CoChat
Sign Up
Cited by 9Face Recognition and PerceptionPsychosomatic Disorders and Their TreatmentsNeural and Behavioral Psychology Studies

Enhanced bodily states of fear facilitates bias perception of fearful faces

Open access
Jung, Won-Mo, Lee, Ye-Seul, Lee, In-Seon, Wallraven, Christian, Ryu, Yeonhee, Chae, Younbyoung·2020·Molecular Brain
DOI 10.1186/s13041-020-00674-6PMC PMC7682010
Open this paper in CoChat — free accountOpen PDF

Abstract

We investigated whether enhanced interoceptive bodily states of fear would facilitate recognition of the fearful faces. Participants performed an emotional judgment task after a bodily imagery task inside a functional magnetic resonance imaging scanner. In the bodily imagery task, participants were instructed to imagine feeling the bodily sensations of two specific somatotopic patterns: a fear-associated bodily sensation (FBS) or a disgust-associated bodily sensation (DBS). They were shown faces expressing various levels of fearfulness and disgust and instructed to classify the facial expression as fear or disgust. We found a stronger bias favoring the “fearful face” under the congruent FBS condition than under the incongruent DBS condition. The brain response to fearful versus intermediate faces increased in the fronto-insular-temporal network under the FBS condition, but not the DBS condition. The fearful face elicited activity in the anterior cingulate cortex and extrastriate body area under the FBS condition relative to the DBS condition. Furthermore, functional connectivity between the anterior cingulate cortex/extrastriate body area and the fronto-insular-temporal network was modulated according to the specific bodily sensation. Our findings suggest that somatotopic patterns of bodily sensation provide informative access to the collective visceral state in the fear processing via the fronto-insular-temporal network.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/s13041-020-00674-6

