Clonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

James, C., Ugo, V., Couedic, J. P. L., Staerk, J., Delhommeau, F., Lacout, C., Garçon, L., Raslová, H., Berger, R., Griscelli, A. B., et al. (2005) · Nature · doi:10.1038/nature03546 · Cited by 3,542

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531

A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders

Kralovics, R., Passamonti, F., Buser, A. S., Teo, S.-S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., & Skoda, R. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051113 · Cited by 3,470

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J. P., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.03.023 · Cited by 2,993

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Ito, S., D’Alessio, A. C., Taranova, O., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,628

Mutation in TET2 in Myeloid Cancers

Delhommeau, F., Dupont, S., Valle, V. D., James, C., Trannoy, S., Massé, A., Kosmider, O., Le Couedic, J.-P., Robert, F., Alberdi, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810069 · Cited by 1,776

High burden and pervasive positive selection of somatic mutations in normal human skin

Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770

The origin and evolution of mutations in acute myeloid leukemia

Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575

IFNα activates dormant haematopoietic stem cells in vivo

Essers, M. A. G., Offner, S., Blanco-Bose, W. E., Waibler, Z., Kalinke, U., Duchosal, M. A., & Trumpp, A. (2009) · Nature · doi:10.1038/nature07815 · Cited by 1,368

Dnmt3a is essential for hematopoietic stem cell differentiation

Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics · doi:10.1038/ng.1009 · Cited by 1,122

Somatic mutant clones colonize the human esophagus with age

Martincorena, I., Fowler, J. C., Wabik, A., Lawson, A. R. J., Abascal, F., Hall, M. W. J., Cagan, A., Murai, K., Mahbubani, K., Stratton, M. R., et al. (2018) · Science · doi:10.1126/science.aau3879 · Cited by 1,113

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

Wong, T. N., Ramsingh, G., Young, A. L., Miller, C. A., Touma, W., Welch, J. S., Lamprecht, T. L., Shen, D., Hundal, J., Fulton, R. S., et al. (2015) · Nature · doi:10.1038/nature13968 · Cited by 892

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

Baldridge, M. T., King, K. Y., Boles, N. C., Weksberg, D. C., & Goodell, M. A. (2010) · Nature · doi:10.1038/nature09135 · Cited by 877

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807

Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b

Chen, T., Ueda, Y., Dodge, J. E., Wang, Z., & Li, E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5594-5605.2003 · Cited by 751

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

Abdel-Wahab, O., Mullally, A., Hedvat, C., Garcia-Manero, G., Patel, J., Wadleigh, M., Malinge, S., Yao, J., Kilpivaara, O., Bhat, R., et al. (2009) · Blood · doi:10.1182/blood-2009-03-210039 · Cited by 727

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Young, A. L., Challen, G. A., Birmann, B. M., & Druley, T. E. (2016) · Nature Communications · doi:10.1038/ncomms12484 · Cited by 692

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

Li, Z., Cai, X., Cai, C.-L., Wang, J., Zhang, W., Petersen, B. E., Yang, F.-C., & Xu, M. (2011) · Blood · doi:10.1182/blood-2010-12-325241 · Cited by 671

Population dynamics of normal human blood inferred from somatic mutations

Lee-Six, H., Øbro, N. F., Shepherd, M. S., Grossmann, S., Dawson, K., Belmonte, M., Osborne, R. J., Huntly, B. J. P., Martincorena, I., Anderson, E., et al. (2018) · Nature · doi:10.1038/s41586-018-0497-0 · Cited by 604

DNMT3A in haematological malignancies

Yang, L., Rau, R. E., & Goodell, M. A. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3895 · Cited by 525

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

Weinberg, D. N., Papillon-Cavanagh, S., Chen, H., Yue, Y., Chen, X., Rajagopalan, K. N., Horth, C., McGuire, J. T., Xu, X., Nikbakht, H., et al. (2019) · Nature · doi:10.1038/s41586-019-1534-3 · Cited by 524

