Cited by 167Gut microbiota and healthAutism Spectrum Disorder ResearchTryptophan and brain disorders

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia

Shaw, William·2010·Nutritional Neuroscience

Open this paper in CoChat — free account

Abstract

A compound identified as 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) was found in higher concentrations in urine samples of children with autism compared to age and sex appropriate controls and in an adult with recurrent diarrhea due to Clostridium difficile infections. The highest value measured in urine samples was 7500 mmol/mol creatinine, a value 300 times the median normal adult value, in a patient with acute schizophrenia during an acute psychotic episode. The psychosis remitted after treatment with oral vancomycin with a concomitant marked decrease in HPHPA. The source of this compound appears to be multiple species of anaerobic bacteria of the Clostridium genus. The significance of this compound is that it is a probable metabolite of m-tyrosine (3-hydroxyphenylalanine), a tyrosine analog which depletes brain catecholamines and causes symptoms of autism (stereotypical behavior, hyperactivity, and hyper-reactivity) in experimental animals.

Integrity signals

Registry

Crossref · 10.1179/147683010x12611460763968

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Goodman and Gilman's the Pharmacological Basis of Therapeutics
Stigelman, W. H., & Pharm, D. (1986) · Military Medicine · doi:10.1093/milmed/151.1.386 · Cited by 6,796
Harrison's Principles of Internal Medicine.
(1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-1-167_1 · Cited by 1,527
Oxygen Radical Absorbing Capacity of Phenolics in Blueberries, Cranberries, Chokeberries, and Lingonberries
Zheng, W., & Wang, S. Y. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020728u · Cited by 814
Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children
Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784
Gastrointestinal Microflora Studies in Late‐Onset Autism
Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742
Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism
Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Väisänen, M.-L., Nelson, M. N., & Wexler, H. M. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500701 · Cited by 614
Major Phenolics in Apple and Their Contribution to the Total Antioxidant Capacity
Lee, K. W., Kim, Y. J., Kim, D., Lee, H. J., & Lee, C. Y. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034475w · Cited by 611
Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children
Song, Y., Liu, C., & Finegold, S. M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6459-6465.2004 · Cited by 556
SUCCESSFUL TREATMENT OF RELAPSING CLOSTRIDIUM DIFFICILE COLITIS WITH LACTOBACILLUS GG
Gorbach, S., Chang, T., & Goldin, B. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92646-8 · Cited by 467
Antibiotic-Associated Diarrhea
Bartlett, J. G. (1992) · Clinical Infectious Diseases · doi:10.1093/clind/15.4.573 · Cited by 414

Show all 41 references

Research works printed but not linked: 6

Finegold S, 1986, Scand J Infect Dis, 49, 160
Rollo I, 1970, Goodman and Gilmans The Pharmacological Basis of Therapeutics
1993, The Physicians Desk Reference
Kirby WM, 1983, Harrisons Principles of Internal Medicine, 872
Waring R, 1993, Biological Perspectives in Autism Conference, 25
Conway P, 1995, Human Colonic Bacteria, 1

Sorted by citations

Emerging applications of metabolomics in drug discovery and precision medicine
Wishart, D. S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.32 · Cited by 1,543
Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health
Oliphant, K., & Allen-Vercoe, E. (2019) · Microbiome · doi:10.1186/s40168-019-0704-8 · Cited by 1,327
Metabolomics for Investigating Physiological and Pathophysiological Processes
Wishart, D. S. (2019) · Physiological Reviews · doi:10.1152/physrev.00035.2018 · Cited by 1,295
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 940
The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857
The Microbiota–Gut–Brain Axis in Psychiatric Disorders
Góralczyk-Bińkowska, A., Szmajda‐Krygier, D., & Kozłowska, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911245 · Cited by 569
Microbiome–microglia connections via the gut–brain axis
Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180794 · Cited by 471
“West et al., 2006; Severance et al., 2010, 2015; Shaw, 2010; Diaz Heijtz et al., 2011; Miller et al., 2011; Monji et al., 2013; Hercher et al., 2014; Na et al., 2014; Yolken and Dickerson, 2014; Castro-Nallar et al., 2015; Reisinger et al., 2015; Bloomfield et al., 2016; Sekar et al., 2016; van…”
Background
Autism Spectrum Disorders and the Gut Microbiota
Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484
The Gut Microbiota and Autism Spectrum Disorders
Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462
The microbiota regulate neuronal function and fear extinction learning
Chu, C., Murdock, M. H., Jing, D., Won, T. H., Chung, H., Kressel, A. M., Tsaava, T., Addorisio, M. E., Putzel, G. G., Zhou, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1644-y · Cited by 421
Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols
Williamson, G., & Clifford, M. N. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.03.012 · Cited by 360
Brain-Gut-Microbiota Axis and Mental Health
Dinan, T. G., & Cryan, J. F. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000519 · Cited by 325
Autism spectrum disorders and intestinal microbiota
De Angelis, M., Francavilla, R., Piccolo, M., De Giacomo, A., & Gobbetti, M. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1035855 · Cited by 311
Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior
Gacias, M., Gaspari, S., Santos, P.-M. G., Tamburini, S., Andrade, M., Zhang, F., Shen, N., Tolstikov, V., Kiebish, M. A., Dupree, J. L., et al. (2016) · eLife · doi:10.7554/elife.13442 · Cited by 308
Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats
Kieffer, D. A., Piccolo, B. D., Vaziri, N. D., Liu, S., Lau, W. L., Khazaeli, M., Nazertehrani, S., Moore, M. E., Marco, M. L., Martin, R. J., et al. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00513.2015 · Cited by 308
Altered brain-gut axis in autism: comorbidity or causative mechanisms
Mayer, E. A., Padua, D., & Tillisch, K. (2014) · BioEssays · doi:10.1002/bies.201400075 · Cited by 304
May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry
Sherwin, E., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2016) · CNS Drugs · doi:10.1007/s40263-016-0370-3 · Cited by 309
Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases
Samsel, A., & Seneff, S. (2013) · Entropy · doi:10.3390/e15041416 · Cited by 307
Communication of gut microbiota and brain via immune and neuroendocrine signaling
Kasarełło, K., Cudnoch‐Jędrzejewska, A., & Czarzasta, K. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1118529 · Cited by 283
The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders
Hughes, H. K., Rose, D., & Ashwood, P. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0887-6 · Cited by 225
Role of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation
Taniya, M. A., Chung, H.-J., Al Mamun, A., Alam, S., Aziz, M. A., Emon, N. U., Islam, M. M., Hong, S.-T. S., Podder, B. R., Ara Mimi, A., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.915701 · Cited by 207
Urinary p-cresol in autism spectrum disorder
Persico, A. M., & Napolioni, V. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.09.002 · Cited by 189
Gastrointestinal symptoms and autism spectrum disorder: links and risks – a possible new overlap syndrome
Wasilewska, J., & Klukowski, M. (2015) · Pediatric Health Medicine and Therapeutics · doi:10.2147/phmt.s85717 · Cited by 191
Genomics of schizophrenia: time to consider the gut microbiome?
Dinan, T. G., Borre, Y. E., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.93 · Cited by 177
Gut bacteria in children with autism spectrum disorders: challenges and promise of studying how a complex community influences a complex disease
