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A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration

Wang, Yiming, Chen, Song, Yan, Zuoqin, Pei, Ming·2019·Cell & Bioscience
DOI 10.1186/s13578-018-0264-9PMC PMC6321683
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Fig. 1 A schematic diagram of immortalization strategy combined with the decellularized cell-deposited extracellular matrix approach to overcome cell senescence and promote tissue regeneration
Fig. 1 A schematic diagram of immortalization strategy combined with the decellularized cell-deposited extracellular matrix approach to overcome cell senescence and promote tissue regenerationCC BY · PubMed Central
Fig. 2 Signaling pathways mediating the cellular senescence process. In response to telomere erosion, ROS production, the expression of oncogenes and the loss of tumor suppressors, various signaling pathways including TGFβ, BMP, Wnt, MAPK, FGF, IGF, HIF and Hippo pathways are all actively involved in cell cycle regulation, which eventually influences the cellular senescence process of primary cells
Fig. 2 Signaling pathways mediating the cellular senescence process. In response to telomere erosion, ROS production, the expression of oncogenes and the loss of tumor suppressors, various signaling pathways including TGFβ, BMP, Wnt, MAPK, FGF, IGF, HIF and Hippo pathways are all actively involved in cell cycle regulation, which eventually influences the cellular senescence process of primary cellsCC BY · PubMed Central

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Metadata

Authors
Wang, Y., Chen, S., Yan, Z., & Pei, M.
Venue
Cell & Bioscience
Publisher
Springer Science and Business Media LLC
Published
2019-01-05
Volume
9
Issue
1
ISSN
2045-3701
DOI
10.1186/s13578-018-0264-9
PMC
PMC6321683
Cited by
56
References
41
Language
en
Licence
Funders
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR067747-01A1)
  • Musculoskeletal Transplant Foundation (Established Investigator Award)
  • National Natural Science Foundation of China (81672157, 81601889)

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