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

Yizhak, K., Aguet, F., Kim, J., Hess, J. M., Kübler, K., Grimsby, J., Frazer, R., Zhang, H., Haradhvala, N. J., Rosebrock, D., et al. (2019) · Science · doi:10.1126/science.aaw0726 · Cited by 500

TET2 and DNMT3A Mutations in Human T-Cell Lymphoma

Couronné, L., Bastard, C., & Bernard, O. (2012) · New England Journal of Medicine · doi:10.1056/nejmc1111708 · Cited by 494

The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

Russler-Germain, D. A., Spencer, D. H., Young, M. A., Lamprecht, T. L., Miller, C. A., Fulton, R., Meyer, M. R., Erdmann-Gilmore, P., Townsend, R. R., Wilson, R. K., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.02.010 · Cited by 452

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

Bowman, R. L., Busque, L., & Levine, R. L. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.01.011 · Cited by 448

The evolutionary dynamics and fitness landscape of clonal hematopoiesis

Watson, C. J., Papula, A. L., Poon, G. Y. P., Wong, W. H., Young, A. L., Druley, T. E., Fisher, D. S., & Blundell, J. R. (2020) · Science · doi:10.1126/science.aay9333 · Cited by 444

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

Boettcher, S., Miller, P. G., Sharma, R., McConkey, M., Leventhal, M., Krivtsov, A. V., Giacomelli, A. O., Wong, W., Kim, J., Chao, S., et al. (2019) · Science · doi:10.1126/science.aax3649 · Cited by 441

A targeted mutational landscape of angioimmunoblastic T-cell lymphoma

Odejide, O. O., Weigert, O., Lane, A. A., Toscano, D. T., Lunning, M. A., Kopp, N., Kim, S. S., van Bodegom, D., Bolla, S., Schatz, J. H., et al. (2013) · Blood · doi:10.1182/blood-2013-10-531509 · Cited by 435

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

Hsu, J. I., Dayaram, T., Tovy, A., De Braekeleer, E., Jeong, M., Wang, F., Zhang, J., Heffernan, T. P., Gera, S., Kovacs, J. J., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.10.004 · Cited by 425

Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis

Bick, A. G., Pirruccello, J. P., Griffin, G. K., Gupta, N., Gabriel, S., Saleheen, D., Libby, P., Kathiresan, S., & Natarajan, P. (2019) · Circulation · doi:10.1161/circulationaha.119.044362 · Cited by 422

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

Meisel, M., Hinterleitner, R., Pacis, A., Chen, L., Earley, Z. M., Mayassi, T., Pierre, J. F., Ernest, J. D., Galipeau, H. J., Thuille, N., et al. (2018) · Nature · doi:10.1038/s41586-018-0125-z · Cited by 406

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

Cai, Z., Kotzin, J. J., Ramdas, B., Chen, S., Nelanuthala, S., Palam, L. R., Pandey, R., Mali, R. S., Liu, Y., Kelley, M. R., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.10.013 · Cited by 394

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

Buscarlet, M., Provost, S., Zada, Y. F., Barhdadi, A., Bourgoin, V., Lépine, G., Mollica, L., Szuber, N., Dubé, M.-P., & Busque, L. (2017) · Blood · doi:10.1182/blood-2017-04-777029 · Cited by 383

Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells

Challen, G. A., Sun, D., Mayle, A., Jeong, M., Luo, M., Rodriguez, B., Mallaney, C., Celik, H., Yang, L., Xia, Z., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.018 · Cited by 354

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

Bondar, T., & Medzhitov, R. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.03.002 · Cited by 342

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

Abdel-Wahab, O. I., Gao, J., Adli, M., Dey, A., Trimarchi, T., Chung, Y. R., Kuscu, C., Hricik, T., Ndiaye‐Lobry, D., LaFave, L. M., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131141 · Cited by 335

Large conserved domains of low DNA methylation maintained by Dnmt3a

Jeong, M., Sun, D., Luo, M., Huang, Y., Challen, G. A., Rodriguez, B., Zhang, X., Chavez, L., Wang, H., Hannah, R., et al. (2014) · Nature Genetics · doi:10.1038/ng.2836 · Cited by 324

Single-cell, genome-wide sequencing identifies clonal somatic copy-number variation in the human brain

Cai, X., Evrony, G. D., Lehmann, H. S., Elhosary, P. C., Mehta, B. K., Poduri, A., & Walsh, C. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.043 · Cited by 318

Tet2 restrains inflammatory gene expression in macrophages

Cull, A. H., Snetsinger, B., Buckstein, R., Wells, R. A., & Rauh, M. J. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.08.001 · Cited by 295

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

Shirai, C. L., Ley, J. N., White, B. S., Kim, S., Tibbitts, J., Shao, J., Ndonwi, M., Wadugu, B., Duncavage, E. J., Okeyo-Owuor, T., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.008 · Cited by 287

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

Rasmussen, K. D., Jia, G., Johansen, J. V., Pedersen, M. T., Rapin, N., Bagger, F. O., Porse, B. T., Bernard, O. A., Christensen, J., & Helin, K. (2015) · Genes & Development · doi:10.1101/gad.260174.115 · Cited by 270

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

for the International Working Group for MDS Molecular Prognostic Committee, Haase, D., Stevenson, K. E., Neuberg, D., Maciejewski, J. P., Nazha, A., Sekeres, M. A., Ebert, B. L., Garcia-Manero, G., Haferlach, C., et al. (2019) · Leukemia · doi:10.1038/s41375-018-0351-2 · Cited by 259

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

Zhang, X., Su, J., Jeong, M., Ko, M., Huang, Y., Park, H. J., Guzman, A., Lei, Y., Huang, Y.-H., Rao, A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3610 · Cited by 258

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

Guryanova, O. A., Shank, K., Spitzer, B., Luciani, L., Koche, R. P., Garrett-Bakelman, F. E., Ganzel, C., Durham, B. H., Mohanty, A., Hoermann, G., et al. (2016) · Nature Medicine · doi:10.1038/nm.4210 · Cited by 256

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

Dumble, M. L., Moore, L. M., Chambers, S. M., Geiger, H., Zant, G. E. V., Goodell, M. A., & Donehower, L. A. (2006) · Blood · doi:10.1182/blood-2006-03-010413 · Cited by 249

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

Jeong, M., Park, H. J., Celik, H., Ostrander, E. L., Reyes, J. M., Guzman, A., Rodriguez, B., Lei, Y., Lee, Y., Ding, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.025 · Cited by 243

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

Mayle, A., Yang, L., Rodriguez, B., Zhou, T., Chang, E., Curry, C. V., Challen, G. A., Li, W., Wheeler, D., Rebel, V. I., et al. (2015) · Blood · doi:10.1182/blood-2014-08-594648 · Cited by 235

PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

Kahn, J. D., Miller, P. G., Silver, A. J., Sellar, R. S., Bhatt, S., Gibson, C., McConkey, M., Adams, D., Mar, B., Mertins, P., et al. (2018) · Blood · doi:10.1182/blood-2018-05-850339 · Cited by 225

Role of donor clonal hematopoiesis in allogeneic hematopoietic stem-cell transplantation

Frick, M., Chan, W., Arends, C. M., Hablesreiter, R., Halik, A., Heuser, M., Michonneau, D., Blau, O., Hoyer, K., Christen, F., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.2018.79.2184 · Cited by 223

CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression

Spencer, D. H., Russler-Germain, D. A., Ketkar, S., Helton, N. M., Lamprecht, T. L., Fulton, R. S., Fronick, C. C., O’Laughlin, M., Heath, S. E., Shinawi, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.01.021 · Cited by 219

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

Lee, S. C.-W., North, K., Kim, E., Jang, E., Obeng, E., Lu, S. X., Liu, B., Inoue, D., Yoshimi, A., Ki, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.07.003 · Cited by 219

Cordua S, Kjaer L, Skov V, Pallisgaard N, Hasselbalch HC, Ellervik C. Prevalence and phenotypes of JAK2 V617F and calreticulin mutations in a Danish general population. Blood. 2019;134(5):469-479.

Cordua, S., Kjær, L., Skov, V., Pallisgaard, N., Hasselbalch, H. C., & Ellervik, C. (2019) · Blood · doi:10.1182/blood.2019001113 · Cited by 216

Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice

Rossi, L., Lin, K. K., Boles, N. C., Yang, L., King, K. Y., Jeong, M., Mayle, A., & Goodell, M. A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.08.006 · Cited by 205

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

Wong, T. N., Miller, C. A., Jotte, M. R. M., Bagegni, N. A., Baty, J., Schmidt, A. P., Cashen, A. F., Duncavage, E. J., Helton, N., Fiala, M. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02858-0 · Cited by 201

Clonal hematopoiesis and non-hematologic disorders

Jaiswal, S. (2020) · Blood · doi:10.1182/blood.2019000989 · Cited by 182

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

Kim, S. J., Zhao, H., Hardikar, S., Singh, A. K., Goodell, M. A., & Chen, T. (2013) · Blood · doi:10.1182/blood-2013-02-483487 · Cited by 180

JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα

Hasan, S., Lacout, C., Marty, C., Cuingnet, M., Solary, É., Vainchenker, W., & Villeval, J. (2013) · Blood · doi:10.1182/blood-2013-04-498956 · Cited by 173

Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation

Viny, A. D., Bowman, R. L., Liu, Y., Lavallée, V., Eisman, S. E., Xiao, W., Durham, B. H., Navitski, A., Park, J., Braunstein, S., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.08.003 · Cited by 172

DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias

Yang, L., Rodriguez, B. A. T., Mayle, A., Park, H. J., Lin, X., Luo, M., Jeong, M., Curry, C. V., Kim, S.-B., Ruau, D., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.003 · Cited by 165

DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells

Gu, T., Lin, X., Cullen, S. M., Luo, M., Jeong, M., Estecio, M. R., Shen, J., Hardikar, S., Sun, D., Su, J., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1464-7 · Cited by 163

Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients

Zhang, C. R. C., Nix, D., Gregory, M., Ciorba, M. A., Ostrander, E. L., Newberry, R. D., Spencer, D. H., & Challen, G. A. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.11.008 · Cited by 137

Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis

Loberg, M. A., Bell, R. K., Goodwin, L. O., Eudy, E., Miles, L. A., SanMiguel, J. M., Young, K. A., Bergstrom, D. E., Levine, R. L., Schneider, R. K., et al. (2019) · Leukemia · doi:10.1038/s41375-018-0368-6 · Cited by 134

Isoform‐specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands

Manzo, M., Wirz, J., Ambrosi, C. M., Villaseñor, R., Roschitzki, B., & Baubec, T. (2017) · The EMBO Journal · doi:10.15252/embj.201797038 · Cited by 128

The aging gut microbiota: New perspectives

Biagi, E., Candela, M., Franceschi, C., & Brigidi, P. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.03.004 · Cited by 118

Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML

Wong, T. N., Miller, C. A., Klco, J. M., Petti, A. A., Demeter, R., Helton, N., Li, T., Fulton, R. S., Heath, S. E., Mardis, E. R., et al. (2015) · Blood · doi:10.1182/blood-2015-10-677021 · Cited by 108

DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells

Xu, J., Wang, Y., Dai, Y., Zhang, W., Zhang, W.-N., Xiong, S.-M., Gu, Z., Wang, K., Zeng, R., Zhu, C. H., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400150111 · Cited by 104

DNMT3A Haploinsufficiency Transforms FLT3 ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia

Meyer, S. E., Qin, T., Muench, D. E., Masuda, K., Venkatasubramanian, M., Orr, E., Suarez, L., Gore, S. D., Delwel, R., Paietta, E. M., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0008 · Cited by 101

Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis

Madžo, J., Liu, H., Rodriguez, A., Vasanthakumar, A., Sundaravel, S., Caces, D. B., Looney, T. J., Zhang, L., Lepore, J. B., Macrae, T. A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.11.044 · Cited by 99

Clonal hematopoiesis and risk for hematologic malignancy

Warren, J. T., & Link, D. C. (2020) · Blood · doi:10.1182/blood.2019000991 · Cited by 98

Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness

Ostrander, E. L., Kramer, A. C., Mallaney, C., Celik, H., Koh, W. K., Fairchild, J., Haussler, E., Zhang, C. R., & Challen, G. A. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.02.011 · Cited by 97

Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity

Zhang, X., Jeong, M., Huang, X., Wang, X. Q. D., Wang, X., Zhou, W., Shamim, M. S., Gore, H., Himadewi, P., Liu, Y., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.018 · Cited by 95

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

Celik, H., Mallaney, C., Kothari, A., Ostrander, E. L., Eultgen, E., Martens, A., Miller, C. A., Hundal, J., Klco, J. M., & Challen, G. A. (2015) · Blood · doi:10.1182/blood-2014-08-594564 · Cited by 95

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Sowers, L. C., Ito, S., Taranova, O., Hong, K., D’Alessio, A. C., & Zhang, Y. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/mdef-cm08 · Cited by 95

Self-Renewal of Single Mouse Hematopoietic Stem Cells Is Reduced by JAK2V617F Without Compromising Progenitor Cell Expansion

Kent, D. G., Li, J., Tanna, H., Fink, J., Kirschner, K., Pask, D. C., Silber, Y., Hamilton, T. L., Sneade, R., Simons, B. D., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001576 · Cited by 87

Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera.

Mullally, A., Poveromo, L., Schneider, R., Al-Shahrour, F., Lane, S., & Ebert, B. (2012) · Blood · doi:10.1182/blood-2012-01-402396 · Cited by 80

Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation

Boettcher, S., Wilk, C. M., Singer, J., Beier, F., Burcklen, E., Beisel, C., Ferreira, M. S. V., Gourri, E., Gassner, C., Frey, B. M., et al. (2020) · Blood · doi:10.1182/blood.2019003079 · Cited by 80

Environmental influences on clonal hematopoiesis

King, K. Y., Huang, Y., Nakada, D., & Goodell, M. A. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.12.005 · Cited by 75

Clonal hematopoiesis in the inherited bone marrow failure syndromes

Tsai, F. D., & Lindsley, R. C. (2020) · Blood · doi:10.1182/blood.2019000990 · Cited by 69

Dnmt3a Is Essential for Hematopoietic Stem Cell Differentiation

Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelı́nek, J., Vasanthakumar, A., Meissner, A., Issa, J. J., Godley, L. A., Li, W., et al. (2011) · Blood · doi:10.1182/blood.v118.21.386.386 · Cited by 56

The kinetics of clonal dominance in myeloproliferative disorders

Catlin, S. N., Guttorp, P. M., & Abkowitz, J. L. (2005) · Blood · doi:10.1182/blood-2005-03-1240 · Cited by 54

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

Boettcher, S., Miller, P. G., Sharma, R., McConkey, M., Leventhal, M. J., Krivtsov, A. V., Giacomelli, A. O., Wong, W. J., Kim, J., Chao, S. X., et al. (2019) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-239025 · Cited by 53

Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation

Wong, W., Bhatt, S. T., Trinkaus, K. M., Pusic, I., Elliott, K., Mahajan, N., Wan, F., Switzer, G. E., Confer, D. L., DiPersio, J. F., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax6249 · Cited by 52

