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Cited by 505

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The course of geriatric depression with "reversible dementia": a controlled study

·1993·American Journal of Psychiatry
DOI 10.1176/ajp.150.11.1693
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Abstract

OBJECTIVE: The goals of this longitudinal investigation were 1) to study the rate of development of irreversible dementia in elderly depressed patients with a dementia syndrome that subsided after improvement of depression and 2) to compare it with that of depressed, never-demented patients. METHOD: The subjects were 57 elderly patients consecutively hospitalized for major depression. At entry into the study, 23 subjects also met criteria for "reversible dementia," while 34 were without dementia. After a systematic clinical evaluation, the subjects were followed up at approximately yearly intervals for an average of 33.8 months. RESULTS: Irreversible dementia developed significantly more frequently in the depressed group with reversible dementia (43%) than in the group with depression alone (12%). Survival analysis showed that the group with reversible dementia had a 4.69-times higher chance of having developed dementia at follow-up than the patients with depression alone. No clinical characteristics at entry into the study were found to discriminate the subjects who developed irreversible dementia during the follow-up period from those who remained nondemented. CONCLUSIONS: These findings suggest that geriatric depression with reversible dementia is a clinical entity that includes a group of patients with early-stage dementing disorders. Therefore, identification of a reversible dementia syndrome is an indication for a thorough diagnostic workup and frequent follow-ups in order to identify treatable neurological disorders.

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Metadata

Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
1993-11
Volume
150
Issue
11
Pages
1693-1699
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.150.11.1693
OpenAlex
W68901995
Cited by
505
References
3
FWCI
10.17
Type
journal article
Language
en
Open access
closed

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