Uncovering sex differences of rodent microglia

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

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The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313

Microglial M1/M2 polarization and metabolic states

Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070

Policy: NIH to balance sex in cell and animal studies

Clayton, J. A., & Collins, F. S. (2014) · Nature · doi:10.1038/509282a · Cited by 1,816

New tools for studying microglia in the mouse and human CNS

Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804

Microglia emerge as central players in brain disease

Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767

Microglia Biology: One Century of Evolving Concepts

Prinz, M., Jung, S., & Priller, J. (2019) · Cell · doi:10.1016/j.cell.2019.08.053 · Cited by 1,525

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

Masuda, T., Sankowski, R., Staszewski, O., Böttcher, C., Amann, L., Sagar, Scheiwe, C., Nessler, S., Kunz, P., van Loo, G., et al. (2019) · Nature · doi:10.1038/s41586-019-0924-x · Cited by 1,310

Irradiation induces neural precursor-cell dysfunction

Monje, M. L., Mizumatsu, S., Fike, J. R., & Palmer, T. D. (2002) · Nature Medicine · doi:10.1038/nm749 · Cited by 1,271

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

Li, Q., Cheng, Z., Zhou, L., Darmanis, S., Neff, N. F., Okamoto, J., Gulati, G., Bennett, M. L., Sun, L. O., Clarke, L. E., et al. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.006 · Cited by 1,129

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Yun, S. P., Kam, T.-I., Panicker, N., Kim, S., Oh, Y., Park, J.-S., Kwon, S.-H., Park, Y. J., Karuppagounder, S. S., Park, H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0051-5 · Cited by 1,123

Microglial signatures and their role in health and disease

Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046

Innate immune memory in the brain shapes neurological disease hallmarks

Wendeln, A.-C., Degenhardt, K., Kaurani, L., Gertig, M., Ulas, T., Jain, G., Wagner, J., Häsler, L. M., Wild, K., Skodras, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0023-4 · Cited by 956

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

Thion, M. S., Low, D., Silvin, A., Chen, J., Grisel, P., Schulte-Schrepping, J., Blecher, R., Ulas, T., Squarzoni, P., Hoeffel, G., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.042 · Cited by 779

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

Askew, K., Li, K., Olmos-Alonso, A., Garcia-Moreno, F., Liang, Y., Richardson, P., Tipton, T., Chapman, M. A., Riecken, K., Beccari, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.041 · Cited by 726

Phagocytosis of Microglia in the Central Nervous System Diseases

Fu, R., Shen, Q., Xu, P., Luo, J. J., & Tang, Y. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8620-6 · Cited by 687

Sex differences in microglial colonization of the developing rat brain

Schwarz, J. M., Sholar, P. W., & Bilbo, S. D. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07630.x · Cited by 672

Sex-specific features of microglia from adult mice

Villa, A., Gelosa, P., Castiglioni, L., Cimino, M., Rizzi, N., Pepe, G., Lolli, F., Marcello, E., Sironi, L., Vegeto, E., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.048 · Cited by 651

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

Lian, H., Litvinchuk, A., Chiang, A. C.-A., Aithmitti, N., Jankowsky, J. L., & Zheng, H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2117-15.2016 · Cited by 597

Sall1 is a transcriptional regulator defining microglia identity and function

Buttgereit, A., Lelios, I., Yu, X., Vrohlings, M., Krakoski, N. R., Gautier, E. L., Nishinakamura, R., Becher, B., & Greter, M. (2016) · Nature Immunology · doi:10.1038/ni.3585 · Cited by 570

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

Huang, Y., Xu, Z., Xiong, S., Sun, F., Qin, G., Hu, G., Wang, J., Zhao, L., Liang, Y.-X., Wu, T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0090-8 · Cited by 560

Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood

Hagemeyer, N., Hanft, K.-M., Akriditou, M.-A., Unger, N., Park, E. S., Stanley, E. R., Staszewski, O., Dimou, L., & Prinz, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1747-1 · Cited by 558

Neuroinflammation in the central nervous system: Symphony of glial cells

Yang, Q., & Zhou, J. (2018) · Glia · doi:10.1002/glia.23571 · Cited by 539

Cholinergic modulation of microglial activation by α7 nicotinic receptors

Shytle, R. D., Mori, T., Townsend, K. P., Vendrame, M., Sun, N., Zeng, J., Ehrhart, J. C., Silver, A. A., Sanberg, P. R., & Tan, J. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2004.02347.x · Cited by 537

Microglia Are Essential to Masculinization of Brain and Behavior

Lenz, K. M., Nugent, B. M., Haliyur, R., & McCarthy, M. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1268-12.2013 · Cited by 526

Transcriptional and Translational Differences of Microglia from Male and Female Brains

Guneykaya, D., Ivanov, A., Hernandez, D. P., Haage, V., Wojtas, B., Meyer, N., Maricos, M., Jordan, P., Buonfiglioli, A., Gielniewski, B., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.001 · Cited by 477

Microglia and early brain development: An intimate journey

Thion, M. S., Ginhoux, F., & Garel, S. (2018) · Science · doi:10.1126/science.aat0474 · Cited by 465

Astrocytes and microglia: In sickness and in health

Vainchtein, I. D., & Molofsky, A. V. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.01.003 · Cited by 450

Brain feminization requires active repression of masculinization via DNA methylation

Nugent, B. M., Wright, C. L., Shetty, A. C., Hodes, G. E., Lenz, K. M., Mahurkar, A., Russo, S. J., Devine, S. E., & McCarthy, M. M. (2015) · Nature Neuroscience · doi:10.1038/nn.3988 · Cited by 413

Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development

Hanamsagar, R., & Bilbo, S. D. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.09.039 · Cited by 404

Microglia: Architects of the Developing Nervous System

Frost, J. L., & Schafer, D. P. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.02.006 · Cited by 385

Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity

Hanamsagar, R., Alter, M. D., Block, C. S., Sullivan, H., Bolton, J. L., & Bilbo, S. D. (2017) · Glia · doi:10.1002/glia.23176 · Cited by 384

Utilization of special education services and educational attainment among long‐term survivors of childhood cancer

Mitby, P. A., Robison, L. L., Whitton, J. A., Zevon, M. A., Gibbs, I. C., Tersak, J. M., Meadows, A. T., Stovall, M. A., Zeltzer, L. K., & Mertens, A. C. (2003) · Cancer · doi:10.1002/cncr.11117 · Cited by 364

A Starring Role for Microglia in Brain Sex Differences

Lenz, K. M., & McCarthy, M. M. (2015) · The Neuroscientist · doi:10.1177/1073858414536468 · Cited by 342

Sexual dimorphism in the inflammatory response to traumatic brain injury

Villapol, S., Loane, D. J., & Burns, M. P. (2017) · Glia · doi:10.1002/glia.23171 · Cited by 320

X chromosome regulation: diverse patterns in development, tissues and disease

Deng, X., Berletch, J. B., Nguyen, D. K., & Distèche, C. M. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3687 · Cited by 316

The identity and function of microglia in neurodegeneration

Song, W. M., & Colonna, M. (2018) · Nature Immunology · doi:10.1038/s41590-018-0212-1 · Cited by 308

Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity

Hanamsagar, R., Alter, M. D., Block, C. L., Sullivan, H. K., Bolton, J. L., & Bilbo, S. D. (2017) · Glia · doi:10.1002/glia.23277 · Cited by 297

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

Du, L., Zhang, Y., Chen, Y., Zhu, J., Yang, Y., & Zhang, H.-L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0245-0 · Cited by 280

The “Big‐Bang” for modern glial biology: Translation and comments on Pío del Río‐Hortega 1919 series of papers on microglia

Sierra, A., de Castro, F., del Río‐Hortega, J., Rafael Iglesias‐Rozas, J., Garrosa, M., & Kettenmann, H. (2016) · Glia · doi:10.1002/glia.23046 · Cited by 266

Immunological implications of pregnancy-induced microchimerism

Kinder, J. M., Stelzer, I. A., Arck, P., & Way, S. S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.38 · Cited by 266

The Kaleidoscope of Microglial Phenotypes

Dubbelaar, M. L., Kracht, L., Eggen, B. J. L., & Boddeke, E. W. G. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01753 · Cited by 260

Cien Años de Microglía: Milestones in a Century of Microglial Research

Sierra, A., Paolicelli, R. C., & Kettenmann, H. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.09.004 · Cited by 244

Differential effects of stress on microglial cell activation in male and female medial prefrontal cortex

Bollinger, J. L., Burns, C. M. B., & Wellman, C. L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.10.003 · Cited by 229

Guidelines for Identification of, Advocacy for, and Intervention in Neurocognitive Problems in Survivors of Childhood Cancer

Nathan, P. C. (2007) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.161.8.798 · Cited by 229

CSF1R -related leukoencephalopathy: A major player in primary microgliopathies

Konno, T., Kasanuki, K., Ikeuchi, T., Dickson, D. W., & Wszolek, Z. K. (2018) · Neurology · doi:10.1212/wnl.0000000000006642 · Cited by 208

Sex differences in histone modifications in the neonatal mouse brain

Tsai, H., Grant, P. A., & Rissman, E. F. (2009) · Epigenetics · doi:10.4161/epi.4.1.7288 · Cited by 206

Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

Datta, M., Staszewski, O., Raschi, E., Frosch, M., Hagemeyer, N., Tay, T. L., Blank, T., Kreutzfeldt, M., Merkler, D., Ziegler-Waldkirch, S., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.02.016 · Cited by 206

Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats

Loram, L. C., Sholar, P. W., Taylor, F. R., Wiesler, J. L., Babb, J. A., Strand, K. A., Berkelhammer, D. L., Day, H. E. W., Maier, S. F., & Watkins, L. R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.018 · Cited by 196

Sex differences in microglial phagocytosis in the neonatal hippocampus

Nelson, L. H., Warden, S., & Lenz, K. M. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.010 · Cited by 189

Incidence of MS has increased markedly over six decades in Denmark particularly with late onset and in women

Koch-Henriksen, N., Thygesen, L. C., Stenager, E., Laursen, B., & Magyari, M. (2018) · Neurology · doi:10.1212/wnl.0000000000005612 · Cited by 188

A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration

Jin, M.-M., Wang, F., Qi, D., Liu, W.-W., Gu, C., Mao, C.-J., Yang, Y.-P., Zhao, Z., Hu, L.-F., & Liu, C.-F. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00378 · Cited by 180

Clinical and genetic characterization of adult‐onset leukoencephalopathy with axonal spheroids and pigmented glia associated with CSF 1R mutation

Konno, T., Yoshida, K., Mizuno, T., Kawarai, T., Tada, M., Nozaki, H., Ikeda, S. ‐., Nishizawa, M., Onodera, O., Wszolek, Z. K., et al. (2017) · European Journal of Neurology · doi:10.1111/ene.13125 · Cited by 179 · cited 1×

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

Dorfman, M. D., Krull, J. E., Douglass, J. D., Fasnacht, R. D., Lara-Lince, F., Meek, T. H., Shi, X., Damian, V. M., Hồng, N. T., Matsen, M. E., et al. (2017) · Nature Communications · doi:10.1038/ncomms14556 · Cited by 175

Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies

Green, T., Flash, S., & Reiss, A. L. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0153-2 · Cited by 175

Sex differences in microglia activity within the periaqueductal gray of the rat: A potential mechanism driving the dimorphic effects of morphine

Doyle, H. H., Eidson, L. N., Sinkiewicz, D. M., & Murphy, A. Z. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2906-16.2017 · Cited by 166

Epigenetics Control Microglia Plasticity

Cheray, M., & Joseph, B. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00243 · Cited by 157

Traumatic brain injury‐induced neuronal damage in the somatosensory cortex causes formation of rod‐shaped microglia that promote astrogliosis and persistent neuroinflammation

Witcher, K. G., Bray, C. E., Dziabis, J. E., McKim, D. B., Benner, B. N., Rowe, R. K., Kokiko‐Cochran, O. N., Popovich, P. G., Lifshitz, J., Eiferman, D. S., et al. (2018) · Glia · doi:10.1002/glia.23523 · Cited by 153

Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain

Ratnu, V. S., Emami, M. R., & Bredy, T. W. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23886 · Cited by 144

Siglec‐H is a microglia‐specific marker that discriminates microglia from CNS‐associated macrophages and CNS‐infiltrating monocytes

Konishi, H., Kobayashi, M., Kunisawa, T., Imai, K., Sayo, A., MALISSEN, B., Crocker, P. R., Sato, K., & Kiyama, H. (2017) · Glia · doi:10.1002/glia.23204 · Cited by 141

Sexual differentiation of microglia

Villa, A. M., Torre, S. D., & Maggi, A. C. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.11.003 · Cited by 135

How to reprogram microglia toward beneficial functions

Fumagalli, M., Lombardi, M., Gressèns, P., & Verderio, C. (2018) · Glia · doi:10.1002/glia.23484 · Cited by 134

New Insights into the Role of Histone Changes in Aging

Yi, S.-J., & Kim, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218241 · Cited by 134

Male Microchimerism in the Human Female Brain

Chan, W. F. N., Gurnot, C., Montine, T. J., Sonnen, J. A., Guthrie, K. A., & Nelson, J. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045592 · Cited by 129

Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid

Yanguas‐Casás, N., Crespo‐Castrillo, A., CEBALLOS, M. L. D., Chowen, J. A., Azcoitia, Í., Arévalo, M., & García‐Segura, L. M. (2017) · Glia · doi:10.1002/glia.23263 · Cited by 126

Microglia and sexual differentiation of the developing brain: A focus on ontogeny and intrinsic factors

Bordt, E. A., Ceasrine, A. M., & Bilbo, S. D. (2020) · Glia · doi:10.1002/glia.23753 · Cited by 125

Sex differences in autoimmune disorders of the central nervous system

Gold, S. M., Willing, A., Leypoldt, F., Paul, F., & Friese, M. A. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0723-8 · Cited by 122

Microglial microRNAs mediate sex-specific responses to tau pathology

Kodama, L., Guzman, E., Etchegaray, J. I., Li, Y., Sayed, F. A., Zhou, L., Zhou, Y., Zhan, L., Le, D., Udeochu, J. C., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0560-7 · Cited by 115

Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour

Rosin, J. M., Vora, S. R., & Kurrasch, D. M. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.023 · Cited by 113

Behavioral stress alters corticolimbic microglia in a sex- and brain region-specific manner

Bollinger, J. L., Collins, K. E., Patel, R., & Wellman, C. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187631 · Cited by 105

Brain Response to Injuries: When Microglia Go Sexist

Rahimian, R., Cordeau, P., & Križ, J. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.048 · Cited by 101

Sex‐dependent differences in behavior and hippocampal neurogenesis after irradiation to the young mouse brain

Roughton, K., Kalm, M., & Blomgren, K. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08197.x · Cited by 100

Microglia: Driving critical periods and sexual differentiation of the brain

VanRyzin, J. W., Pickett, L. A., & McCarthy, M. M. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22569 · Cited by 97

Sex differences in the neuroimmune system

Osborne, B. F., Turano, A., & Schwarz, J. M. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.05.007 · Cited by 90

Microglia heterogeneity along a spatio–temporal axis: More questions than answers

Silvin, A., & Ginhoux, F. (2018) · Glia · doi:10.1002/glia.23458 · Cited by 90

Non-Reproductive Effects of Sex Steroids: Their Immunoregulatory Role

Morales-Montor, J., Togno-Pierce, C., & Munoz-Cruz, S. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611796117630 · Cited by 87

Unique role for dentate gyrus microglia in neuroblast survival and in VEGF‐induced activation

Kreisel, T., Wolf, B., Keshet, E., & Licht, T. (2018) · Glia · doi:10.1002/glia.23505 · Cited by 86

Microglia and sexual differentiation of the developing brain: A focus on extrinsic factors

VanRyzin, J. W., Marquardt, A. E., Pickett, L. A., & McCarthy, M. M. (2019) · Glia · doi:10.1002/glia.23740 · Cited by 84

Microglial Function across the Spectrum of Age and Gender

Nissen, J. C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030561 · Cited by 83

Epigenetics and autoimmune diseases: the X chromosome-nucleolus nexus

Brooks, W. H., & Renaudineau, Y. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00022 · Cited by 77

Microglia along sex lines: From brain colonization, maturation and function, to implication in neurodevelopmental disorders

Bordeleau, M., Carrier, M., Luheshi, G. N., & Tremblay, M.-È. (2019) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2019.06.001 · Cited by 75

Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood

Desplats, P., Gutierrez, A. M., Antonelli, M. C., & Frasch, M. G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.013 · Cited by 74

The Kinetics of Myelin Antigen Uptake by Myeloid Cells in the Central Nervous System during Experimental Autoimmune Encephalomyelitis

Sosa, R. A., Murphey, C. L., Ji, N., Cardona, A. E., & Forsthuber, T. G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300771 · Cited by 73

Microglia Receptors in Animal Models of Traumatic Brain Injury

Younger, D., Murugan, M., Rao, K. V. R., Wu, L., & Chandra, N. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1428-7 · Cited by 69

Roles of Progesterone, Testosterone and Their Nuclear Receptors in Central Nervous System Myelination and Remyelination

Ghoumari, A. M., Abi‐Ghanem, C., Asbelaoui, N., Schumacher, M., & Hussain, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093163 · Cited by 68

Microglial replacement therapy: a potential therapeutic strategy for incurable CSF1R-related leukoencephalopathy

Han, J., Sarlus, H., Wszolek, Z. K., Karrenbauer, V. D., & Harris, R. A. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01093-3 · Cited by 65

Scholastic achievements of children with brain tumors at the end of comprehensive education

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Small cells with big implications: Microglia and sex differences in brain development, plasticity and behavioral health

Nelson, L. H., Saulsbery, A. I., & Lenz, K. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.09.002 · Cited by 62

Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge

Murtaj, V., Belloli, S., Di Grigoli, G., Pannese, M., Ballarini, E., Rodriguez-Menendez, V., Marmiroli, P., Cappelli, A., Masiello, V., Monterisi, C., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00299 · Cited by 58

Microglial innate memory and epigenetic reprogramming in neurological disorders

Martins-Ferreira, R., Leal, B., Costa, P., & Ballestar, E. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101971 · Cited by 55

Environmental Signals on Microglial Function during Brain Development, Neuroplasticity, and Disease

Chagas, L. D. S., Sandre, P. C., Ribeiro, N. C. A. R. E., Marcondes, H., Silva, P. O., Savino, W., & Serfaty, C. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062111 · Cited by 53

Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation

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Comprehensive clinical follow-up of late effects in childhood cancer survivors shows the need for early and well-timed intervention

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Shaping Microglial Phenotypes Through Estrogen Receptors: Relevance to Sex-Specific Neuroinflammatory Responses to Brain Injury and Disease

Acosta-Martínez, M. (2020) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.264598 · Cited by 51

Early Sex Differences in the Immune-Inflammatory Responses to Neonatal Ischemic Stroke

Villapol, S., Faivre, V., Joshi, P., Moretti, R., Besson, V. C., & Charriaut‐Marlangue, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153809 · Cited by 50

Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder

Lobentanzer, S., Hanin, G., Klein, J., & Soreq, H. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.017 · Cited by 50

Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View

Eggen, B. J. L., Boddeke, E. W. G. M., & Kooistra, S. M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.010 · Cited by 34

α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis

Cortes, M., Cao, M., Liu, H. L., Moore, C. S., Durosier, L. D., Burns, P., Fecteau, G., Desrochers, A., Barreiro, L. B., Antel, J. P., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09439-z · Cited by 32

A nationwide, population‐based study of school grades, delayed graduation, and qualification for school years 10‐12, in children with brain tumors in Sweden

Lönnerblad, M., Hooft, I. V., Blomgren, K., & Berglund, E. (2019) · Pediatric Blood & Cancer · doi:10.1002/pbc.28014 · Cited by 25

Sex- and Development-Dependent Responses of Rat Microglia to Pro- and Anti-inflammatory Stimulation

Lively, S. S., Wong, R., Lam, D., & Schlichter, L. C. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00433 · Cited by 20

Cholino‐ncRNAs modulate sex‐specific‐ and age‐related acetylcholine signals

Madrer, N., & Soreq, H. (2020) · FEBS Letters · doi:10.1002/1873-3468.13789 · Cited by 20

A translational concept of immuno-radiobiology

Lippitz, B. E., & Harris, R. A. (2019) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2019.06.001 · Cited by 18

Strain‐specific differential expression of astrocytes and microglia in the mouse hippocampus

Kim, J. W., Nam, S. M., Yoo, D. Y., Jung, H. Y., Hwang, I. K., Seong, J. K., & Yoon, Y. S. (2018) · Brain and Behavior · doi:10.1002/brb3.961 · Cited by 17

Lipopolysaccharide sensitized male and female juvenile brains to ionizing radiation

Kalm, M., Roughton, K., & Blomgren, K. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.482 · Cited by 16

Sex on the brain: Unraveling the differences between women and men in neurodegenerative disease

May, M. (2016) · Nature Medicine · doi:10.1038/nm1216-1370 · Cited by 16

Sex-Specific Effects of Microglia-Like Cell Engraftment during Experimental Autoimmune Encephalomyelitis

Han, J., Zhu, K., Zhou, K., Hakim, R., Sankavaram, S. R., Blomgren, K., Lund, H., Zhang, X., & Harris, R. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186824 · Cited by 16

A Novel Missense Mutation of the CSF1R Gene Causes Incurable CSF1R-Related Leukoencephalopathy: Case Report and Review of Literature

Chen, J., Luo, S., Li, N., Li, H., Han, J., & Li, L. (2020) · International Journal of General Medicine · doi:10.2147/ijgm.s286421 · Cited by 14

Sex differences in microglial appetites during development: Inferences and implications

Bilbo, S. D. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.05.010 · Cited by 12

The diverse culinary habits of microglia

Bilbo, S. D. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0196-z · Cited by 5

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.020 · Cited by 1,973

Microglia morphophysiological diversity and its implications for the CNS

Vidal-Itriago, A., Radford, R. A. W., Aramideh, J. A., Maurel, C., Scherer, N. M., Don, E. K., Lee, A., Chung, R. S., Graeber, M. B., & Morsch, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.997786 · Cited by 451

Mechanisms of sex differences in Alzheimer’s disease

Lopez-Lee, C., Torres, E. R. S., Carling, G., & Gan, L. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.024 · Cited by 376

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Fernández-Calle, R., Konings, S. C., Frontiñán-Rubio, J., García-Revilla, J., Camprubí-Ferrer, L., Svensson, M., Martinson, I., Boza-Serrano, A., Venero, J. L., Nielsen, H. M., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00566-4 · Cited by 278

Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?

Porter, G. A., & O’Connor, J. C. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i1.77 · Cited by 188

Sex on the brain: Unraveling the differences between women and men in neurodegenerative disease

May, M. (2016) · Nature Medicine · doi:10.1038/nm1216-1370 · Cited by 16

Transcriptional and translational differences of microglia from male and female brains

Güneykaya, D. (2019) · Refubium (Universitätsbibliothek der Freien Universität Berlin) · doi:10.17169/refubium-2637

Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?

Kodama, L., & Gan, L. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.05.001 · Cited by 118

Sexual differentiation of microglia

Villa, A. M., Torre, S. D., & Maggi, A. C. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.11.003 · Cited by 135

Sex-specific features of microglia from adult mice

Villa, A., Gelosa, P., Castiglioni, L., Cimino, M., Rizzi, N., Pepe, G., Lolli, F., Marcello, E., Sironi, L., Vegeto, E., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.048 · Cited by 651