New insights into the biology of acute myeloid leukemia with mutated NPM1

Brunetti, L., Gundry, M. C., & Goodell, M. A. (2019) · International Journal of Hematology · doi:10.1007/s12185-018-02578-7 · Cited by 48

What To Tell Your Patient With Clonal Hematopoiesis And Why: Insights From Two Specialized Clinics

Steensma, D. P., & Bolton, K. L. (2020) · Blood · doi:10.1182/blood.2019004291 · Cited by 45

Single-cell, genome-wide sequencing identifies clonal somatic copy-number variation in the human brain

Cai, X., Evrony, G. D., Lehmann, H. S., Elhosary, P. C., Mehta, B. K., Poduri, A., & Walsh, C. A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.028 · Cited by 42

TET2 and DNMT3A Mutations in Human T-Cell Lymphoma

Daignault, S. D., & Bk, H. (2012) · Cited by 29

Visualizing hematopoiesis as a stochastic process

Xu, J., Wang, Y., Guttorp, P. M., & Abkowitz, J. L. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018023705 · Cited by 17

Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain

Tagad, H. D., Debnath, S., Clausse, V., Saha, M., Mazur, S. J., Appella, E., & Appella, D. H. (2018) · ChemMedChem · doi:10.1002/cmdc.201700779 · Cited by 10

Enforced Differentiation of Dnmt3a-Null Bone Marrow Leads to Failure with c-Kit Mutations Driving Leukemic Transformation

Celik, H., Mallaney, C., Kothari, A., Miller, C. A., Hundal, J., Klco, J. M., & Challen, G. A. (2014) · Blood · doi:10.1182/blood.v124.21.837.837 · Cited by 4

Ageing and rejuvenation of tissue stem cells and their niches

Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407

Non-relapse mortality after CAR T-cell therapy: A systematic review and meta-analysis of 7,604 lymphoma and myeloma patients

dos Santos, D. M. C., Tix, T., Shouval, R., Gafter-Gvili, A., Alberge, J.-B., Cliff, E. R. S., Theurich, S., von Bergwelt-Baildon, M., Ghobrial, I., Subklewe, M., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03084-6 · Cited by 266

Leukemic stem cells and therapy resistance in acute myeloid leukemia

Stelmach, P., & Trumpp, A. (2023) · Haematologica · doi:10.3324/haematol.2022.280800 · Cited by 273

Somatic Mutations in “Benign” Disease

Mustjoki, S. M., & Young, N. S. (2021) · New England Journal of Medicine · doi:10.1056/nejmra2101920 · Cited by 169

Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

Robertson, N. A., Latorre-Crespo, E., Terradas-Terradas, M., Lemos-Portela, J., Purcell, A. C., Livesey, B. J., Hillary, R. F., Murphy, L., Fawkes, A., MacGillivray, L., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01883-3 · Cited by 132

Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and agingPreprint

Jakobsen, N. A., Turkalj, S., Zeng, A. G. X., Stoilova, B., Metzner, M., Nagree, M. S., Shah, S., Moore, R., Usukhbayar, B., Salazar, M. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.12.557322 · Cited by 11

Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging

Jakobsen, N. A., Turkalj, S., Zeng, A. G. X., Stoilova, B., Metzner, M., Rahmig, S., Nagree, M. S., Shah, S., Moore, R., Usukhbayar, B., et al. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.05.010 · Cited by 130

Advances in understanding the molecular basis of clonal hematopoiesis

Alagpulinsa, D. A., Toribio, M. P., Alhallak, I., & Reis, R. J. S. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.03.002 · Cited by 11

[Aging and clonal hematopoesis.]

Bogdanov, A. N., Волошин, С. В., Куневич, Е. О., & Mikhaleva, M. A. (2024) · PubMed

CHIP: is clonal hematopoiesis a surrogate for aging and other disease?

Gondek, L. P. (2021) · Hematology · doi:10.1182/hematology.2021000270 · Cited by 21