Krajmalnik‐Brown, R., Lozupone, C., Kang, D., & Adams, J. B. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26914 · Cited by 175
Urinary p-cresol is elevated in small children with severe autism spectrum disorder
Altieri, L., Neri, C., Sacco, R., Curatolo, P., Benvenuto, A., Muratori, F., Santocchi, E., Bravaccio, C., Lenti, C., Saccani, M., et al. (2011) · Biomarkers · doi:10.3109/1354750x.2010.548010 · Cited by 161
Urinary Biomarkers of Brain Diseases
An, M., & Gao, Y. (2015) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2015.08.005 · Cited by 142
Role of the Gut Microbiome in Autism Spectrum Disorders
Pulikkan, J., Mazumder, A., & Grace, T. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-05542-4_13 · Cited by 142
Friends or Foes—Microbial Interactions in Nature
Weiland‐Bräuer, N. (2021) · Biology · doi:10.3390/biology10060496 · Cited by 144
The mind-body-microbial continuum
Gonzalez, A., Stombaugh, J., Lozupone, C., Turnbaugh, P. J., Gordon, J. I., & Knight, R. D. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/agonzalez · Cited by 134
Gut microbiota and neurological effects of glyphosate
Rueda‐Ruzafa, L., Cruz, F., Román, P., & Cardona, D. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.08.006 · Cited by 124
The Role of Microbiome, Dietary Supplements, and Probiotics in Autism Spectrum Disorder
Sivamaruthi, B. S., Suganthy, N., Kesika, P., & Chaiyasut, C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082647 · Cited by 133
A descriptive review on the prevalence of gastrointestinal disturbances and their multiple associations in autism spectrum disorder
Lefter, R., Ciobica, A., Timofte, D., Stanciu, C., & Trifan, A. (2019) · Medicina · doi:10.3390/medicina56010011 · Cited by 120
The urinary metabolomics profile of an Italian autistic children population and their unaffected siblings
Noto, A., Fanos, V., Barberini, L., Grapov, D., Fattuoni, C., Zaffanello, M., Casanova, A., Fenu, G., De Giacomo, A., De Angelis, M., et al. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.954784 · Cited by 113
Autism Spectrum Disorder Associated With Gut Microbiota at Immune, Metabolomic, and Neuroactive Level
García-Gutiérrez, E., Narbad, A., & Rodríguez, J. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.578666 · Cited by 118
Eating and feeding problems and gastrointestinal dysfunction in Autism Spectrum Disorders
Vissoker, R. E., Latzer, Y., & Gal, E. (2015) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2014.12.010 · Cited by 105
Dietary Considerations in Autism Spectrum Disorders: The Potential Role of Protein Digestion and Microbial Putrefaction in the Gut-Brain Axis
Sanctuary, M. R., Kain, J. N., Angkustsiri, K., & German, J. B. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00040 · Cited by 97
Metabolomics analysis of microbiota-gut-brain axis in neurodegenerative and psychiatric diseases
Konjevod, M., Perković, M. N., Sáiz, J., Štrac, D. Š., Barbas, C., & Rojo, D. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113681 · Cited by 99
Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders
Xiong, X., Liu, D., Wang, Y., Zeng, T., & Peng, Y. (2016) · BioMed Research International · doi:10.1155/2016/9485412 · Cited by 90
Metabolic differences underlying two distinct rat urinary phenotypes, a suggested role for gut microbial metabolism of phenylalanine and a possible connection to autism
Clayton, T. A. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.01.049 · Cited by 82
The gut microbiota in neuropsychiatric disorders
Grochowska, M., Wojnar, M., & Radkowski, M. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-008 · Cited by 77
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms
Frye, R. E., Slattery, J. M., MacFabe, D. F., Allen‐Vercoe, E., Parker, W., Rodakis, J., Adams, J. B., Krajmalnik‐Brown, R., Bolte, E. R., Kahler, S. G., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26878 · Cited by 78
Microbiome in Precision Psychiatry: An Overview of the Ethical Challenges Regarding Microbiome Big Data and Microbiome-Based Interventions
Ahmed, E., & Hens, K. (2021) · AJOB Neuroscience · doi:10.1080/21507740.2021.1958096 · Cited by 70
Environment, dysbiosis, immunity and sex-specific susceptibility: A translational hypothesis for regressive autism pathogenesis
Mezzelani, A., Landini, M., Facchiano, F., Raggi, M. E., Villa, L. M., Molteni, M., Santis, B. D., Brera, C., Caroli, A. M., Milanesi, L., et al. (2014) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000108 · Cited by 73
The use of biomarkers associated with leaky gut as a diagnostic tool for early intervention in autism spectrum disorder: a systematic review
AL-Ayadhi, L. Y., Zayed, N., Bhat, R. S., Moubayed, N., Al-Muammar, M. N., & El-Ansary, A. (2021) · Gut Pathogens · doi:10.1186/s13099-021-00448-y · Cited by 78
Infectious diseases, autoantibodies, and autoimmunity
Johnson, D., & Jiang, W. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102962 · Cited by 77
Gastrointestinal Microbiota and Metabolite Biomarkers in Children With Autism Spectrum Disorders
Wang, L., Conlon, M. A., Christophersen, C. T., Sorich, M. J., & Angley, M. T. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.12 · Cited by 72
Microbiome to Brain: Unravelling the Multidirectional Axes of Communication
Aidy, S. E., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-20215-0_15 · Cited by 65
Mitochondrial dysfunction: A hidden trigger of autism?
Vellingiri, B., Rajagopalan, K., Jayaramayya, K., Jeevanandam, M., & Iyer, M. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.07.002 · Cited by 65
Functional analysis of gut microbiota and immunoinflammation in children with autism spectrum disorders
Carissimi, C., Laudadio, I., Palone, F., Fulci, V., Cesi, V., Cardona, F., Alfonsi, C., Cucchiara, S., Isoldi, S., & Stronati, L. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.06.006 · Cited by 62
Environmental Chemical Diethylhexyl Phthalate Alters Intestinal Microbiota Community Structure and Metabolite Profile in Mice
Lei, M., Menon, R., Manteiga, S., Alden, N., Hunt, C. L., Alaniz, R. C., Lee, K., & Jayaraman, A. (2019) · mSystems · doi:10.1128/msystems.00724-19 · Cited by 65
The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders
Marzal, L. N. P., Prince, N., Bajić, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810052 · Cited by 67
A review of probiotics in the treatment of autism spectrum disorders: Perspectives from the gut–brain axis
Feng, P., Zhao, S., Zhang, Y., & Li, E. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1123462 · Cited by 62
Potential etiologic factors of microbiome disruption in autism
Buie, T. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.04.001 · Cited by 55
Changes in urinary metabolic profiles of colorectal cancer patients enrolled in a prospective cohort study (ColoCare)
Liesenfeld, D. B., Habermann, N., Tóth, R., Owen, R. W., Frei, E., Böhm, J., Schrotz‐King, P., Klika, K. D., & Ulrich, C. M. (2014) · Metabolomics · doi:10.1007/s11306-014-0758-3 · Cited by 48
The Urine Metabolome of Young Autistic Children Correlates with Their Clinical Profile Severity
Mussap, M., Siracusano, M., Noto, A., Fattuoni, C., Riccioni, A., Rajula, H. S. R., Fanos, V., Curatolo, P., Barberini, L., & Mazzone, L. (2020) · Metabolites · doi:10.3390/metabo10110476 · Cited by 47
A review of candidate urinary biomarkers for autism spectrum disorder
Wang, L., Angley, M. T., Gerber, C., & Sorich, M. J. (2011) · Biomarkers · doi:10.3109/1354750x.2011.598564 · Cited by 43
Elevated Urinary Glyphosate and Clostridia Metabolites With Altered Dopamine Metabolism in Triplets With Autistic Spectrum Disorder or Suspected Seizure Disorder: A Case Study.
Shaw, W. (2017) · Europe PMC (PubMed Central) · Cited by 41
Self-citation
Paving the Way toward Personalized Medicine: Current Advances and Challenges in Multi-OMICS Approach in Autism Spectrum Disorder for Biomarkers Discovery and Patient Stratification
Mesleh, A. G., Abdulla, S. A., & El‐Agnaf, O. M. A. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11010041 · Cited by 41
INVESTIGATION OF THE RELATION BETWEEN ANAEROBIC BACTERIA GENUSCLOSTRIDIUMAND LATE-ONSET AUTISM ETIOLOGY IN CHILDREN
Keşli, R., Gökçen, C., Buluğ, U., & Terzi, Y. (2013) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2013.792834 · Cited by 39
Gut microbiota metabolites in autistic children: An epigenetic perspective
Sabit, H., Tombuloğlu, H., Rehman, S., Almandil, N. B., Çevik, E., Abdel-Ghany, S. E., Rashwan, S., Abasiyanik, M. F., & Waye, M. M. Y. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06105 · Cited by 40
Microbes and Monoamines: Potential Neuropsychiatric Consequences of Dysbiosis
Skolnick, S. D., & Greig, N. H. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.005 · Cited by 36
The transformative possibilities of the microbiota and mycobiota for health, disease, aging, and technological innovation
Jones, L., Kumar, J., Mistry, A., Sankar Chittoor Mana, T., Perry, G., Reddy, V. P., & Obrenovich, M. (2019) · Biomedicines · doi:10.3390/biomedicines7020024 · Cited by 34
The Microbiota‐Gut‐Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders
Faysal, M. F., Zehravi, M., Sutradhar, B., Amin, M. A., Shanmugarajan, T. S., Arjun, U. V. N. V., Ethiraj, S., Durairaj, A., Dayalan, G., Ahamad, S. K., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70593 · Cited by 41
Mental Health Disorders Associated with Foodborne Pathogens
Bolton, D., & Robertson, L. J. (2016) · Journal of Food Protection · doi:10.4315/0362-028x.jfp-15-587 · Cited by 36
Quantification of Phenolic Acid Metabolites in Humans by LC–MS: A Structural and Targeted Metabolomics Approach
Obrenovich, M. E., Donskey, C. J., Schiefer, I. T., Bongiovanni, R., Li, L., & Jaskiw, G. E. (2018) · Bioanalysis · doi:10.4155/bio-2018-0140 · Cited by 32
Mucosa-associated specific bacterial species disrupt the intestinal epithelial barrier in the autism phenome
Agarwala, S., Naik, B., & Ramachandra, N. B. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100269 · Cited by 32
Metabolomics: Perspectives on Clinical Employment in Autism Spectrum Disorder
Siracusano, M., Arturi, L., Riccioni, A., Noto, A., Mussap, M., & Mazzone, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713404 · Cited by 29
Urinary metabolite markers characterizing tuberculosis treatment failure
Luies, L., Mienie, L. J., Motshwane, C., Ronacher, K., Walzl, G., & Loots, D. T. (2017) · Metabolomics · doi:10.1007/s11306-017-1261-4 · Cited by 30
Children with Autism and Their Typically Developing Siblings Differ in Amplicon Sequence Variants and Predicted Functions of Stool-Associated Microbes
David, M. M., Tataru, C. A., Daniels, J., Schwartz, J. N., Keating, J., Hampton‐Marcell, J., Gottel, N., Gilbert, J. A., & Wall, D. P. (2021) · mSystems · doi:10.1128/msystems.00193-20 · Cited by 33
Workshop report: Toward the development of a human whole stool reference material for metabolomic and metagenomic gut microbiome measurements
Mandal, R., Cano, R. J., Davis, C. D., Hayashi, D. K., Jackson, S. A., Jones, C. M., Lampe, J. W., Latulippe, M. E., Lin, N. J., Lippa, K. A., et al. (2020) · Metabolomics · doi:10.1007/s11306-020-01744-5 · Cited by 30
Polyphenols and Small Phenolic Acids as Cellular Metabolic Regulators
Obrenovich, M. E., Li, Y., Tayahi, M. B., & Reddy, V. P. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44090285 · Cited by 33
Neuronutrition and Nrf2 Brain Resilience Signaling: Epigenomics and Metabolomics for Personalized Medicine in Nervous System Disorders from Bench to Clinic
Scuto, M. C., Anfuso, C. D., Lombardo, C., Fatta, E. D., Ferri, R., Musso, N., Zerbo, G., Terrana, M., Majzúnová, M., Lupo, G., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199391 · Cited by 31
Gut Microbiota as a Source of Uremic Toxins
Popkov, V. A., Zharikova, A. A., Demchenko, E. A., Andrianova, N. V., Zorov, D. B., & Plotnikov, E. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010483 · Cited by 29
The Urinary Metabolome of Healthy Newborns
López‐Hernández, Y., Oropeza-Valdez, J. J., Blanco-Sandate, J. O., Oostdam, A. S. H.-V., Zheng, J., Guo, A. C., Lima‐Rogel, V., Rajabzadeh, R., Salgado‐Bustamante, M., López, J. A., et al. (2020) · Metabolites · doi:10.3390/metabo10040165 · Cited by 26
Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward
d’Oplinter, A. D. W., Verce, M., Huwart, S. J. P., Lessard‐Lord, J., Depommier, C., Hul, M. V., Desjardins, Y., Cani, P. D., & Everard, A. (2023) · Microbiome · doi:10.1186/s40168-023-01526-w · Cited by 25
Pediatric Acute-onset Neuropsychiatric Syndrome and Mycoplasma Pneumoniae Infection: A Case Report Analysis with a Metabolomics Approach
Piras, C., Pintus, R., Pruna, D., Dessì, A., Atzori, L., & Fanos, V. (2019) · Current Pediatric Reviews · doi:10.2174/1573396315666191022102925 · Cited by 25
Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia
Morillon, A.-C., Williamson, R. D., Baker, P. N., Kell, D. B., Kenny, L. C., English, J. A., McCarthy, F. P., & McCarthy, C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230977 · Cited by 24
Comparison of the Metabolic Profiles in the Plasma and Urine Samples Between Autistic and Typically Developing Boys: A Preliminary Study
Xu, X., Cai, X., Meng, F., Song, T.-J., Wang, X., Wei, Y.-Z., Zhai, F.-J., Long, B., Wang, J., You, X., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.657105 · Cited by 24
Exploration for biomarkers of postpartum depression based on metabolomics: A systematic review
Li, S., Yang, Z., Yao, M., Shen, Y., Zhu, H., Jiang, Y., Ji, Y., & Yin, J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.043 · Cited by 23
The microbiome and inborn errors of metabolism: Why we should look carefully at their interplay?
Colonetti, K., Roesch, L. F. W., & Schwartz, I. V. D. (2018) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2017-0235 · Cited by 22
Investigating the Impacts of Diet, Supplementation, Microbiota, Gut–Brain Axis on Schizophrenia: A Narrative Review
Zajkowska, I., Niczyporuk, P., Urbaniak, A. D., Tomaszek, N., Modzelewski, S., & Waszkiewicz, N. (2024) · Nutrients · doi:10.3390/nu16142228 · Cited by 24
Fecal Microbiota Transplant to Treat Recurrent Clostridium difficile Infections
Boyle, M. L., Ruth-Sahd, L. A., & Zhou, Z. (2015) · Critical Care Nurse · doi:10.4037/ccn2015356 · Cited by 20
Metabolism of phenolics in coffee and plant-based foods by canonical pathways: an assessment of the role of fatty acid β-oxidation to generate biologically-active and -inactive intermediates
Clifford, M. N., King, L. J., Kerimi, A., Pereira‐Caro, G., & Williamson, G. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2131730 · Cited by 19
Robust Regression Analysis of GCMS Data Reveals Differential Rewiring of Metabolic Networks in Hepatitis B and C Patients
Simillion, C., Semmo, N., Idle, J. R., & Beyoğlu, D. (2017) · Metabolites · doi:10.3390/metabo7040051 · Cited by 18
Effect of Supplementation on Levels of Homovanillic and Vanillylmandelic Acids in Children with Autism Spectrum Disorders
Gątarek, P., & Kałużna‐Czaplińska, J. (2022) · Metabolites · doi:10.3390/metabo12050423 · Cited by 17
Biological plausibility of the gut–brain axis in autism
Vasquez, A. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13516 · Cited by 16
Targeted Biomedical Treatment for Autism Spectrum Disorders
Pacheva, I. H., & Ivanov, I. S. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191205091312 · Cited by 17
Autism genes and the leukocyte transcriptome in autistic toddlers relate to pathogen interactomes, infection and the immune system. A role for excess neurotrophic sAPPα and reduced antimicrobial Aβ
Carter, C. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.03.007 · Cited by 15
Interactions between the intestinal microbiota and epigenome in individuals with autism spectrum disorder
Kushak, R. I., Sengupta, A., & Winter, H. S. (2021) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.15052 · Cited by 16
Microbiome function and neurodevelopment in Black infants: vitamin B 12 emerges as a key factor
Oliphant, K., Ayala, W. C., Ilyumzhinova, R., Mbayiwa, K., Sroka, A. W., Xie, B., Andrews, B., Keenan, K. E., & Claud, E. C. (2024) · Gut Microbes · doi:10.1080/19490976.2023.2298697 · Cited by 14
Gut Microbiome and Autism: Recent Advances and Future Perspectives
Liu, J., Zhang, M., & Kong, X. (2016) · North American Journal of Medicine and Science · Cited by 14
A Simple and Convenient Synthesis of Unlabeled and 13C-Labeled 3-(3-Hydroxyphenyl)-3-Hydroxypropionic Acid and Its Quantification in Human Urine Samples
Khaniani, Y., Lipfert, M., Bhattacharyya, D., Pérez, R., Zheng, J., & Wishart, D. S. (2018) · Metabolites · doi:10.3390/metabo8040080 · Cited by 14
Gut Microorganisms and Neurological Disease Perspectives
Faruqui, N. A., Prium, D. H., Mowna, S. A., Ullah, M. A., Araf, Y., Sarkar, B., Zohora, U. S., & Rahman, M. S. (2021) · Future Neurology · doi:10.2217/fnl-2020-0026 · Cited by 15
The phenolic interactome and gut microbiota: opportunities and challenges in developing applications for schizophrenia and autism
Jaskiw, G. E., Obrenovich, M. E., & Donskey, C. J. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05267-3 · Cited by 13
Exploring environmental exposomes and the gut-brain nexus: Unveiling the impact of pesticide exposure
Khoo, S. C., Zhang, N., Luang‐In, V., Goh, M. S., Sonne, C., & Ling, N. (2024) · Environmental Research · doi:10.1016/j.envres.2024.118441 · Cited by 13
FMT intervention decreases urine 5-HIAA levels: a randomized double-blind controlled study
Wang, L., Yu, L., Liu, Z., Che, C., Wang, Y., Zhao, Y., Zhu, M., Yang, G., & Cao, A. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1411089 · Cited by 13
IUPHAR review: Targeted therapies of signaling pathways based on the gut microbiome in autism spectrum disorders: Mechanistic and therapeutic applications
Mamun, A. A., Geng, P., Wang, S., Shao, C., & Xiao, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107559 · Cited by 15
Intestinal microbiota, metabolome and gender dimorphism in autism spectrum disorders
Kushak, R. I., & Winter, H. S. (2018) · Research in Autism · doi:10.1016/j.rasd.2018.01.009 · Cited by 15
The Endocannabinoids-Microbiota Partnership in Gut-Brain Axis Homeostasis: Implications for Autism Spectrum Disorders
Coccurello, R., Marrone, M. C., & Maccarrone, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.869606 · Cited by 12

