Medical Comorbidities in Autism: Challenges to Diagnosis and Treatment

Bauman, Margaret L.

doi:10.1016/j.nurt.2010.06.001

Cited by 374Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesGenetics and Neurodevelopmental Disorders

Medical Comorbidities in Autism: Challenges to Diagnosis and Treatment

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Bauman, Margaret L.·2010·Neurotherapeutics

DOI 10.1016/j.nurt.2010.06.001PMC PMC5084236

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Abstract

Ever since its original description by Leo Kanner in l943, autism has been generally defined by its clinical characteristics and core symptoms that include impaired social skills, isolated areas of interest, and delayed and disordered language. Over time, it has become apparent that autism is a heterogeneous disorder with regard to its clinical presentation, etiology, underlying neurobiology, and degree of severity. As a result, the termed diagnosis of autism spectrum disorders (ASDs) has come into common usage. With advancements in clinical care, there has come the appreciation that many ASD children, adolescents, and adults may have medically relevant disorders that may negatively impact their developmental progress and behavior, but which frequently go undetected. Many of these medical conditions are treatable, often resulting in improved developmental gains and quality of life for the patient and family. In addition, the possibility exists that some of these medical conditions may suggest the presence of important genetic and/or biologic markers, which, if identified, can refine our ability to be more precise in categorizing clinical and genetic subtypes within the autism spectrum.

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In clinical cases, other neurodevelopmental conditions, psychiatric disorders and somatic disorders are often co-occurring complications.
“In clinical cases, other neurodevelopmental conditions, psychiatric disorders and somatic disorders are often co-occurring complications [13–15].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [15]
A variety of GI issues commonly occur in ASD, including lower GI symptoms (constipation, diarrhea) and upper GI symptoms (nausea and vomiting, stomach aches and pains).
“A variety of gastrointestinal (GI) issues commonly occur in ASD, including lower GI symptoms (i.e., constipation, diarrhea) and upper GI symptoms (i.e., nausea and vomiting, stomach aches and pains) (2–10), but the etiology is poorly understood.”
From The Relationship Among Gastrointestinal Symptoms, Problem Behaviors, and Internalizing Symptoms in Children and Adolescents with Autism Spectrum Disorder (2019) · cites this paper as [8]
Non-verbal patients may demonstrate GI distress as constant eating or drinking, chewing on non-edible objects and abdominal pressure.
“Non-verbal patients may also demonstrate GI distress as constant eating or drinking, chewing on non-edible objects and abdominal pressure 40.”
From Gastrointestinal Issues and Autism Spectrum Disorder (2020) · cites this paper as [40]

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Authors: Bauman, M. L.
Affiliations: Massachusetts General Hospital (US)
Corresponding author: Bauman, Margaret L.
ORCID: Bauman, Margaret L.
Venue: Neurotherapeutics
Publisher: Elsevier BV
Published: 2010-07
Volume: 7
Issue: 3
Pages: 320-327
ISSN: 1878-7479 (ISSN-L)
DOI: 10.1016/j.nurt.2010.06.001
PMC: PMC5084236
OpenAlex: W1987839624
Cited by: 372
References: 46
Citations by year: 2026: 10 · 2025: 13 · 2024: 23 · 2023: 20 · 2022: 30 · 2021: 42 · 2020: 32 · 2019: 36 · 2018: 34 · 2017: 23 · 2016: 20 · 2015: 26 · 2014: 18 · 2013: 17 · 2012: 15
FWCI: 1.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4789 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neurotherapeutics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: autism spectrum disorder, comorbidities, autism heterogeneity, developmental outcomes, quality of life, genetic markers, autism subtypes
MeSH terms: Autistic Disorder, Endocrine System Diseases, Epilepsy, Gastrointestinal Diseases, Humans, Metabolic Diseases, Sleep Wake Disorders, Comorbidity

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