The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Differential effects of MDMA and methylphenidate on social cognition
Open accessAbstract
Social cognition is important in everyday-life social interactions. The social cognitive effects of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and methylphenidate (both used for neuroenhancement and as party drugs) are largely unknown. We investigated the acute effects of MDMA (75 mg), methylphenidate (40 mg) and placebo using the Facial Emotion Recognition Task, Multifaceted Empathy Test, Movie for the Assessment of Social Cognition, Social Value Orientation Test and the Moral Judgment Task in a cross-over study in 30 healthy subjects. Additionally, subjective, autonomic, pharmacokinetic, endocrine and adverse drug effects were measured. MDMA enhanced emotional empathy for positive emotionally charged situations in the MET and tended to reduce the recognition of sad faces in the Facial Emotion Recognition Task. MDMA had no effects on cognitive empathy in the Multifaceted Empathy Test or social cognitive inferences in the Movie for the Assessment of Social Cognition. MDMA produced subjective 'empathogenic' effects, such as drug liking, closeness to others, openness and trust. In contrast, methylphenidate lacked such subjective effects and did not alter emotional processing, empathy or mental perspective-taking. MDMA but not methylphenidate increased the plasma levels of oxytocin and prolactin. None of the drugs influenced moral judgment. Effects on emotion recognition and emotional empathy were evident at a low dose of MDMA and likely contribute to the popularity of the drug.
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In the citing paper
“By decreasing reactivity to perceived criticism and enhancing emotional empathy (152), MDMA may help narcissistic patients tolerate vulnerability and interpersonal closeness without triggering defensiveness.”
From Psychoanalytically informed MDMA-assisted therapy for pathological narcissism: a novel theoretical approach (2025) · cites this paper as [152]
In the citing paper
“It enhances affective empathy for positive emotions while impairing recognition of negative emotions, such as sadness or fear, which could potentially help narcissistic individuals tolerate and engage with emotions they would otherwise suppress (152).”
From Psychoanalytically informed MDMA-assisted therapy for pathological narcissism: a novel theoretical approach (2025) · cites this paper as [152]
In the citing paper
“In two studies this increase was particularly pronounced in response to positive stimuli and in male participants (10, 51).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [51]
In the citing paper
“One hundred twenty-five milligrams as well as 75 mg MDMA increased emotional empathy (10, 51, 52).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [51]
In the citing paper
“In line with this, MDMA (75, 100, & 125 mg), GHB (20 mg/kg), and psilocybin (0.215 mg/kg) did not affect cognitive empathy on the MET (10, 12, 51–53, 62).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [51]
In the citing paper
“Using moral dilemma tasks, it has been shown that neither MDMA (75 mg) nor psilocybin (0.215 mg/kg) influenced moral decision making (12, 51).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [51]
In the citing paper
“While MDMA did not change behavior on the SVO when administered in a lower dose (75 mg) (51)”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [51]
In the citing paper
“For example, increases in emotional empathy, impaired identification of negative emotions, enhanced decoding of positive facial expressions, and increased altruistic choices after MDMA administration were not related to oxytocin plasma levels or other neuroendocrine effects (10, 51, 52, 54).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [51]
In the citing paper
“Interestingly, these social functions were not influenced by acute administration of MDMA in controlled studies (10, 51, 52).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [51]
In the citing paper
“Decreased recognition of negative emotions induced by psilocybin on the RMET was blocked by pretreatment with the 5-HT2A receptor antagonist ketanserin (51).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [51]
In the citing paper
“Furthermore, methylphenidate lacked the empathy enhancing properties of MDMA (51).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [51]
In the citing paper
“LSD and MDMA have shown some dose-dependent effects on empathy and altruistic behavior (10, 33, 51), indicating that robust modulations are measurable at doses of 100 mg MDMA/100µg LSD and above.”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [51]
Citations
Cites
Measuring Social Value OrientationPreprint
