Cited by 369Gut microbiota and healthGastrointestinal motility and disordersAutism Spectrum Disorder Research

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

A prebiotic intervention study in children with autism spectrum disorders (ASDs)

Open access

Grimaldi, Roberta, Gibson, Glenn R., Vulevic, Jelena, Giallourou, Natasa, Castro-Mejía, Josué L., Hansen, Lars H., Leigh Gibson, E., Nielsen, Dennis S., Costabile, Adele·2018·Microbiome

DOI 10.1186/s40168-018-0523-3PMC PMC6091020

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Different dietary approaches, such as gluten and casein free diets, or the use of probiotics and prebiotics have been suggested in autistic spectrum disorders in order to reduce gastrointestinal (GI) disturbances. GI symptoms are of particular interest in this population due to prevalence and correlation with the severity of behavioural traits. Nowadays, there is lack of strong evidence about the effect of dietary interventions on these problems, particularly prebiotics. Therefore, we assessed the impact of exclusion diets and a 6-week Bimuno® galactooligosaccharide (B-GOS®) prebiotic intervention in 30 autistic children. RESULTS: The results showed that children on exclusion diets reported significantly lower scores of abdominal pain and bowel movement, as well as lower abundance of Bifidobacterium spp. and Veillonellaceae family, but higher presence of Faecalibacterium prausnitzii and Bacteroides spp. In addition, significant correlations were found between bacterial populations and faecal amino acids in this group, compared to children following an unrestricted diet. Following B-GOS® intervention, we observed improvements in anti-social behaviour, significant increase of Lachnospiraceae family, and significant changes in faecal and urine metabolites. CONCLUSIONS: To our knowledge, this is the first study where the effect of exclusion diets and prebiotics has been evaluated in autism, showing potential beneficial effects. A combined dietary approach resulted in significant changes in gut microbiota composition and metabolism suggesting that multiple interventions might be more relevant for the improvement of these aspects as well as psychological traits. TRIAL REGISTRATION: NCT02720900 ; registered in November 2015.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/s40168-018-0523-3

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Fig. 1 GI symptom assessment during 3 weeks baseline data collection. S exclusion diets; N unrestricted diet; *P < 0.05; ***P < 0.001CC BY · PubMed Central

Fig. 2 a ATEC questionnaire. Results showed consistent reduction over time in anti-sociability score in children on the combination of the exclusion diet and B-GOS intervention, with the most apparent difference occurring at follow-up (time × diet × treatment interaction, p = 0.05; adjusted for age). Placebo:Maltodextrin. b AQ questionnaire. After intervention and including follow-up, social skills were improved (i.e. scores were lower) by B-GOS treatment in children on the exclusion diet only (diet × treatment interaction, P < 0.05). Results were reported as estimated marginal means ± standard error (SE). NB, post-hoc comparisons are not valid where covariates are includedCC BY · PubMed Central

Fig. 3 a PCA plot showing differences in microbial genera based on diet as determined by RDA analysis. b PCA plot displaying differences in microbial genera after B-GOS treatment in un-restricted diet group as determined by RDA analysis. Blue dots: after B-GOS® intervention; pink dots: before B-GOS® intervention. X displays the loading positions of the most discriminative bacterial generaCC BY · PubMed Central

Fig. 4 Summary of the correlation between bacterial changes and metabolic variation in faecal samples of children following exclusion diet a and those in un-restricted diet b. OUTs: bacterial groups. Arrows: metabolites identified; Squares: bacteria involved in the metabolic pathway. OTU001: Bifidobacterium spp.; OUT002: Bifidobacterium longum; OTU003: Coriobacteriaceae; OTU004: Eggerthella lenta; OTU005: Bacteroides spp.; OTU006: B. fragilis; OTU007: B. ovatus; OTU008: B. uniformis; OTU009: Rikenellaceae spp.; OTU010: Lactococcus spp.; OTU011: Streptococcus arginosus; OTU012: Clostridiales; OUT013: Clostridiaceae; OTU014: Dehalobacterium spp.; OTU015: Roseburia spp., OTU016: F. prausnitzii; OTU017: Coprobacillus spp.; OTU018: Akkermansia muciphilaCC BY · PubMed Central