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 62

  1. [3]Garfinkel SN Critchley HD Threat and the Body: How the Heart Supports Fear Processing Trends in cognitive sciences 2016 20 1 34 46 10.1016/j.tics.2015.10.005 26628111 · DOI · Paper page
  2. [4]Levenson RW Blood, sweat, and fears: the autonomic architecture of emotion Ann N Y Acad Sci 2003 1000 348 366 10.1196/annals.1280.016 14766648 · DOI
  3. [8]Tsakiris M Tajadura-Jimenez A Costantini M Just a heartbeat away from one's body: interoceptive sensitivity predicts malleability of body-representations Proc Biol Sci 2011 278 1717 2470 2476 21208964 PMC3125630
  4. [9]Dunn BD Galton HC Morgan R Evans D Oliver C Meyer M Cusack R Lawrence AD Dalgleish T Listening to your heart. How interoception shapes emotion experience and intuitive decision making Psychol Sci 2010 21 12 1835 1844 10.1177/0956797610389191 21106893 · DOI · Paper page
  5. [12]Leppanen JM Milders M Bell JS Terriere E Hietanen JK Depression biases the recognition of emotionally neutral faces Psychiatry Res 2004 128 2 123 133 10.1016/j.psychres.2004.05.020 15488955 · DOI
  6. [13]Surcinelli P Codispoti M Montebarocci O Rossi N Baldaro B Facial emotion recognition in trait anxiety J Anxiety Disord 2006 20 1 110 117 10.1016/j.janxdis.2004.11.010 16325118 · DOI
  7. [14]Bell C Bourke C Colhoun H Carter F Frampton C Porter R The misclassification of facial expressions in generalised social phobia J Anxiety Disord 2011 25 2 278 283 10.1016/j.janxdis.2010.10.001 21041060 · DOI
  8. [15]Sterling P Allostasis: a model of predictive regulation Physiol Behav 2012 106 1 5 15 10.1016/j.physbeh.2011.06.004 21684297 · DOI · Paper page
  9. [16]Knill DC Pouget A The Bayesian brain: the role of uncertainty in neural coding and computation Trends Neurosci 2004 27 12 712 719 10.1016/j.tins.2004.10.007 15541511 · DOI · Paper page
  10. [18]O'Reilly JX Jbabdi S Behrens TE How can a Bayesian approach inform neuroscience? Eur J Neurosci 2012 35 7 1169 1179 10.1111/j.1460-9568.2012.08010.x 22487045 · DOI
  11. [21]Hietanen JK Glerean E Hari R Nummenmaa L Bodily maps of emotions across child development Dev Sci 2016 19 6 1111 1118 10.1111/desc.12389 26898716 · DOI · Paper page
  12. [22]Jung WM Ryu Y Lee YS Wallraven C Chae Y Role of interoceptive accuracy in topographical changes in emotion-induced bodily sensations PLoS ONE 2017 12 9 e0183211 10.1371/journal.pone.0183211 28877218 PMC5587262 · DOI · Paper page
  13. [24]Allen M Friston KJ From cognitivism to autopoiesis: towards a computational framework for the embodied mind Synthese 2018 195 6 2459 2482 10.1007/s11229-016-1288-5 29887647 PMC5972168 · DOI · Paper page
  14. [25]Owens AP Allen M Ondobaka S Friston KJ Interoceptive inference: from computational neuroscience to clinic Neurosci Biobehav Rev 2018 90 174 183 10.1016/j.neubiorev.2018.04.017 29694845 · DOI
  15. [26]Allen M Frank D Schwarzkopf DS Fardo F Winston JS Hauser TU Rees G Unexpected arousal modulates the influence of sensory noise on confidence Elife 2016 5 1 PMC5079750 27776633
  16. [27]Barrett LF Simmons WK Interoceptive predictions in the brain Nat Rev Neurosci 2015 16 7 419 429 10.1038/nrn3950 26016744 PMC4731102 · DOI · Paper page
  17. [29]Durnez J, Degryse J, Moerkerke B, Seurinck R, Sochat V, Poldrack RA, Nichols TE: Power and sample size calculations for fMRI studies based on the prevalence of active peaks. BioRxiv 2016.
  18. [30]Susskind JM Lee DH Cusi A Feiman R Grabski W Anderson AK Expressing fear enhances sensory acquisition Nat Neurosci 2008 11 7 843 850 10.1038/nn.2138 18552843 · DOI · Paper page
  19. [31]Thielscher A Pessoa L Neural correlates of perceptual choice and decision making during fear-disgust discrimination J Neurosci 2007 27 11 2908 2917 10.1523/JNEUROSCI.3024-06.2007 17360913 PMC6672587 · DOI
  20. [32]Jung WM Shim W Lee T Park HJ Ryu Y Beissner F Chae Y More than DeQi: spatial patterns of acupuncture-induced bodily sensations Front Neurosci 2016 10 462 10.3389/fnins.2016.00462 27807402 PMC5069343 · DOI · Paper page
  21. [33]Jung WM Lee SH Lee YS Chae Y Exploring spatial patterns of acupoint indications from clinical data: A STROBE-compliant article Medicine 2017 96 17 e6768 10.1097/MD.0000000000006768 28445309 PMC5413274 · DOI
  22. [34]Wichmann FA Hill NJ The psychometric function: I Fitting, sampling, and goodness of fit Percept Psychophys 2001 63 8 1293 1313 10.3758/BF03194544 11800458 · DOI
  23. [35]Traschutz A Zinke W Wegener D Speed change detection in foveal and peripheral vision Vision Res 2012 72 1 13 10.1016/j.visres.2012.08.019 22982685 · DOI
  24. [36]Cox RW AFNI: software for analysis and visualization of functional magnetic resonance neuroimages Comput Biomed Res 1996 29 3 162 173 10.1006/cbmr.1996.0014 8812068 · DOI · Paper page
  25. [37]Paus T Otaky N Caramanos Z MacDonald D Zijdenbos A D'Avirro D Gutmans D Holmes C Tomaiuolo F Evans AC In vivo morphometry of the intrasulcal gray matter in the human cingulate, paracingulate, and superior-rostral sulci: hemispheric asymmetries, gender differences and probability maps J Comp Neurol 1996 376 4 664 673 10.1002/(SICI)1096-9861(19961223)376:4<664::AID-CNE12>3.0.CO;2-M 8978477 · DOI
  26. [38]Forman SD Cohen JD Fitzgerald M Eddy WF Mintun MA Noll DC Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold Magn Reson Med 1995 33 5 636 647 10.1002/mrm.1910330508 7596267 · DOI · Paper page
  27. [39]de Andrade TG Peterson KR Cunha AF Moreira LS Fattori A Saad ST Costa FF Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster Blood Cells Mol Dis 2006 37 2 82 90 10.1016/j.bcmd.2006.07.003 16952470 · DOI
  28. [40]Cox RW Chen G Glen DR Reynolds RC Taylor PA fMRI clustering and false-positive rates Proc Natl Acad Sci USA 2017 114 17 E3370 e3371 10.1073/pnas.1614961114 28420798 PMC5410825 · DOI · Paper page
  29. [42]Phillips ML Williams LM Heining M Herba CM Russell T Andrew C Bullmore ET Brammer MJ Williams SC Morgan M Differential neural responses to overt and covert presentations of facial expressions of fear and disgust Neuroimage 2004 21 4 1484 1496 10.1016/j.neuroimage.2003.12.013 15050573 · DOI · Paper page
  30. [43]Shah SG Klumpp H Angstadt M Nathan PJ Phan KL Amygdala and insula response to emotional images in patients with generalized social anxiety disorder J Psychiatry Neurosci 2009 34 4 296 302 19568481 PMC2702447
  31. [44]Zald DH The human amygdala and the emotional evaluation of sensory stimuli Brain Res Brain Res Rev 2003 41 1 88 123 10.1016/S0165-0173(02)00248-5 12505650 · DOI · Paper page
  32. [45]Desikan RS Segonne F Fischl B Quinn BT Dickerson BC Blacker D Buckner RL Dale AM Maguire RP Hyman BT An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest Neuroimage 2006 31 3 968 980 10.1016/j.neuroimage.2006.01.021 16530430 · DOI · Paper page
  33. [46]Allen M Poggiali D Whitaker K Marshall TR Kievit RA Raincloud plots: a multi-platform tool for robust data visualization Wellcome Open Res 2019 4 63 10.12688/wellcomeopenres.15191.1 31069261 PMC6480976 · DOI
  34. [48]Cisler JM Bush K Steele JS A comparison of statistical methods for detecting context-modulated functional connectivity in fMRI Neuroimage 2014 84 1042 1052 10.1016/j.neuroimage.2013.09.018 24055504 PMC4019671 · DOI
  35. [49]Davidson TL Jarrard LE A role for hippocampus in the utilization of hunger signals Behavioral and neural biology 1993 59 2 167 171 10.1016/0163-1047(93)90925-8 8476385 · DOI
  36. [50]Davidson TL Kanoski SE Chan K Clegg DJ Benoit SC Jarrard LE Hippocampal lesions impair retention of discriminative responding based on energy state cues Behav Neurosci 2010 124 1 97 105 10.1037/a0018402 20141284 PMC2850045 · DOI
  37. [51]Suzuki K Garfinkel SN Critchley HD Seth AK Multisensory integration across exteroceptive and interoceptive domains modulates self-experience in the rubber-hand illusion Neuropsychologia 2013 51 13 2909 2917 10.1016/j.neuropsychologia.2013.08.014 23993906 · DOI · Paper page
  38. [52]Sel A, Azevedo RT, Tsakiris M: Heartfelt Self: Cardio-Visual Integration Affects Self-Face Recognition and Interoceptive Cortical Processing. Cerebral cortex (New York, NY: 1991) 2016:1–12. 28334126
  39. [54]Phillips ML Young AW Scott SK Calder AJ Andrew C Giampietro V Williams SC Bullmore ET Brammer M Gray JA Neural responses to facial and vocal expressions of fear and disgust Proc Biol Sci 1998 265 1408 1809 1817 10.1098/rspb.1998.0506 9802236 PMC1689379 · DOI
  40. [55]Breiter HC Etcoff NL Whalen PJ Kennedy WA Rauch SL Buckner RL Strauss MM Hyman SE Rosen BR Response and habituation of the human amygdala during visual processing of facial expression Neuron 1996 17 5 875 887 10.1016/S0896-6273(00)80219-6 8938120 · DOI · Paper page
  41. [56]Morris JS Frith CD Perrett DI Rowland D Young AW Calder AJ Dolan RJ A differential neural response in the human amygdala to fearful and happy facial expressions Nature 1996 383 6603 812 815 10.1038/383812a0 8893004 · DOI · Paper page
  42. [57]Phillips ML Young AW Senior C Brammer M Andrew C Calder AJ Bullmore ET Perrett DI Rowland D Williams SC A specific neural substrate for perceiving facial expressions of disgust Nature 1997 389 6650 495 498 10.1038/39051 9333238 · DOI · Paper page
  43. [58]Haxby JV Hoffman EA Gobbini MI The distributed human neural system for face perception Trends in cognitive sciences 2000 4 6 223 233 10.1016/S1364-6613(00)01482-0 10827445 · DOI · Paper page
  44. [59]Barbas H, Rempel-Clower N: Cortical structure predicts the pattern of corticocortical connections. Cerebral cortex (New York, NY: 1991) 1997, 7(7):635–646. 9373019
  45. [60]Shipp S Adams RA Friston KJ Reflections on agranular architecture: predictive coding in the motor cortex Trends Neurosci 2013 36 12 706 716 10.1016/j.tins.2013.09.004 24157198 PMC3858810 · DOI · Paper page
  46. [61]van den Heuvel MP Sporns O An anatomical substrate for integration among functional networks in human cortex J Neurosci 2013 33 36 14489 14500 10.1523/JNEUROSCI.2128-13.2013 24005300 PMC6618386 · DOI · Paper page
  47. [63]Critchley HD Melmed RN Featherstone E Mathias CJ Dolan RJ Brain activity during biofeedback relaxation: a functional neuroimaging investigation Brain 2001 124 Pt 5 1003 1012 10.1093/brain/124.5.1003 11335702 · DOI
  48. [64]Holtz K Pane-Farre CA Wendt J Lotze M Hamm AO Brain activation during anticipation of interoceptive threat Neuroimage 2012 61 4 857 865 10.1016/j.neuroimage.2012.03.019 22440646 · DOI
  49. [66]Limanowski J Lutti A Blankenburg F The extrastriate body area is involved in illusory limb ownership Neuroimage 2014 86 514 524 10.1016/j.neuroimage.2013.10.035 24185016 · DOI
  50. [67]Wold A Limanowski J Walter H Blankenburg F Proprioceptive drift in the rubber hand illusion is intensified following 1 Hz TMS of the left EBA Front Hum Neurosci 2014 8 390 10.3389/fnhum.2014.00390 24926247 PMC4045244 · DOI
  51. [69]Tsakiris M Hesse MD Boy C Haggard P Fink GR Neural signatures of body ownership: a sensory network for bodily self-consciousness Cereb Cortex 2007 17 10 2235 2244 10.1093/cercor/bhl131 17138596 · DOI · Paper page
  52. [70]Taylor JC Wiggett AJ Downing PE Functional MRI analysis of body and body part representations in the extrastriate and fusiform body areas J Neurophysiol 2007 98 3 1626 1633 10.1152/jn.00012.2007 17596425 · DOI
  53. [71]Peelen MV Atkinson AP Andersson F Vuilleumier P Emotional modulation of body-selective visual areas Social cognitive and affective neuroscience 2007 2 4 274 283 10.1093/scan/nsm023 18985133 PMC2566760 · DOI
  54. [72]Atkinson AP Vuong QC Smithson HE Modulation of the face- and body-selective visual regions by the motion and emotion of point-light face and body stimuli Neuroimage 2012 59 2 1700 1712 10.1016/j.neuroimage.2011.08.073 21924368 · DOI
  55. [74]van de Riet WA Grezes J de Gelder B Specific and common brain regions involved in the perception of faces and bodies and the representation of their emotional expressions Soc Neurosci 2009 4 2 101 120 10.1080/17470910701865367 19255912 · DOI
  56. [75]Ronchi R Bernasconi F Pfeiffer C Bello-Ruiz J Kaliuzhna M Blanke O Interoceptive signals impact visual processing: Cardiac modulation of visual body perception Neuroimage 2017 158 176 185 10.1016/j.neuroimage.2017.06.064 28669917 · DOI
  57. [76]Downing PE Peelen MV The role of occipitotemporal body-selective regions in person perception Cognitive neuroscience 2011 2 3–4 186 203 10.1080/17588928.2011.582945 24168534 · DOI
  58. [77]Amoruso L Couto B Ibanez A Beyond Extrastriate Body Area (EBA) and Fusiform Body Area (FBA): Context Integration in the Meaning of Actions Front Hum Neurosci 2011 5 124 10.3389/fnhum.2011.00124 22053154 PMC3205482 · DOI
  59. [78]Van Dijk KR Hedden T Venkataraman A Evans KC Lazar SW Buckner RL Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization J Neurophysiol 2010 103 1 297 321 10.1152/jn.00783.2009 19889849 PMC2807224 · DOI · Paper page
  60. [79]Murphy K Birn RM Handwerker DA Jones TB Bandettini PA The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? Neuroimage 2009 44 3 893 905 10.1016/j.neuroimage.2008.09.036 18976716 PMC2750906 · DOI · Paper page
  61. [80]Fox MD Zhang D Snyder AZ Raichle ME The global signal and observed anticorrelated resting state brain networks J Neurophysiol 2009 101 6 3270 3283 10.1152/jn.90777.2008 19339462 PMC2694109 · DOI · Paper page
  62. [81]Poldrack RA Baker CI Durnez J Gorgolewski KJ Matthews PM Munafo MR Nichols TE Poline JB Vul E Yarkoni T Scanning the horizon: towards transparent and reproducible neuroimaging research Nat Rev Neurosci 2017 18 2 115 126 10.1038/nrn.2016.167 28053326 PMC6910649 · DOI · Paper page

Cited by

Sorted by citations

Authors
Jung, W.-M., Lee, Y.-S., Lee, I.-S., Wallraven, C., Ryu, Y., & Chae, Y.
Affiliations
  • Kyung Hee University (KR)
  • Gachon University (KR)
  • Korea University (KR)
  • Korea Institute of Oriental Medicine (KR)
Corresponding author
Chae, Younbyoung
ORCID
Venue
Molecular Brain
Publisher
Springer Science and Business Media LLC
Published
2020-11-23
Volume
13
Issue
1
Pages
157-157
ISSN
1756-6606 (ISSN-L)
DOI
10.1186/s13041-020-00674-6
PMC
PMC7682010
OpenAlex
W3109314060
Cited by
9
References
18
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 1 · 2021: 1
FWCI
0.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Brain (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Basic Science Research Program through the National Research Foundation of Korea (2018R1D1A1B07042313)
  • Korea Institute of Oriental Medicine (K18181)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
fear, bodily sensations, interoception, facial expression recognition, fearful faces, disgust, anterior cingulate cortex, extrastriate body area, functional connectivity, emotion perception
MeSH terms
Disgust, Arousal, Brain, Facial Expression, Fear, Female, Humans, Judgment, Magnetic Resonance Imaging, Male, Nerve Net, Perception, Sensation, Bias, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review