Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 30

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Evolution of the p53-MDM2 pathway

Åberg, Emma, Saccoccia, Fulvio, Grabherr, Manfred, Ore, Wai Ying Josefin, Jemth, Per, Hultqvist, Greta·2017·BMC Evolutionary Biology
DOI 10.1186/s12862-017-1023-y
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/s12862-017-1023-y

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 49

  1. Aktipis CA, Boddy AM, Jansen G, Hibner U, Hochberg ME, Maley CC, et al. Cancer across the tree of life: cooperation and cheating in multicellularity. Philos Trans R Soc Lond B Biol Sci. 2015;370(1673). · DOI · Paper page
  2. Chen J. The cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression. Cold Spring Harb Perspect Med. 2016;6:a026104. · DOI · Paper page
  3. Lane D, Levine A. p53 research : the past thirty years and the next thirty years p53 research : the past thirty years and. Cold Spring Harb Perspect Biol. 2010;2:1–11.
  4. Khoo KH, Hoe KK, Verma CS, Lane DP. Drugging the p53 pathway: understanding the route to clinical efficacy. Nat Rev Drug Discov. 2014;13:217–36. · DOI · Paper page
  5. Belyi VA, Ak P, Markert E, Wang H, Hu W, Puzio-Kuter A, et al. The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol. 2010;2:a001198. · DOI · Paper page
  6. Momand J, Villegas A, Belyi VA. The evolution of MDM2 family genes. Gene. 2011;486:23–30. · DOI · Paper page
  7. Harms KL, Chen X. The functional domains in p53 family proteins exhibit both common and distinct properties. Cell Death Differ. 2006;13:890–7. · DOI
  8. Dötsch V, Bernassola F, Coutandin D, Candi E, Melino G. P63 and P73, the ancestors of P53. Cold Spring Harb Perspect Biol. 2010;2:1–15. · DOI · Paper page
  9. Muttray AF, O’Toole TF, Morrill W, Van Beneden RJ, Baldwin SA. An invertebrate mdm homolog interacts with p53 and is differentially expressed together with p53 and ras in neoplastic Mytilus Trossulus haemocytes. Comp Biochem Physiol B Biochem Mol Biol. 2010;156:298–308. · DOI
  10. Lane DP, Cheok CF, Brown CJ, Madhumalar A, Ghadessy FJ, Verma C. The Mdm2 and p53 genes are conserved in the arachnids. Cell Cycle. 2010;9:748–54. · DOI
  11. Lane DP, Cheok CF, Brown C, Madhumalar A, Ghadessy FJ, Verma C. Mdm2 and p53 are highly conserved from placozoans to man. Cell Cycle. 2010;9:540–7. · DOI
  12. Gomes Dos Santos H, Nunez-Castilla J, Siltberg-Liberles J. Functional Diversification after Gene Duplication: Paralog Specific Regions of Structural Disorder and Phosphorylation in p53, p63, and p73. PLoS One. 2016;11(3):1–27. · DOI
  13. Rutkowski R, Hofmann K, Gartner A. Phylogeny and function of the invertebrate p53 superfamily. Cold Spring Harb Perspect Biol. 2010;2:a001131. · DOI
  14. Pintus SS, Fomin ES, Oshurkov IS, Ivanisenko VA. Phylogenetic analysis of the p53 and p63/p73 gene families. In Silico Biol. 2007;7:319–32.
  15. Belyi VA, Levine AJ. One billion years of p53/p63/p73 evolution. Proc Natl Acad Sci U S A. 2009;106:17609–10. · DOI
  16. Oldfield CJ, Meng J, Yang JY, Yang MQ, Uversky VN, Dunker a K. Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics. 2008;9 Suppl 1:S1. · DOI · Paper page
  17. Nedelcu AM, Tan C. Early diversification and complex evolutionary history of the p53 tumor suppressor gene family. Dev Genes Evol. 2007;217:801–6. · DOI
  18. Sulak M, Fong L, Mika K, Chigurupati S, Yon L, Mongan NP, et al. TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. elife. 2016;5:e11994. · DOI · Paper page
  19. Karakostis K, Ponnuswamy A, Fusée LTS, Bailly X, Laguerre L, Worall E, Vojtesek B, Nylander K, Fåhraeus R. p53 mRNA and p53 protein structures have evolved independently to interact with MDM2; 2015. p. 1–32.
  20. Brown CJ, Johnson AK, Dunker AK, Daughdrill GW. Evolution and disorder. Curr Opin Struct Biol. 2011;21:441–6. · DOI · Paper page
  21. Forman-Kay JD, Mittag T. From sequence and forces to structure, function, and evolution of intrinsically disordered proteins. Structure Elsevier Ltd. 2013;21:1492–9.
  22. Letunic I, Bork P. Interactive tree of life v2: online annotation and display of phylogenetic trees made easy. Nucleic Acids Res. 2011;39:W475–8. · DOI · Paper page
  23. Dehal P, Boore JL. Two rounds of whole genome duplication in the ancestral vertebrate. PLoS Biol. 2005;3:e314. · DOI · Paper page
  24. Mendoza M, Mandani G, Momand J. The MDM2 gene family. Biomol Concepts. 2014;5:9–19. · DOI
  25. Meyer A, Van De Peer Y. From 2R to 3R: evidence for a fish-specific genome duplication (FSGD). BioEssays. 2005;27:937–45. · DOI · Paper page
  26. Schon O, Friedler A, Bycroft M, Freund SM, Fersht AR. Molecular mechanism of the interaction between MDM2 and p53. J Mol Biol. 2002;323:491–501. · DOI · Paper page
  27. Iakoucheva LM, Radivojac P, Brown CJ, O’Connor TR, Sikes JG, Obradovic Z, et al. The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res. 2004;32:1037–49. · DOI · Paper page
  28. Teufel DP, Bycroft M, Fersht AR. Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2. Oncogene. 2009;28:2112–8. · DOI · Paper page
  29. Lee CW, Ferreon JC, Ferreon ACM, Arai M, Wright PE. Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A. 2010;107:19290–5. · DOI · Paper page
  30. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Nucleic Acids Res. 2015;43:D512–20. · DOI · Paper page
  31. Light S, Sagit R, Sachenkova O, Ekman D, Elofsson A. Protein expansion is primarily due to indels in intrinsically disordered regions. Mol Biol Evol. 2013;30:2645–53. · DOI
  32. Borcherds W, Theillet F, Katzer A, Finzel A, Mishall KM, Powell AT, et al. Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells. Nat Chem Biol. 2014;10(12):1000–2. · DOI · Paper page
  33. Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, et al. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science. 1996;274:948–53. · DOI · Paper page
  34. Shin J-S, Ha J-H, Lee D-H, Ryu K-S, Bae K-H, Park BC, et al. Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition. Cell Cycle. 2015;14(4):533–43. · DOI
  35. Coffill CR, Lee AP, Siau JW, Chee SM, Joseph TL, Tan YS, et al. The p53 – Mdm2 interaction and the E3 ligase activity of Mdm2 / Mdm4 are conserved from lampreys to humans. Genes Dev. 2016;30(3):281–92. · DOI · Paper page
  36. Zdzalik M, Pustelny K, Kedracka-Krok S, Huben K, Pecak A, Wladyka B, et al. Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73. Cell Cycle. 2010;9:4584–91. · DOI
  37. Tanimura S, Ohtsuka S, Mitsui K, Shirouzu K, Yoshimura A, Ohtsubo M. MDM2 interacts with MDMX through their RING finger domains. FEBS Lett. 1999;447:5–9. · DOI · Paper page
  38. Flicek P, Ahmed I, Amode MR, Barrell D, Beal K, Brent S, et al. Ensembl 2013. Nucleic Acids Res. 2013;41:D48–55. · DOI · Paper page
  39. Waterhouse RM, Tegenfeldt F, Li J, Zdobnov EM, Kriventseva EV. OrthoDB: a hierarchical catalog of animal, fungal and bacterial orthologs. Nucleic Acids Res. 2013;41:D358–65. · DOI · Paper page
  40. Li C, Pazgier M, Li C, Yuan W, Liu M, Wei G, et al. Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions. J Mol Biol. 2010;398:200–13. · DOI
  41. Penn O, Privman E, Ashkenazy H, Landan G, Graur D, Pupko T. GUIDANCE: a web server for assessing alignment confidence scores. Nucleic Acids Res. 2010;38:W23–8. · DOI · Paper page
  42. Schwarz G. Estimating the dimension of a model. Ann Stat Institute of Mathematical Statistics. 1978;6:461–4.
  43. Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol. 2013;30:2725–9. · DOI · Paper page
  44. Guindon S, Dufayard J-F, Lefort V, Anisimova M, Hordijk W, Gascuel O. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol. 2010;59:307–21. · DOI · Paper page
  45. Wang Q, Arighi CN, King BL, Polson SW, Vincent J, Chen C, et al. Community annotation and bioinformatics workforce development in concert--Little Skate Genome Annotation Workshops and Jamborees. Database (Oxford). 2012;0:bar064. · DOI
  46. Venkatesh B, Lee AP, Ravi V, Maurya AK, Lian MM, Swann JB, et al. Elephant shark genome provides unique insights into gnathostome evolution. Nature. 2014;505:174–9. · DOI · Paper page
  47. Cameron RA, Samanta M, Yuan A, He D, Davidson E. SpBase: the sea urchin genome database and web site. Nucleic Acids Res. 2009;37:D750–4. · DOI · Paper page
  48. Voskoboynik A, Neff NF, Sahoo D, Newman AM, Pushkarev D, Koh W, et al. The genome sequence of the colonial chordate, Botryllus Schlosseri. elife. 2013;2:e00569. · DOI · Paper page
  49. Privman E, Penn O, Pupko T. Improving the performance of positive selection inference by filtering unreliable alignment regions. Mol Biol Evol. 2012;29(1):1–5. · DOI

Cited by

See all 30

Metadata

Authors
Åberg, E., Saccoccia, F., Grabherr, M., Ore, W. Y. J., Jemth, P., & Hultqvist, G.
Venue
BMC Evolutionary Biology
Publisher
Springer Science and Business Media LLC
Published
2017-08-03
Volume
17
Issue
1
ISSN
1471-2148
DOI
10.1186/s12862-017-1023-y
Cited by
30
References
5
Language
en
Funders
Vetenskapsrådet

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Evolution of the p53-MDM2 pathway. https://app.cochat.ai/papers/10.1186/s12862-017-1023-y
The paper
Åberg, E., Saccoccia, F., Grabherr, M., Ore, W. Y. J., Jemth, P., & Hultqvist, G. (2017). Evolution of the p53-MDM2 pathway. BMC Evolutionary Biology. https://doi.org/10.1186/s12862-017-1023-y

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.