Fig. 5 Study information. a Flow of participants through the study. b Study designCC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,770
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634
Self-citation
An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea
McDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,144
Stool form scale as a useful guide to intestinal transit time
Lewis, S. J., & Heaton, K. W. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709011203 · Cited by 3,244
Differential abundance analysis for microbial marker-gene surveys
Paulson, J. N., Stine, O. C., Bravo, H. C., & Pop, M. (2013) · Nature Methods · doi:10.1038/nmeth.2658 · Cited by 2,471
The Domain-specific Probe EUB338 is Insufficient for the Detection of all Bacteria: Development and Evaluation of a more Comprehensive Probe Set
Daims, H., Brühl, A., Amann, R., SCHLEIFER, K. H., & Wagner, M. (1999) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(99)80053-8 · Cited by 2,273
The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics
Swanson, K. S., Gibson, G. R., Hutkins, R., Reimer, R. A., Reid, G., Verbeke, K., Scott, K. P., Holscher, H. D., Azad, M. B., Delzenne, N. M., et al. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0344-2 · Cited by 2,196
Self-citation
Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity
Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076
New evidences on the altered gut microbiota in autism spectrum disorders
Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0242-1 · Cited by 1,040
Pyrosequencing study of fecal microflora of autistic and control children
Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977
Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976
Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in fecal samples
Langendijk-Genevaux, P. S., Schut, F., Jansen, G. J., Raangs, G. C., Kamphuis, G. R., Wilkinson, M. H. F., & Welling, G. W. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.8.3069-3075.1995 · Cited by 974
The role of microbial amino acid metabolism in host metabolism
Neis, E., Dejong, C., & Rensen, S. (2015) · Nutrients · doi:10.3390/nu7042930 · Cited by 920
Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein claudin-1 transcription
Wang, H.-B., Wang, P.-Y., Wang, X., Wan, Y.-L., & Liu, Y.-C. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2259-4 · Cited by 827
A parent-report measure of children's anxiety: psychometric properties and comparison with child-report in a clinic and normal sample
Nauta, M. H., Scholing, A., Rapee, R. M., Abbott, M., Spence, S. H., & Waters, A. (2004) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(03)00200-6 · Cited by 763
Probiotics: Definition, Sources, Selection, and Uses
Sanders, M. E. (2008) · Clinical Infectious Diseases · doi:10.1086/523341 · Cited by 662
The Autism Spectrum Quotient: Children’s Version (AQ-Child)
Bonnie Auyeung, B., Baron‐Cohen, S., Wheelwright, S. J., & Allison, C. L. (2007) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0504-z · Cited by 650
Gastrointestinal microbiota in children with autism in Slovakia
Tomova, A., Husarova, V., Lakatosova, S., Bakos, J., Vlkova, B., Babinska, K., & Ostatnikova, D. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.033 · Cited by 632
Rapid and Noninvasive Metabonomic Characterization of Inflammatory Bowel Disease
Marchesi, J. R., Holmes, E. C., Khan, F. M. A., Kochhar, S., Scanlan, P. D., Shanahan, F., Wilson, I. D., & Wang, Y. (2007) · Journal of Proteome Research · doi:10.1021/pr060470d · Cited by 632
Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers
Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., Murphy, E., Cryan, J. F., Dinan, T. G., & Clarke, G. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.191 · Cited by 513
The Gut Microbiota and Autism Spectrum Disorders
Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462
The Children’s Empathy Quotient and Systemizing Quotient: Sex Differences in Typical Development and in Autism Spectrum Conditions
Bonnie Auyeung, B., Wheelwright, S. J., Allison, C. L., Atkinson, M., Samarawickrema, N., & Baron‐Cohen, S. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0772-x · Cited by 355
Erratum to: Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing
Greninger, A. L., Messacar, K., Dunnebacke, T. H., Naccache, S. N., Federman, S., Bouquet, J., Mirsky, D. M., Nomura, Y., Yagi, S., Glaser, C. A., et al. (2016) · Genome Medicine · doi:10.1186/s13073-015-0257-9 · Cited by 333
The Gluten-Free, Casein-Free Diet In Autism: Results of A Preliminary Double Blind Clinical Trial
Elder, J. H., Shankar, M. N., Shuster, J. J., Theriaque, D. W., Burns, S., & Sherrill, L. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0079-0 · Cited by 312
Autism spectrum disorders and intestinal microbiota
De Angelis, M., Francavilla, R., Piccolo, M., De Giacomo, A., & Gobbetti, M. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1035855 · Cited by 311
The influence of a short-term gluten-free diet on the human gut microbiome
Bonder, M. J., Tigchelaar, E. F., Cai, X., Trynka, G., Cénit, M. C., Hrdličková, B., Zhong, H., Vatanen, T., Gevers, D., Wijmenga, C., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0295-y · Cited by 299
Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders
Nankova, B. B., Agarwal, R., MacFabe, D. F., & La Gamma, E. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103740 · Cited by 294
The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders
Whiteley, P., Haracopos, D., Knivsberg, A.-M., Reichelt, K. L., Parlar, S., Jacobsen, J., Seim, A., Pedersen, L., Schondel, M., & Shattock, P. (2010) · Nutritional Neuroscience · doi:10.1179/147683010x12611460763922 · Cited by 266
Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet
Candela, M., Biagi, E., Soverini, M., Consolandi, C., Quercia, S., Severgnini, M., Peano, C., Turroni, S., Rampelli, S., Pozzilli, P., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001045 · Cited by 260
Impact of Diet on Human Intestinal Microbiota and Health
Salonen, A., & de Vos, W. M. (2014) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030212-182554 · Cited by 220
Deletion of Type 3 Adenylyl Cyclase Perturbs the Postnatal Maturation of Olfactory Sensory Neurons and Olfactory Cilium Ultrastructure in Mice
Zhang, Z., Yang, D. J., Zhang, M., Zhu, N., Zhou, Y., Storm, D. R., & Wang, Z. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00001 · Cited by 220
Autism and Clostridium tetani
Bolte, E. R. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90107-4 · Cited by 213
Gastrointestinal issues in autism spectrum disorder
Hsiao, E. Y. (2014) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000029 · Cited by 209
Intestinal Pathophysiology in Autism
White, J. F. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322800601 · Cited by 197
The gluten-free/casein-free diet: a double-blind challenge trial in children with autism
Hyman, S. L., Stewart, P. A., Foley, J., Cain, U., Peck, R., Morris, D. D., Wang, H., & Smith, T. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2564-9 · Cited by 192
The level of arabinitol in autistic children after probiotic therapy
Kałużna-Czaplińska, J., & Błaszczyk, S. (2012) · Nutrition · doi:10.1016/j.nut.2011.08.002 · Cited by 189
Rhizosphere microbiomes of potato cultivated in the High Andes show stable and dynamic core microbiomes with different responses to plant development
Pfeiffer, S., Mitter, B., Oswald, A., Schloter-Hai, B., Schloter, M., Declerck, S., & Sessitsch, A. (2016) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiw242 · Cited by 188
Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: Based on parental report
Pennesi, C. M., & Klein, L. C. (2012) · Nutritional Neuroscience · doi:10.1179/1476830512y.0000000003 · Cited by 180
Vitamin D and autism, what’s new?
Cannell, J. J. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-017-9409-0 · Cited by 178
Vitamin D and autism: Clinical review
Kočovská, E., Fernell, E., Billstedt, E., Minnis, H., & Gillberg, C. (2012) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2012.02.015 · Cited by 176
Gluten-free and casein-free diets in the treatment of autism spectrum disorders: A systematic review
Mulloy, A. M., Lang, R. B., O’Reilly, M. F., Sigafoos, J., Lancioni, G. E., & Rispoli, M. J. (2009) · Research in Autism · doi:10.1016/j.rasd.2009.10.008 · Cited by 172
A double-blind, placebo-controlled, crossover-designed probiotic feeding study in children diagnosed with autistic spectrum disorders.
Parracho, H. M. R. T., Gibson, G. R., Knott, F., Bosscher, D., Kleerebezem, M., & McCartney, A. L. (2010) · International Journal of Probiotics and Prebiotics · Cited by 162
Self-citation
Eating behaviors, diet quality, and gastrointestinal symptoms in children with autism spectrum disorders: a brief review
Kral, T. V. E., Eriksen, W. T., Souders, M. C., & Pinto-Martin, J. A. (2013) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2013.01.008 · Cited by 153
Application of Weibull model for survival of patients with gastric cancer
Zhu, H. P., Xia, X. P., Yu, C. H., Adnan, A., Liu, S. F., & Du, Y. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-1 · Cited by 151
Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway
DeCastro, M., Nankova, B. B., Shah, P., Patel, P., Mally, P. V., Mishra, R., & La Gamma, E. F. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.09.002 · Cited by 149
A Comparison of the Autism Treatment Evaluation Checklist (ATEC) and the Childhood Autism Rating Scale (CARS) for the Quantitative Evaluation of Autism
Geier, D. A., Kern, J. K., & Geier, M. R. (2013) · Journal of Mental Health Research in Intellectual Disabilities · doi:10.1080/19315864.2012.681340 · Cited by 121
Elimination diets’ efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder
Ly, V., Bottelier, M. A., Hoekstra, P. J., Vásquez, A. A., Buitelaar, J. K., & Rommelse, N. N. J. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-0959-1 · Cited by 120
A Novel Rodent Model of Autism: Intraventricular Infusions of Propionic Acid Increase Locomotor Activity and Induce Neuroinflammation and Oxidative Stress in Discrete Regions of Adult Rat Brain
MacFabe, D. F., Rodríguez-Capote, K., Hoffman, J. E., Franklin, A. E., Mohammad-A, Y., Taylor, A. R., Boon, F. H., Cain, D. P., Kavaliers, M., Possmayer, F., et al. (2008) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2008.146.166 · Cited by 115
Metabolomic Analysis of Biochemical Changes in the Plasma and Urine of First-Episode Neuroleptic-Naïve Schizophrenia Patients after Treatment with Risperidone
Cai, H., Huan-de, L., Yan, X., Sun, B. H., Zhang, Q., Yan, M., Zhang, W., Jiang, P., Zhu, R., Liu, Y., et al. (2012) · Journal of Proteome Research · doi:10.1021/pr300459d · Cited by 115
Gestational vitamin D deficiency and autism spectrum disorder
Vinkhuyzen, A. A. E., Eyles, D. W., Burne, T. H. J., Blanken, L. M. E., Kruithof, C. J., Verhulst, F. C., White, T. J. H., Jaddoe, V. W. V., Tiemeier, H. W., & McGrath, J. J. (2017) · BJPsych Open · doi:10.1192/bjpo.bp.116.004077 · Cited by 113
In vitro fermentation of B-GOS: impact on faecal bacterial populations and metabolic activity in autistic and non-autistic children
Grimaldi, R., Cela, D., Swann, J. R., Vulevic, J., Gibson, G. R., Tzortzis, G., & Costabile, A. (2017) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiw233 · Cited by 109
Self-citation
Effects of Gluten Free / Casein Free Diet in Young Children with Autism: A Pilot Study
Johnson, C. R., Handen, B. L., Zimmer, M., Sacco, K. A., & Turner, K. S. (2010) · Journal of Developmental and Physical Disabilities · doi:10.1007/s10882-010-9217-x · Cited by 92
A Comprehensive Approach to Treating Autism and Attention-Deficit Hyperactivity Disorder: A Prepilot Study
Patel, K., & Curtis, L. T. (2007) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2007.0611 · Cited by 78
Nutritional Impact of a Gluten-Free Casein-Free Diet in Children with Autism Spectrum Disorder
Marí-Bauset, S., Llopis-González, A., Zazpe, I., Marí-Sanchis, A., & Suárez-Varela, M. M. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2582-7 · Cited by 75
Short chain fatty acids induce TH gene expression via ERK-dependent phosphorylation of CREB protein
Shah, P. G., Nankova, B. B., Parab, S., & Gamma, E. F. L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.097 · Cited by 71
Comparison of nutritional status between children with autism spectrum disorder and typically developing children in the Mediterranean Region (Valencia, Spain)
Marí-Bauset, S., González, A. L., Zazpe, I., Marí-Sanchis, A., & Morales‐Suárez‐Varela, M. (2016) · Autism · doi:10.1177/1362361316636976 · Cited by 60
Gluten and casein supplementation does not increase symptoms in children with autism spectrum disorder
Pusponegoro, H. D., Ismael, S., Firmansyah, A., Sastroasmoro, S., & Vandenplas, Y. (2015) · Acta Paediatrica · doi:10.1111/apa.13108 · Cited by 54
The human gut microbiota with reference to autism spectrum disorder: considering the whole as more than a sum of its parts
Toh, M. C. W., & Allen‐Vercoe, E. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26309 · Cited by 51
A pilot study to evaluate nutritional influences on gastrointestinal symptoms and behavior patterns in children with Autism Spectrum Disorder
Harris, C., & Card, B. (2012) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2012.08.004 · Cited by 51
NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers
Fukuhara, K., Ohno, A., Ota, Y., Senoo, Y., Maekawa, K., Okuda, H., Kurihara, M., Okuno, A., Niida, S., Saito, Y., et al. (2013) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.12-118 · Cited by 50
Fermentation properties and potential prebiotic activity of Bimuno®galacto-oligosaccharide (65 % galacto-oligosaccharide content) onin vitrogut microbiota parameters
Grimaldi, R., Swann, J. R., Vulevic, J., Gibson, G. R., & Costabile, A. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002269 · Cited by 48
Self-citation
Metabolic adaptation of colonic microbiota to galactooligosaccharides: a proof‐of‐concept‐study
Mego, M., Manichanh, C., Accarino, A. M., Campos, D., Pozuelo, M., Varela, E., Vulevic, J., Tzortzis, G., Gibson, G. R., Guarner, F., et al. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13931 · Cited by 46
Self-citation
A review of candidate urinary biomarkers for autism spectrum disorder
Wang, L., Angley, M. T., Gerber, C., & Sorich, M. J. (2011) · Biomarkers · doi:10.3109/1354750x.2011.598564 · Cited by 43
Butyrate, a gut-derived environmental signal, regulates tyrosine hydroxylase gene expression via a novel promoter element
Patel, P., Nankova, B. B., & LaGamma, E. F. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.08.005 · Cited by 40
Differential regulation of the tyrosine hydroxylase and enkephalin neuropeptide transmitter genes in rat PC12 cells by short chain fatty acids: Concentration-dependent effects on transcription and RNA stability
Parab, S., Nankova, B. B., & Gamma, E. F. L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.013 · Cited by 36
The gluten- and casein-free diet and autism: Communication outcomes from a preliminary double-blind clinical trial.
Seung, H., Rogalski, Y., Shankar, M. N., & Elder, J. H. (2007) · Journal of medical speech-language pathology · Cited by 34
Intestinal permeability and nutritional status in developmental disorders.
Souza, N. C., Mendonça, J. N., Portari, G. V., Jordão, A. A., Marchini, J. S., & Chiarello, P. G. (2012) · PubMed · Cited by 32
Nicotinic Induction of Preproenkephalin and Tyrosine Hydroxylase Gene Expression in Butyrate-Differentiated Rat PC12 Cells: A Model for Adaptation to Gut-Derived Environmental Signals
Nankova, B. B., Chua, J., Mishra, R., Kobasiuk, C. D., & Gamma, E. F. L. (2003) · Pediatric Research · doi:10.1203/00006450-200301000-00019 · Cited by 22
Impact of Casein and Gluten Free Dietary Intervention on Selected Autistic Children
Nazni, P., Wesely, E. G., & Nishadevi, V. (2008) · TSpace (University of Toronto) · Cited by 16
Diet and the Gut Microbiota – How the Gut
Tuohy, K. M., Venuti, P., Cuva, S., Furlanello, C., Gasperotti, M., Mancini, A., Ceppa, F., Cavalieri, D., Filippo, C. D., Vrhovšek, U., et al. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407825-3.00015-0 · Cited by 10
EFFICACY OF NUTRITIONAL ERGOGENIC AIDS IN HOT ENVIRONMENTS
Ely, B. R., & Cheuvront, S. N. (2010) · Current Topics in Nutraceutical Research · Cited by 9
A large cross-sectional, descriptive study of self-reports after biofield therapy in Japan: demography, symptomology, and circumstances of treatment administration.
Suzuki, K., Uchida, S., Kimura, T., & Katamura, H. (2012) · PubMed · Cited by 7

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
The gut microbiome in neurological disorders
Cryan, J. F., O'Riordan, K. J., Sandhu, K., Peterson, V., & Dinan, T. G. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30356-4 · Cited by 1,336
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182
Faecalibacterium : a bacterial genus with promising human health applications
Martín, R., Ríos-Covián, D., Huillet, E., Auger, S., Khazaal, S., Bermúdez‐Humarán, L. G., Sokol, H., Chatel, J., & Langella, P. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad039 · Cited by 630
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Esfehani, R. J., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 586

See all 369

Authors: Grimaldi, R., Gibson, G. R., Vulevic, J., Giallourou, N., Castro-Mejía, J. L., Hansen, L. H., Leigh Gibson, E., Nielsen, D. S., & Costabile, A.
Affiliations: Clasado BioSciences (United Kingdom) (GB)
University of Reading (GB)
Imperial College London (GB)
University of Copenhagen (DK)
Aarhus University (DK)
University of Roehampton (GB)
Corresponding author: Grimaldi, Roberta
ORCID: Grimaldi, Roberta
Gibson, Glenn R.
Vulevic, Jelena
Giallourou, Natasa
Castro-Mejía, Josué L.
Hansen, Lars H.
Nielsen, Dennis S.
Costabile, Adele
Venue: Microbiome
Publisher: Springer Science and Business Media LLC
Published: 2018-08-02
Volume: 6
Issue: 1
Pages: 133-133
ISSN: 2049-2618 (ISSN-L)
DOI: 10.1186/s40168-018-0523-3
PMC: PMC6091020
OpenAlex: W2887688374
Cited by: 369
References: 73
Citations by year: 2026: 26 · 2025: 46 · 2024: 47 · 2023: 58 · 2022: 60 · 2021: 47 · 2020: 51 · 2019: 31 · 2018: 3
FWCI: 11.74
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: Microbiome (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
CentAUR (University of Reading) (acceptedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Spiral (Imperial College London) (submittedVersion, cc-by)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords: autism spectrum disorder, prebiotics, galactooligosaccharides, elimination diet, gluten-free diet, casein-free diet, gut microbiota, gastrointestinal symptoms, abdominal pain, Faecalibacterium prausnitzii, Bifidobacterium, urinary metabolites, antisocial behavior, children
MeSH terms: Autism Spectrum Disorder, Bacteria, Child, Child, Preschool, Double-Blind Method, Feces, Female, Humans, Male, Urine, Gastrointestinal Tract, Prebiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A prebiotic intervention study in children with autism spectrum disorders (ASDs)

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks