The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment
Open accessAbstract
Plenty of immune cells infiltrate into the tumor microenvironment (TME) during tumor progression, in which myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells with immunosuppressive activity. Tumor cells and stromal cells facilitate the activation and expansion of MDSCs in TME via intercellular communication, and expanded MDSCs suppress anti-tumor immune responses through direct and indirect mechanisms. Currently, exosomes, which are a kind of extracellular vesicles (EVs) that can convey functional components, are demonstrated to participate in the local and distal intercellular communication between cells. Numerous studies have supposed that tumor-derived exosomes (TEXs), whose assembly and release can be modulated by TME, are capable of modulating the cell biology of MDSCs, including facilitating their activation, promoting the expansion, and enhancing the immunosuppressive function. Therefore, in this review, we mainly focus on the role of TEXs in the cell-cell communication between tumor cells and MDSCs, and discuss their clinical applications.
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Cites
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Challenges and advances in clinical applications of mesenchymal stromal cells
Zhou, T., Yuan, Z., Weng, J., Pei, D., Du, X., He, C., & Lai, P. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01037-x · Cited by 712
Application of exosomes as liquid biopsy in clinical diagnosis
Zhou, B., Xu, K., Zheng, X., Chen, T., Wang, J., Song, Y., Shao, Y., & Zheng, S. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00258-9 · Cited by 685
The role of cancer-derived microRNAs in cancer immune escape
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Metadata
- Authors
- Tian, X., Shen, H., Li, Z., Wang, T., & Wang, S.
- Venue
- Journal of Hematology & Oncology
- Published
- 2019-08-22
- Volume
- 12
- Issue
- 1
- Pages
- 84-84
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W2969934413
- Cited by
- 264
- References
- 144
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- gold
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