumor immune microenvironment and nano-immunotherapeutics in colorectal cancer
Xiong, Y., Wang, Y., & Tiruthani, K. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102034 · Cited by 88
Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells
Li, J., Lan, T., Zhang, C., Zeng, C., Hou, J., Yang, Z., Zhang, M., Liu, J., & Liu, B. (2015) · Oncotarget · doi:10.18632/oncotarget.2671 · Cited by 93
Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts
Olsen, C. J., Moreira, J. M. A., Lukanidin, E. M., & Ambartsumian, N. S. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-444 · Cited by 90
Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats
Sun, K., Guo, X.-L., Zhao, Q.-D., Jing, Y.-Y., Kou, X.-R., Xie, X.-Q., Zhou, Y., Cai, N., Gao, L., Zhao, X., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.35 · Cited by 91
Tumor stress, cell death and the ensuing immune response
Ullrich, E., Bonmort, M., Mignot, G., Kroemer, G., & Zitvogel, L. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402266 · Cited by 90
Chronic Ethanol Feeding Accelerates Hepatocellular Carcinoma Progression in a Sex‐Dependent Manner in a Mouse Model of Hepatocarcinogenesis
Brandon‐Warner, E., Walling, T. L., Schrum, L. W., & McKillop, I. H. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01660.x · Cited by 88
Molecular damage in cancer: an argument for mTOR-driven aging
Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100422 · Cited by 88
Fashionable, but What is Their Real Clinical Usefulness? NLR, LMR, and PLR as a Promising Indicator in Colorectal Cancer Prognosis: A Systematic Review
Misiewicz, A., & Dymicka-Piekarska, V. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s391932 · Cited by 87
A Review of Mathematical Models of Cancer–Immune Interactions in the Context of Tumor Dormancy
Wilkie, K. P. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-1445-2_10 · Cited by 87
Synergistic Anti-inflammatory Effects of Nobiletin and Sulforaphane in Lipopolysaccharide-Stimulated RAW 264.7 Cells
Guo, S., Qiu, P., Xu, G. H., Wu, X., Dong, P., Yang, G., Zheng, J., McClements, D. J., & Xiao, H. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300129t · Cited by 87
Impact of microenvironment and stem-like plasticity in cholangiocarcinoma: Molecular networks and biological concepts
Raggi, C., Invernizzi, P., & Andersen, J. B. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.09.007 · Cited by 87
Humoral innate immune response and disease
Shishido, S. N., Varahan, S., Yuan, K., Li, X., & Fleming, S. D. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.06.002 · Cited by 88
Microbial Patterns Signaling via Toll-Like Receptors 2 and 5 Contribute to Epithelial Repair, Growth and Survival
Shaykhiev, R., Behr, J., & Bals, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001393 · Cited by 86
Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11bhighGr1low macrophages
Schiechl, G., Bauer, B., Fuss, I. J., Lang, S. A., Moser, C., Ruemmele, P., Rose‐John, S., Neurath, M. F., Geissler, E. K., Schlitt, H. J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42540 · Cited by 87
CircPVT1 promotes ER‐positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS
Jia, Y., Wang, L., Hu, G.-S., Zhang, Y., Du, J., Ding, J., Ji, X., Shen, H., Huang, H., Ye, F., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112408 · Cited by 92
Suppression of Implanted MDA-MB 231 Human Breast Cancer Growth in Nude Mice by Dietary Walnut
Hardman, W. E., & Ion, G. (2008) · Nutrition and Cancer · doi:10.1080/01635580802065302 · Cited by 86
Effect of mesenchymal stem cells‐derived exosomes on tumor microenvironment: Tumor progression versus tumor suppression
Shojaei, S., Hashemi, S. M., Ghanbarian, H., Salehi, M., & Mohammadi‐Yeganeh, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27326 · Cited by 89
Depression and cancer: An unexplored and unresolved emergent issue in elderly patients
Spoletini, I., Gianni, W., Repetto, L., Bria, P., Caltagirone, C., Bossù, P., & Spalletta, G. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.10.005 · Cited by 84
Evaluation of the antitumor immune responses of probiotic Bifidobacterium bifidum in human papillomavirus-induced tumor model
Abdolalipour, E., Mahooti, M., Salehzadeh, A., Torabi, A., Mohebbi, S. R., Gorji, A., & Ghaemi, A. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104207 · Cited by 83
Expression of TREM ‐1 in hepatic stellate cells and prognostic value in hepatitis B ‐related hepatocellular carcinoma
Liao, R., Sun, T., Yi, Y., Wu, H., Li, Y., Wang, J., Zhou, J., Shi, Y., Cheng, Y., Qiu, S., et al. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02273.x · Cited by 83
Impact of Toll-like receptor 4 polymorphisms on risk of cancer
Kutikhin, A. G. (2010) · Human Immunology · doi:10.1016/j.humimm.2010.11.003 · Cited by 83
Altered TAB1:IκB Kinase Interaction Promotes Transforming Growth Factor β–Mediated Nuclear Factor-κB Activation during Breast Cancer Progression
Neil, J. R., & Schiemann, W. P. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3094 · Cited by 83
Elevated Plasma YKL-40 Predicts Increased Risk of Gastrointestinal Cancer and Decreased Survival After Any Cancer Diagnosis in the General Population
Johansen, J. S., Bojesen, S. E., Mylin, A. K., Frikke‐Schmidt, R., Price, P. A., & Nordestgaard, B. G. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.8367 · Cited by 83
The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)
Kell, D. B., & Pretorius, E. (2014) · Integrative Biology · doi:10.1039/c4ib00173g · Cited by 81
Epigenetic Regulation of Inflammatory Cytokine-Induced Epithelial-To-Mesenchymal Cell Transition and Cancer Stem Cell Generation
Markopoulos, G. S., Roupakia, E., Marcu, K. B., & Kolettas, E. (2019) · Cells · doi:10.3390/cells8101143 · Cited by 84
Roles of inflammatory cytokines in the progression of gastric cancer: friends or foes?
Tsujimoto, H., Ono, S., Ichikura, T., Matsumoto, Y., Yamamoto, J., & Hase, K. (2010) · Gastric Cancer · doi:10.1007/s10120-010-0568-x · Cited by 82
Vaccine against MUC1 Antigen Expressed in Inflammatory Bowel Disease and Cancer Lessens Colonic Inflammation and Prevents Progression to Colitis-Associated Colon Cancer
Beatty, P. L., Narayanan, S., Gariépy, J., Ranganathan, S., & Finn, O. J. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0194 · Cited by 82
Exploring the immunomodulatory and anticancer properties of zerumbone
Haque, M. A., Jantan, I., Arshad, L., & Bukhari, S. N. A. (2017) · Food & Function · doi:10.1039/c7fo00595d · Cited by 82
Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer
Paradkar, P. H., Joshi, J. V., Mertia, P. N., Agashe, S., & Vaidya, R. A. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.9.3851 · Cited by 84
Nanotheranostics to target antibiotic-resistant bacteria: Strategies and applications
Bhattacharjee, R., Negi, A., Bhattacharya, B., Dey, T., Mitra, P., Preetam, S., Kumar, L., Kar, S., Das, S. S., Iqbal, D., et al. (2023) · OpenNano · doi:10.1016/j.onano.2023.100138 · Cited by 86
Colorectal cancer chemoprevention by 2 β‐cyclodextrin inclusion compounds of auraptene and 4′‐geranyloxyferulic acid
Tanaka, T., de Azevedo, M. B. M., Durán, N., Alderete, J. B., Epifano, F., Genovese, S., Tanaka, M., Tanaka, T., & Curini, M. (2009) · International Journal of Cancer · doi:10.1002/ijc.24833 · Cited by 81
Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy
Schürch, C. M., Roelli, M. A., Forster, S., Wasmer, M.-H., Bruehl, F. K., Maire, R., Pancrazio, S. D., Ruepp, M., Giger, R., Perren, A. A., et al. (2019) · Thyroid · doi:10.1089/thy.2018.0555 · Cited by 81
YKL-40—A Protein in the Field of Translational Medicine: A Role as a Biomarker in Cancer Patients?
Schultz, N. A., & Johansen, J. S. (2010) · Cancers · doi:10.3390/cancers2031453 · Cited by 79
Tumor-Derived Exosomes in Tumor-Induced Immune Suppression
Hao, Q., Wu, Y., Wu, Y., Wang, P., & Vadgama, J. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031461 · Cited by 83
Macrophages and cancer
Nardin, A. (2008) · Frontiers in bioscience · doi:10.2741/2944 · Cited by 80
7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-κB in LPS-stimulated RAW264.7 macrophages
Shao, J., Li, Y., Wang, Z., Xiao, M., Yin, P., Lü, Y., Qian, X. H., Xu, Y. F., & Liu, J. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.06.008 · Cited by 79
Characterization and Regulation of Bv8 in Human Blood Cells
Zhong, C., Qu, X., Tan, M., Meng, Y. G., & Ferrara, N. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1954 · Cited by 78
Melatonin's role as a co-adjuvant treatment in colonic diseases: A review
Zubero, E. E., López‐Pingarrón, L., Alatorre-Jiménez, M. A., Ochoa-Moneo, P., Celia, B.-R., Rivas-Jiménez, M., Castán-Ruiz, S., Antoñanzas-Lombarte, Á., Tan, D., García, J. J., et al. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.11.031 · Cited by 81
p38 MAPK Controls Prothrombin Expression by Regulated RNA 3′ End Processing
Danckwardt, S., Gantzert, A.-S., Macher‐Goeppinger, S., Probst, H. C., Gentzel, M., Wilm, M. S., Gröne, H., Schirmacher, P., Hentze, M. W., & Kulozik, A. E. (2011) · Molecular Cell · doi:10.1016/j.molcel.2010.12.032 · Cited by 79

Authors: Lin, W.-W., & Karin, M.
Affiliations: National Taiwan University (TW)
University of California San Diego (US)
Corresponding author: Karin, Michael
ORCID: Lin, Wan-Wan
Karin, Michael
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2007-05-01
Volume: 117
Issue: 5
Pages: 1175-1183
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci31537
PMC: PMC1857251
OpenAlex: W2133439754
Cited by: 1,940
References: 128
Citations by year: 2026: 18 · 2025: 39 · 2024: 60 · 2023: 92 · 2022: 93 · 2021: 117 · 2020: 117 · 2019: 102 · 2018: 93 · 2017: 123 · 2016: 104 · 2015: 127 · 2014: 134 · 2013: 130 · 2012: 124
FWCI: 8.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords: cytokines, innate immunity, inflammation, cancer, chronic inflammation, tumor microenvironment, tumor promotion, tumor progression, infection and cancer, tumor initiation, inflammatory cells
MeSH terms: Animals, Humans, Immunity, Innate, Inflammation, Neoplasms, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A cytokine-mediated link between innate immunity, inflammation, and cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks