The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study
Open accessAbstract
BACKGROUND: Fruits and vegetables are important sources of fiber and nutrients with a recognized antioxidant capacity, which could have beneficial effects on the proinflammatory status as well as some metabolic syndrome and cardiovascular disease features. The current study assessed the potential relationships of fruit and vegetable consumption with the plasma concentrations and mRNA expression values of some proinflammatory markers in young adults. METHODS: One-hundred and twenty healthy subjects (50 men/70 women; 20.8 +/- 2.6 y; 22.3 +/- 2.8 kg/m2) were enrolled. Experimental determinations included anthropometry, blood pressure and lifestyle features as well as blood biochemical and inflammatory measurements. The mRNA was isolated from peripheral blood mononuclear cells (PBMC) and the gene expression concerning selected inflammatory markers was assessed by quantitative real-time PCR. Nutritional intakes were estimated by a validated semi-quantitative food-frequency questionnaire. RESULTS: The highest tertile of energy-adjusted fruit and vegetable consumption (>660 g/d) was associated with lower plasma concentrations of C-reactive protein (CRP) and homocysteine and with lower ICAM1, IL1R1, IL6, TNFalpha and NFkappaB1 gene expression in PBMC (P for trend < 0.05), independently of gender, age, energy intake, physical activity, smoking, body mass index, systolic blood pressure and circulating non-esterified fatty acids. In addition, plasma CRP, homocysteine and TNFalpha concentrations and ICAM1, TNFalpha and NFkappaB1 gene expression in PBMC showed a descending trend as increased fiber intake (>19.5 g/d) from fruits and vegetables (P for trend < 0.05). Furthermore, the participants within the higher tertile (>11.8 mmol/d) of dietary total antioxidant capacity showed lower plasma CRP and mRNA values of ICAM1, IL1R1, IL6, TNFalpha and NFkappaB1 genes (P for trend < 0.05). The inverse association between fruit and vegetable consumption and study proinflammatory markers followed the same trend and remained statistically significant, after the inclusion of other foods/nutrients in the linear regression models. CONCLUSION: A higher fruit and vegetable consumption was independently associated not only with reduced CRP and homocysteine concentrations but also with a lower mRNA expression in PBMC of some relevant proinflammatory markers in healthy young adults.
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“This was first identified by Grimble et al. (649) who showed that the ability of fish oil to lower the LPS-stimulated production of TNF-a by blood mononuclear cells was determined in part by polymorphisms within the TNF-a and TNF-b genes.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [649]
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“Discussion A high intake of fruits and vegetables has been inversely associated with metabolic syndrome features [5,6], cardiovascular diseases [31,32], and total mortality [33], while greater values of proinflammatory markers such Figure 1 Ratios of protein levels of selected proinflammatory markers, calculated from…”
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ResultReproducibility of an FFQ validated in Spain
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Association between dietary fiber and serum C-reactive protein
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“Discussion A high intake of fruits and vegetables has been inversely associated with metabolic syndrome features [5,6], cardiovascular diseases [31,32], and total mortality [33], while greater values of proinflammatory markers such Figure 1 Ratios of protein levels of selected proinflammatory markers, calculated from…”
BackgroundRuiz, P. A., Braune, A., Hölzlwimmer, G., Quintanilla-Fend, L., & Haller, D. (2007) · Journal of Nutrition · doi:10.1093/jn/137.5.1208 · Cited by 281 · cited 1×
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“Furthermore, fruits and vegetables contain several flavonoids and carotenoids with recognized antioxidant properties, which may play a role in the inverse relationship between intake of fruits and vegetables and inflammatory status [9,38,47].”
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“Discussion A high intake of fruits and vegetables has been inversely associated with metabolic syndrome features [5,6], cardiovascular diseases [31,32], and total mortality [33], while greater values of proinflammatory markers such Figure 1 Ratios of protein levels of selected proinflammatory markers, calculated from…”
BackgroundSánchez-Villegas, A., Delgado-Rodríguez, M., Martínez-González, M. A., & de Irala-Estévez, J. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601528 · Cited by 220 · cited 8×
“Martínez-González MA, López-Fontana C, Varo JJ, Sánchez-Villegas A, Martínez JA: Validation of the Spanish version of the physical activity questionnaire used in the Nurses' Health Study and the Health Professionals' Follow-up Study.”
