Role of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation
Open accessAbstract
Autism spectrum disorder (ASD) is a neurological disorder that affects normal brain development. The recent finding of the microbiota–gut–brain axis indicates the bidirectional connection between our gut and brain, demonstrating that gut microbiota can influence many neurological disorders such as autism. Most autistic patients suffer from gastrointestinal (GI) symptoms. Many studies have shown that early colonization, mode of delivery, and antibiotic usage significantly affect the gut microbiome and the onset of autism. Microbial fermentation of plant-based fiber can produce different types of short-chain fatty acid (SCFA) that may have a beneficial or detrimental effect on the gut and neurological development of autistic patients. Several comprehensive studies of the gut microbiome and microbiota–gut–brain axis help to understand the mechanism that leads to the onset of neurological disorders and find possible treatments for autism. This review integrates the findings of recent years on the gut microbiota and ASD association, mainly focusing on the characterization of specific microbiota that leads to ASD and addressing potential therapeutic interventions to restore a healthy balance of gut microbiome composition that can treat autism-associated symptoms.
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Research suggests that individuals with ASD experiencing chronic GI issues such as persistent constipation, diarrhea, bloating, or irritable bowel syndrome-like symptoms may benefit most from fecal microbiota transplantation.
“Research suggests that those who may benefit the most include individuals with ASD experiencing chronic GI issues such as persistent constipation, diarrhea, bloating, or irritable bowel syndrome (IBS)-like symptoms [130].”
From The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders (2025) · cites this paper as [130]
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Comparative Genomics of Host–Symbiont and Free-Living Oceanobacillus Species
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The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders
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- Authors
- Taniya, M. A., Chung, H.-J., Al Mamun, A., Alam, S., Aziz, M. A., Emon, N. U., Islam, M. M., Hong, S.-T. S., Podder, B. R., Ara Mimi, A., Aktar Suchi, S., & Xiao, J.
- Affiliations
- Independent University, Bangladesh (BD)
- Korea Basic Science Institute (KR)
- Bangladesh Council of Scientific and Industrial Research (BD)
- State University of Bangladesh (BD)
- International Islamic University Chittagong (BD)
- Jeonbuk National University (KR)
- University of Dhaka (BD)
- Wenzhou Medical University (CN)
- Corresponding author
- Chung, Hea-Jong
- Xiao, Jian
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2022-07-22
- Volume
- 12
- Pages
- 915701-915701
- ISSN
- 2235-2988 (ISSN-L)
- PMC
- PMC9355470
- OpenAlex
- W4286587455
- Cited by
- 207
- References
- 143
- Citations by year
- 2026: 49 · 2025: 65 · 2024: 56 · 2023: 33 · 2022: 4
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Greater South Information System
- Funders
- Korea Basic Science Institute (C280320, C210500, C220000)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- autism spectrum disorder, gut microbiota, microbiota-gut-brain axis, gastrointestinal symptoms, short-chain fatty acids, mode of delivery, antibiotic use, autism treatment
- MeSH terms
- Autism Spectrum Disorder, Gastrointestinal Microbiome, Fatty Acids, Volatile, Gastrointestinal Diseases, Humans, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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