Authors: Shaw, W.
Corresponding author: Shaw, William
Venue: Nutritional Neuroscience
Publisher: Informa UK Limited
Published: 2010-06
Volume: 13
Issue: 3
Pages: 135-143
ISSN: 1028-415X (ISSN-L)
1476-8305
DOI: 10.1179/147683010x12611460763968
OpenAlex: W2016430945
Cited by: 162
References: 41
Citations by year: 2026: 7 · 2025: 9 · 2024: 11 · 2023: 8 · 2022: 12 · 2021: 17 · 2020: 15 · 2019: 18 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 8 · 2013: 6 · 2012: 3
FWCI: 1.83
Type: journal article
Language: en
Open access: closed
Locations: Nutritional Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: urinary biomarkers, autism spectrum disorder, schizophrenia, Clostridium, Clostridium difficile infection, m-tyrosine, phenylalanine metabolism, vancomycin, anaerobic gut bacteria, catecholamine depletion
MeSH terms: Acute Disease, Adolescent, Adult, Autistic Disorder, Child, Child, Preschool, Clostridium, Clostridium Infections, Enterocolitis, Pseudomembranous, Female, Humans, Male, Middle Aged, Phenylalanine, Phenylpropionates, Schizophrenia, Sex Characteristics, Vancomycin, Clostridioides difficile, Gastrointestinal Tract, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks