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Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice
Open accessAbstract
Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form the mucus gel layer overlying the gut epithelium. Impaired expression of intestinal O-glycans has been observed in patients with ulcerative colitis (UC), but its role in the etiology of this disease is unknown. Here, we report that mice with intestinal epithelial cell-specific deficiency of core 1-derived O-glycans, the predominant form of O-glycans, developed spontaneous colitis that resembled human UC, including massive myeloid infiltrates and crypt abscesses. The colitis manifested in these mice was also characterized by TNF-producing myeloid infiltrates in colon mucosa in the absence of lymphocytes, supporting an essential role for myeloid cells in colitis initiation. Furthermore, induced deletion of intestinal core 1-derived O-glycans caused spontaneous colitis in adult mice. These data indicate a causal role for the loss of core 1-derived O-glycans in colitis. Finally, we detected a biosynthetic intermediate typically exposed in the absence of core 1 O-glycan, Tn antigen, in the colon epithelium of a subset of UC patients. Somatic mutations in the X-linked gene that encodes core 1 β1,3-galactosyltransferase-specific chaperone 1 (C1GALT1C1, also known as Cosmc), which is essential for core 1 O-glycosylation, were found in Tn-positive epithelia. These data suggest what we believe to be a new molecular mechanism for the pathogenesis of UC.
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“The importance of sufficiently complex mucin glycans was demonstrated in studies of mice with truncated glycans as found in O-glycan core 1 or core 3 deficient mice 19, 28.”
From The composition of the gut microbiota shapes the colon mucus barrier (2015) · cites this paper as [19]
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Cites
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401
ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES
Kornfeld, R., & Kornfeld, S. A. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.003215 · Cited by 4,863
Unravelling the pathogenesis of inflammatory bowel disease
Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
RAG-1-deficient mice have no mature B and T lymphocytes
Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90030-g · Cited by 2,898
Abraham, C., & Cho, J. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804647 · Cited by 2,712
Varki, A. P., Cummings, R. D., Esko, J. D., Freeze, H. H., Stanley, P., Bertozzi, C. R., Hart, G. W., & Etzler, M. E. (1999) · Cited by 2,384
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200
Self-citationVan der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684
Johansson, M., Larsson, J. M. H., & Hansson, G. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006451107 · Cited by 1,535
Self-citation
Research works printed but not linked: 2
- Johansson, Proc Natl Acad Sci U S A.
- Samali, Int J Cell Biol.
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Self-citationPelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A., van der Post, S., Svensson, F., Rodríguez‐Piñeiro, A. M., Nyström, E. E. L., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12182 · Cited by 1,363
Self-citationPotential of fecal microbiota for early-stage detection of colorectal cancer
Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375
The composition of the gut microbiota throughout life, with an emphasis on early life
Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,414
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Odenwald, M. A., & Turner, J. R. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.169 · Cited by 1,288
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Self-citationEichele, D. D., & Kharbanda, K. K. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i33.6016 · Cited by 923
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Self-citationMucins: A biologically relevant glycan barrier in mucosal protection
Corfield, A. P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.05.003 · Cited by 590
Composition and functional role of the mucus layers in the intestine
Johansson, M., Ambort, D., Pelaseyed, T., Schutte, A. H., Gustafsson, J. K., Ermund, A., Subramani, D. B., Holmén‐Larsson, J., Thomsson, K. A., Bergström, J. H., et al. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0822-3 · Cited by 594
Self-citationNormalization of host intestinal mucus layers requires long-term microbial colonization
Johansson, M. E. V., Jakobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodríguez-Piñeiro, A. M., Arike, L., Wising, C., Svensson, F., Bäckhed, F., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.10.007 · Cited by 549
Self-citationCockburn, D. W., & Koropatkin, N. M. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.06.021 · Cited by 561
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Hansson, G. C. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.11.002 · Cited by 488
Self-citationGrondin, J. A., Kwon, Y. H., Far, P. M., Haq, S., & Khan, W. I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02054 · Cited by 487
Quantitative imaging of gut microbiota spatial organization
Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., & Sonnenburg, J. L. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.09.002 · Cited by 433
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Hasnain, S. Z., Tauro, S., Das, I., Tong, H., Chen, A. C. –., Jeffery, P. L., McDonald, V., Florin, T. H., & McGuckin, M. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.043 · Cited by 262
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Zhang, S., Langer, R., & Traverso, G. (2017) · Nano Today · doi:10.1016/j.nantod.2017.08.006 · Cited by 258
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Self-citationHolmberg, S. M., Feeney, R. H., K., V., Puértolas-Balint, F., Singh, D. K., Wongkuna, S., Zandbergen, L. M., Hauner, H., Brandl, B., Nieminen, A. I., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47594-w · Cited by 262
Microbiota-mediated inflammation and antimicrobial defense in the intestine
Caballero, S., & Pamer, E. G. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120238 · Cited by 238
Rajca, S., Grondin, V., Louis, E. J., Vernier-Massouille, G., Grimaud, J., Bouhnik, Y., Laharie, D., Dupas, J., Pillant, H., Picon, L., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000036 · Cited by 247
Lee, J. W. J., Plichta, D. R., Hogstrom, L. J., Borren, N. Z., Lau, H., Gregory, S. M., Tan, W., Khalili, H., Clish, C. B., Vlamakis, H. C., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.06.019 · Cited by 245
Arike, L., & Hansson, G. C. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.02.010 · Cited by 233
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Parekh, P. J., Balart, L. A., & Johnson, D. A. (2015) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2015.16 · Cited by 219
Herath, M., Hosie, S., Bornstein, J. C., Franks, A. E., & Hill‐Yardin, E. L. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00248 · Cited by 236
Pinho, S. S., Alves, I., Gaifem, J., & Rabinovich, G. A. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01074-1 · Cited by 227
Johansson, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041009 · Cited by 218
Self-citationLarsson, J. M. H., Thomsson, K. A., Rodríguez-Piñeiro, A. M., Karlsson, H., & Hansson, G. C. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00048.2013 · Cited by 207
Self-citationReprograming of gut microbiome energy metabolism by the FUT2 Crohn’s disease risk polymorphism
Tong, M., McHardy, I. H., Ruegger, P. M., Goudarzi, M., Kashyap, P., Haritunians, T., Li, X., Graeber, T. G., Schwager, E., Huttenhower, C., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.64 · Cited by 213
Self-citationA single sulfatase is required to access colonic mucin by a gut bacterium
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Self-citationNowarski, R., Jackson, R., & Flavell, R. A. (2017) · Cell · doi:10.1016/j.cell.2016.11.040 · Cited by 191
Bergstrom, K., Fu, J., Johansson, M., Liu, X., Gao, N., Wu, Q., Song, J., McDaniel, J. M., McGee, S., Chen, W., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.45 · Cited by 188
Self-citationSymbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans
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Etienne‐Mesmin, L., Chassaing, B., Desvaux, M., Paepe, K. D., Gresse, R., Sauvaitre, T., Forano, É., de Wiele, T. V., Schüller, S., Juge, N., et al. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz013 · Cited by 193
Tong, M., Li, X., Parfrey, L. W., Roth, B. E., Ippoliti, A., Wei, B., Borneman, J., McGovern, D. P. B., Frank, D. N., Li, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080702 · Cited by 184
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Inflammatory Bowel Disease Associates with Proinflammatory Potential of the Immunoglobulin G Glycome
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Global functions of O‐glycosylation: promises and challenges in O‐glycobiology
Wandall, H. H., Nielsen, M. I., King‐Smith, S., de Haan, N., & Bagdonaite, I. (2021) · FEBS Journal · doi:10.1111/febs.16148 · Cited by 173
T n and sialyl‐Tn antigens, aberrant O ‐glycomics as human disease markers
Ju, T., Wang, Y., Aryal, R. P., Lehoux, S. D., Ding, X., Kudelka, M. R., Cutler, C. E., Zeng, J., Wang, J., Sun, X., et al. (2013) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201300024 · Cited by 165
Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice
Bergstrom, K., Liu, X., Zhao, Y., Gao, N., Wu, Q., Song, K., Cui, Y. W., Li, Y., McDaniel, J. M., McGee, S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.039 · Cited by 166
Self-citationAhmad, R., Chaturvedi, R., Olivares–Villagómez, D., Habib, T., Asim, M., Punit, S., Polk, D. B., Wilson, K. T., Washington, M. K., Kaer, L. V., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.21 · Cited by 162
The role of glycosylation in IBD
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Ju, T., Aryal, R. P., Kudelka, M. R., Wang, Y., & Cummings, R. D. (2014) · Cancer Biomarkers · doi:10.3233/cbm-130375 · Cited by 153
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Boltin, D., Perets, T. T., Vilkin, A., & Niv, Y. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182688e73 · Cited by 155
Sommer, F., Adam, N., Johansson, M., Xia, L., Hansson, G. C., & Bäckhed, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085254 · Cited by 150
Self-citationColeman, O. I., Lobner, E. M., Bierwirth, S., Sorbie, A., Waldschmitt, N., Rath, E., Berger, E., Lagkouvardos, I., Clavel, T., McCoy, K., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.028 · Cited by 150
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Magalhães, A., Duarte, H. O., & Reis, C. A. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100964 · Cited by 152
Wang, L., Cao, H., Liu, L., Wang, B., Walker, W. A., Acra, S. A., & Yan, F. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.553800 · Cited by 146
Crouch, L. I., Liberato, M. V., Urbanowicz, P. A., Baslé, A., Lamb, C. A., Stewart, C. J., Cooke, K., Doona, M., Needham, S. J., Brady, R. R. W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17847-5 · Cited by 143
Chen, Z., Li, S., Fu, Y., Li, C., Chen, D., & Chen, H. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.02.007 · Cited by 147
Self-citationVerhelst, X., Dias, A. M., Colombel, J., Vermeire, S., Vlierberghe, H. V., Callewaert, N., & Pinho, S. S. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.08.060 · Cited by 151
GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway
Kiryluk, K., Li, Y., Moldoveanu, Z., Suzuki, H., Reily, C., Hou, P., Xie, J., Mladkova, N., Prakash, S., Fischman, C. J., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006609 · Cited by 138
The intestinal epithelium as guardian of gut barrier integrity
Zhang, K., Hornef, M. W., & Dupont, A. (2015) · Cellular Microbiology · doi:10.1111/cmi.12501 · Cited by 138
HumanClostridium difficileinfection: altered mucus production and composition
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Corfield, A. P. (2018) · Microorganisms · doi:10.3390/microorganisms6030078 · Cited by 140
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Bevins, C. L., & Salzman, N. H. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0830-3 · Cited by 134
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Self-citationMicrobiome and immunological interactions
Kelly, D., & Mulder, I. E. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00498.x · Cited by 131
Tsuboi, K., Nishitani, M., Takakura, A., Imai, Y., Komatsu, M., & Kawashima, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.632257 · Cited by 126
Wenzel, U. A., Magnusson, M. K., Rydström, A., Jonstrand, C., Hengst, J., Johansson, M., Velcich, A., Öhman, L., Strid, H., Sjövall, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100217 · Cited by 125
Self-citationYuan, Y., Xie, K.-X., Wang, S.-L., & Yuan, L. (2018) · Gastroenterology report · doi:10.1093/gastro/goy011 · Cited by 127
Holota, Y., Dovbynchuk, T., Kaji, I., Vareniuk, І., Dzyubenko, N., Chervinska, T., Zakordonets, L. V., Стецька, В. О., Остапченко, Л. І., Serhiichuk, T., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220642 · Cited by 126
Johansson, M., & Hansson, G. C. (2013) · Digestive Diseases · doi:10.1159/000354683 · Cited by 119
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Li, Y., Fu, J., Ling, Y., Yago, T., McDaniel, J. M., Song, J., Bai, X., Kondo, Y., Qin, Y., Hoover, C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707662114 · Cited by 119
Self-citationGrootjans, J., Hundscheid, I. H. R., Lenaerts, K., Boonen, B., Renes, I. B., Verheyen, F., Dejong, C. H. C., MEYENFELDT, M. F. V., Beets, G. L., & Buurman, W. A. (2012) · Gut · doi:10.1136/gutjnl-2011-301956 · Cited by 111
Camilleri, M., Lyle, B. J., Madsen, K. L., Sonnenburg, J. L., Verbeke, K., & Wu, G. D. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00063.2019 · Cited by 115
Coker, J. K. C., Moyne, O., Rodionov, D. A., & Zengler, K. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1869502 · Cited by 117
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Oehlers, S. H., Flores, M. V., Hall, C. J., Okuda, K. S., Sison, J. O., Crosier, K. E., & Crosier, P. S. (2013) · Zebrafish · doi:10.1089/zeb.2012.0824 · Cited by 113
Yoo, J., Naeem, M., Choi, M., Cao, J., Yoon, S., Kim, M., Jung, Y., Lee, J., Moon, H. R., Ikram, M., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s88672 · Cited by 108
Metadata
- Authors
- Fu, J., Wei, B., Wen, T., Johansson, M. E. V., Liu, X., Bradford, E., Thomsson, K. A., McGee, S., Mansour, L., Tong, M., McDaniel, J. M., Sferra, T. J., Turner, J. R., Chen, H., Hansson, G. C., Braun, J., & Xia, L.
- Affiliations
- Oklahoma Medical Research Foundation (US)
- University of California, Los Angeles (US)
- University of Gothenburg (SE)
- Central South University (CN)
- University of Chicago (US)
- University of Oklahoma (US)
- Corresponding author
- Xia, Lijun
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2011-04-01
- Volume
- 121
- Issue
- 4
- Pages
- 1657-1666
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3069788
- OpenAlex
- W2051146429
- Cited by
- 366
- References
- 59
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 29 · 2023: 21 · 2022: 18 · 2021: 30 · 2020: 21 · 2019: 15 · 2018: 27 · 2017: 22 · 2016: 24 · 2015: 32 · 2014: 37 · 2013: 25 · 2012: 16
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Oklahoma Medical Research Foundation
- Stiftelsen för Strategisk Forskning
- Central South University
- Xiangya Hospital, Central South University
- National Institute of Allergy and Infectious Diseases (U01AI095473)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK046763, P01DK067887, R56DK094954, R01DK085691, R01DK061931)
- National Center for Research Resources (RR 018758, P20RR018758)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Keywords
- core 1 O-glycans, ulcerative colitis, spontaneous colitis, intestinal epithelial cells, Tn antigen, Cosmc, crypt abscesses, TNF-α, colonic mucus, colitis pathogenesis, X-linked mutations
- MeSH terms
- Animals, Base Sequence, Colitis, Colon, Disease Models, Animal, Galactosyltransferases, Humans, Intestinal Mucosa, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Polysaccharides, Antigens, Tumor-Associated, Carbohydrate, DNA Primers, Mice, Knockout, Molecular Chaperones, Mice, Mice, 129 Strain
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