Association Between Amygdala Volume and Anxiety Level: Magnetic Resonance Imaging (MRI) Study in Autistic Children
Abstract
Our objective was to evaluate brain-behavior relationships between amygdala volume and anxious/depressed scores on the Child Behavior Checklist in a well-characterized population of autistic children. Volumes for the amygdala, hippocampus, and whole brain were obtained from three-dimensional magnetic resonance images (MRIs) captured from 42 children who met the criteria for autistic disorder. Anxious/depressed symptoms were assessed in these children by the Anxious/Depressed subscale of the Child Behavior Checklist. To investigate the association between anxious/depressed scores on the Child Behavior Checklist and amygdala volume, data were analyzed using linear regression methods with Pearson correlation coefficients. A multivariate model was used to adjust for potential covariates associated with amygdala volume, including age at MRI and total brain size. We found that anxious/depressed symptoms were significantly correlated with increased total amygdala volume (r = .386, P = .012) and right amygdala volume (r = .469, P = .002). The correlation between anxious/depressed symptoms and left amygdala volume did not reach statistical significance (r = .249, P = .112). Child Behavior Checklist anxious/depressed scores were found to be a significant predictor of amygdala total (P = .014) and right amygdala (P = .002) volumes. In conclusion, we have identified a significant brain-behavior relationship between amygdala volume and anxious/depressed scores on the Child Behavior Checkl…
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Aspects of neurobiological differences in brain networks responsible for emotional processing have been associated with anxiety symptom severity.
“and aspects of these differences have been associated with anxiety symptom severity [69,70].”
From Functional autonomic nervous system profile in children with autism spectrum disorder (2014) · cites this paper as [69]
Total and right amygdala volumes have been positively associated with scores on the anxiety subscale of the Child Behavior Checklist in a sample of children with autism spectrum disorder.
“For example, total and right amygdala volumes have been positively associated with scores on the anxiety subscale of the Child Behavior Checklist [69] in a sample of children with ASD.”
From Functional autonomic nervous system profile in children with autism spectrum disorder (2014) · cites this paper as [69]
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Self-citation
- Authors
- Juranek, J., Filipek, P. A., Berenji, G. R., Modahl, C., Osann, K., & Spence, M. A.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Juranek, Jenifer
- Venue
- Journal of Child Neurology
- Publisher
- SAGE Publications
- Published
- 2006-12
- Volume
- 21
- Issue
- 12
- Pages
- 1051-1058
- ISSN
- 0883-0738 (ISSN-L)
- 1708-8283
- OpenAlex
- W2035245686
- Cited by
- 147
- References
- 28
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 17 · 2023: 4 · 2022: 8 · 2021: 15 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 11 · 2014: 8 · 2013: 8 · 2012: 12
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- amygdala volume, autism spectrum disorder, anxiety, depression, Child Behavior Checklist, brain-behavior relationship, hippocampus, psychiatric comorbidity, children with autism
- MeSH terms
- Adolescent, Amygdala, Anxiety Disorders, Autistic Disorder, Child, Child, Preschool, Depressive Disorder, Female, Humans, Hypertrophy, Functional Laterality, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Predictive Value of Tests, Statistics as Topic, Comorbidity
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