Confirmation That a Specific Haplotype of the Dopamine Transporter Gene Is Associated With Combined-Type ADHD
Open accessAbstract
OBJECTIVE: The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across published studies. METHOD: The authors previously reported the association of ADHD with a subgroup of chromosomes containing specific alleles of two variable-number tandem repeat polymorphisms within the 3' untranslated region and intron 8 of the dopamine transporter gene. They now report on this association in a sample of ADHD combined-type probands. RESULTS: The original observations were confirmed, with an overall odds ratio of 1.4 across samples. CONCLUSIONS: These data challenge results of meta-analyses suggesting that dopamine transporter variation does not have an effect on the risk for ADHD, and they indicate that further investigation of functional variation in the gene is required.
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- Authors
- Asherson, P., Brookes, K., Franke, B., Chen, W., Gill, M., Ebstein, R. P., Buitelaar, J., Banaschewski, T., Sonuga-Barke, E., Eisenberg, J., Manor, I., Miranda, A., Oades, R. D., Roeyers, H., Rothenberger, A., Sergeant, J., Steinhausen, H.-C., & Faraone, S. V.
- Affiliations
- King's College London (GB)
- Corresponding author
- Asherson, Philip
- Venue
- American Journal of Psychiatry
- Published
- 2007-04
- Volume
- 164
- Issue
- 4
- Pages
- 674-677
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2165295601
- Cited by
- 128
- References
- 15
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 8 · 2014: 8 · 2013: 4 · 2012: 10
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- green
- research.vu.nl
- Licence
- other-oa
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- DuEPublico (University of Duisburg-Essen) (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- edoc (University of Basel) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- GRO (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- National Institute of Mental Health (R01 MH 62873, R01MH062873)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- attention deficit hyperactivity disorder, combined type ADHD, dopamine transporter gene, DAT1, haplotype association, variable number tandem repeat polymorphism, 3' untranslated region, intron 8, genetic susceptibility, meta-analysis heterogeneity
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Female, Haplotypes, Humans, Male, Polymorphism, Genetic, Risk Factors, Genetic Variation, Reproducibility of Results, Tandem Repeat Sequences, Dopamine Plasma Membrane Transport Proteins
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