MethodInfluentialWatzl, B., Kulling, S. E., Möseneder, J., Barth, S. W., & Bub, A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.1052 · Cited by 220 · cited 2×
“Thus, the intake of fruits and vegetables has been related to marked reductions in proinflammatory and oxidative stress markers [9-12].”
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“In fact, several in vitro studies have evidenced an anti-inflammatory effect of flavonoids and carotenoids, by an inhibition of NFκB activity, through suppressing the activation-related phosphorylation, and inhibiting the nuclear translocation [ 48-50 ].”
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MethodWorld Health Organisation–International Society of Hypertension (WHO/ISH) Hypertension Guidelines
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“Furthermore dietary total antioxidant capacity (TAC), expressed as mmol/d, was calculated by a proxy previously validated to this food-frequency questionnaire [20].”
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“In turn, fruits and vegetables contain components such as plant proteins, potassium, magnesium, fiber, and others compounds with antioxidant capacity, whose consumption may reduce the risk of suffering metabolic syndrome manifestations [5-8].”
BackgroundAlonso, Á., de la Fuente, C., Martin-Arnau, A., de Irala, J., Martínez, J. A., & Martínez‐González, M. Á. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041196 · Cited by 152 · cited 3×
“These results are in accordance with findings obtained in the SUN Study [5,51] and in The Dietary Approaches to Stop Hypertension (DASH) trial [52,53].”
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TABLA DE COMPOSICIÓN DE ALIMENTOS
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Inflammation meets oxidation: NF-κB as a mediator of initial lesion development in atherosclerosis
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“Thus, the intake of fruits and vegetables has been related to marked reductions in proinflammatory and oxidative stress markers [9-12].”
BackgroundHelmersson, J., Ärnlöv, J., Larsson, A. O., & Basu, S. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508147377 · Cited by 112
[Inflammatory biomarkers: the link between obesity and associated pathologies].
Zulet, M. Á., Puchau, B., Navarro, C., Martí, A., & Martínez, J. A. (2007) · PubMed · Cited by 106
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“In this context, the potential relationships between specific dietary factors and proinflammatory markers are being currently investigated [19-21,34].”
BackgroundCrujeiras, A. B., Parra, M. D., Rodríguez, M. C., de Morentin, B. E. M., & Martínez, J. A. (2006) · Nutrition · doi:10.1016/j.nut.2006.03.008 · Cited by 90 · cited 3×
“Fruits and vegetables also are important sources of dietary fiber, which appears to have an anti-inflammatory role [10,41].”
BackgroundDifferences in reported winter and summer dietary intakes in young adults in Spain
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“These results are consistent with some earlier cross-sectional studies carried out on children and adolescents [38,39] as well as middle-age adults [7,40].”
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“Thus, the intake of fruits and vegetables has been related to marked reductions in proinflammatory and oxidative stress markers [9-12].”
BackgroundZulet, M. Á., Puchau, B., Hermsdorff, H. H. M., Navarro, C., & Martínez, J. A. (2009) · Nutrition Research · doi:10.1016/j.nutres.2008.11.003 · Cited by 57 · cited 3×
“In this context, the potential relationships between specific dietary factors and proinflammatory markers are being currently investigated [19-21,34].”
BackgroundMethodHermsdorff, H. H. M., Puchau, B., Zulet, M. Á., & Martínez, J. A. (2010) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2009.0125 · Cited by 48 · cited 1×
“In turn, it has been also reported a positive association of proinflammatory marker concentrations and gene expression in PBMC with body fat distribution [54] in healthy young adults.”
BackgroundHermsdorff, H. H. M., Zulet, M. Á., Puchau, B., Bressan, J., & Martínez, J. A. (2008) · Nutrition · doi:10.1016/j.nut.2008.09.015 · Cited by 47 · cited 4×
“In this context, the potential relationships between specific dietary factors and proinflammatory markers are being currently investigated [19-21,34].”
BackgroundMethodInfluentialMilagro, F. I., Campión, J., & Martínez, J. A. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.10.006 · Cited by 46 · cited 1×
“Gene expression levels were assessed and normalized by using 18s rRNA as internal control following previously described protocols [26,27].”
MethodBressan, J., Hermsdorff, H. H. M., Zulet, M. Á., & Martínez, J. A. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000500010 · Cited by 45 · cited 2×
“Fruits and vegetables also are important sources of dietary fiber, which appears to have an anti-inflammatory role [10,41].”
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“In this context, nutrigenomic approaches have been performed as a potential useful tool to increase fundamental knowledge concerning the interactions between diet and gene expression [13, 14 ].”
BackgroundMethodStea, T. H., Mansoor, M. A., Wandel, M., Uglem, S., & Frølich, W. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0714-y · Cited by 41 · cited 1×
“For example, the intake of folate, vitamin C, and magnesium, for those fruits and vegetables have relevant content, have been associated with lower homocysteine, CRP, IL6 and E-selectin concentrations [42-44].”
BackgroundA cross-sectional study of food group intake and C-reactive protein among children
Qureshi, M. M., Singer, M. R., & Moore, L. L. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-40 · Cited by 36 · cited 1×
“These results are consistent with some earlier cross-sectional studies carried out on children and adolescents [38,39] as well as middle-age adults [7,40].”
ResultOccurrence of the Vibrio cholerae Seventh Pandemic VSP-I Island and a New Variant
Grim, C. J., Choi, J., Chun, J., Jeon, Y.-S., Taviani, E., Hasan, N. A., Haley, B. J., Huq, A., & Colwell, R. R. (2010) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2009.0087 · Cited by 35
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“In turn, fruits and vegetables contain components such as plant proteins, potassium, magnesium, fiber, and others compounds with antioxidant capacity, whose consumption may reduce the risk of suffering metabolic syndrome manifestations [5-8].”
BackgroundPuchau, B., Hermsdorff, H. H. M., Zulet, M. Á., & Martínez, J. A. (2009) · Disease Markers · doi:10.1155/2009/978157 · Cited by 12
Puchau, B., Hermsdorff, H. H. M., Zulet, M. Á., et al. (2009) · PubMed · doi:10.3233/dma-2009-0650 · Cited by 9
Self-citation
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Cited by
Sorted by citations
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
“A recent study reported that a high intake of vegetables and fruits was associated with a lower peripheral blood mononuclear cell gene expression for several pro-inflammatory cytokines and adhesion molecules((326)).”
Shivappa, N., Steck, S. E., Hurley, T. G., Hussey, J. R., Ma, Y., Ockene, I. S., Tabung, F. K., & Hébert, J. R. (2013) · Public Health Nutrition · doi:10.1017/s1368980013002565 · Cited by 724
“In addition, CRP and inflammatory cytokines such as IL-6 and TNF-a are increased among obese individuals, positively correlated with BMI, and central adiposity has been shown to be associated with increased inflammation(7).”
BackgroundAge-associated chronic diseases require age-old medicine: Role of chronic inflammation
Prasad, S., Sung, B., & Aggarwal, B. B. (2011) · Preventive Medicine · doi:10.1016/j.ypmed.2011.11.011 · Cited by 317
“Fruits and vegetables have been shown to suppress CVD biomarkers, including CRP, in in vitro models (Hermsdorff et al., 2010), animals (Rein et al., 2006), and humans (Franzini et al., 2010).”
BackgroundRuiz‐Canela, M., Zazpe, I., Shivappa, N., Hébert, J. R., Sánchez‐Tainta, A., Corella, D., Salas‐Salvadó, J., Fitó, M., Lamuela-Raventós, R. M., Rekondo, J., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514004401 · Cited by 285
Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trial
Martínez‐Lapiscina, E. H., Clavero, P., Toledo, E., Julian, B. S., Sánchez‐Tainta, A., Corella, D., Lamuela-Raventós, R. M., Martínez, J. A., & Martínez‐González, M. Á. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0027-6 · Cited by 267
Metadata
- Authors
- Hermsdorff, H. H. M., Zulet, M. Á., Puchau, B., & Martínez, J. A.
- Affiliations
- Universidad de Navarra (ES)
- Corresponding author
- Martínez, José Alfredo
- Venue
- Nutrition & Metabolism
- Published
- 2010-05-13
- Volume
- 7
- Issue
- 1
- Pages
- 42-42
- ISSN
- 1743-7075 (ISSN-L)
- PMC
- PMC2882916
- OpenAlex
- W2161028038
- Cited by
- 141
- References
- 58
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 4 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 13 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 13 · 2012: 6
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Nutrition & Metabolism (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Universidad de Navarra (LE/97)
- Gobierno de Navarra
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- fruit and vegetable intake, dietary fiber, pro-inflammatory gene expression, peripheral blood mononuclear cells, C-reactive protein, homocysteine, TNF-α, NFKB1, ICAM-1, IL-1 receptor, interleukin-6, total antioxidant capacity, young adults, inflammation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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