Cited by 1,940Immune cells in cancerCytokine Signaling Pathways and InteractionsChemokine receptors and signaling

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A cytokine-mediated link between innate immunity, inflammation, and cancer

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Lin, Wan-Wan, Karin, Michael·2007·Journal of Clinical Investigation

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Abstract

It has been established that cancer can be promoted and/or exacerbated by inflammation and infections. Indeed, chronic inflammation orchestrates a tumor-supporting microenvironment that is an indispensable participant in the neoplastic process. The mechanisms that link infection, innate immunity, inflammation, and cancer are being unraveled at a fast pace. Important components in this linkage are the cytokines produced by activated innate immune cells that stimulate tumor growth and progression. In addition, soluble mediators produced by cancer cells recruit and activate inflammatory cells, which further stimulate tumor progression. However, inflammatory cells also produce cytokines that can limit tumor growth. Here we provide an overview of the current understanding of the role of inflammation-induced cytokines in tumor initiation, promotion, and progression.

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The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Inflammation and cancer
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,498
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265

Show all 128 references

Research works printed but not linked: 12

Shacter, 2002, Oncology., 16, 217
Sehouli, 2002, Anticancer Res., 22, 3421
Kitakata, 2002, Cancer Res., 62, 6682
Gado, 2001, Haematologica., 86, 227
Tartour, 1999, Cancer Res., 59, 3698
Trinchieri, 2003, Nat. Rev., 3, 133
Erdman, 2003, Cancer Res., 63, 6042
Kohno, 2003, Cancer Res., 63, 5091
Alas, 2001, Clin. Cancer Res., 7, 709
Lech-Maranda, 2006, Eur. Cytokine Netw., 17, 60
Parsons, 1995, Cancer Res., 55, 5548
Engle, 2002, Cancer Res., 62, 6362

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Authors: Lin, W.-W., & Karin, M.
Affiliations: National Taiwan University (TW)
University of California San Diego (US)
Corresponding author: Karin, Michael
ORCID: Lin, Wan-Wan
Karin, Michael
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2007-05-01
Volume: 117
Issue: 5
Pages: 1175-1183
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci31537
PMC: PMC1857251
OpenAlex: W2133439754
Cited by: 1,940
References: 128
Citations by year: 2026: 18 · 2025: 39 · 2024: 60 · 2023: 92 · 2022: 93 · 2021: 117 · 2020: 117 · 2019: 102 · 2018: 93 · 2017: 123 · 2016: 104 · 2015: 127 · 2014: 134 · 2013: 130 · 2012: 124
FWCI: 8.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords: cytokines, innate immunity, inflammation, cancer, chronic inflammation, tumor microenvironment, tumor promotion, tumor progression, infection and cancer, tumor initiation, inflammatory cells
MeSH terms: Animals, Humans, Immunity, Innate, Inflammation, Neoplasms, Cytokines

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A cytokine-mediated link between innate immunity, inflammation, and cancer

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