Murphy, R. O., Ackermann, K., & Handgraaf, M. (2011) · Social Science Research Network · doi:10.2139/ssrn.1804189 · Cited by 1,099
Dziobek, I., Rogers, K., Fleck, S., Bahnemann, M., Heekeren, H. R., Wolf, O. T., & Convit, A. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0486-x · Cited by 951
Measuring Social Value Orientation
Murphy, R. O., Ackermann, K. A., & Handgraaf, M. J. J. (2011) · Judgment and Decision Making · doi:10.1017/s1930297500004204 · Cited by 948
Introducing MASC: A Movie for the Assessment of Social Cognition
Dziobek, I., Fleck, S., Kalbe, E., Rogers, K., Hassenstab, J., Brand, M., Kessler, J., Woike, J. K., Wolf, O. T., & Convit, A. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0107-0 · Cited by 926
McCabe, S. E., Knight, J. R., Teter, C. J., & Wechsler, H. (2004) · Addiction · doi:10.1111/j.1360-0443.2005.00944.x · Cited by 880
Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., Dziobek, I., Gallinat, J., Wagner, M., Maier, W., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5538-09.2010 · Cited by 771
Psychometric evaluation of the altered states of consciousness rating scale (OAV)
Studerus, E., Gamma, A., & Vollenweider, F. X. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012412 · Cited by 683
Mithoefer, M. C., Wagner, M. T., Mithoefer, A. T., Jerome, L., & Doblin, R. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110378371 · Cited by 674
Harmer, C. J., Shelley, N. C., Cowen, P. J., & Goodwin, G. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1256 · Cited by 554
Serotonin selectively influences moral judgment and behavior through effects on harm aversion
Crockett, M. J., Clark, L., Hauser, M. D., & Robbins, T. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009396107 · Cited by 526
Self-citationIncreased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511
Moore, A., Clark, B. A., & Kane, M. J. (2008) · Psychological Science · doi:10.1111/j.1467-9280.2008.02122.x · Cited by 425
Oehen, P., Traber, R., Widmer, V., & Schnyder, U. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112464827 · Cited by 424
Kometer, M., Schmidt, A., Bachmann, R., Studerus, E., Seifritz, E., & Vollenweider, F. X. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.005 · Cited by 298
Differential subjective effects of D-amphetamine by gender, hormone levels and menstrual cycle phase
White, T. L., Justice, A. J. H., & de Wit, H. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00818-3 · Cited by 248 · cited 1×
“Female subjects were investigated during the follicular phase of their menstrual cycle (days 2–14) when the reactivity to amphetamines is expected to be similar to men (White et al., 2002).”
BackgroundBedi, G., Hyman, D., & de Wit, H. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.003 · Cited by 247
Dumont, G. J. H., Sweep, F. C. G. J., van der Steen, R., Hermsen, R., Donders, A. R. T., Touw, D. J., van Gerven, J. M. A., Buitelaar, J. K., & Verkes, R. J. (2009) · Social Neuroscience · doi:10.1080/17470910802649470 · Cited by 238
Thompson, M. R., Callaghan, P. D., Hunt, G. E., Cornish, J. L., & McGregor, I. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.032 · Cited by 237
Di Simplicio, M., Massey-Chase, R., Cowen, P., & Harmer, C. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108095705 · Cited by 229
Williams, L. M., Hermens, D. F., Palmer, D., Kohn, M., Clarke, S., Keage, H., Clark, C. R., & Gordon, E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.022 · Cited by 207
Impaired emotional empathy and related social network deficits in cocaine users
Preller, K. H., Hulka, L. M., Vonmoos, M., Jenni, D., Baumgartner, M. R., Seifritz, E., Dziobek, I., & Quednow, B. B. (2013) · Addiction Biology · doi:10.1111/adb.12070 · Cited by 168
Self-citationHysek, C. M., Simmler, L. D., Nicola, V. G., Vischer, N., Donzelli, M., Krähenbühl, S., Grouzmann, E., Huwyler, J., Hoener, M. C., & Liechti, M. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036476 · Cited by 164
Self-citationHysek, C. M., Simmler, L. D., Ineichen, M., Grouzmann, E., Hoener, M. C., Brenneisen, R., Huwyler, J., & Liechti, M. E. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.78 · Cited by 152
Self-citationMDMA enhances “mind reading” of positive emotions and impairs “mind reading” of negative emotions
Hysek, C. M., Domes, G., & Liechti, M. E. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2645-9 · Cited by 144
Self-citationHysek, C. M., Simmler, L. D., Schillinger, N., Meyer, N., Schmid, Y., Donzelli, M., Grouzmann, E., & Liechti, M. E. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001132 · Cited by 134
Self-citationRamos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.125 · Cited by 128
Morgan, C. J. A., Noronha, L. A., Muetzelfeldt, M., Feilding, A., & Curran, H. V. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113477744 · Cited by 92
Linking the pharmacological content of ecstasy tablets to the subjective experiences of drug users
Brunt, T. M., Koeter, M. W. J., Niesink, R. J. M., & van den Brink, W. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2529-4 · Cited by 91
The Neurochemistry of Fairness
Crockett, M. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04506.x · Cited by 91
Self-citationSex Differences in the Effects of MDMA (Ecstasy) on Plasma Copeptin in Healthy Subjects
Simmler, L. D., Hysek, C. M., & Liechti, M. E. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1143 · Cited by 91
Self-citationDunand, M., Gubian, D., Stauffer, M., Abid, K., & Grouzmann, E. (2013) · Analytical Chemistry · doi:10.1021/ac4004584 · Cited by 72
Hysek, C. M., & Liechti, M. E. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2761-6 · Cited by 61
Self-citationStimulants improve theory of mind in children with attention deficit/hyperactivity disorder
Maoz, H., Tsviban, L., Gvirts, H. Z., Shamay‐Tsoory, S., Levkovitz, Y., Watemberg, N. M., & Bloch, Y. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113492030 · Cited by 60
Amphetamine as a social drug: effects of d-amphetamine on social processing and behavior
Wardle, M. C., Garner, M. J., Munafo, M. R., & de Wit, H. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2708-y · Cited by 50
Schmeichel, B. E., & Berridge, C. W. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.6 · Cited by 43
Kamboj, S. K., Joye, A., Bisby, J. A., Das, R., Platt, B., & Curran, H. V. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2940-5 · Cited by 30
Theory of Mind Deficits following Acute Alcohol Intoxication
Mitchell, I., Beck, S. R., Boyal, A., & Edwards, V. R. (2011) · European Addiction Research · doi:10.1159/000324871 · Cited by 20
Research works printed but not linked: 3
- Hysek CM, 2013, Soc Cogn Affect Neurosci
- Janke W, 1978, Die Eigenschaftswörterliste
- Zerssen DV, 1976, Die Beschwerden-Liste. Münchener Informationssystem
Cited by
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Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects
Schmid, Y., Enzler, F., Gasser, P., Grouzmann, E., Preller, K. H., Vollenweider, F. X., Brenneisen, R., Müller, F., Borgwardt, S., & Liechti, M. E. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.015 · Cited by 427
Self-citationReviewing the Potential of Psychedelics for the Treatment of PTSD
Krediet, E., Bostoen, T., Breeksema, J., van Schagen, A., Passie, T., & Vermetten, E. (2020) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa018 · Cited by 260
LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality
Dolder, P. C., Schmid, Y., Müller, F., Borgwardt, S., & Liechti, M. E. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.82 · Cited by 247
Self-citationDistinct acute effects of LSD, MDMA, and d-amphetamine in healthy subjects
Holze, F., Vizeli, P., Müller, F., Ley, L., Duerig, R., Varghese, N., Eckert, A., Borgwardt, S., & Liechti, M. E. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0569-3 · Cited by 247
Self-citation
Metadata
- Authors
- Schmid, Y., Hysek, C. M., Simmler, L. D., Crockett, M. J., Quednow, B. B., & Liechti, M. E.
- Affiliations
- University Hospital of Basel (CH)
- Wellcome Centre for Human Neuroimaging (GB)
- University Hospital Zurich (CH)
- Corresponding author
- Liechti, Matthias E
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2014-07-22
- Volume
- 28
- Issue
- 9
- Pages
- 847-856
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2073612520
- Cited by
- 155
- References
- 37
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 16 · 2023: 14 · 2022: 7 · 2021: 12 · 2020: 10 · 2019: 10 · 2018: 18 · 2017: 16 · 2016: 14 · 2015: 12 · 2014: 4
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- green
- edoc.unibas.ch
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- edoc (University of Basel) (acceptedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- edoc (University of Basel)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Arts and Humanities › Philosophy › Neuroethics, Human Enhancement, Biomedical Innovations
- Keywords
- MDMA, ecstasy, methylphenidate, social cognition, affective empathy, cognitive empathy, facial emotion recognition, social value orientation, moral judgment, oxytocin, prolactin, subjective effects, acute drug effects, cognitive enhancement
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Cognition, Dose-Response Relationship, Drug, Double-Blind Method, Emotions, Empathy, Epinephrine, Facial Expression, Female, Hallucinogens, Humans, Hydrocortisone, Judgment, Male, Methylphenidate, Oxytocin, Prolactin, Cross-Over Studies, N-Methyl-3,4-methylenedioxyamphetamine, Recognition, Psychology, Young Adult
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