Cited by 1,940Immune cells in cancerCytokine Signaling Pathways and InteractionsChemokine receptors and signaling

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A cytokine-mediated link between innate immunity, inflammation, and cancer

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Lin, Wan-Wan, Karin, Michael·2007·Journal of Clinical Investigation

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Abstract

It has been established that cancer can be promoted and/or exacerbated by inflammation and infections. Indeed, chronic inflammation orchestrates a tumor-supporting microenvironment that is an indispensable participant in the neoplastic process. The mechanisms that link infection, innate immunity, inflammation, and cancer are being unraveled at a fast pace. Important components in this linkage are the cytokines produced by activated innate immune cells that stimulate tumor growth and progression. In addition, soluble mediators produced by cancer cells recruit and activate inflammatory cells, which further stimulate tumor progression. However, inflammatory cells also produce cytokines that can limit tumor growth. Here we provide an overview of the current understanding of the role of inflammation-induced cytokines in tumor initiation, promotion, and progression.

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Authors: Lin, W.-W., & Karin, M.
Affiliations: National Taiwan University (TW)
University of California San Diego (US)
Corresponding author: Karin, Michael
ORCID: Lin, Wan-Wan
Karin, Michael
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2007-05-01
Volume: 117
Issue: 5
Pages: 1175-1183
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci31537
PMC: PMC1857251
OpenAlex: W2133439754
Cited by: 1,940
References: 128
Citations by year: 2026: 18 · 2025: 39 · 2024: 60 · 2023: 92 · 2022: 93 · 2021: 117 · 2020: 117 · 2019: 102 · 2018: 93 · 2017: 123 · 2016: 104 · 2015: 127 · 2014: 134 · 2013: 130 · 2012: 124
FWCI: 8.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords: cytokines, innate immunity, inflammation, cancer, chronic inflammation, tumor microenvironment, tumor promotion, tumor progression, infection and cancer, tumor initiation, inflammatory cells
MeSH terms: Animals, Humans, Immunity, Innate, Inflammation, Neoplasms, Cytokines

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A cytokine-mediated link between innate immunity, inflammation, and cancer

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