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Cited by 184Autism Spectrum Disorder ResearchNeuroendocrine regulation and behaviorFace Recognition and Perception

The DOI matches its Crossref record; 65 of the 66 references it cites were found in a registry or an index.

The amygdala and autism: implications from non-human primate studies

Open access
Amaral, D. G., Bauman, M. D., Mills Schumann, C.·2003·Genes, Brain and Behavior
DOI 10.1034/j.1601-183x.2003.00043.x
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Abstract

Brothers (1990) has proposed that the amygdala is an important component of the neural network that underlies social behavior. Kemper and Bauman (1993) identified neuropathology in the amygdala of the postmortem autistic brain. These findings, along with recent functional neuroimaging data, have led Baron-Cohen et al. (2000) to propose that dysfunction of the amygdala may be responsible, in part, for the impairment of social behavior that is a hallmark feature of autism. Recent data from studies in our laboratory on the effects of amygdala lesions in the adult and infant macaque monkey do not support a fundamental role for the amygdala in social behavior. If the amygdala is not essential for the component processes of social behavior, as seems to be case in both non-human primates and selected patients with bilateral amygdala damage, then it is unlikely to be the primary substrate for the impaired social behavior of autism. However, damage to the amygdala does have an effect on a monkey's response to normally fear-inducing stimuli, such as snakes, and removes a natural reluctance to engage novel conspecifics in social interactions. These findings lead to the conclusion that an important role for the amygdala is in the detection of threats and mobilizing an appropriate behavioral response, part of which is fear. Interestingly, an important comorbid feature of autism is anxiety (Muris et al. 1998). If the amygdala is pathological in subjects with autism, it may contribute to their abnormal fears and increased anxiety rather than their abnormal social behavior.

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Crossref · 10.1034/j.1601-183x.2003.00043.x

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  • Reduced modulation of limbic activity via higher cortical systems may result in chronic, unchecked perception of threat and subsequent anxiety.

    “This same reasoning applies just as well to explanations for anxiety: reduced modulation of limbic activity via higher cortical systems may result in chronic, unchecked perception of threat and subsequent anxiety (Amaral et al., 2003).”

    From Sensory, emotional and cognitive contributions to anxiety in autism spectrum disorders (2017) · cites this paper as Amaral et al., 2003

    The Conclusions (page not supplied) say the amygdala plays a prominent role in detecting threats and that its dysfunction could contribute to fear and anxiety in autism. The paper does not describe reduced modulation by higher cortical systems or a chronic, unchecked perception of threat. (LLM, conf=0.86)

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1 of the 66 references couldn’t be matched to a known paper.

Research works printed but not linked: 7

  1. Bauman M.D., 2003, Abstract Viewer/Itinerary Planner: Society for Neuroscience
  2. Brothers L., 1990, Concepts Neuroscience, 1, 27
  3. Kling A.S., 1992, The Amygdala: Neurobiological Aspects of Emotion, Memory, and Dysfunction
  4. Prather M.D., 2001, Neonatal amygdala lesions in the nonhuman primate ‐ implications for an animal model of autism., Abstract Viewer/Itinerary Planner: International Meeting for Autism Research, 2001. San Diego.
  5. Ritvo E.R., 1984, Pediatr Ann, 13, 298
  6. Suomi S.J., 1991, Ciba Found Symp, 156, 171
  7. Thompson C.I., 1981, The Amygdaloid Complex, 259

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Metadata

Authors
Amaral, D. G., Bauman, M. D., & Mills Schumann, C.
Affiliations
University of California, Davis (US)
Corresponding author
Amaral, D. G.
ORCID
Venue
Genes, Brain and Behavior
Publisher
Wiley
Published
2003-10
Volume
2
Issue
5
Pages
295-302
ISSN
  • 1601-183X (ISSN-L)
  • 1601-1848
DOI
10.1034/j.1601-183x.2003.00043.x
OpenAlex
W1561508305
Cited by
184
References
66
Citations by year
2026: 2 · 2025: 2 · 2024: 16 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 9 · 2018: 1 · 2017: 11 · 2016: 6 · 2015: 5 · 2014: 11 · 2013: 7 · 2012: 15
FWCI
1.08
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 15 d)
Locations
  • Genes Brain & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • John D. and Catherine T. MacArthur Foundation
  • National Institutes of Health
  • National Institute of Mental Health (R01MH057502)
  • National Center for Research Resources (P51RR000169, RR-00169)
  • California National Primate Research Center (RR00169)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
Keywords
amygdala, autism spectrum disorder, social behavior, amygdala lesions, macaque, fear, threat detection, anxiety, social interaction, autism comorbidity
MeSH terms
Amygdala, Animals, Haplorhini, Autistic Disorder, Brain Damage, Chronic, Brain Mapping, Disease Models, Animal, Humans

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