A cytokine-mediated link between innate immunity, inflammation, and cancer

The hallmarks of cancer

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Inflammation and cancer

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Pathogen Recognition and Innate Immunity

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Inflammation and cancer: back to Virchow?

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Interleukin-10 and the Interleukin-10 Receptor

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

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Smad-dependent and Smad-independent pathways in TGF-β family signalling

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Toll-like receptors and innate immunity

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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Modulators affecting the immune dialogue between human immune and colon cancer cells

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Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state

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Metabolomic analysis reveals altered metabolic pathways in a rat model of gastric carcinogenesis

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The Association Between Lung Carcinoma and Tuberculosis

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Metabolic adaptation to high-starch diet in largemouth bass ( Micropterus salmoides ) was associated with the restoration of metabolic functions via inflammation, bile acid synthesis and energy metabolism

Chen, P., Zhu, Y., Wu, X., Gu, X., Xue, M., & Liang, X. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522001180 · Cited by 48

Serum cytokines and neutrophil-to-lymphocyte ratio as predictive biomarkers of benefit from PD-1 inhibitors in gastric cancer

Hou, Y., Li, X., Yang, Y., Shi, H., Wang, S., & Gao, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1274431 · Cited by 48

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets

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Association of IL-12, IL-18 variants and serum IL-18 with bladder cancer susceptibility in North Indian population

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Inflammation Amplification by Versican: The First Mediator

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Inflammation induced by human papillomavirus in cervical cancer and its implication in prevention

Parida, S., & Mandal, M. (2014) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000023 · Cited by 48

Primary Tumor Resection in Patients With Metastatic Colorectal Cancer Is Associated With Reversal of Systemic Inflammation and Improved Survival

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Single nucleotide polymorphism and haplotype association of the interleukin-8 gene with nasopharyngeal carcinoma

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Oct4-related cytokine effects regulate tumorigenic properties of colorectal cancer cells

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Esculin attenuates endotoxin shock induced by lipopolysaccharide in mouse and NO production in vitro through inhibition of NF-κB activation

Li, W., Wang, Y., Wang, X., He, Z., Liu, F., Zhi, W., Zhang, H., & Niu, X. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.10.013 · Cited by 48

Immunomodulation effects of polyphenols from thinned peach treated by different drying methods on RAW264.7 cells through the NF-κB and Nrf2 pathways

Guo, C., Bi, J., Li, X., Lyu, J., Liu, X., Wu, X., & Liu, J. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127931 · Cited by 48

Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy

Hak, C. C. W., Rullan, A., Patin, E. C., Pedersen, M., Melcher, A. A., & Harrington, K. J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.971959 · Cited by 50

The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways

Rahmani, A. H., Almatroudi, A., Khan, A. A., Babiker, A. Y., Alanezi, M., & Allemailem, K. S. (2022) · Molecules · doi:10.3390/molecules27228023 · Cited by 47

Associations between Diabetes Mellitus and Selected Cancers

Pliszka, M., & Szablewski, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137476 · Cited by 53

Circulating Levels of GDF15, MMP7 and miR-200c as a Poor Prognostic Signature in Gastric Cancer

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Immunotherapeutic strategies in kidney cancer—when TKIs are not enough

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Novel synthetic curcumin analogs as potent antiangiogenic agents in colorectal cancer

Rajitha, B., Nagaraju, G. P., Shaib, W. L., Alese, O. B., Snyder, J. P., Shoji, M., Pattnaik, S., Alam, A., & El‐Rayes, B. F. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22492 · Cited by 48

STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence

Bryson, B. L., Junk, D. J., Cipriano, R., & Jackson, M. W. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1259037 · Cited by 47

Relationship of inflammatory profile of elderly patients serum and senescence-associated secretory phenotype with human breast cancer cells proliferation: Role of IL6/IL8 ratio

Barajas-Gómez, B. A., Rosas‐Carrasco, Ó., Morales-Rosales, S. L., Pedraza-Vázquez, G., González‐Puertos, V. Y., Juárez‐Cedillo, T., García, J. A., López‐Díazguerrero, N. E., Damián‐Matsumura, P., Königsberg, M., et al. (2016) · Cytokine · doi:10.1016/j.cyto.2016.12.001 · Cited by 48

The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents

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Exosomes Function in Tumor Immune Microenvironment

Huang, Y., Liu, K., Li, Q., Yao, Y., & Wang, Y. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-74470-4_7 · Cited by 48

Alfalfa polysaccharide prevents H2O2-induced oxidative damage in MEFs by activating MAPK/Nrf2 signaling pathways and suppressing NF-κB signaling pathways

Wang, L., Xie, Y., Yang, W., Yang, Z., Jiang, S., Zhang, C., & Zhang, G. (2019) · Scientific Reports · doi:10.1038/s41598-018-38466-7 · Cited by 47

Biomarkers in Vestibular Schwannoma–Associated Hearing Loss

Lassaletta, L., Calvino, M., Morales‐Puebla, J. M., Lapunzina, P. D., la Rosa, L. R., Varela‐Nieto, I., & Martínez‐Glez, V. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00978 · Cited by 47

Pulmonary Tuberculosis and the Incidence of Lung Cancer among Patients with Chronic Obstructive Pulmonary Disease

Park, H. Y., Kang, D., Shin, S. H., Choi, H., Jang, S. H., Lee, C., Kim, H., Kwon, O. J., Rhee, C. K., & Cho, J. (2021) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202010-1240oc · Cited by 47

The Prodrug Platin‐A: Simultaneous Release of Cisplatin and Aspirin

Pathak, R., Marrache, S., Choi, J. H., Berding, T. B., & Dhar, S. (2014) · Angewandte Chemie · doi:10.1002/ange.201308899 · Cited by 47

CpG-ODN but not other TLR-ligands restore the antitumor responses in old mice: the implications for vaccinations in the aged

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β‐Escin sodium inhibits inducible nitric oxide synthase expression via downregulation of the JAK/STAT pathway in A549 cells

Ji, D.-B., Xu, B., Liu, J.-T., Ran, F.-X., & Cui, J.-R. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20762 · Cited by 45

The 786-0 renal cancer cell-derived exosomes promote angiogenesis by downregulating the expression of hepatocyte cell adhesion molecule

Zhang, L., Wu, X., Luo, C., Chen, X., Yang, L., TAO, J., & Shi, J. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1458 · Cited by 48

Gastroprotective effect of esculin on ethanol-induced gastric lesion in mice

Li, W., Wang, Y., Wang, X., Zhang, H., He, Z., Zhi, W., Liu, F., & Niu, X. (2016) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12255 · Cited by 46

Adoptive Cellular Therapy

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Computational Modeling of Interactions between Multiple Myeloma and the Bone Microenvironment

Wang, Y., Pivonka, P., Buenzli, P., Smith, D., & Dunstan, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027494 · Cited by 47

MSCs and inflammation: new insights into the potential association between ALCL and breast implants

Orciani, M., Sorgentoni, G., Torresetti, M., Primio, R. D., & Benedetto, G. D. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3745-8 · Cited by 45

Effectiveness of Chitosan as a Dietary Supplement in Lowering Cholesterol in Murine Models: A Meta-Analysis

Ahn, S., Cho, S., & Choi, N. (2021) · Marine Drugs · doi:10.3390/md19010026 · Cited by 45

Combination of Dacarbazine and Dimethylfumarate Efficiently Reduces Melanoma Lymph Node Metastasis

Valero, T., Steele, S., Neumüller, K., Bracher, A., Niederleithner, H., Pehamberger, H., Petzelbauer, P., & Loewe, R. P. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.368 · Cited by 45

Cytokine and chemokine modification by T oll‐like receptor polymorphisms is associated with nasopharyngeal carcinoma

Yang, Z., Dai, Q., Gu, Y., Guo, Q., & Gong, L. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02210.x · Cited by 45

Involvement of HIF-2α-mediated inflammation in arsenite-induced transformation of human bronchial epithelial cells

Xu, Y., Zhao, Y., Xu, W., Luo, F., Wang, B., Li, Y., Pang, Y., & Liu, Q. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.06.017 · Cited by 45

4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2/STAT3 pathway

Park, K., Yun, H., Quang, T.-H., Oh, H., Lee, D., Auh, Q., & Kim, E.-C. (2016) · Oncotarget · doi:10.18632/oncotarget.6873 · Cited by 45

Sarcopenia predicts survival outcomes among patients with urothelial carcinoma of the upper urinary tract undergoing radical nephroureterectomy: a retrospective multi-institution study

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Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer

Ma, X., Yan, F., Deng, Q., Li, F., Lu, Z., Liu, M., Wang, L., Conklin, D. J., McCracken, J., Srivastava, S., et al. (2015) · Cell Discovery · doi:10.1038/celldisc.2015.5 · Cited by 44

Clinical Significance of Serum Glutamine Level in Patients with Colorectal Cancer

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Identification of an immune-related risk signature for predicting prognosis in clear cell renal cell carcinoma

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Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs

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An NF-κB p65-cIAP2 link is necessary for mediating resistance to TNF-α induced cell death in gliomas

Zhao, X., Laver, T., Hong, S. W., Twitty, G. B., DeVos, A., DeVos, M., Benveniste, E. N., & Nozell, S. E. (2011) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0346-y · Cited by 46

The Lung Microbiota and Lung Cancer: A Growing Relationship

Zerdan, M. B., Kassab, J. T., Meouchy, P., Haroun, E., Nehme, R., Zerdan, M. B., Fahed, G., Petrosino, M., Dutta, D., & Graziano, S. L. (2022) · Cancers · doi:10.3390/cancers14194813 · Cited by 46

Regulation of MET receptor tyrosine kinase signaling by suppressor of cytokine signaling 1 in hepatocellular carcinoma

Gui, Y., Yeganeh, M., Donates, Y.-C., Tobelaim, W.-S., Chababi, W., Mayhue, M., Yoshimura, A., Ramanathan, S., Saucier, C., & Ilangumaran, S. (2015) · Oncogene · doi:10.1038/onc.2015.20 · Cited by 44

Inhibition of TGF-β signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol

Serwe, A., Rudolph, K., Anke, T., & Erkel, G. (2011) · Investigational New Drugs · doi:10.1007/s10637-011-9643-3 · Cited by 46

A systematic evaluation of hydroxyethyl starch as a potential nanocarrier for parenteral drug delivery

Narayanan, D., Nair, S. V., & Menon, D. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.12.012 · Cited by 44

Leukotriene B4 Creates a Favorable Microenvironment for Murine Melanoma Growth

Bachi, A. L. L., Kim, F. J. K., Nonogaki, S., Carneiro, C. R. W., Lopes, J. D., Jasiulionis, M. G., & Correa, M. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0038 · Cited by 44

Geraniol attenuates 2-acetylaminofluorene induced oxidative stress, inflammation and apoptosis in the liver of wistar rats

Hasan, S. K., & Sultana, S. (2015) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2015.1070225 · Cited by 46

Th17 Cells and IL-17 As Novel Immune Targets in Ovarian Cancer Therapy

Bilska, M., Pawłowska, A., Zakrzewska, E., Chudzik, A., Suszczyk, D., Gogacz, M., & Wertel, I. (2020) · Journal of Oncology · doi:10.1155/2020/8797683 · Cited by 47

Depletion of Regulatory T Cells Facilitates Growth of Established Tumors: A Mechanism Involving the Regulation of Myeloid-Derived Suppressor Cells by Lipoxin A4

Zhang, B., Jia, H., Liu, J., Yang, Z., Jiang, T., Tang, K., Li, D., Huang, C., Ma, J., Shen, G., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001876 · Cited by 44

Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals

Li, C., Ma, Q., Gao, X., Wang, X., & Zhang, B.-L. (2021) · Marine Drugs · doi:10.3390/md19100572 · Cited by 46

Nucleos(t)ide analogues associated with a reduced risk of hepatocellular carcinoma in hepatitis B patients: A population‐based cohort study

Wang, J. P., Kao, F., Wu, C., Hung, Y., Chao, Y., Chou, Y., & Li, C. (2014) · Cancer · doi:10.1002/cncr.29159 · Cited by 43

Mannose Receptor (MR) Engagement by Mesothelin GPI Anchor Polarizes Tumor-Associated Macrophages and Is Blocked by Anti-MR Human Recombinant Antibody

Laniti, D. D., Abbott, K. L., Mookerjee, A., Zhao, A., Kirby, P. S., Sandaltzopoulos, R., Powell, D. J., Lamazière, A., Siegel, D. L., Wolf, C., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028386 · Cited by 42

Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study

Glass, O., Inman, B. A., Broadwater, G., Courneya, K. S., Mackey, J. R., Goruk, S. D., Nelson, E. R., Jasper, J., Field, C. J., Bain, J. R., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2014.662 · Cited by 43

Effect of Interleukin-10 Gene Polymorphisms on Clinical Outcome of Patients with Aggressive Non-Hodgkin's Lymphoma: An Exploratory Study

Kube, D., Hua, T.-D., von Bonin, F., Schoof, N., Zeynalova, S., Klöss, M., Gocht, D., Potthoff, B., Tzvetkov, M. V., Brockmöller, J., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-5182 · Cited by 43

Herpesviruses: Hijacking the Ras signaling pathway

Filippakis, H., Spandidos, D. A., & Sourvinos, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.03.007 · Cited by 43

Molecular Alterations of Colorectal Cancer with Inflammatory Bowel Disease

Yashiro, M. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3646-4 · Cited by 44

Biogenic terbium oxide nanoparticles as the vanguard against osteosarcoma

Iram, S., Khan, S., Ansary, A. A., Arshad, M., Siddiqui, S., Ahmad, E., Khan, R. H., & Khan, M. S. (2016) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2016.05.053 · Cited by 43

Interleukin‑17A and heparanase promote angiogenesis and cell proliferation and invasion in cervical cancer

Lv, Q., Wu, K., Liu, F., Wu, W., Chen, Y., & Zhang, W. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4503 · Cited by 43

A 5-microRNA signature identified from serum microRNA profiling predicts survival in patients with advanced stage non-small cell lung cancer

Zhang, Y., Roth, J. A., Yu, H., Ye, Y., Xie, K., Zhao, H., Chang, D. W., Huang, M., Li, H., Qu, J., et al. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy132 · Cited by 43

Carcinoma-Derived Interleukin-8 Disorients Dendritic Cell Migration Without Impairing T-Cell Stimulation

Alfaro, C., Suárez, N., Martínez‐Forero, I., Palazón, A., Rouzaut, A., Solano, S., Feijoó, E., Gúrpide, A., Bolaños, E., Erro, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017922 · Cited by 46

Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma

Paillet, J., Plantureux, C., Lévesque, S., Le Naour, J., Stoll, G., Sauvat, A., Caudana, P., Tosello Boari, J., Bloy, N., Lachkar, S., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20200853 · Cited by 41

Revisiting of TAMs in tumor immune microenvironment: Insight from NF-κB signaling pathway

He, R., He, Y., Du, R., Liu, C., Chen, Z., Zeng, A., & Song, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115090 · Cited by 45

Targeting inflammation-induced transcription factor activation: an open frontier for glioma therapy

Sen, E. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.09.003 · Cited by 42

Differential Post-Surgical Metastasis and Survival in SCID, NOD-SCID and NOD-SCID-IL-2Rγnull Mice with Parental and Subline Variants of Human Breast Cancer: Implications for Host Defense Mechanisms Regulating Metastasis

Milsom, C., Lee, C. R., Hackl, C., Man, S., & Kerbel, R. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071270 · Cited by 42

Immune impairment in patients with terminal cancers: influence of cancer treatments and cytomegalovirus infection

Chen, I.-H., Lai, Y., Wu, C., Chang, Y., Chu, C., Tsai, I., Sun, F., & Lu, Y. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-009-0753-0 · Cited by 42

Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer

Liu, J. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i10.1362 · Cited by 42

Tumor-associated macrophages favor C26 murine colon carcinoma cell proliferation in an oxidative stress-dependent manner

Lupuţ, L., Licărete, E., Sesărman, A., Pătraș, L., Alupei, M. C., & Banciu, M. (2017) · Oncology Reports · doi:10.3892/or.2017.5466 · Cited by 42

Oral Neutrophils: Underestimated Players in Oral Cancer

Domnich, M., Riedesel, J., Pylaeva, E., Kürten, C. H. L., Buer, J., Lang, S., & Jabłońska, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.565683 · Cited by 42

IL-8 −251 T > A Polymorphism Is Associated with Bladder Cancer Susceptibility and Outcome after BCG Immunotherapy in a Northern Indian Cohort

Ahirwar, D. K., Mandhani, A., & Mittal, R. D. (2010) · Archives of Medical Research · doi:10.1016/j.arcmed.2010.03.005 · Cited by 42

Inhibitory Effect of a Glycoprotein Isolated from Golden Oyster Mushroom (Pleurotus citrinopileatus) on the Lipopolysaccharide-Induced Inflammatory Reaction in RAW 264.7 Macrophage

Chen, J., de Mejı́a, E. G., & Wu, J. S. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201335g · Cited by 42

Lancemaside A inhibits lipopolysaccharide‐induced inflammation by targeting LPS/TLR4 complex

Joh, E., & Kim, D. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22773 · Cited by 43

New Insights into the Role of Chronic Inflammation and Cytokines in the Etiopathogenesis of Gastroenteropancreatic Neuroendocrine Tumors

Berković, M. C., Čaćev, T., Ivković, T. C., Zjačić-Rotkvić, V., & Kapitanović, S. (2014) · Neuroendocrinology · doi:10.1159/000362339 · Cited by 41

Metformin Suppresses Pancreatic Tumor Growth With Inhibition of NFκB/STAT3 Inflammatory Signaling

Tan, X., Bhattacharyya, K. K., Dutta, S. K., Bamlet, W. R., Rabe, K. G., Wang, E., Smyrk, T. C., Oberg, A. L., Petersen, G. M., & Mukhopadhyay, D. (2015) · Pancreas · doi:10.1097/mpa.0000000000000308 · Cited by 41

NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions

Sharma, N., & Jha, S. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2123-8 · Cited by 41

Until Death Do Us Part: Necrosis and Oxidation Promote the Tumor Microenvironment

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Sugar-Borate Esters – Potential Chemical Agents in Prostate Cancer Chemoprevention

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